Flice-Inhibitory Protein Is a Key Regulator of Germinal Center B Cell Apoptosis

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Molecular characterization of mitochondrial apoptosis-inducing factor

1999 • 4,031 citations

FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex

1996 • 3,065 citations

Two CD95 (APO-1/Fas) signaling pathways

1998 • 3,045 citations

Inhibition of death receptor signals by cellular FLIP

1997 • 2,577 citations

FADD, a novel death domain-containing protein, interacts with the death domain of fas and initiates apoptosis

1995 • 2,436 citations

Involvement of MACH, a Novel MORT1/FADD-Interacting Protease, in Fas/APO-1- and TNF Receptor–Induced Cell Death

1996 • 2,306 citations

Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor.

1995 • 2,142 citations

TRADD–TRAF2 and TRADD–FADD Interactions Define Two Distinct TNF Receptor 1 Signal Transduction Pathways

1996 • 1,976 citations

Monoclonal Antibody-Mediated Tumor Regression by Induction of Apoptosis

1989 • 1,739 citations

Mechanism of antigen-driven selection in germinal centres

1989 • 1,097 citations

A Novel Protein That Interacts with the Death Domain of Fas/APO1 Contains a Sequence Motif Related to the Death Domain

1995 • 1,007 citations

Apoptosis signaling by death receptors

1998 • 976 citations

Apo2L/TRAIL-Dependent Recruitment of Endogenous FADD and Caspase-8 to Death Receptors 4 and 5

2000 • 968 citations

The Role of c-FLIP in Modulation of CD95-induced Apoptosis

1999 • 823 citations

FADD/MORT1 and Caspase-8 Are Recruited to TRAIL Receptors 1 and 2 and Are Essential for Apoptosis Mediated by TRAIL Receptor 2

2000 • 792 citations

Fas-mediated apoptosis and activation-induced T-cell proliferation are defective in mice lacking FADD/Mort1

1998 • 704 citations

Fas Preassociation Required for Apoptosis Signaling and Dominant Inhibition by Pathogenic Mutations

2000 • 650 citations

Inhibition of Fas death signals by FLIPs

1998 • 531 citations

Molecular ordering of the Fas-apoptotic pathway: The Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteine proteases

1996 • 519 citations

Germinal center cells express bcl‐2 protein after activation by signals which prevent their entry into apoptosis

1991 • 446 citations

Prevention of Constitutive TNF Receptor 1 Signaling by Silencer of Death Domains

1999 • 408 citations

CD95(APO-1/Fas)-Mediated Apoptosis: Live and Let Die

1998 • 405 citations

FLICE Is Predominantly Expressed as Two Functionally Active Isoforms, Caspase-8/a and Caspase-8/b

1997 • 405 citations

Self-association of the “Death Domains” of the p55 Tumor Necrosis Factor (TNF) Receptor and Fas/APO1 Prompts Signaling for TNF and Fas/APO1 Effects

1995 • 383 citations

Protection against Fas/APO-1- and tumor necrosis factor-mediated cell death by a novel protein, sentrin.

1996 • 323 citations

Life and Death in Germinal Centers (Redux)

1996 • 315 citations

TRAMP, a Novel Apoptosis-Mediating Receptor with Sequence Homology to Tumor Necrosis Factor Receptor 1 and Fas(Apo-1/CD95)

1997 • 268 citations

Activation-induced death of mature T cells in the regulation of immune responses

1995 • 248 citations

bcl-2 Transgene Expression Inhibits Apoptosis in the Germinal Center and Reveals Differences in the Selection of Memory B Cells and Bone Marrow Antibody-Forming Cells

2000 • 220 citations

Human germinal center B cells express the apoptosis-inducing genes Fas, c-myc, P53, and Bax but not the survival gene bcl-2.

1996 • 211 citations

Suppression of apoptosis in normal and neoplastic human B lymphocytes by CD40 ligand is independent of Bcl‐2 induction

1993 • 180 citations

FAS is highly expressed in the germinal center but is not required for regulation of the B-cell response to antigen.

1995 • 134 citations

Bcl-2 increases memory B cell recruitment but does not perturb selection in germinal centers

1994 • 133 citations

Functional CD95 ligand and CD95 death-inducing signaling complex in activation-induced cell death and doxorubicin-induced apoptosis in leukemic T cells

2000 • 128 citations

Concurrent engagement of CD40 and the antigen receptor protects naive and memory human B cells from APO-1/Fas-mediated apoptosis.

1996 • 117 citations

Relaxed Negative Selection in Germinal Centers and Impaired Affinity Maturation in bcl-xL Transgenic Mice

1999 • 110 citations

Sequential triggering of apoptosis, somatic mutation and isotype switch during germinal center development

1996 • 108 citations

Follicular dendritic cells inhibit apoptosis in human B lymphocytes by a rapid and irreversible blockade of preexisting endonuclease.

1995 • 86 citations

Regulation of the Fas Death Pathway by FLICE-Inhibitory Protein in Primary Human B Cells

2000 • 76 citations

Isolation and characteristics of tonsil centroblasts with reference to Ig class switching

1995 • 73 citations

Germinal Center B Cell Apoptosis Requires Both Caspase and Cathepsin Activity

1999 • 72 citations

Follicular dendritic cells and apoptosis: Life and death in the germinal centre

1995 • 42 citations

Antigen receptor‐induced apoptosis of human germinal center B cells is targeted to a centrocytic subset

1997 • 40 citations

Follicular dendritic cells and apoptosis: Life and death in the germinal centre

1995 • 31 citations