PHARMACOLOGY AND FUNCTIONS OF METABOTROPIC GLUTAMATE RECEPTORS

Cloned Glutamate Receptors

1994 • 3,989 citations

Cloning and characterization of an extracellular Ca2+-sensing receptor from bovine parathyroid

1993 • 2,625 citations

Molecular Diversity of Glutamate Receptors and Implications for Brain Function

1992 • 2,535 citations

The metabotropic glutamate receptors: Structure and functions

1995 • 2,269 citations

Sequence and expression of a metabotropic glutamate receptor

1991 • 1,200 citations

Mutations in the human Ca2+-sensing receptor gene cause familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism

1993 • 1,038 citations

A family of metabotropic glutamate receptors

1992 • 873 citations

Molecular characterization of a novel metabotropic glutamate receptor mGluR5 coupled to inositol phosphate/Ca2+ signal transduction.

1992 • 814 citations

Metabotropic glutamate receptors in brain function and pathology

1993 • 799 citations

A new type of glutamate receptor linked to inositol phospholipid metabolism

1987 • 743 citations

Glutamate stimulates inositol phosphate formation in striatal neurones

1985 • 734 citations

Molecular characterization of a novel retinal metabotropic glutamate receptor mGluR6 with a high agonist selectivity for L-2-amino-4-phosphonobutyrate

1993 • 724 citations

The ligand-binding domain in metabotropic glutamate receptors is related to bacterial periplasmic binding proteins

1993 • 695 citations

Distribution of metabotropic glutamate receptor mGluR5 immunoreactivity in rat brain

1995 • 669 citations

Autosomal dominant hypocalcaemia caused by a Ca2+-sensing receptor gene mutation

1994 • 589 citations

Signal transduction, pharmacological properties, and expression patterns of two rat metabotropic glutamate receptors, mGluR3 and mGluR4

1993 • 585 citations

Signal transduction and pharmacological characteristics of a metabotropic glutamate receptor, mGluRl, in transfected CHO cells

1992 • 539 citations

Cloning, Expression, and Gene Structure of a G Protein-Coupled Glutamate Receptor from Rat Brain

1991 • 524 citations

Molecular Cloning and Functional Expression of Human Parathyroid Calcium Receptor cDNAs

1995 • 498 citations

In vitro mutagenesis and the search for structure-function relationships among G protein-coupled receptors

1992 • 470 citations

Cloning and functional expression of a rat kidney extracellular calcium/polyvalent cation-sensing receptor.

1995 • 469 citations

Molecular characterization of a new metabotropic glutamate receptor mGluR7 coupled to inhibitory cyclic AMP signal transduction.

1994 • 466 citations

Pharmacological and functional characteristics of metabotropic excitatory amino acid receptors

1990 • 464 citations

Potassium conductances in hippocampal neurons blocked by excitatory amino-acid transmitters

1990 • 436 citations

Agonists at metabotropic glutamate receptors presynaptically inhibit EPSCs in neonatal rat hippocampus.

1991 • 431 citations

Agonist selectivity of glutamate receptors is specified by two domains structurally related to bacterial amino acid-binding proteins

1994 • 424 citations

Mutational analysis of the glycine-binding site of the NMDA receptor: Structural similarity with bacterial amino acid-binding proteins

1994 • 381 citations

Calcium sensing receptor: molecular cloning in rat and localization to nerve terminals.

1995 • 376 citations

Role of a metabotropic glutamate receptor in synaptic modulation in the accessory olfactory bulb

1993 • 355 citations

Positive feedback of glutamate exocytosis by metabotropic presynaptic receptor stimulation

1992 • 354 citations

Multiple presynaptic metabotropic glutamate receptors modulate excitatory and inhibitory synaptic transmission in hippocampal area CA1

1995 • 354 citations

A novel metabotropic glutamate receptor expressed in the retina and olfactory bulb

1995 • 328 citations

Analysis of agonist and antagonist activities of phenylglycine derivatives for different cloned metabotropic glutamate receptor subtypes

1994 • 323 citations

Micromolar L-2-amino-4-phosphonobutyric acid selectively inhibits perforant path synapses from lateral entorhinal cortex

1981 • 307 citations

Activation of metabotropic glutamate receptors differentially affects two classes of hippocampal interneurons and potentiates excitatory synaptic transmission

1994 • 295 citations

Molecular, functional, and pharmacological characterization of the metabotropic glutamate receptor type 5 splice variants: comparison with mGluR1

1995 • 275 citations

3,5‐Dihydroxyphenylglycine Is a Highly Selective Agonist for Phosphoinositide‐Linked Metabotropic Glutamate Receptors in the Rat Hippocampus

1994 • 270 citations

Cloning and expression of a new member of the L-2-amino-4-phosphonobutyric acid-sensitive class of metabotropic glutamate receptors.

1994 • 246 citations

Metabotropic glutamate receptor-mediated presynaptic depression at corticostriatal synapses involves mGLuR2 or 3

1995 • 238 citations

Alternative splicing generates metabotropic glutamate receptors inducing different patterns of calcium release in Xenopus oocytes.

1992 • 226 citations

Competitive antagonism at metabotropic glutamate receptors by (S) -4-carboxyphenylglycine and (RS) -α-methyl-4-carboxyphenylglycine

1993 • 219 citations

Atomic structures of periplasmic binding proteins and the high-affinity active transport systems in bacteria

1990 • 213 citations

L-AP4 inhibits calcium currents and synaptic transmission via a G- protein-coupled glutamate receptor

1992 • 210 citations

Immunocytochemical localization of group III metabotropic glutamate receptors in the hippocampus with subtype-specific antibodies

1996 • 208 citations

Identification of a receptor/G-protein contact site critical for signaling specificity and G-protein activation.

1995 • 204 citations

A novel metabotropic glutamate receptor agonist: marked depression of monosynaptic excitation in the newborn rat isolated spinal cord

1993 • 197 citations

Domains involved in the specificity of G protein activation in phospholipase C-coupled metabotropic glutamate receptors.

1994 • 197 citations

Molecular dissection of the agonist binding site of an AMPA receptor.

1995 • 196 citations

3,5-Dihydroxyphenylglycine

1992 • 195 citations

Activation of hippocampal metabotropic excitatory amino acid receptors leads to seizures and neuronal damage

1992 • 193 citations

Mutagenesis of the beta2-Adrenergic Receptor: How Structure Elucidates Function

1992 • 192 citations

Agonist analysis of 2‐(carboxycyclopropyl)glycine isomers for cloned metabotropic glutamate receptor subtypes expressed in Chinese hamster ovary cells

1992 • 189 citations

Differential involvement of group II and group III mGluRs as autoreceptors at lateral and medial perforant path synapses

1996 • 188 citations

Amyloid precursor protein processing is stimulated by metabotropic glutamate receptors.

1995 • 182 citations

Activation of group I mG1uRs potentiates NMDA responses in rat hippocampal slices

1996 • 179 citations

A novel class of antagonists for metabotropic glutamate receptors, 7-(Hydroxyimino)cyclopropa[b]chromen-1a-carboxylates

1996 • 178 citations

Phenylglycine derivatives discriminate between mGluR1- and mGluR5-mediated responses

1995 • 175 citations

1-Aminoindan-1,5-dicarboxylic Acid: A Novel Antagonist at Phospholipase C-Linked Metabotropic Glutamate Receptors

1995 • 173 citations

Activation of metabotropic glutamate receptors coupled to inositol phospholipid hydrolysis amplifies NMDA-induced neuronal degeneration in cultured cortical cells

1995 • 169 citations

Activation of a nonselective cationic conductance by metabotropic glutamatergic and muscarinic agonists in CA3 pyramidal neurons of the rat hippocampus

1995 • 168 citations

Excitatory effects of ACPD receptor activation in the hippocampus are mediated by direct effects on pyramidal cells and blockade of synaptic inhibition

1991 • 168 citations

Activation of metabotropic glutamate receptors protects cultured neurons against apoptosis induced by beta-amyloid peptide.

1995 • 168 citations

Metabotropic glutamate receptors potentiate ionotropic glutamate responses in the rat dorsal horn.

1992 • 165 citations

Requirement of Metabotropic Glutamate Receptors for the Generation of Inflammation‐evoked Hyperexcitability in Rat Spinal Cord Neurons

1994 • 162 citations

Inhibition of calcium channels in rat CA3 pyramidal neurons by a metabotropic glutamate receptor

1992 • 162 citations

Roles of specific metabotropic glutamate receptor subtypes in regulation of hippocampal CA1 pyramidal cell excitability

1995 • 159 citations

Get receptive to metabotropic glutamate receptors

1995 • 157 citations

The Second Intracellular Loop of Metabotropic Glutamate Receptor 1 Cooperates with the Other Intracellular Domains to Control Coupling to G-proteins

1996 • 155 citations

Metabotropic glutamate receptors mediate excitatory transmission in the nucleus of the solitary tract

1992 • 151 citations

Dual modulation of synaptic inhibition by distinct metabotropic glutamate receptors in the rat hippocampus.

1995 • 149 citations

Activation of Class II or III Metabotropic Glutamate Receptors Protects Cultured Cortical Neurons Against Excitotoxic Degeneration

1995 • 147 citations

Presynaptic inhibition of excitatory synaptic transmission by muscarinic and metabotropic glutamate receptor activation in the hippocampus: are Ca2+ channels involved?

1995 • 143 citations

Role of the large extracellular domain of metabotropic glutamate receptors in agonist selectivity determination.

1993 • 141 citations

Toward an understanding of the role of glutamate in experimental parkinsonism: Agonist‐sensitive sites in the basal ganglia

1993 • 141 citations

Glutamate metabotropic receptors increase a Ca(2+)-activated nonspecific cationic current in CA1 hippocampal neurons

1994 • 141 citations

Responses to Metabotropic Glutamate Receptor Activation in Cerebellar Purkinje Cells: Induction of an Inward Current

1992 • 140 citations

Induction or protection of limbic seizures in mice by mGluR subtype selective agonists

1995 • 140 citations

Changes in the carboxyl-terminal domain of metabotropic glutamate receptor 1 by alternative splicing generate receptors with differing agonist-independent activity.

1996 • 139 citations

Actions of phenylglycine analogs at subtypes of the metabotropic glutamate receptor family

1994 • 139 citations

Growth factor upregulation of a phosphoinositide-coupled metabotropic glutamate receptor in cortical astrocytes

1995 • 136 citations

Selective activation of quisqualate metabotropic receptor potentiates NMDA but not AMPA responses

1991 • 135 citations

Two Pathways of Cyclic GMP Production Through Glutamate Receptor‐Mediated Nitric Oxide Synthesis

1992 • 130 citations

Glutamate-evoked release of arachidonic acid from mouse brain astrocytes

1994 • 129 citations

Modulation of calcium currents by a metabotropic glutamate receptor involves fast and slow kinetic components in cultured hippocampal neurons

1993 • 126 citations

Distinct presynaptic metabotropic receptors for l-AP4 and CCG1 on GABAergic terminals: Pharmacological evidence using novel α-methyl derivative mGluR antagonists, MAP4 and MCCG, in the rat thalamus in vivo

1995 • 125 citations

Heterologous expression of metabotropic glutamate receptors in adult rat sympathetic neurons: Subtype-specific coupling to ion channels

1995 • 123 citations

Reduction of resting K+ current by metabotropic glutamate and muscarinic receptors in rat CA3 cells: mediation by G‐proteins.

1994 • 123 citations

Activation of Metabotropic Glutamate Receptors Prevents Neuronal Apoptosis in Culture

1995 • 119 citations

Metabotropic glutamate receptor modulation of voltage-gated Ca2+ channels involves multiple receptor subtypes in cortical neurons

1996 • 118 citations

Metabotropic Glutamate Receptor Activation Produces Extrapyramidal Motor System Activation That Is Mediated by Striatal Dopamine

1992 • 117 citations

Cloning and functional expression of a Drosophila metabotropic glutamate receptor expressed in the embryonic CNS.

1996 • 116 citations

Activation of metabotropic glutamate receptors increases cAMP accumulation in hippocampus by potentiating responses to endogenous adenosine

1993 • 113 citations

Trans-ACPD, a metabotropic receptor agonist, produces calcium mobilization and an inward current in cultured cerebellar Purkinje neurons

1994 • 113 citations

Metabotropic glutamate receptor-mediated suppression of L-type calcium current in acutely isolated neocortical neurons

1992 • 111 citations

Molecular and functional characterization of recombinant human metabotropic glutamate receptor subtype 5

1995 • 111 citations

2-Amino-4-phosphonobutyrate selectively blocks mossy fiber-CA3 responses in guinea pig but not rat hippocampus

1984 • 108 citations

Pharmacology of metabotropic glutamate receptors at the mossy fiber synapses of the guinea pig hippocampus

1995 • 107 citations

Coupling of metabotropic glutamate receptors 2 and 4 to G alpha 15, G alpha 16, and chimeric G alpha q/i proteins: characterization of new antagonists.

1996 • 105 citations

Modulation of AMPA and NMDA responses in rat spinal dorsal horn neurons by trans-1-aminocyclopentane-1,3-dicarboxylic acid

1992 • 104 citations

Metabotropic Glutamate Receptors Inhibiting Excitatory Synapses in the CA1 Area of Rat Hippocampus

1995 • 104 citations

Expression of the mRNA of Seven Metabotropic Glutamate Receptors (mGluR1 to 7) in the Rat Retina. An In Situ Hybridization Study on Tissue Sections and Isolated Cells

1995 • 103 citations

A Comparison of Two Alternatively Spliced Forms of a Metabotropic Glutamate Receptor Coupled to Phosphoinositide Turnover

1993 • 101 citations

Pharmacology of postsynaptic metabotropic glutamate receptors in rat hippocampal CA1 pyramidal neurones

1995 • 101 citations

Pharmacological tools for the investigation of metabotropic glutamate receptors (mGluRs): Phenylglycine derivatives and other selective antagonists—an update

1995 • 99 citations

Cloning and Functional Expression of aDrosophilaMetabotropic Glutamate Receptor Expressed in the Embryonic CNS

1996 • 97 citations

A pharmacological characterization of the mGluR1α subtype of the metabotropic glutamate receptor expressed in a cloned baby hamster kidney cell line

1993 • 96 citations

Glutamate stably enhances the activity of two cytosolic forms of phospholipase A2 in brain cortical cultures

1995 • 95 citations

Activation of metabotropic glutamate receptors inhibits calcium currents and GABA-mediated synaptic potentials in striatal neurons

1994 • 93 citations

Selective activation of phosphoinositide hydrolysis by a rigid analogue of glutamate

1990 • 92 citations

Pharmacological analysis of 4-carboxyphenylglycine derivatives: Comparison of effects on mGluR1α and mGluR5a subtypes

1995 • 91 citations

The involvement of metabotropic glutamate receptors and their intracellular signalling pathways in sustained nociceptive transmission in rat dorsal horn neurons

1995 • 90 citations

Potentiation of cAMP responses by metabotropic glutamate receptors depresses excitatory synaptic transmission by a kinase-independent mechanism

1994 • 89 citations

Pharmacological characterization of metabotropic glutamate receptors in several types of brain cells in primary cultures.

1994 • 88 citations

Activation of postsynaptic metabotropic glutamate receptors by trans- ACPD hyperpolarizes neurons of the basolateral amygdala

1994 • 79 citations

(R,S)-α-Methyl-4-carboxyphenylglycine (MCPG) blocks spatial learning in rats and long-term potentiation in the dentate gyrus in vivo

1994 • 78 citations

Molecular Cloning, Functional Expression and Pharmacological Characterization of the Human Metabotropic Glutamate Receptor Type 2

1995 • 76 citations

DCG‐IV Selectively Attenuates Rapidly Triggered NMDA‐induced Neurotoxicity in Cortical Neurons

1996 • 75 citations

Zinc protoporphyrin-IX blocks the effects of metabotropic glutamate receptor activation in the rat nucleus tractus solitarii.

1993 • 74 citations

Selective inhibition of forskolin-stimulated cyclic AMP formation in rat hippocampus by a novel mGluR agonist, 2R,4R-4-aminopyrrolidine-2,4-dicarboxylate

1995 • 73 citations

Cloning and expression of a human metabotropic glutamate receptor 1 alpha: enhanced coupling on co-transfection with a glutamate transporter.

1995 • 71 citations

Molecular Cloning and the Functional Expression of Two Isoforms of Human Metabotropic Glutamate Receptor Subtype 5

1994 • 71 citations

Activation of metabotropic glutamate receptors induces an inward current in rat dopamine mesencephalic neurons

1993 • 69 citations

Novel glial‐neuronal signalling by coactivation of metabotropic glutamate and beta‐adrenergic receptors in rat hippocampus.

1996 • 68 citations

The C‐Terminal Domain of the mGluR1 Metabotropic Glutamate Receptor Affects Sensitivity to Agonists

1996 • 67 citations

Stimulation by glutamate receptors of arachidonic acid release depends on the Na+/Ca2+ exchanger in neuronal cells.

1993 • 67 citations

Changes in Metabotropic Glutamate Receptor mRNA Levels Following Global Ischemia: Increase of a Putative Presynaptic Subtype (mGluR4) in Highly Vulnerable Rat Brain Areas

1994 • 67 citations

Pharmacological evidence for an involvement of group II and group III mGluRs in the presynaptic regulation of excitatory synaptic responses in the CA1 region of rat hippocampal slices

1995 • 66 citations

Intrastriatal and intrasubthalamic stimulation of metabotropic glutamate receptors: A behavioral and Fos immunohistochemical study

1995 • 66 citations

Type 4a metabotropic glutamate receptor: identification of new potent agonists and differentiation from the L-(+)-2-amino-4-phosphonobutanoic acid-sensitive receptor in the lateral perforant pathway in rats.

1995 • 64 citations

Metabotropic glutamate receptor-induced disinhibition is mediated by reduced transmission at excitatory synapses onto interneurons and inhibitory synapses onto pyramidal cells

1994 • 63 citations

Molecular cloning, functional expression and pharmacological characterization of the human metabotropic glutamate receptor type 4

1995 • 61 citations

Evidence for a kynurenate-insensitive glutamate receptor in nucleus tractus solitarii

1992 • 61 citations

Presynaptic inhibitory action of a metabotropic glutamate receptor agonist on excitatory transmission in visual cortical neurons

1993 • 61 citations

Modulation of calcium channels by metabotropic glutamate receptors in cerebellar granule cells

1995 • 60 citations

(S)‐Carboxy‐3‐Hydroxyphenylglycine, an Antagonist of Metabotropic Glutamate Receptor (mGluR)1a and an Agonist of mGluR2, Protects Against Audiogenic Seizures in DBA/2 Mice

1994 • 59 citations

(2S,4S)-2-Amino-4-(4,4-diphenylbut-1-yl)- pentane-1,5-dioic Acid: A Potent and Selective Antagonist for Metabotropic Glutamate Receptors Negatively Linked to Adenylate Cyclase

1996 • 58 citations

L-cysteine sulfinic acid as an endogenous agonist of a novel metabotropic receptor coupled to stimulation of phospholipase D activity.

1994 • 58 citations

G protein-coupled receptors mediate a fast excitatory postsynaptic current in CA3 pyramidal neurons in hippocampal slices

1995 • 57 citations

Antagonism of the synaptic depressant actions of l-AP4 in the lateral perforant path by MAP4

1995 • 57 citations

Multiple metabotropic glutamate receptors regulate hippocampal function

1992 • 57 citations

Rapid agonist mediated phosphorylation of the metabotropic glutamate receptor 1α by protein kinase C in permanently transfected BHK cells

1995 • 57 citations

Acute Regulation of Synaptic Transmission by Metabotropic Glutamate Receptors

1994 • 55 citations

Mechanisms underlying developmental changes in the expression of metabotropic glutamate receptors in cultured cerebellar granule cells: homologous desensitization and interactive effects involving N-methyl-D-aspartate receptors.

1993 • 54 citations

A slowly inactivating potassium current in CA3 pyramidal cells of rat hippocampus in vitro

1996 • 53 citations

HmGlu1d, a novel splice variant of the human type I metabotropic glutamate receptor

1996 • 53 citations

Metabotropic Glutamate Receptor (mGluR)‐Mediated Potentiation of Cyclic AMP Responses Does Not Require Phosphoinositide Hydrolysis: Mediation by a Group II‐Like mGluR

1995 • 53 citations

Metabotropic glutamate receptors modulateN-methyl-d-aspartate receptor function in neostriatal neurons

1994 • 53 citations

The glutamate-receptor linked cGMP cascade of retinal on-bipolar cells is pertussis and cholera toxinsensitive

1992 • 52 citations

Physiological and pharmacological profile oftrans-azetidine-2,4-dicarboxylic acid: Metabotropic glutamate receptor agonism and effects on long-term potentiation

1996 • 51 citations

Metabotropic glutamate receptor modulation of synaptic transmission in corticostriatal co-cultures: Role of calcium influx

1995 • 51 citations

Facilitatory coupling between a glutamate metabotropic receptor and dihydropyridine-sensitive calcium channels in cultured cerebellar granule cells

1995 • 51 citations

Glutamate Activates Phospholipase D in Hippocampal Slices of Newborn and Adult Rats

1993 • 51 citations

Trans-azetidine-2, 4-dicarboxylic acid activates neuronal metabotropic receptors

1993 • 50 citations

(2S,1'S,2'S,3'R)-2-(2'-carboxy-3'-phenylcyclopropyl)glycine, a potent and selective antagonist of type 2 metabotropic glutamate receptors.

1996 • 48 citations

The agonist selectivity of a class III metabotropic glutamate receptor, human mGluR4a, is determined by the N-terminal extracellular domain.

1995 • 48 citations

Modulation of seizure activity in mice by metabotropic glutamate receptor ligands.

1996 • 47 citations

(1S,3R)‐1‐Aminocyclopentane‐1,3‐Dicarboxylic Acid‐Induced Increases in Cyclic AMP Formation in the Neonatal Rat Hippocampus Are Mediated by a Synergistic Interaction Between Phosphoinositide‐ and Inhibitory Cyclic AMP‐Coupled mGluRs

1996 • 46 citations

Structure‐activity relationships for a series of phenylglycine derivatives acting at metabotropic glutamate receptors (mGluRs)

1995 • 43 citations

Potentiating and depressant effects of metabotropic glutamate receptor agonists on high-voltage-activated calcium currents in cultured retinal ganglion neurons from postnatal mice

1994 • 42 citations

Activation of the metabotropic glutamate receptor is neuroprotective during nitric oxide toxicity in primary hippocampal neurons of rats

1995 • 42 citations

The Metabotropic Glutamate Receptor mGluR4, but Not mGluR1α, Is Palmitoylated when Expressed in BHK Cells

1995 • 39 citations

Insertion mutagenesis as a tool to predict the secondary structure of a muscarinic receptor domain determining specificity of G-protein coupling.

1994 • 39 citations

(2S,1′R,2′R,3′R)-2-(2,3-Dicarboxycyclopropyl) glycine enhances quisqualate-stimulated inositol phospholipid hydrolysis in hippocampal slices

1993 • 39 citations

Characterization of metabotropic glutamate receptor‐mediated facilitation of N‐methyl‐D‐aspartate depolarization of neocortical neurones

1996 • 38 citations

The function of metabotropic excitatory amino acid receptors in synaptic transmission in the thalamus: Studies with novel phenylglycine antagonists☆

1994 • 38 citations

A comparison of the effects of selective metabotropic glutamate receptor agonists on synaptically evoked whole cell currents of rat spinal ventral horn neurones in vitro

1995 • 38 citations

Functional coupling of rat group II metabotropic glutamate receptors to an omega-conotoxin GVIA-sensitive calcium channel in human embryonic kidney 293 cells.

1996 • 37 citations

Metabotropic glutamate group II receptors are responsible for the depression of synaptic transmission induced by ACPD in the dentate gyrus

1995 • 35 citations

Concurrent blockade of hippocampal metabotropic glutamate andN-methyl-d-aspartate receptors disrupts working memory in the rat

1996 • 30 citations

Second-messenger responses in brain slices to elucidate novel glutamate receptors

1995 • 30 citations

Co-administration of (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid and arachidonic acid potentiates synaptic transmission in rat hippocampal slices

1993 • 30 citations

Anatomical Distribution of Metabotropic Glutamate Receptors in Mammalian Brain

1994 • 30 citations

Differentiation of group 2 and group 3 metabotropic glutamate receptor cAMP responses in the rat hippocampus

1996 • 29 citations

[24] Dynamic palmitoylation of G-protein-coupled receptors in eukaryotic cells

1995 • 29 citations

The agonist selectivity of a class III metabotropic glutamate receptor, human mGluR4a, is determined by the N-terminal extracellular domain

1995 • 28 citations

Novel agonists for metabotropic glutamate receptors: trans- and cis-2-(2-carboxy-3-methoxymethylcyclopropyl)glycine (trans- and cis-MCG-I)

1995 • 28 citations

Profiling of trans-azetidine-2,4-dicarboxylic acid at the human metabotropic glutamate receptors mGlu1b, -2, -4a and -5a

1995 • 27 citations

Identification of 2-amino-2-methyl-4-phosphonobutanoic acid as an antagonist at the mGlu4a receptor

1995 • 26 citations

Molecular Cloning, Functional Expression, Pharmacological Characterization and Chromosomal Localization of the Human Metabotropic Glutamate Receptor Type 3

1996 • 24 citations

Activation of a metabotropic excitatory amino acid receptor potentiates A2b adenosine receptor-stimulated cyclic AMP accumulation

1992 • 24 citations

1S,3R-ACPD-preferring Inward current in rat dorsolateral septal neurons is mediated by a novel excitatory amino acid receptor

1995 • 24 citations

Modulation of Ionic Currents by Metabotropic Glutamate Receptors in the CNS

1994 • 23 citations

Role of metabotropic glutamate receptor, mGluR2, in synaptic modulation in the accessory olfactory bulb

1994 • 23 citations

Carboxyl domain of glutamate receptor directs its coupling to metabolic pathways

1993 • 22 citations

Pharmacological analysis of carboxyphenylglycines at metabotropic glutamate receptors

1994 • 20 citations

Characterization of metabotropic glutamate receptor‐stimulated phosphoinositide hydrolysis in rat cultured cerebellar granule cells

1995 • 19 citations

4‐Bromohomoibotenic Acid Selectively Activates a 1‐Aminocyclopentane‐1S,3R‐Dicarboxylic Acid‐Insensitive Metabotropic Glutamate Receptor Coupled to Phosphoinositide Hydrolysis in Rat Cortical Slices

1994 • 18 citations

Effect of Thiol Reagents on Phosphoinositide Hydrolysis in Rat Brain Synaptoneurosomes

1993 • 16 citations

Long-Lasting Modulation of Synaptic Transmission by Metabotropic Glutamate Receptors

1994 • 15 citations

Actions of (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD) in retinal ON bipolar cells indicate that it is an agonist at L-AP4 receptors.

1994 • 15 citations

Competitive Antagonism by Phenylglycine Derivatives at Type 1 Metabotropic Glutamate Receptors

1994 • 15 citations

Synthesis of conformationally-constrained stereospecific analogs of glutamic acid as antagonists of metabotropic receptors

1995 • 14 citations

Effects of the selective metabotropic glutamate receptor agonist, L-CCG-I, on acquisition of a Morris task by rats

1995 • 10 citations

Opposing effects on blood pressure following the activation of metabotropic and ionotropic glutamate receptors in raphe obscurus in the anaesthetized rat

1996 • 10 citations

Effects of bromohomoibotenate on metabotropic glutamate receptors

1994 • 9 citations

Metabotropic excitatory amino acid receptor agonists selectively potentiate behavioral effects induced by ionotropic excitatory amino acid receptor agonists in mice

1993 • 8 citations

Regulation of Neuronal Circuits and Animal Behavior by Metabotropic Glutamate Receptors

1994 • 8 citations

Characterization of an ACPD-insensitive mGluR coupled to phosphoinositide hydrolysis

1996 • 1 citations