2 å crystal structure of an extracellular fragment of human CD40 ligand

The CCP4 suite: programs for protein crystallography

1994 • 17,203 citations

Solvent content of protein crystals

1968 • 7,954 citations

Free R value: a novel statistical quantity for assessing the accuracy of crystal structures

1992 • 3,863 citations

Sparse matrix sampling: a screening method for crystallization of proteins

1991 • 2,050 citations

Crystallographic R Factor Refinement by Molecular Dynamics

1987 • 1,982 citations

A Hot Spot of Binding Energy in a Hormone-Receptor Interface

1995 • 1,943 citations

Crystal structure of the soluble human 55 kd TNF receptor-human TNFβ complex: Implications for TNF receptor activation

1993 • 1,073 citations

Molecular and biological characterization of a murine ligand for CD40

1992 • 1,029 citations

Preparation and analysis of protein crystals

1982 • 976 citations

The CD40 ligand, gp39, is defective in activated T cells from patients with X-linked hyper-IgM syndrome

1993 • 840 citations

CD40 Ligand Gene Defects Responsible for X-Linked Hyper-IgM Syndrome

1993 • 836 citations

A 39-kDa protein on activated helper T cells binds CD40 and transduces the signal for cognate activation of B cells.

1992 • 818 citations

Mice deficient for the CD40 ligand

1994 • 753 citations

Defective expression of T-cell CD40 ligand causes X-linked immunodeficiency with hyper-IgM

1993 • 739 citations

CD40 ligand mutations in X-linked immunodeficiency with hyper-IgM

1993 • 719 citations

Humoral immune responses in CD40 ligand-deficient mice.

1994 • 541 citations

Structure of tumour necrosis factor

1989 • 512 citations

The structure of tumor necrosis factor-alpha at 2.6 A resolution. Implications for receptor binding.

1989 • 511 citations

Prevention of Collagen-Induced Arthritis with an Antibody to gp39, the Ligand for CD40

1993 • 471 citations

The Structure of Tumor Necrosis Factor-α at 2.6 Å Resolution

1989 • 441 citations

Recombinant human CD40 ligand stimulates B cell proliferation and immunoglobulin E secretion.

1992 • 409 citations

Model bias in macromolecular crystal structures

1992 • 397 citations

Interaction between CD40 and its ligand gp39 in the development of murine lupus nephritis.

1995 • 371 citations

Preparation and analysis of protein crystals

1982 • 366 citations

Identification of a novel surface protein on activated CD4+ T cells that induces contact-dependent B cell differentiation (help).

1992 • 357 citations

Activated human T cells express a ligand for the human B cell‐associated antigen CD40 which participates in T cell‐dependent activation of B lymphocytes

1992 • 323 citations

Cloning of TRAP, a ligand for CD40 on human T cells

1992 • 280 citations

Molecular interactions mediating T-B lymphocyte collaboration in human lymphoid follicles. Roles of T cell-B-cell-activating molecule (5c8 antigen) and CD40 in contact-dependent help.

1992 • 194 citations

The structure of human lymphotoxin (tumor necrosis factor-beta) at 1.9-A resolution.

1992 • 187 citations

A 3-D model for the CD40 ligand predicts that it is a compact trimer similar to the tumor necrosis factors

1993 • 168 citations

A system for collection and on-line integration of X-ray diffraction data from a multiwire area detector

1987 • 129 citations

Knowledge‐based model building of proteins: Concepts and examples

1993 • 116 citations

Emerging families of cytokines and receptors

1993 • 105 citations

Expression and function of CD40 on Hodgkin and Reed-Sternberg cells and the possible relevance for Hodgkin's disease

1994 • 96 citations

Identification of Residues on CD40 and Its Ligand Which Are Critical for the Receptor-Ligand Interaction

1995 • 74 citations

Structure-activity studies of human tumour necrosis factors

1994 • 72 citations

Deletions in the ligand for CD40 in X-linked immunoglobulin deficiency with normal or elevated IgM (HIGMX-1)

1993 • 67 citations

CD40 ligand has potent antiviral activity

1995 • 48 citations

Characterization of nine novel mutations in the CD40 ligand gene in patients with X-linked hyper IgM syndrome of various ancestry.

1995 • 37 citations

Isolation of cDNAS encoding T-BAM, a surface glycoprotein on CD4+ T cells mediating contact-dependent helper function for B cells: Identity with the CD40-ligand

1994 • 29 citations