CD40 stimulation accelerates deletion of tumor-specific CD8⁺T cells in the absence of tumor-antigen vaccination

Novel p19 Protein Engages IL-12p40 to Form a Cytokine, IL-23, with Biological Activities Similar as Well as Distinct from IL-12

2000 • 2,755 citations

T-cell help for cytotoxic T lymphocytes is mediated by CD40–CD40L interactions

1998 • 2,615 citations

A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell

1998 • 2,373 citations

Help for cytotoxic-T-cell responses is mediated by CD40 signalling

1998 • 2,106 citations

The Central Role of CD4+ T Cells in the Antitumor Immune Response

1998 • 1,332 citations

Characterization of circulating T cells specific for tumor-associated antigens in melanoma patients

1999 • 1,131 citations

Prognostic value of tumor infiltrating lymphocytes in the vertical growth phase of primary cutaneous melanoma

1996 • 1,110 citations

CD40 Triggering of Heterodimeric IL-12 p70 Production by Dendritic Cells In Vivo Requires a Microbial Priming Signal

2000 • 558 citations

Ex Vivo Staining of Metastatic Lymph Nodes by Class I Major Histocompatibility Complex Tetramers Reveals High Numbers of Antigen-experienced Tumor-specific Cytolytic T Lymphocytes

1998 • 534 citations

High Frequencies of Naive Melan-a/Mart-1–Specific Cd8+ T Cells in a Large Proportion of Human Histocompatibility Leukocyte Antigen (Hla)-A2 Individuals

1999 • 497 citations

Detection of Antigen-Specific T Cells with Multivalent Soluble Class II MHC Covalent Peptide Complexes

1998 • 465 citations

CD40 activation in vivo overcomes peptide-induced peripheral cytotoxic T-lymphocyte tolerance and augments anti-tumor vaccine efficacy

1999 • 463 citations

Melanocyte Destruction after Antigen-Specific Immunotherapy of Melanoma

2000 • 423 citations

Isolation of High Avidity Melanoma-Reactive CTL from Heterogeneous Populations Using Peptide-MHC Tetramers

1999 • 423 citations

T Cells Compete for Access to Antigen-Bearing Antigen-Presenting Cells

2000 • 423 citations

Conversion of tumor-specific CD4+ T-cell tolerance to T-cell priming through in vivo ligation of CD40

1999 • 409 citations

Vaccination with a recombinant vaccinia virus encoding a “self” antigen induces autoimmune vitiligo and tumor cell destruction in mice: Requirement for CD4⁺T lymphocytes

1999 • 383 citations

Tumor infiltrating lymphocytes in lymph node melanoma metastases: a histopathologic prognostic indicator and an expression of local immune response.

1996 • 319 citations

Serological identification of human tumor antigens

1997 • 318 citations

Tumour progression and the nature of cancer

1991 • 273 citations

Inflammatory cytokines enhance the in vivo clonal expansion and differentiation of antigen-activated CD4+ T cells.

1997 • 263 citations

Lipopolysaccharide interferes with the induction of peripheral T cell death

1995 • 240 citations

Cationic Liposome-mediated Intravenous Gene Delivery

1995 • 228 citations

Antigen processing in vivo and the elicitation of primary CTL responses.

1995 • 226 citations

Serological analysis of human tumor antigens: molecular definition and implications

1997 • 216 citations

Use of adoptive transfer of T‐cell antigen‐receptor‐transgenic T cells for the study of T‐cell activation in vivo

1997 • 205 citations

An Expanded Peripheral T Cell Population to a Cytotoxic T Lymphocyte (Ctl)-Defined, Melanocyte-Specific Antigen in Metastatic Melanoma Patients Impacts on Generation of Peptide-Specific Ctls but Does Not Overcome Tumor Escape from Immune Surveillance in Metastatic Lesions

1999 • 197 citations

Role of gamma interferon and tumor necrosis factor alpha during T-cell-independent and -dependent phases of Mycobacterium avium infection

1994 • 182 citations

Monoclonal antibodies to murine CD40 define two distinct functional epitopes

1994 • 152 citations

T-cell subsets in delayed-type hypersensitivity, protection, and granuloma formation in primary and secondary Listeria infection in mice: superior role of Lyt-2+ cells in acquired immunity

1988 • 150 citations

Spontaneous regression of human melanoma/nonmelanoma skin cancer: Association with infiltrating CD4⁺ T cells

1995 • 146 citations

Adjuvant Effect of IL-12: Conversion of Peptide Antigen Administration from Tolerizing to Immunizing for CD8+ T Cells In Vivo

1999 • 138 citations

Therapeutic activity of agonistic monoclonal antibodies against CD40 in a chronic autoimmune inflammatory process

2000 • 121 citations

T‐cell‐independent granuloma formation in response to Mycobacterium avium: role of tumour necrosis factor‐α and interferon‐γ

1997 • 113 citations

Cytokines in cancer therapy

2000 • 93 citations

Bystander Virus Infection Prolongs Activated T Cell Survival

1999 • 90 citations

Mutant ras epitopes as targets for cancer vaccines.

1996 • 87 citations

Accumulation of Identical T Cells in Melanoma and Vitiligo-Like Leukoderma

1999 • 80 citations

In Situ T Cell Responses Against Melanoma Comprise High Numbers of Locally Expanded T Cell Clonotypes

1999 • 64 citations

In situ T cells in melanoma

1999 • 59 citations

T-cell recognition of self peptides as tumor rejection antigens

1996 • 58 citations

p53: A Potential Target Antigen for Immunotherapy of Cancer

2000 • 57 citations

Insight into the mechanism(s) through which TNF promotes the generation of T cell-mediated antitumor cytotoxicity by tumor bearer splenic cells.

1996 • 55 citations

CML vaccines as a paradigm of the specific immunotherapy of cancer

2000 • 52 citations

Migration and activation of antigen-specific CD8+ T cells upon in vivo stimulation with allogeneic tumor.

1997 • 49 citations

Clinical diagnosis and therapy of cutaneous melanoma in situ

1996 • 41 citations

Medical management of stage IV malignant melanoma. Medical issues

1995 • 39 citations

Tumor-specific adoptive T-cell therapy for CD40+ B-cell malignancies

1998 • 14 citations

Prevention of anergy induction in cloned T cells by interleukin 12

1994 • 7 citations