Pharmacological agents acting at subtypes of metabotropic glutamate receptors

Inositol trisphosphate, a novel second messenger in cellular signal transduction

1984 • 6,088 citations

PHARMACOLOGY AND FUNCTIONS OF METABOTROPIC GLUTAMATE RECEPTORS

1997 • 3,070 citations

Cloning and characterization of an extracellular Ca2+-sensing receptor from bovine parathyroid

1993 • 2,625 citations

Molecular Diversity of Glutamate Receptors and Implications for Brain Function

1992 • 2,535 citations

The metabotropic glutamate receptors: Structure and functions

1995 • 2,269 citations

The Excitatory Amino Acid Receptors: Their Classes, Pharmacology, and Distinct Properties in the Function of the Central Nervous System

1989 • 2,203 citations

Lithium amplifies agonist-dependent phosphatidylinositol responses in brain and salivary glands

1982 • 2,148 citations

Turnover of Inositol Phospholipids and Signal Transduction

1984 • 1,629 citations

Sequence and expression of a metabotropic glutamate receptor

1991 • 1,200 citations

Glutamate receptors in the mammalian central nervous system

1998 • 1,126 citations

STRUCTURE AND FUNCTION OF G PROTEIN-COUPLED RECEPTORS

1994 • 1,070 citations

Expression cloning of GABAB receptors uncovers similarity to metabotropic glutamate receptors

1997 • 1,020 citations

Reversal of Phencyclidine Effects by a Group II Metabotropic Glutamate Receptor Agonist in Rats

1998 • 1,002 citations

Structure-activity relationships in the development of excitatory ammo acid receptor agonists and competitive antagonists

1990 • 905 citations

A family of metabotropic glutamate receptors

1992 • 873 citations

Molecular characterization of a novel metabotropic glutamate receptor mGluR5 coupled to inositol phosphate/Ca2+ signal transduction.

1992 • 814 citations

Metabotropic glutamate receptors in brain function and pathology

1993 • 799 citations

A new type of glutamate receptor linked to inositol phospholipid metabolism

1987 • 743 citations

Glutamate stimulates inositol phosphate formation in striatal neurones

1985 • 734 citations

2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist

1999 • 724 citations

Molecular characterization of a novel retinal metabotropic glutamate receptor mGluR6 with a high agonist selectivity for L-2-amino-4-phosphonobutyrate

1993 • 724 citations

The ligand-binding domain in metabotropic glutamate receptors is related to bacterial periplasmic binding proteins

1993 • 695 citations

Signal transduction, pharmacological properties, and expression patterns of two rat metabotropic glutamate receptors, mGluR3 and mGluR4

1993 • 585 citations

Role of Heteromer Formation in GABA _B Receptor Function

1999 • 545 citations

Cloning, Expression, and Gene Structure of a G Protein-Coupled Glutamate Receptor from Rat Brain

1991 • 524 citations

Metabotropic Glutamate Receptor 5 Is a Disulfide-linked Dimer

1996 • 512 citations

Molecular characterization of a new metabotropic glutamate receptor mGluR7 coupled to inhibitory cyclic AMP signal transduction.

1994 • 466 citations

Pharmacological and functional characteristics of metabotropic excitatory amino acid receptors

1990 • 464 citations

Coupling of Inositol Phospholipid Metabolism with Excitatory Amino Acid Recognition Sites in Rat Hippocampus

1986 • 444 citations

Metabotropic glutamate receptors: a new target for the therapy of neurodegenerative disorders?

1996 • 437 citations

The activation of inositol phospholipid metabolism as a signal- transducing system for excitatory amino acids in primary cultures of cerebellar granule cells

1986 • 431 citations

Excitatory amino acid recognition sites coupled with inositol phospholipid metabolism: developmental changes and interaction with alpha 1-adrenoceptors.

1986 • 399 citations

Design, Synthesis, and Pharmacological Characterization of (+)-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY354740): A Potent, Selective, and Orally Active Group 2 Metabotropic Glutamate Receptor Agonist Possessing Anticonvulsant and Anxiolytic Properties

1997 • 389 citations

Calcium sensing receptor: molecular cloning in rat and localization to nerve terminals.

1995 • 376 citations

The family of G‐protein‐coupled receptors

1995 • 369 citations

LY341495 is a nanomolar potent and selective antagonist of group II metabotropic glutamate receptors

1998 • 360 citations

Role of a metabotropic glutamate receptor in synaptic modulation in the accessory olfactory bulb

1993 • 355 citations

A novel metabotropic glutamate receptor expressed in the retina and olfactory bulb

1995 • 328 citations

CPCCOEt, a noncompetitive metabotropic glutamate receptor 1 antagonist, inhibits receptor signaling without affecting glutamate binding.

1999 • 324 citations

Analysis of agonist and antagonist activities of phenylglycine derivatives for different cloned metabotropic glutamate receptor subtypes

1994 • 323 citations

Trans-ACPD, a selective agonist of the phosphoinositide-coupled excitatory amino acid receptor

1989 • 318 citations

Micromolar L-2-amino-4-phosphonobutyric acid selectively inhibits perforant path synapses from lateral entorhinal cortex

1981 • 307 citations

(RS)-2-Chloro-5-Hydroxyphenylglycine (CHPG) Activates mGlu5, but not mGlu1, Receptors Expressed in CHO Cells and Potentiates NMDA Responses in the Hippocampus

1997 • 306 citations

Phenylglycine derivatives as antagonists of metabotropic glutamate receptors

1994 • 303 citations

N‐Acetylaspartylglutamate Selectively Activates mGluR3 Receptors in Transfected Cells

1997 • 295 citations

Synthesis, Pharmacological Characterization, and Molecular Modeling of Heterobicyclic Amino Acids Related to (+)-2-Aminobicyclo[3.1.0]hexane- 2,6-dicarboxylic Acid (LY354740): Identification of Two New Potent, Selective, and Systemically Active Agonists for Group II Metabotropic Glutamate Receptors

1999 • 290 citations

Anxiolytic and side-effect profile of LY354740: a potent, highly selective, orally active agonist for group II metabotropic glutamate receptors.

1998 • 277 citations

Molecular, functional, and pharmacological characterization of the metabotropic glutamate receptor type 5 splice variants: comparison with mGluR1

1995 • 275 citations

3,5‐Dihydroxyphenylglycine Is a Highly Selective Agonist for Phosphoinositide‐Linked Metabotropic Glutamate Receptors in the Rat Hippocampus

1994 • 270 citations

Metabotropic Glutamate Receptors: Novel Targets for Drug Development

1995 • 261 citations

Cloning and expression of a new member of the L-2-amino-4-phosphonobutyric acid-sensitive class of metabotropic glutamate receptors.

1994 • 246 citations

Alternative splicing generates metabotropic glutamate receptors inducing different patterns of calcium release in Xenopus oocytes.

1992 • 226 citations

LY354740 is a Potent and Highly Selective Group II Metabotropic Glutamate Receptor Agonist in Cells Expressing Human Glutamate Receptors

1997 • 223 citations

Competitive antagonism at metabotropic glutamate receptors by (S) -4-carboxyphenylglycine and (RS) -α-methyl-4-carboxyphenylglycine

1993 • 219 citations

Structural Basis for a Ca ²⁺ -Sensing Function of the Metabotropic Glutamate Receptors

1998 • 216 citations

A glutamate receptor regulates Ca2+ mobilization in hippocampal neurons.

1988 • 210 citations

Cloning and Expression of Rat Metabotropic Glutamate Receptor 8 Reveals a Distinct Pharmacological Profile

1997 • 209 citations

Domains involved in the specificity of G protein activation in phospholipase C-coupled metabotropic glutamate receptors.

1994 • 197 citations

A novel metabotropic glutamate receptor agonist: marked depression of monosynaptic excitation in the newborn rat isolated spinal cord

1993 • 197 citations

3,5-Dihydroxyphenylglycine

1992 • 195 citations

Agonist analysis of 2‐(carboxycyclopropyl)glycine isomers for cloned metabotropic glutamate receptor subtypes expressed in Chinese hamster ovary cells

1992 • 189 citations

Actions of two new antagonists showing selectivity for different sub‐types of metabotropic glutamate receptor in the neonatal rat spinal cord

1994 • 188 citations

Astrocyte glutamate receptor activation promotes inositol phospholipid turnover and calcium flux

1986 • 187 citations

Excitatory Amino Acid Agonist‐Antagonist Interactions at 2‐Amino‐4‐Phosphonobutyric Acid‐Sensitive Quisqualate Receptors Coupled to Phosphoinositide Hydrolysis in Slices of Rat Hippocampus

1988 • 181 citations

A novel class of antagonists for metabotropic glutamate receptors, 7-(Hydroxyimino)cyclopropa[b]chromen-1a-carboxylates

1996 • 178 citations

Phenylglycine derivatives discriminate between mGluR1- and mGluR5-mediated responses

1995 • 175 citations

Pharmacological characterization of 1-aminoindan-1,5-dicarboxylic acid, a potent mGluR1 antagonist.

1997 • 173 citations

1-Aminoindan-1,5-dicarboxylic Acid: A Novel Antagonist at Phospholipase C-Linked Metabotropic Glutamate Receptors

1995 • 173 citations

In vivo inhibition of veratridine-evoked release of striatal excitatory amino acids by the group II metabotropic glutamate receptor agonist LY354740 in rats

1997 • 165 citations

1S,3R-ACPD stimulates and L-AP3 blocks Ca2+ mobilization in rat cerebellar neurons

1990 • 163 citations

The potent mGlu receptor antagonist LY341495 identifies roles for both cloned and novel mGlu receptors in hippocampal synaptic plasticity

1998 • 161 citations

Roles of specific metabotropic glutamate receptor subtypes in regulation of hippocampal CA1 pyramidal cell excitability

1995 • 159 citations

Inhibition of Cyclic AMP Formation by a Selective Metabotropic Glutamate Receptor Agonist

1992 • 158 citations

The Second Intracellular Loop of Metabotropic Glutamate Receptor 1 Cooperates with the Other Intracellular Domains to Control Coupling to G-proteins

1996 • 155 citations

Comparative effect of l-CCG-I, DCG-IV and γ-carboxy-l-glutamate on all cloned metabotropic glutamate receptor subtypes

1998 • 152 citations

(S)-(+)-2-(3‘-Carboxybicyclo[1.1.1]pentyl)- glycine, a Structurally New Group I Metabotropic Glutamate Receptor Antagonist

1996 • 150 citations

Expression and Purification of the Extracellular Ligand Binding Region of Metabotropic Glutamate Receptor Subtype 1

1998 • 147 citations

Phenylglycine derivatives as new pharmacological tools for investigating the role of metabotropic glutamate receptors in the central nervous system

1993 • 144 citations

Synthesis and Pharmacological Characterization of Aminocyclopentanetricarboxylic Acids: New Tools to Discriminate between Metabotropic Glutamate Receptor Subtypes

1997 • 142 citations

Role of the large extracellular domain of metabotropic glutamate receptors in agonist selectivity determination.

1993 • 141 citations

Actions of phenylglycine analogs at subtypes of the metabotropic glutamate receptor family

1994 • 139 citations

Potent antagonists at the L-AP4- and (1S,3S)-ACPD-sensitive presynaptic metabotropic glutamate receptors in the neonatal rat spinal cord

1996 • 137 citations

(+)-2-Methyl-4-carboxyphenylglycine (LY367385) selectively antagonises metabotropic glutamate mGluR1 receptors

1997 • 136 citations

L-2-amino-4-phosphonobutyrate (L-AP4) is an agonist at the type iv metabotropic glutamate receptor which is negatively coupled to adenylate cyclase

1992 • 135 citations

Characterization of subtypes of excitatory amino acid receptors involved in the stimulation of inositol phosphate synthesis in rat brain synaptoneurosomes

1987 • 129 citations

Cloning and characterization of alternative mRNA forms for the rat metabotropic glutamate receptors mGluR7 and mGluR8

1998 • 127 citations

Distinct presynaptic metabotropic receptors for l-AP4 and CCG1 on GABAergic terminals: Pharmacological evidence using novel α-methyl derivative mGluR antagonists, MAP4 and MCCG, in the rat thalamus in vivo

1995 • 125 citations

Cloning and functional expression of a Drosophila metabotropic glutamate receptor expressed in the embryonic CNS.

1996 • 116 citations

Domains determining ligand specificity for Ca2+ receptors.

1999 • 115 citations

Inhibition of Excitatory Amino Acid‐Stimulated Phosphoinositide Hydrolysis in the Neonatal Rat Hippocampus by 2‐Amino‐3‐Phosphonopropionate

1989 • 114 citations

Group III human metabotropic glutamate receptors 4, 7 and 8: Molecular cloning, functional expression, and comparison of pharmacological properties in RGT cells

1998 • 113 citations

Molecular and functional characterization of recombinant human metabotropic glutamate receptor subtype 5

1995 • 111 citations

A Novel Splice Variant of a Metabotropic Glutamate Receptor, Human mGluR7b

1997 • 109 citations

Coupling of metabotropic glutamate receptors 2 and 4 to G alpha 15, G alpha 16, and chimeric G alpha q/i proteins: characterization of new antagonists.

1996 • 105 citations

New phenylglycine derivatives with potent and selective antagonist activity at presynaptic glutamate receptors in neonatal rat spinal cord

1995 • 105 citations

(trans)-1-amino-cyclopentyl-1,3-dicarboxylate stimulates quisqualate phosphoinositide-coupled receptors but not ionotropic glutamate receptors in striatal neurons and Xenopus oocytes.

1990 • 105 citations

The Novel Metabotropic Glutamate Receptor Agonist 2 R ,4 R -APDC Potentiates Stimulation of Phosphoinositide Hydrolysis in the Rat Hippocampus by 3,5-dihydroxyphenylglycine: Evidence for a Synergistic Interaction Between Group 1 and Group 2 Receptors

1996 • 104 citations

Glutamate receptors and phosphoinositide metabolism: stimulation via quisqualate receptors is inhibited by receptor activation

1988 • 104 citations

LY354740: a metabotropic glutamate receptor agonist which ameliorates symptoms of nicotine withdrawal in rats

1997 • 104 citations

A Variant of Metabotropic Glutamate Receptor Subtype 5: An Evolutionally Conserved Insertion with No Termination Codon

1993 • 103 citations

Pharmacological antagonism of the actions of group II and III mGluR agonists in the lateral perforant path of rat hippocampal slices

1996 • 102 citations

A Comparison of Two Alternatively Spliced Forms of a Metabotropic Glutamate Receptor Coupled to Phosphoinositide Turnover

1993 • 101 citations

[3H]-LY341495 as a novel antagonist radioligand for group II metabotropic glutamate (mGlu) receptors: characterization of binding to membranes of mGlu receptor subtype expressing cells

1999 • 100 citations

Pharmacological tools for the investigation of metabotropic glutamate receptors (mGluRs): Phenylglycine derivatives and other selective antagonists—an update

1995 • 99 citations

Glutamate receptor agonists stimulate diverse calcium responses in different types of cultured rat cortical glial cells

1994 • 99 citations

2-Substituted (2SR)-2-Amino-2-((1SR,2SR)-2-carboxycycloprop-1-yl)glycines as Potent and Selective Antagonists of Group II Metabotropic Glutamate Receptors. 2. Effects of Aromatic Substitution, Pharmacological Characterization, and Bioavailability

1998 • 99 citations

Structure‐activity relationships of new agonists and antagonists of different metabotropic glutamate receptor subtypes

1996 • 97 citations

Mutational analysis of the cysteines in the extracellular domain of the human Ca²⁺ receptor: effects on cell surface expression, dimerization and signal transduction

1998 • 97 citations

Presynaptic inhibitory action of the group II metabotropic glutamate receptor agonists, LY354740 and DCG-IV

1998 • 97 citations

Cloning and Functional Expression of aDrosophilaMetabotropic Glutamate Receptor Expressed in the Embryonic CNS

1996 • 97 citations

The excitation of mammalian central neurones by amino acids.

1979 • 97 citations

A pharmacological characterization of the mGluR1α subtype of the metabotropic glutamate receptor expressed in a cloned baby hamster kidney cell line

1993 • 96 citations

Antagonism of presynaptically mediated depressant responses and cyclic AMP-coupled metabotropic glutamate receptors

1994 • 95 citations

Stereospecific antagonism by (+)-α-methyl-4-carboxyphenylglycine (MCPG) of (1S,3R)-ACPD-induced effects in neonatal rat motoneurones and rat thalamic neurones

1993 • 93 citations

The selective mGlu2/3 receptor agonist LY354740 attenuates morphine-withdrawal-induced activation of locus coeruleus neurons and behavioral signs of morphine withdrawal

1999 • 93 citations

Selective activation of phosphoinositide hydrolysis by a rigid analogue of glutamate

1990 • 92 citations

Pharmacological analysis of 4-carboxyphenylglycine derivatives: Comparison of effects on mGluR1α and mGluR5a subtypes

1995 • 91 citations

A new quisqualate receptor subtype (sAA2) responsible for the glutamate-induced inositol phosphate formation in rat brain synaptoneurosomes

1988 • 90 citations

Metabotropic Excitatory Amino Acid Receptor Activation Stimulates Phospholipase D in Hippocampal Slices

1992 • 87 citations

Synthesis and Pharmacological Characterization of All Sixteen Stereoisomers of 2-(2‘-Carboxy-3‘-phenylcyclopropyl)glycine. Focus on (2S,1‘S,2‘S,3‘R)-2-(2‘-Carboxy-3‘-phenylcyclopropyl)glycine, a Novel and Selective Group II Metabotropic Glutamate Receptors Antagonist

1996 • 86 citations

Comparison of (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD)- and 1R,3S-ACPD-stimulated brain phosphoinositide hydrolysis

1991 • 86 citations

Characterization of [³H]‐(2S,2′R,3′R)‐2‐(2′,3′‐dicarboxy‐ cyclopropyl)glycine ([³H]‐DCG IV) binding to metabotropic mGlu₂ receptor‐transfected cell membranes

1998 • 81 citations

Synthesis, resolution, and absolute configuration of the isomers of the neuronal excitant 1-amino-1,3-cyclopentanedicarboxylic acid

1988 • 81 citations

The effects of (RS)‐α‐cyclopropyl‐4‐phosphonophenylglycine ((RS)‐CPPG), a potent and selective metabotropic glutamate receptor antagonist

1996 • 80 citations

Comparison of Excitatory Amino Acid‐Stimulated Phosphoinositide Hydrolysis and N‐[³H]Acetylaspartylglutamate Binding in Rat Brain: Selective Inhibition of Phosphoinositide Hydrolysis by 2‐Amino‐3‐Phosphonopropionate

1989 • 80 citations

Evidence for presynaptic depression of monosynaptic excitation in neonatal rat motoneurones by (1S,3S)‐ and (1S,3R)‐ACPD

1992 • 80 citations

A potent metabotropic glutamate receptor agonist: electrophysiological actions of a conformationally restricted glutamate analogue in the rat spinal cord and Xenopus oocytes

1990 • 79 citations

Pharmacological characterization of metabotropic glutamate receptors coupled to phospholipase D in the rat hippocampus

1996 • 78 citations

Ligand Binding to the Amino-terminal Domain of the mGluR4 Subtype of Metabotropic Glutamate Receptor

1999 • 77 citations

Synthesis of L-2-(2,3-dicarboxyclopropyl)glycines. Novel conformationally restricted glutamate analogues.

1993 • 76 citations

Molecular Cloning, Functional Expression and Pharmacological Characterization of the Human Metabotropic Glutamate Receptor Type 2

1995 • 76 citations

α-methyl derivatives of serine-O-phosphate as novel, selective competitive metabotropic glutamate receptor antagonists

1996 • 75 citations

The G Protein-Coupling Profile of Metabotropic Glutamate Receptors, as Determined with Exogenous G Proteins, Is Independent of Their Ligand Recognition Domain

1998 • 75 citations

(2S,3S,4S) α-(Carboxycyclopropyl) glycine is a novel agonist of metabotropic glutamate receptors

1990 • 74 citations

Selective inhibition of forskolin-stimulated cyclic AMP formation in rat hippocampus by a novel mGluR agonist, 2R,4R-4-aminopyrrolidine-2,4-dicarboxylate

1995 • 73 citations

2-Substituted (2SR)-2-Amino-2-((1SR,2SR)-2-carboxycycloprop-1-yl)glycines as Potent and Selective Antagonists of Group II Metabotropic Glutamate Receptors. 1. Effects of Alkyl, Arylalkyl, and Diarylalkyl Substitution

1998 • 72 citations

Metabotropic glutamate receptor agonist DCG-IV as NMDA receptor agonist in immature rat hippocampal neurons

1994 • 72 citations

Cloning and functional expression of alternative spliced variants of the human metabotropic glutamate receptor 8

1999 • 72 citations

Cloning and expression of a human metabotropic glutamate receptor 1 alpha: enhanced coupling on co-transfection with a glutamate transporter.

1995 • 71 citations

Molecular Cloning and the Functional Expression of Two Isoforms of Human Metabotropic Glutamate Receptor Subtype 5

1994 • 71 citations

Glutamate stimulates release of Ca2+ from internal stores in astroglia

1990 • 69 citations

Pharmacological characterization of the metabotropic glutamate receptor inhibiting <scp>d</scp>‐[³H]‐aspartate output in rat striatum

1993 • 68 citations

The C‐Terminal Domain of the mGluR1 Metabotropic Glutamate Receptor Affects Sensitivity to Agonists

1996 • 67 citations

Human metabotropic glutamate receptor type 7: Molecular cloning and mRNA distribution in the CNS

1996 • 67 citations

In Vitro and In Vivo Pharmacology of trans‐ and cis‐(±)‐1‐Amino‐1,3‐Cyclopentanedicarboxylic Acid: Dissociation of Metabotropic and Ionotropic Excitatory Amino Acid Receptor Effects

1991 • 66 citations

Pharmacological evidence for an involvement of group II and group III mGluRs in the presynaptic regulation of excitatory synaptic responses in the CA1 region of rat hippocampal slices

1995 • 66 citations

A New Highly Selective Metabotropic Excitatory Amino Acid Agonist: 2-Amino-4-(3-hydroxy-5-methylisoxazol-4-yl)butyric Acid

1996 • 65 citations

Type 4a metabotropic glutamate receptor: identification of new potent agonists and differentiation from the L-(+)-2-amino-4-phosphonobutanoic acid-sensitive receptor in the lateral perforant pathway in rats.

1995 • 64 citations

Reduction of sensory and metabotropic glutamate receptor responses in the thalamus by the novel metabotropic glutamate receptor-1-selective antagonist S-2-methyl-4-carboxy-phenylglycine

1998 • 63 citations

Molecular cloning, functional expression and pharmacological characterization of the human metabotropic glutamate receptor type 4

1995 • 61 citations

<scp>l</scp>‐Glutamate Uptake Inhibitors May Stimulate Phosphoinositide Hydrolysis in Baby Hamster Kidney Cells Expressing mGluR1a via Heteroexchange with <scp>l</scp>‐Glutamate Without Direct Activation of mGluR1a

1994 • 60 citations

Synthesis and Biology of the Conformationally Restricted ACPD Analogue, 2-Aminobicyclo[2.1.1]hexane-2,5-dicarboxylic Acid-I, a Potent mGluR Agonist

1998 • 58 citations

L-cysteine sulfinic acid as an endogenous agonist of a novel metabotropic receptor coupled to stimulation of phospholipase D activity.

1994 • 58 citations

(2S,4S)-2-Amino-4-(4,4-diphenylbut-1-yl)- pentane-1,5-dioic Acid: A Potent and Selective Antagonist for Metabotropic Glutamate Receptors Negatively Linked to Adenylate Cyclase

1996 • 58 citations

Molecular characterization and localization of human metabotropic glutamate receptor type 3

1996 • 58 citations

Antagonism of the synaptic depressant actions of l-AP4 in the lateral perforant path by MAP4

1995 • 57 citations

Synthesis of the Four Isomers of 4-Aminopyrrolidine-2,4-dicarboxylate: Identification of a Potent, Highly Selective, and Systemically-Active Agonist for Metabotropic Glutamate Receptors Negatively Coupled to Adenylate Cyclase

1996 • 57 citations

Expression pattern and pharmacology of the rat type IV metabotropic glutamate receptor

1993 • 56 citations

Effects of varying the expression level of recombinant human mGlu1α receptors on the pharmacological properties of agonists and antagonists

1999 • 55 citations

(S)-Homo-AMPA, a Specific Agonist at the mGlu₆ Subtype of Metabotropic Glutamic Acid Receptors

1997 • 55 citations

Reversible and non-competitive antagonist profile of CPCCOEt at the human type 1α metabotropic glutamate receptor

1998 • 54 citations

Ionotropic and metabotropic neurotransmission

1979 • 53 citations

HmGlu1d, a novel splice variant of the human type I metabotropic glutamate receptor

1996 • 53 citations

[³H]‐L‐2‐amino‐4‐phosphonobutyrate labels a metabotropic glutamate receptor, mGluR4a

1995 • 51 citations

Glutamate Activates Phospholipase D in Hippocampal Slices of Newborn and Adult Rats

1993 • 51 citations

Pharmacological characterization of MCCG and MAP4 at the mGluR1b, mGluR2 and mGluR4a human metabotropic glutamate receptor subtypes

1995 • 50 citations

Trans-azetidine-2, 4-dicarboxylic acid activates neuronal metabotropic receptors

1993 • 50 citations

The l-AP4 receptor

1997 • 49 citations

Cloning and stable expression of the mGluR1b subtype of human metabotropic receptors and pharmacological comparison with the mGluR5a subtype

1997 • 49 citations

Cloning and Characterization of a Metabotropic Glutamate Receptor, mGluR4b

1997 • 48 citations

(2S,1'S,2'S,3'R)-2-(2'-carboxy-3'-phenylcyclopropyl)glycine, a potent and selective antagonist of type 2 metabotropic glutamate receptors.

1996 • 48 citations

The agonist selectivity of a class III metabotropic glutamate receptor, human mGluR4a, is determined by the N-terminal extracellular domain.

1995 • 48 citations

Group I Metabotropic Glutamate Receptors Mediate Phospholipase D Stimulation in Rat Cultured Astrocytes

1999 • 48 citations

Cloning, Distribution and Functional Expression of the Human mGlu6 Metabotropic Glutamate Receptor

1997 • 47 citations

Homology Modeling of Metabotropic Glutamate Receptors. (mGluRs) Structural Motifs Affecting Binding Modes and Pharmacological Profile of mGluR1 Agonists and Competitive Antagonists

1996 • 47 citations

Molecular characterization and localization of human metabotropic glutamate receptor type 4

1996 • 46 citations

Synthesis and preliminary evaluation of (S)-2-(4′-carboxycubyl)glycine, a new selective mGluR1 antagonist

1998 • 45 citations

Glutamate metabotropic receptor activation in neonatal rat cerebral cortex by sulphur-containing excitatory amino acids

1993 • 44 citations

DCG-IV, a potent metabotropic glutamate receptor agonist, as an NMDA receptor agonist in the rat cortical slice

1997 • 44 citations

[3H]LY341495, a highly potent, selective and novel radioligand for labeling group II metabotropic glutamate receptors

1998 • 43 citations

Ontogenetic and Pharmacological Studies on Metabotropic Glutamate Receptors Coupled to Phospholipase D Activation

1997 • 43 citations

Molecular pharmacology of homologues of ibotenic acid at cloned metabotropic glutamic acid receptors

1998 • 41 citations

Sulphur-containing amino acids are agonists for group 1 metabotropic receptors expressed in clonal RGT cell lines

1998 • 41 citations

(2 S ,1′ R ,2′ R ,3′ R )-2-(2,3-dicarboxycyclopropyl) glycine positively modulates metabotropic glutamate receptors coupled to polyphosphoinositide hydrolysis in rat hippocampal slices

1994 • 41 citations

Pharmacological characterization of type 1α metabotropic glutamate receptor‐stimulated [³⁵S]‐GTPγS binding

1997 • 39 citations

(2S,1′R,2′R,3′R)-2-(2,3-Dicarboxycyclopropyl) glycine enhances quisqualate-stimulated inositol phospholipid hydrolysis in hippocampal slices

1993 • 39 citations

Cyclic analogs of 2-amino-4-phosphonobutanoic acid (APB) and their inhibition of hippocampal excitatory transmission and displacement of [3H]APB binding

1986 • 37 citations

Preparation of difluoro analogs of CCGs and their pharmacological evaluations

1998 • 37 citations

Characterization of (2S,2′R,3′R)‐2‐(2′,3′‐[³H]‐Dicarboxycyclopropyl)glycine Binding in Rat Brain

1998 • 37 citations

Synthesis, molecular modeling, and biology of the 1-benzyl derivative of APDC-an apparent mGluR6 selective ligand

1997 • 37 citations

Enzymatic resolution and pharmacological activity of the enantiomers of 3,5-dihydroxyphenylglycine, a metabotropic glutamate receptor agonist

1995 • 36 citations

Pharmacology of (S)‐homoquisqualic acid and (S)‐2‐amino‐5‐phosphonopentanoic acid [(S)‐AP5] at cloned metabotropic glutamate receptors

1998 • 36 citations

Synthesis of the 2-amino-4-phosphonobutanoic acid analogs (E)- and (Z)-2-amino-2,3-methano-4-phosphonobutanoic acid and their evaluation as inhibitors of hippocampal excitatory neurotransmission

1991 • 35 citations

The Human Metabotropic Glutamate Receptor 8 (GRM8) Gene: A Disproportionately Large Gene Located at 7q31.3–q32.1

1997 • 35 citations

The Whole Nucleotide Sequence and Chromosomal Localization of the Gene for Human Metabotropic Glutamate Receptor Subtype 6

1997 • 34 citations

A novel metabotropic glutamate receptor agonist: (2S, 1′S,2′R,3′R)-2-(2-carboxy-3-methoxymethylcyclopropyl)glycine (cis-MCG-I)

1994 • 34 citations

Metabotropic Glutamate Receptors and Brain Function

1998 • 34 citations

Synthesis and biological activity of cyclic analogues of MPPG and MCPG as metabotropic glutamate receptor antagonists

1997 • 32 citations

Potent, stereoselective, and brain region selective modulation of second messengers in the rat brain by (+)LY354740, a novel group II metabotropic glutamate receptor agonist

1998 • 32 citations

L-2-amino-3-phosphonopropionic acid competitively antagonizes metabotropic glutamate receptors 1α and 5 in Xenopus oocytes

1995 • 32 citations

Subtypes of metabotropic excitatory amino acid receptor distinguished by stereoisomers of the rigid glutamate analogue, 1-aminocyclopentane-1,3-dicar☐ylate

1993 • 31 citations

(2S,4S)-2-Amino-4-(2,2-diphenylethyl)pentanedioic acid selective group 2 metabotropic glutamate receptor antagonist

1998 • 31 citations

Antagonist activity of α‐substituted 4‐carboxyphenylglycine analogues at group I metabotropic glutamate receptors expressed in CHO cells

1999 • 31 citations

Pharmacological characterization of metabotropic glutamate receptors linked to the inhibition of adenylate cyclase activity in rat striatal slices

1997 • 30 citations

Second-messenger responses in brain slices to elucidate novel glutamate receptors

1995 • 30 citations

Serine-O-phosphate has affinity for type IV, but not type I, metabotropic glutamate receptor.

1993 • 30 citations

Human Metabotropic Glutamate Receptor 1: mRNA Distribution, Chromosome Localization and Functional Expression of Two Splice Variants

1996 • 30 citations

(S)‐homoquisqualate: a potent agonist at the glutamate metabotropic receptor

1992 • 30 citations

Molecular pharmacology of 4-substituted glutamic acid analogues at ionotropic and metabotropic excitatory amino acid receptors

1997 • 29 citations

Contribution of Metabotropic Glutamate Receptor mGluR4 to L‐2‐[³H]Amino‐4‐Phosphonobutyrate Binding in Mouse Brain

1999 • 29 citations

Pharmacological characterization of desensitization in a human mGlulα‐expressing non‐neuronal cell line co‐transfected with a glutamate transporter

1996 • 28 citations

The metabotropic glutamate receptors: their second intracellular loop plays a critical role in the G-protein coupling specificity

1995 • 28 citations

Novel agonists for metabotropic glutamate receptors: trans- and cis-2-(2-carboxy-3-methoxymethylcyclopropyl)glycine (trans- and cis-MCG-I)

1995 • 28 citations

Synthesis and biology of the rigidified glutamate analogue, trans-2-carboxyazetidine-3-acetic acid (t-CAA)

1996 • 28 citations

The agonist selectivity of a class III metabotropic glutamate receptor, human mGluR4a, is determined by the N-terminal extracellular domain

1995 • 28 citations

Metabotropic glutamate receptor antagonists, like GABAB antagonists, potentiate dorsal root-evoked excitatory synaptic transmission at neonatal rat spinal motoneurons in vitro

1997 • 28 citations

Agonists of cyclic AMP-coupled metabotropic glutamate receptors in adult rat cortical slices

1996 • 27 citations

Profiling of trans-azetidine-2,4-dicarboxylic acid at the human metabotropic glutamate receptors mGlu1b, -2, -4a and -5a

1995 • 27 citations

Cloning and characterization of a bifunctional metabotropic receptor activated by both extracellular calcium and glutamate

1996 • 26 citations

Identification of 2-amino-2-methyl-4-phosphonobutanoic acid as an antagonist at the mGlu4a receptor

1995 • 26 citations

Metabotropic glutamate receptor agonists stimulate polyphosphoinositide hydrolysis in primary cultures of rat hepatocytes

1997 • 26 citations

Antagonist pharmacology of metabotropic glutamate receptors coupled to phospholipase D activation in adult rat hippocampus: focus on (2R,1'S,2'R,3'S)-2-(2'-carboxy-3'-phenylcyclopropyl)glycine versus 3, 5-dihydroxyphenylglycine.

1999 • 26 citations

Molecular Cloning, Functional Expression, Pharmacological Characterization and Chromosomal Localization of the Human Metabotropic Glutamate Receptor Type 3

1996 • 24 citations

Effects of quisqualic acid analogs on metabotropic glutamate receptors coupled to phosphoinositide hydrolysis in rat hippocampus

1995 • 24 citations

Inversion of cis-Substituted α-Cyclopropyl Acyl Anion. Stereoselective Entry to the Synthesis of a Potent Metabotropic Glutamate Agonist, (2S,1′S,2′S)-2-(Carboxycyclopropyl)glycine (L-CCG-I), and Its 3′-Substituted Analogues

1993 • 22 citations

4-Methylhomoibotenic acid activates a novel metabotropic glutamate receptor coupled to phosphoinositide hydrolysis.

1997 • 21 citations

Utilization of a cyclopentane analog of glutamate (cis-1-amino-1,3-dicarboxycyclopentane) by glutamine synthetase

1972 • 21 citations

Ligand binding profile of the rat metabotropic glutamate receptor mGluR3 expressed in a transfected cell line

1995 • 21 citations

Selective activation of oscillatory currents by trans-ACPD in rat brain mRNA-injected Xenopus oocytes and their blockade by NMDA

1990 • 20 citations

Antagonism of mGlu Receptors and Potentiation of EPSCs at Rat Spinal Motoneurones In Vitro

1997 • 20 citations

Possible heterogeneity of metabotropic glutamate receptors in duced in Xenopus oocytes by rat brain mRNA

1991 • 20 citations

Photocycloaddition of α,β-unsaturated-γ-lactam with ethylene. Synthesis of conformationally restricted glutamate analogs, l-2-(2-carboxycyclobutyl)glycines

1998 • 19 citations

Potentiation by <scp>DL</scp>‐α‐aminopimelate of the inhibitory action of a novel mGluR agonist (L‐F₂CCG‐I) on monosynaptic excitation in the rat spinal cord

1998 • 17 citations

Enhanced Type 1α Metabotropic Glutamate Receptor-Stimulated Phosphoinositide Signaling after Pertussis Toxin Treatment

1997 • 17 citations

Two Phenylglycine Derivatives Antagonize Responses to l -AP4 in ON Bipolar Cells of the Amphibian Retina

1997 • 16 citations

Antagonism of the presumed presynaptic action of l-AP4 on GABAergic transmission in the ventrobasal thalamus by the novel mGluR antagonist MPPG

1996 • 16 citations

Cyclobutane Quisqualic Acid Analogues as Selective mGluR5a Metabotropic Glutamic Acid Receptor Ligands

1999 • 15 citations

Synthesis and metabotropic glutamate receptor antagonist activity of N1-substituted analogs of 2R,4R-4-aminopyrrolidine-2,4-dicarboxylic acid

1998 • 15 citations

(S)-4-carboxy-3-hydroxyphenylglycine activates phosphatidyl inositol linked metabotropic glutamate receptors in different brain regions of the neonatal rat

1998 • 15 citations

2,3′-disubstituted-2-(2′-carboxycyclopropyl)glycines as potent and selective antagonists of metabotropic glutamate receptors

1998 • 14 citations

Actions of the four isomers of 1 aminocyclopentane 1 3 dicarboxylate acpd in the hemisected isolated spinal cord of the neonatal rat

1991 • 13 citations

α-substituted quisqualic acid analogs: New metabotropic glutamate receptor group II selective antagonists

1998 • 12 citations

Activity of the conformationally rigid 2-amino-4-phosphonobutanoic acid (AP4) analogue (RS)-1-amino-3-(phosphonomethylene)cyclobutane-1-carboxyclic acid (cyclobutylene AP5) on evoked responses in the perforant pathway of rat hippocampus

1992 • 12 citations

Synthesis and biological evaluation of two analogues of (S)-α-methyl-3-carboxyphenylalanine

1998 • 11 citations

Effect of 781094, a new selective α‐adrenoceptor antagonist, on the aggregatory responses of human blood platelets and on binding of [³H]‐dihydroergocryptine to these cells

1983 • 11 citations

Synthesis and biology of the regidified glutamate analogue, trans-2-carboxyazetidine-3-acetic acid (t-CAA)

1996 • 10 citations

New analogues of ACPD with selective activity for group II metabotropic glutamate receptors

1997 • 9 citations

The actions of cyclopentane analogues of glutamic acid at binding sites for kainic and glutamic acids

1988 • 8 citations

Synthesis and metabotropic glutamate receptor activity of a 2-aminobicyclo[3.2.0]heptane-2,5-dicarboxylic acid, a molecule possessing an extended glutamate conformation

1998 • 7 citations

Phosphono Substituted Amino Acids as Selective Metabotropic Glutamate Receptor Antagonists

1996 • 7 citations

DHPMP: a novel group I specific metabotropic glutamate receptor agonist

1996 • 7 citations

Metabotropic glutamate receptors coupled to phospholipase D

1996 • 5 citations

Absolute Configuration of (+)-α-Methyl-4-carboxyphenylglycine (MCPG), a Metabotropic Glutamate Receptor Antagonist

1997 • 5 citations

Phosphono Substituted Amino Acids as Selective Metabotropic Glutamate Receptor Antagonists

1996 • 4 citations

Phenylglycines as antagonists of (1S,3R)-ACPD-induced depolarizations in the neonatal rat spinal cord

1996 • 1 citations