CD40 antibody evokes a cytotoxic T-cell response that eradicates lymphoma and bypasses T-cell help

T-cell help for cytotoxic T lymphocytes is mediated by CD40–CD40L interactions

1998 • 2,615 citations

Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs

1998 • 2,378 citations

A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell

1998 • 2,373 citations

Help for cytotoxic-T-cell responses is mediated by CD40 signalling

1998 • 2,106 citations

CD40 AND CD154 IN CELL-MEDIATED IMMUNITY

1998 • 1,546 citations

Tumor Antigens Recognized by T Lymphocytes

1994 • 1,238 citations

Immature Dendritic Cells Phagocytose Apoptotic Cells via αvβ5 and CD36, and Cross-present Antigens to Cytotoxic T Lymphocytes

1998 • 1,226 citations

Role of Bone Marrow-Derived Cells in Presenting MHC Class I-Restricted Tumor Antigens

1994 • 1,185 citations

Cross-priming for a secondary cytotoxic response to minor H antigens with H-2 congenic cells which do not cross-react in the cytotoxic assay.

1976 • 951 citations

Induction of a CD8+ Cytotoxic T Lymphocyte Response by Cross-priming Requires Cognate CD4+ T Cell Help

1997 • 729 citations

Progressive loss of CD8+ T cell-mediated control of a gamma-herpesvirus in the absence of CD4+ T cells.

1996 • 515 citations

Functions of CD40 on B cells, dendritic cells and other cells

1997 • 490 citations

The SCID but Not the RAG-2 Gene Product Is Required for Sμ–Sε Heavy Chain Class Switching

1996 • 411 citations

Expansion or Elimination of B Cells In Vivo: Dual Roles for CD40- and Fas (CD95)-Ligands Modulated by the B Cell Antigen Receptor

1996 • 405 citations

CTLA-4 blockade synergizes with tumor-derived granulocyte– macrophage colony-stimulating factor for treatment of an experimental mammary carcinoma

1998 • 375 citations

CD40-activated human B cells: an alternative source of highly efficient antigen presenting cells to generate autologous antigen-specific T cells for adoptive immunotherapy.

1997 • 365 citations

CD40 Ligand Is Required for Protective Cell-Mediated Immunity to Leishmania major

1996 • 332 citations

CD40 and its ligand, an essential ligand-receptor pair for thymus-dependent B-cell activation

1992 • 327 citations

Major Histocompatibility Complex Class I–restricted Cross-presentation Is Biased towards High Dose Antigens and Those Released during Cellular Destruction

1998 • 323 citations

Disruption of CD40–CD40 Ligand Interactions Results in an Enhanced Susceptibility to Leishmania amazonensis Infection

1996 • 311 citations

Protective Role of CD40 in Leishmania major Infection at Two Distinct Phases of Cell-Mediated Immunity

1996 • 302 citations

CD4-deficient mice have reduced levels of memory cytotoxic T lymphocytes after immunization and show diminished resistance to subsequent virus challenge

1996 • 287 citations

Gene transfer of CD40-ligand induces autologous immune recognition of chronic lymphocytic leukemia B cells.

1998 • 247 citations

Impaired T cell-mediated macrophage activation in CD40 ligand-deficient mice.

1996 • 237 citations

Inhibition of human B-cell lymphoma growth by CD40 stimulation

1994 • 232 citations

Production of cytokines by human B cells in health and disease

1997 • 221 citations

The induction of skin graft tolerance in major histocompatibility complex‐mismatched or primed recipients: primed T cells can be tolerized in the periphery with anti‐CD4 and anti‐CD8 antibodies

1990 • 157 citations

CD40 Ligand Induces an Antileukemia Immune Response In Vivo

1997 • 142 citations

Anti-idiotypic mechanisms involved in suppression of a mouse B cell lymphoma, BCL1.

1987 • 142 citations

Ex Vivo Generation of Human Anti–Pre-B Leukemia-Specific Autologous Cytolytic T Cells

1997 • 131 citations

Enhancement of T cell-independent immune responses in vivo by CD40 antibodies

1998 • 121 citations

Properties of mouse CD40: Cellular distribution of CD40 and B cell activation by monoclonal anti‐mouse CD40 antibodies

1994 • 112 citations

Monoclonal Antibody Therapy of B Cell Lymphoma: Signaling Activity on Tumor Cells Appears More Important Than Recruitment of Effectors

1998 • 106 citations

Autologous Tumor Infiltrating T Cells Cytotoxic for Follicular Lymphoma Cells Can Be Expanded In Vitro

1997 • 102 citations

The induction of a protective response inLeishmania major-infected BALB/c mice with anti-CD40 mAb

1998 • 76 citations

Engagement of CD40 antigen with soluble CD40 ligand up-regulates peptide transporter expression and restores endogenous processing function in Burkitt's lymphoma cells.

1997 • 64 citations

Exogenous CD40 ligand induces a pulmonary inflammation response.

1997 • 58 citations

Involvement of Transcription Factor Encoded by the Mouse mi Locus (MITF ) in Expression of p75 Receptor of Nerve Growth Factor in Cultured Mast Cells of Mice

1997 • 42 citations

Monoclonal Antibodies Raised Against the Idiotype of the Murine B Cell Lymphoma, BCL₁Act Primarily with Heavy Chain Determinants

1991 • 25 citations

Bispecific Ab therapy of B-cell lymphoma: target cell specificity of antibody derivatives appears critical in determining therapeutic outcome

1997 • 12 citations

Activation and preferential expansion of rat cytotoxic (CD8) T cells in vitro and in vivo with a bispecific (anti-TCR alpha/beta x anti-CD2) F(ab')2 antibody.

1995 • 11 citations