Constitutive activation of the CD40 pathway promotes cell transformation and neoplastic growth

The Hallmarks of Cancer

2000 • 27,569 citations

TNF- and Cancer Therapy-Induced Apoptosis: Potentiation by Inhibition of NF-κB

1996 • 2,665 citations

Induction of TNF Receptor I-Mediated Apoptosis via Two Sequential Signaling Complexes

2003 • 2,545 citations

NF-κB functions as a tumour promoter in inflammation-associated cancer

2004 • 2,370 citations

Creation of human tumour cells with defined genetic elements

1999 • 2,333 citations

Tumor necrosis factor signaling

2003 • 2,262 citations

An EBV membrane protein expressed in immortalized lymphocytes transforms established rodent cells

1985 • 1,257 citations

Induction of apoptosis in mature T cells by tumour necrosis factor

1995 • 1,139 citations

Aberrant rel/nfkb genes and activity in human cancer

1999 • 1,127 citations

Chronic infections and inflammatory processes as cancer risk factors: possible role of nitric oxide in carcinogenesis

1994 • 1,065 citations

Mice deficient in tumor necrosis factor-α are resistant to skin carcinogenesis

1999 • 833 citations

Chronic immune activation and inflammation as the cause of malignancy

2001 • 534 citations

Latent membrane protein 1of Epstein-Barr virus mimics a constitutively active receptor molecule

1997 • 433 citations

Mimicry of CD40 Signals by Epstein-Barr Virus LMP1 in B Lymphocyte Responses

1999 • 430 citations

Interaction between CD40 and its ligand gp39 in the development of murine lupus nephritis.

1995 • 371 citations

Cross-linking CD40 on B cells rapidly activates nuclear factor-kappa B.

1994 • 358 citations

Induction of cell death by tumour necrosis factor (TNF) receptor 2,CD40 and CD30: a role for TNF-R1 activation by endogenous membrane-anchored TNF

1999 • 286 citations

Modulation of NF-κB Activity and Apoptosis in Chronic Lymphocytic Leukemia B Cells

2000 • 278 citations

Activation of the cJun N-terminal kinase (JNK) pathway by the Epstein-Barr virus-encoded latent membrane protein 1 (LMP1)

1998 • 269 citations

Current uses of isolated limb perfusion in the clinic and a model system for new strategies

2003 • 237 citations

LMP1 structure and signal transduction

2001 • 237 citations

Inhibition of human B-cell lymphoma growth by CD40 stimulation

1994 • 232 citations

Phase I Study of Recombinant Human CD40 Ligand in Cancer Patients

2001 • 221 citations

Human monocytic cells contain high levels of intracellular Fas ligand: rapid release following cellular activation.

1997 • 203 citations

A novel function of CD40: induction of cell death in transformed cells.

1996 • 202 citations

Involvement of APO2 ligand/TRAIL in activation-induced death of Jurkat and human peripheral blood T cells

1998 • 188 citations

CD40 Induces Apoptosis in Carcinoma Cells through Activation of Cytotoxic Ligands of the Tumor Necrosis Factor Superfamily

2000 • 168 citations

Functional CD40 ligand is expressed by T cells in rheumatoid arthritis.

1997 • 166 citations

CD40 Ligation on Human Cord Blood CD34+Hematopoietic Progenitors Induces Their Proliferation and Differentiation into Functional Dendritic Cells

1997 • 161 citations

Differential Signaling and Tumor Necrosis Factor Receptor–Associated Factor (Traf) Degradation Mediated by Cd40 and the Epstein-Barr Virus Oncoprotein Latent Membrane Protein 1 (Lmp1)

2001 • 158 citations

The transforming domain alone of the latent membrane protein of Epstein-Barr virus is toxic to cells when expressed at high levels

1989 • 157 citations

Overexpression of Cd40 Ligand in Murine Epidermis Results in Chronic Skin Inflammation and Systemic Autoimmunity

2001 • 143 citations

CD40 and epithelial cells: across the great divide

1998 • 141 citations

Inhibition of Human Breast Carcinoma Growth by a Soluble Recombinant Human CD40 Ligand

1999 • 140 citations

Cytostatic Effect of Epstein–Barr Virus Latent Membrane Protein-1 Analyzed Using Tetracycline-Regulated Expression in B Cell Lines

1996 • 133 citations

Tumor necrosis factor-? in the pathogenesis and treatment of cancer

2004 • 131 citations

The Fas signalling pathway and its role in the pathogenesis of cancer

2004 • 125 citations

A CD40 Signalosome Anchored in Lipid Rafts Leads to Constitutive Activation of NF-κB and Autonomous Cell Growth in B Cell Lymphomas

2002 • 121 citations

Polyoma virus middle T antigen and its role in identifying cancer-related molecules

2002 • 114 citations

Cutting Edge: CD40 Engagement Up-Regulates Cyclooxygenase-2 Expression and Prostaglandin E2 Production in Human Lung Fibroblasts

1998 • 108 citations

Monoclonal Antibody Therapy of B Cell Lymphoma: Signaling Activity on Tumor Cells Appears More Important Than Recruitment of Effectors

1998 • 106 citations

The role of the CD40 pathway in the pathogenesis and treatment of cancer

2004 • 94 citations

Regulation of cytoplasmic, surface and soluble forms of CD40 ligand in mouse B cells

1998 • 84 citations

Blockade of CD40–CD40 Ligand Interactions Protects against Radiation-Induced Pulmonary Inflammation and Fibrosis

1998 • 84 citations

What is the real role of CD40 in cancer immunotherapy?

1999 • 77 citations

Activation of CD40 in Cervical Carcinoma Cells Facilitates CTL Responses and Augments Chemotherapy-Induced Apoptosis

2005 • 71 citations

TRAF1 Is a Critical Regulator of JNK Signaling by the TRAF-Binding Domain of the Epstein-Barr Virus-Encoded Latent Infection Membrane Protein 1 but Not CD40

2002 • 65 citations

The role of CD40 ligand and tumor necrosis factor α signaling in the transgenic K/BxN mouse model of rheumatoid arthritis

2000 • 63 citations

CD40 expression in bladder cancer

1999 • 54 citations

Differential Responses to CD40 Ligation Among Burkitt Lymphoma Lines That Are Uniformly Responsive to Epstein-Barr Virus Latent Membrane Protein 1

1999 • 52 citations

Prolonged Phenotypic, Functional, and Molecular Change in Group I Burkitt Lymphoma Cells on Short-Term Exposure to CD40 Ligand

1998 • 51 citations

CD40 and its ligand: Central players in B lymphocyte survival, growth, and differentiation

1995 • 51 citations

Signaling through death receptors in cancer therapy

2004 • 46 citations

In situ Expression of CD40 and CD40 Ligand in Psoriasis

2004 • 37 citations

COX-2 and its inhibition as a molecular target in the prevention and treatment of lung cancer

2004 • 34 citations

Population depletion activates autonomous CD154-dependent survival in biopsylike Burkitt lymphoma cells

2002 • 34 citations

Inhibition of Human Breast Carcinoma Growth by a Soluble Recombinant Human CD40 Ligand

1999 • 19 citations

Prognostic Value of CD40 in Adult Soft Tissue Sarcomas

2004 • 12 citations

Prolonged Phenotypic, Functional, and Molecular Change in Group I Burkitt Lymphoma Cells on Short-Term Exposure to CD40 Ligand

1998 • 6 citations