Antigen recognition strength regulates the choice between extrafollicular plasma cell and germinal center B cell differentiation

Intraclonal generation of antibody mutants in germinal centres

1991 • 1,083 citations

Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody genes

1989 • 1,015 citations

Maturation of the immune response in germinal centers

1991 • 904 citations

Visualization of Specific B and T Lymphocyte Interactions in the Lymph Node

1998 • 762 citations

Sites of specific B cell activation in primary and secondary responses to T cell‐dependent and T cell‐independent antigens

1991 • 743 citations

Excess BAFF Rescues Self-Reactive B Cells from Peripheral Deletion and Allows Them to Enter Forbidden Follicular and Marginal Zone Niches

2004 • 711 citations

Elimination from peripheral lymphoid tissues of self-reactive B lymphocytes recognizing membrane-bound antigens

1991 • 694 citations

In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. I. The architecture and dynamics of responding cell populations.

1991 • 683 citations

Extrafollicular antibody responses

2003 • 617 citations

Affinity Dependence of the B Cell Response to Antigen: A Threshold, a Ceiling, and the Importance of Off-Rate

1998 • 475 citations

NEUTRALIZING ANTIVIRAL B CELL RESPONSES

1997 • 467 citations

Structure of an antibody-antigen complex: crystal structure of the HyHEL-10 Fab-lysozyme complex.

1989 • 456 citations

In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. II. A common clonal origin for periarteriolar lymphoid sheath-associated foci and germinal centers.

1992 • 456 citations

B‐cell activation by T‐cell‐independent type 2 antigens as an integral part of the humoral immune response to pathogenic microorganisms

2000 • 452 citations

Molecular determinants of immunogenicity: the immunon model of immune response.

1976 • 366 citations

In Situ Studies of the Primary Immune Response to (4-Hydroxy-3-Nitrophenyl)Acetyl. V. Affinity Maturation Develops in Two Stages of Clonal Selection

1998 • 349 citations

Antigen-driven B cell differentiation in vivo.

1993 • 308 citations

Anti-phosphorylcholine antibodies of the T15 idiotype are optimally protective against Streptococcus pneumoniae.

1982 • 303 citations

Germinal Centers without T Cells

2000 • 292 citations

Role of BCR affinity in T cell–dependent antibody responses in vivo

2002 • 288 citations

Role of antigen receptor affinity in T cell–independent antibody responses in vivo

2002 • 263 citations

Early appearance of germinal center–derived memory B cells and plasma cells in blood after primary immunization

2005 • 254 citations

The Choice of T‐Cell Epitopes Utilized on a Protein Antigen Depends on Multiple Factors Distant from, as well as at the Determinant Site

1987 • 247 citations

B Cell Receptor–independent Stimuli Trigger Immunoglobulin (Ig) Class Switch Recombination and Production of IgG Autoantibodies by Anergic Self-Reactive B Cells

2003 • 223 citations

Evidence from the generation of immunoglobulin G–secreting cells that stochastic mechanisms regulate lymphocyte differentiation

2003 • 199 citations

Early high-affinity neutralizing anti-viral IgG responses without further overall improvements of affinity.

1995 • 197 citations

Very Low Affinity B Cells Form Germinal Centers, Become Memory B Cells, and Participate in Secondary Immune Responses When Higher Affinity Competition Is Reduced

2002 • 181 citations

Antigen Drives Very Low Affinity B Cells to Become Plasmacytes and Enter Germinal Centers

1998 • 169 citations

The immunogenicity of soluble haptenated polymers is determined by molecular mass and hapten valence.

1989 • 161 citations

Antigens Varying in Affinity for the B Cell Receptor Induce Differential B Lymphocyte Responses

1998 • 143 citations

CD84 is up-regulated on a major population of human memory B cells and recruits the SH2 domain containing proteins SAP and EAT-2

2002 • 92 citations

Altered Migration, Recruitment, and Somatic Hypermutation in the Early Response of Marginal Zone B Cells to T Cell-Dependent Antigen

2005 • 87 citations

Patterns of antibody specificity during the BALB/c immune response to hen eggwhite lysozyme.

1992 • 77 citations

Reduced Switching inSCIDB Cells Is Associated with Altered Somatic Mutation of Recombined S Regions

2003 • 65 citations

Reevaluation of stoichiometry and affinity/avidity in interactions between anti-hapten antibodies and mono- or multi-valent antigens

2000 • 57 citations

Kinetic epitope mapping of the chicken lysozyme.HyHEL‐10 fab complex: Delineation of docking trajectories

1998 • 46 citations

Membrane IgM-mediated signaling of human B cells. Effect of increased ligand binding site valency on the affinity and concentration requirements for inducing diverse stages of activation.

1992 • 38 citations

Antigen-induced changes in phospholipid metabolism in antigen-binding B lymphocytes.

1987 • 34 citations

Clonal Selection in B‐Cell Growth and Differentiation

1987 • 34 citations

Segmental flexibility and avidity of IgM in the interaction of polyvalent antigens

2003 • 32 citations

Affinity requirements for induction of sequential phases of human B cell activation by membrane IgM-cross-linking ligands.

1991 • 32 citations