In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. II. A common clonal origin for periarteriolar lymphoid sheath-associated foci and germinal centers.

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Molecular cloning: A laboratory manual

1990 • 85,659 citations

Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase

1988 • 17,059 citations

Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase

1988 • 4,259 citations

Mechanism of antigen-driven selection in germinal centres

1989 • 1,097 citations

Intraclonal generation of antibody mutants in germinal centres

1991 • 1,083 citations

Maturation of the immune response in germinal centers

1991 • 904 citations

Fidelity of DNA synthesis by the Thermus aquaticus DNA polymerase

1988 • 814 citations

Sites of specific B cell activation in primary and secondary responses to T cell‐dependent and T cell‐independent antigens

1991 • 743 citations

In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. I. The architecture and dynamics of responding cell populations.

1991 • 683 citations

Heavy chain variable region contribution to the NPb family of antibodies: somatic mutation evident in a γ2a variable region

1981 • 677 citations

Anti-DNA antibodies from autoimmune mice arise by clonal expansion and somatic mutation.

1990 • 672 citations

Insertion of N regions into heavy-chain genes is correlated with expression of terminal deoxytransferase in B cells

1984 • 540 citations

Sequences of five potential recombination sites encoded close to an immunoglobulin kappa constant region gene.

1979 • 472 citations

Most peripheral B cells in mice are ligand selected.

1991 • 424 citations

Inter- and intraclonal diversity in the antibody response to influenza hemagglutinin.

1985 • 319 citations

Analysis of the repertoire of anti‐NP antibodies in C57BL/6 mice by cell fusion. I. Characterization of antibody families in the primary and hyperimmune response

1978 • 316 citations

Kinetic maturation of an immune response

1991 • 274 citations

Relationship of germinal centers in lymphoid tissue to immunologic memory. VI. Transfer of B cell memory with lymph node cells fractionated according to their receptors for peanut agglutinin.

1983 • 274 citations

Heat-stable antigen is a costimulatory molecule for CD4 T cell growth.

1992 • 254 citations

Functional anatomy of germinal centers

1984 • 233 citations

Clonal recruitment and somatic mutation in the generation of immunological memory to the hapten NP.

1986 • 227 citations

Expression and functional significance of the J11d marker on mouse thymocytes.

1987 • 218 citations

Timing, Genetic Requirements and Functional Consequences of Somatic Hypermutation during B‐Cell Development

1987 • 218 citations

Primary antibody-forming cells and secondary B cells are generated from separate precursor cell subpopulations

1989 • 215 citations

The repertoire of somatic antibody mutants accumulating in the memory compartment after primary immunization is restricted through affinity maturation and mirrors that expressed in the secondary response.

1990 • 200 citations

The Evolution of B-Cell Clones

1990 • 185 citations

Idiotypic analysis of the response of C57BL/6 mice to the (4‐hydroxy‐3‐nitrophenyl)acetyl group

1977 • 171 citations

Inherited Immunoglobulin Idiotypes of the Mouse

1977 • 168 citations

Molecular characterization of single memory B cells

1991 • 163 citations

Patterns of Somatic Mutations in Immunoglobulin Variable Genes

1987 • 158 citations

Accumulation of somatic mutants in the B cell compartment after primary immunization with a T cell‐dependent antigen

1992 • 119 citations

A limited number of B cell lineages generates the heterogeneity of a secondary immune response.

1987 • 83 citations

Among naive precursor cell subpopulations only progenitors of memory B cells originate germinal centers

1992 • 69 citations

GAMMA GLOBULIN AND ANTIBODY FORMATION IN VITRO

1962 • 67 citations

Antibody and Gamma Globulin Formation in Vitro in Hemopoietic Organs

1956 • 51 citations

Direct intrafollicular differentiation of memory B cells into plasma cells

1990 • 50 citations

The Path of Memory B‐Cell Development

1992 • 42 citations

Complement activation in human lymphoid germinal centres.

1989 • 41 citations

Chemotaxis of germinal centers B cells in response to C5a

1991 • 40 citations

The Immune Response to the Hapten NP in C57BL/6 Mice: Insights into the Structure of the B‐Cell Repertoire

1988 • 38 citations

Cellular Bases for Relative Radioresistance of the Antibody-Forming System at Advanced Stages of the Secondary Response to Tetanus Toxoid in Mice

1974 • 36 citations

Development of B cell lineages during a primary anti-hapten immune response.

1990 • 27 citations

The De Novo Generation of Germinal Centers is an Oligoclonal Process

1988 • 13 citations

The Effects of Immuno Suppressant Drugs Administered During Germinal Center Proliferation on Preparation for a Secondary Antibody Response in Rabbits

1967 • 11 citations