The l-AP4 receptor

The metabotropic glutamate receptors: Structure and functions

1995 • 2,269 citations

The Excitatory Amino Acid Receptors: Their Classes, Pharmacology, and Distinct Properties in the Function of the Central Nervous System

1989 • 2,203 citations

Topographic organization of the projections from the entorhinal area to the hippocampal formation of the rat

1976 • 872 citations

Molecular characterization of a novel retinal metabotropic glutamate receptor mGluR6 with a high agonist selectivity for L-2-amino-4-phosphonobutyrate

1993 • 724 citations

Distribution of metabotropic glutamate receptor mGluR5 immunoreactivity in rat brain

1995 • 669 citations

Signal transduction, pharmacological properties, and expression patterns of two rat metabotropic glutamate receptors, mGluR3 and mGluR4

1993 • 585 citations

The metabotropic glutamate receptors, MGLUR2 and MGLUR3, show unique postsynaptic, presynaptic and glial localizations

1996 • 584 citations

Molecular characterization of a new metabotropic glutamate receptor mGluR7 coupled to inhibitory cyclic AMP signal transduction.

1994 • 466 citations

THE EFFECTS OF A SERIES OF ω‐PHOSPHONIC α‐CARBOXYLIC AMINO ACIDS ON ELECTRICALLY EVOKED AND EXCITANT AMINO ACID‐INDUCED RESPONSES IN ISOLATED SPINAL CORD PREPARATIONS

1982 • 463 citations

Agonists at metabotropic glutamate receptors presynaptically inhibit EPSCs in neonatal rat hippocampus.

1991 • 431 citations

Switch in glutamate receptor subunit gene expression in CA1 subfield of hippocampus following global ischemia in rats.

1992 • 399 citations

Positive feedback of glutamate exocytosis by metabotropic presynaptic receptor stimulation

1992 • 354 citations

Multiple presynaptic metabotropic glutamate receptors modulate excitatory and inhibitory synaptic transmission in hippocampal area CA1

1995 • 354 citations

A novel metabotropic glutamate receptor expressed in the retina and olfactory bulb

1995 • 328 citations

Analysis of agonist and antagonist activities of phenylglycine derivatives for different cloned metabotropic glutamate receptor subtypes

1994 • 323 citations

Micromolar L-2-amino-4-phosphonobutyric acid selectively inhibits perforant path synapses from lateral entorhinal cortex

1981 • 307 citations

Molecular, functional, and pharmacological characterization of the metabotropic glutamate receptor type 5 splice variants: comparison with mGluR1

1995 • 275 citations

3,5‐Dihydroxyphenylglycine Is a Highly Selective Agonist for Phosphoinositide‐Linked Metabotropic Glutamate Receptors in the Rat Hippocampus

1994 • 270 citations

Presynaptic glutamate receptors depress excitatory monosynaptic transmission between mouse hippocampal neurones.

1990 • 249 citations

Action of glutamate and aspartate analogues on rod horizontal and bipolar cells

1981 • 249 citations

Cloning and expression of a new member of the L-2-amino-4-phosphonobutyric acid-sensitive class of metabotropic glutamate receptors.

1994 • 246 citations

L-AP4 inhibits calcium currents and synaptic transmission via a G- protein-coupled glutamate receptor

1992 • 210 citations

Immunocytochemical localization of group III metabotropic glutamate receptors in the hippocampus with subtype-specific antibodies

1996 • 208 citations

Impaired Cerebellar Synaptic Plasticity and Motor Performance in Mice Lacking the mGluR4 Subtype of Metabotropic Glutamate Receptor

1996 • 204 citations

The excitotoxin hypothesis in relation to cerebral ischemia.

1991 • 204 citations

A novel metabotropic glutamate receptor agonist: marked depression of monosynaptic excitation in the newborn rat isolated spinal cord

1993 • 197 citations

cGMP-gated conductance in retinal bipolar cells is suppressed by the photoreceptor transmitter

1991 • 194 citations

Actions of two new antagonists showing selectivity for different sub‐types of metabotropic glutamate receptor in the neonatal rat spinal cord

1994 • 188 citations

Pre- and postsynaptic localization of a metabotropic glutamate receptor, mGluR2, in the rat brain: an immunohistochemical study with a monoclonal antibody

1996 • 182 citations

Activation of Class II or III Metabotropic Glutamate Receptors Protects Cultured Cortical Neurons Against Excitotoxic Degeneration

1995 • 147 citations

Effects of excitatory amino acid antagonists on evoked and spontaneous excitatory potentials in guinea‐pig hippocampus.

1986 • 147 citations

Metabotropic glutamate receptors are required for the induction of long-term potentiation

1992 • 147 citations

Metabotropic Glutamate Receptors

2017 • 143 citations

Actions of phenylglycine analogs at subtypes of the metabotropic glutamate receptor family

1994 • 139 citations

L-2-amino-4-phosphonobutyrate (L-AP4) is an agonist at the type iv metabotropic glutamate receptor which is negatively coupled to adenylate cyclase

1992 • 135 citations

The metabotropic glutamate receptor types 2/3 inhibit L-type calcium channels via a pertussis toxin-sensitive G-protein in cultured cerebellar granule cells

1994 • 132 citations

Distinct presynaptic metabotropic receptors for l-AP4 and CCG1 on GABAergic terminals: Pharmacological evidence using novel α-methyl derivative mGluR antagonists, MAP4 and MCCG, in the rat thalamus in vivo

1995 • 125 citations

Heterologous expression of metabotropic glutamate receptors in adult rat sympathetic neurons: Subtype-specific coupling to ion channels

1995 • 123 citations

2-Amino-4-phosphonobutyrate selectively blocks mossy fiber-CA3 responses in guinea pig but not rat hippocampus

1984 • 108 citations

Pharmacology of metabotropic glutamate receptors at the mossy fiber synapses of the guinea pig hippocampus

1995 • 107 citations

New phenylglycine derivatives with potent and selective antagonist activity at presynaptic glutamate receptors in neonatal rat spinal cord

1995 • 105 citations

Expression of the mRNA of Seven Metabotropic Glutamate Receptors (mGluR1 to 7) in the Rat Retina. An In Situ Hybridization Study on Tissue Sections and Isolated Cells

1995 • 103 citations

Pharmacological antagonism of the actions of group II and III mGluR agonists in the lateral perforant path of rat hippocampal slices

1996 • 102 citations

Structure‐activity relationships of new agonists and antagonists of different metabotropic glutamate receptor subtypes

1996 • 97 citations

Antagonism of presynaptically mediated depressant responses and cyclic AMP-coupled metabotropic glutamate receptors

1994 • 95 citations

Characterization of an extended glutamate receptor of the on bipolar neuron in the vertebrate retina

1985 • 91 citations

Evidence for presynaptic depression of monosynaptic excitation in neonatal rat motoneurones by (1S,3S)‐ and (1S,3R)‐ACPD

1992 • 80 citations

Trans-ACPD and l-APB presynaptically inhibit excitatory glutamatergic transmission in the basolateral amygdala (BLA)

1992 • 80 citations

Synthesis of [3H]2-Amino-4-phosphonobutyric acid and characterization of its binding to rat brain membranes: a selective ligand for the chloride/calcium-dependent class ofl-glutamate binding sites

1983 • 74 citations

Changes in Metabotropic Glutamate Receptor mRNA Levels Following Global Ischemia: Increase of a Putative Presynaptic Subtype (mGluR4) in Highly Vulnerable Rat Brain Areas

1994 • 67 citations

Regional and developmental profile of modulation of hippocampal synaptic transmission and LTP by AP4-sensitive mGluRs in vivo

1995 • 66 citations

A metabotropic glutamate receptor agonist DCG-IV suppresses synaptic transmission at mossy fiber pathway of the guinea pig hippocampus

1996 • 66 citations

Type 4a metabotropic glutamate receptor: identification of new potent agonists and differentiation from the L-(+)-2-amino-4-phosphonobutanoic acid-sensitive receptor in the lateral perforant pathway in rats.

1995 • 64 citations

Presynaptic localization of a metabotropic glutamate receptor, mGluR8, in the rhinencephalic areas: a light and electron microscope study in the rat

1996 • 63 citations

Characterization of the binding of <scp>dl</scp>‐[³H]‐2‐amino‐4‐phosphonobutyrate to <scp>l</scp>‐glutamate‐sensitive sites on rat brain synaptic membranes

1983 • 62 citations

Modulation of sensory neurone excitatory and inhibitory responses in the ventrobasal thalamus by activation of metabotropic excitatory amino acid receptors

1995 • 61 citations

Characteristics of chloride-dependent incorporation of glutamate into brain membranes argue against a receptor binding site

1987 • 60 citations

(S)‐Carboxy‐3‐Hydroxyphenylglycine, an Antagonist of Metabotropic Glutamate Receptor (mGluR)1a and an Agonist of mGluR2, Protects Against Audiogenic Seizures in DBA/2 Mice

1994 • 59 citations

A Decrease in [Ca²⁺]_c but not in cAMP Mediates L‐AP4 Inhibition of Glutamate Release: PKC‐mediated Suppression of this Inhibitory Pathway

1996 • 57 citations

Mediation of Thalamic Sensory Responses In Vivo by ACPD‐activated Excitatory Amino Acid Receptors

1993 • 57 citations

Expression pattern and pharmacology of the rat type IV metabotropic glutamate receptor

1993 • 56 citations

Cl⁻/Ca²⁺‐dependent L‐glutamate binding sites do not correspond to 2‐amino‐4‐phosphonobutanoate‐sensitive excitatory amino acid receptors

1985 • 52 citations

[³H]‐L‐2‐amino‐4‐phosphonobutyrate labels a metabotropic glutamate receptor, mGluR4a

1995 • 51 citations

Cloning and Characterization of a Metabotropic Glutamate Receptor, mGluR4b

1997 • 48 citations

(2S,1'S,2'S,3'R)-2-(2'-carboxy-3'-phenylcyclopropyl)glycine, a potent and selective antagonist of type 2 metabotropic glutamate receptors.

1996 • 48 citations

Hippocampal cells primed with quisqualate are depolarized by AP4 and AP6, ligands for a putative glutamate uptake site

1987 • 42 citations

Metabotropic glutamate group II receptors are responsible for the depression of synaptic transmission induced by ACPD in the dentate gyrus

1995 • 35 citations

Molecular Cloning, Expression, and Characterization of Metabotropic Glutamate Receptor Subtypes

1994 • 33 citations

Structure - function relationships for gamma-substituted glutamate analogues on dentate granule cells

1983 • 31 citations

Serine-O-phosphate has affinity for type IV, but not type I, metabotropic glutamate receptor.

1993 • 30 citations

Pharmacology of selective and non-selective metabotropic glutamate receptor agonists at l-AP4 receptors in retinal ON bipolar cells

1995 • 27 citations

Displacement of DL-[3H]-2-amino-4-phosphonobutanoic acid ([3H]APB) binding with methyl-substituted APB analogs and glutamate agonists

1985 • 27 citations

Identification of 2-amino-2-methyl-4-phosphonobutanoic acid as an antagonist at the mGlu4a receptor

1995 • 26 citations

Pharmacological similarity between the retinal APB receptor and the family of metabotropic glutamate receptors

1994 • 26 citations

The metabotropic glutamate receptors

1995 • 22 citations

Antagonism of lateral olfactory tract synaptic potentials in rat prepyriform cortex slices

1986 • 22 citations

Possible roles ofl-phosphoserine in the pathogenesis of Alzheimer’s disease

1991 • 21 citations

Utilization of the resolvedl-isomer of 2-amino-6-phosphonohexanoic acid (l-AP6) as a selective agonist for a quisqualate-sensitized site in hippocampal CA1 pyramidal neurons

1994 • 19 citations

Actions of phenylglycine derivatives at L-AP4 receptors in retinal ON bipolar cells

1995 • 16 citations

Quisqualic acid induced sensitization and the active uptake ofl-quisqualic acid by hippocampal slices

1993 • 15 citations

Activity of the conformationally rigid 2-amino-4-phosphonobutanoic acid (AP4) analogue (RS)-1-amino-3-(phosphonomethylene)cyclobutane-1-carboxyclic acid (cyclobutylene AP5) on evoked responses in the perforant pathway of rat hippocampus

1992 • 12 citations

Phenylglycines can Evoke Quisqualate‐primed Depolarizations in Rat Cingulate Cortex: An Effect Associated with [³H]DL‐AP₄ Uptake

1996 • 7 citations