The role of bcl‐x_L in CD40‐mediated rescue from anti‐μ‐induced apoptosis in WEHI‐231 B lymphoma cells

A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry

1991 • 4,682 citations

bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death

1993 • 3,111 citations

Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair

1993 • 1,638 citations

BCL2 protein is topographically restricted in tissues characterized by apoptotic cell death.

1991 • 1,301 citations

bcl-2-Immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation

1989 • 1,252 citations

Mechanism of antigen-driven selection in germinal centres

1989 • 1,097 citations

Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease.

1991 • 876 citations

How B and T cells talk to each other

1994 • 659 citations

Evidence that BCL-2 represses apoptosis by regulating endoplasmic reticulum-associated Ca2+ fluxes.

1994 • 605 citations

Elimination of self-reactive B lymphocytes proceeds in two stages: Arrested development and cell death

1993 • 514 citations

Germinal center cells express bcl‐2 protein after activation by signals which prevent their entry into apoptosis

1991 • 446 citations

bcl-xLx is the major bcl-x mRNA form expressed during murine development and its product localizes to mitochondria

1994 • 435 citations

B-cell apoptosis induced by antigen receptor crosslinking is blocked by a T-cell signal through CD40

1993 • 390 citations

Developmental regulation of the Bcl-2 protein and susceptibility to cell death in B lymphocytes.

1994 • 305 citations

Antigen-induced apoptotic death of Ly-1 B cells responsible for autoimmune disease in transgenic mice

1992 • 281 citations

Identification of immunosuppressant-induced apoptosis in a murine B-cell line and its prevention by bcl-x but not bcl-2.

1994 • 262 citations

The Bcl-2 family of proteins: regulators of cell death and survival

1994 • 238 citations

Deregulated Bcl-2-immunoglobulin transgene expands a resting but responsive immunoglobulin M and D-expressing B-cell population.

1990 • 223 citations

Bcl-2 maintains B cell memory

1991 • 219 citations

Hypercross-linking surface IgM or IgD receptors on mature B cells induces apoptosis that is reversed by costimulation with IL-4 and anti-CD40.

1994 • 210 citations

Suppression of apoptosis in normal and neoplastic human B lymphocytes by CD40 ligand is independent of Bcl‐2 induction

1993 • 180 citations

Programmed cell death by bcl-2-dependent and independent mechanisms in B lymphoma cells.

1993 • 147 citations

Induction of NF-AT in normal B lymphocytes by anti-immunoglobulin or CD40 ligand in conjunction with IL-4

1994 • 125 citations

The bcl-2 gene product inhibits clonal deletion of self-reactive B lymphocytes in the periphery but not in the bone marrow.

1993 • 115 citations

Properties of mouse CD40: Cellular distribution of CD40 and B cell activation by monoclonal anti‐mouse CD40 antibodies

1994 • 112 citations

Pharmacological Tools for Perturbing Intracellular Calcium Storage

1994 • 93 citations

Growth regulation of the B lymphoma cell line WEHI-231 by anti-immunoglobulin, lipopolysaccharide, and other bacterial products.

1986 • 74 citations

Plastic‐immobilized anti‐μ or anti‐δ antibodies induce apoptosis in mature murine B lymphocytes

1994 • 65 citations

Antigen-receptor cross-linking induces peritoneal B-cell apoptosis in normal but not autoimmunity-prone mice

1994 • 62 citations

Expression of thebcl-2 gene in mouse B lymphocytic cell lines is differentiation stage specific

1987 • 46 citations

Membrane IgM cross‐linking is not coupled to protein kinase C translocation in WEHI‐231 B lymphoma cells

1989 • 28 citations

Antibodies to Murine CD40 Protect Normal and Malignant B Cells from Induced Growth Arrest

1994 • 28 citations

Properties of mouse CD40. Ligation of CD40 activates B cells via a Ca⁺⁺‐dependent, FK506‐sensitive pathway

1994 • 26 citations

Physiological cell death in B lymphocytes: I. Differential susceptibility of WEHI-231 sublines to anti-lg inducedphysiological cell death and lack of correlation with bcl-2 expression

1994 • 26 citations