Metabotropic glutamate receptors in brain function and pathology

Molecular Diversity of Glutamate Receptors and Implications for Brain Function

1992 • 2,535 citations

Molecular cloning and characterization of the rat NMDA receptor

1991 • 1,780 citations

Sequence and expression of a metabotropic glutamate receptor

1991 • 1,200 citations

A family of metabotropic glutamate receptors

1992 • 873 citations

Molecular characterization of a novel metabotropic glutamate receptor mGluR5 coupled to inositol phosphate/Ca2+ signal transduction.

1992 • 814 citations

Distribution of the mRNA for a metabotropic glutamate receptor (mGluR1) in the central nervous system: An in situ hybridization study in adult and developing rat

1992 • 645 citations

Signal transduction and pharmacological characteristics of a metabotropic glutamate receptor, mGluRl, in transfected CHO cells

1992 • 539 citations

Cloning, Expression, and Gene Structure of a G Protein-Coupled Glutamate Receptor from Rat Brain

1991 • 524 citations

Pharmacological and functional characteristics of metabotropic excitatory amino acid receptors

1990 • 464 citations

Potassium conductances in hippocampal neurons blocked by excitatory amino-acid transmitters

1990 • 436 citations

Agonists at metabotropic glutamate receptors presynaptically inhibit EPSCs in neonatal rat hippocampus.

1991 • 431 citations

Glutamate receptor channels: novel properties and new clones

1992 • 427 citations

A long-term depression of AMPA currents in cultured cerebellar purkinje neurons

1991 • 405 citations

Excitatory amino acid receptors, second messengers and regulation of intracellular Ca2+ in mammalian neurons

1990 • 355 citations

L-AP4 inhibits calcium currents and synaptic transmission via a G- protein-coupled glutamate receptor

1992 • 210 citations

Protein kinase C‐mediated enhancement of NMDA currents by metabotropic glutamate receptors in Xenopus oocytes.

1992 • 209 citations

Quisqualate Metabotropic Receptors Modulate NMDA Currents and Facilitate Induction of Long‐Term Potentiation Through Protein Kinase C

1992 • 200 citations

Activation of hippocampal metabotropic excitatory amino acid receptors leads to seizures and neuronal damage

1992 • 193 citations

Agonist analysis of 2‐(carboxycyclopropyl)glycine isomers for cloned metabotropic glutamate receptor subtypes expressed in Chinese hamster ovary cells

1992 • 189 citations

Quisqualate receptor-mediated depression of calcium currents in hippocampal neurons

1990 • 185 citations

Excitatory effects of ACPD receptor activation in the hippocampus are mediated by direct effects on pyramidal cells and blockade of synaptic inhibition

1991 • 168 citations

Metabotropic glutamate receptors potentiate ionotropic glutamate responses in the rat dorsal horn.

1992 • 165 citations

1S,3R-ACPD stimulates and L-AP3 blocks Ca2+ mobilization in rat cerebellar neurons

1990 • 163 citations

Inhibition of Cyclic AMP Formation by a Selective Metabotropic Glutamate Receptor Agonist

1992 • 158 citations

Metabotropic glutamate receptors mediate excitatory transmission in the nucleus of the solitary tract

1992 • 151 citations

Metabotropic glutamate receptors are required for the induction of long-term potentiation

1992 • 147 citations

Activation of a Large‐conductance Ca²⁺‐Dependent K⁺ Channel by Stimulation of Glutamate Phosphoinositide‐coupled Receptors in Cultured Cerebellar Granule Cells

1991 • 139 citations

L-2-amino-4-phosphonobutyrate (L-AP4) is an agonist at the type iv metabotropic glutamate receptor which is negatively coupled to adenylate cyclase

1992 • 135 citations

Trans-1-aminocyclopentane-1,3-dicarboxylic acid (t-ACPD) decreases synaptic excitation in rat striatal slices through a presynaptic action

1991 • 133 citations

Metabotropic Glutamate Receptor Activation Produces Extrapyramidal Motor System Activation That Is Mediated by Striatal Dopamine

1992 • 117 citations

(trans)-1-amino-cyclopentyl-1,3-dicarboxylate stimulates quisqualate phosphoinositide-coupled receptors but not ionotropic glutamate receptors in striatal neurons and Xenopus oocytes.

1990 • 105 citations

Activation of quisqualate metabotropic receptors reduces glutamate and GABA-mediated synaptic potentials in the rat striatum

1992 • 94 citations

Effects of ACPD and AP3 on parallel-fibre-mediated EPSPs of Purkinje cells in cerebellar slices in vitro

1991 • 94 citations

Metabotropic Excitatory Amino Acid Receptor Activation Stimulates Phospholipase D in Hippocampal Slices

1992 • 87 citations

Roles of glutamate receptors in long-term potentiation at hippocampal mossy fiber synapses

1991 • 86 citations

Comparison of (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD)- and 1R,3S-ACPD-stimulated brain phosphoinositide hydrolysis

1991 • 86 citations

Activation of the glutamate metabotropic receptor protects retina against N-methyl-D-aspartate toxicity

1992 • 84 citations

Intrastriatal injection of a selective metabotropic excitatory amino acid receptor agonist induces contralateral turning in the rat.

1991 • 83 citations

Trans-ACPD and l-APB presynaptically inhibit excitatory glutamatergic transmission in the basolateral amygdala (BLA)

1992 • 80 citations

Activation of glutamate metabotropic receptors induces long-term potentiation

1992 • 78 citations

Activation of Metabotropic Glutamate Receptors in the Hippocampus Increases Cyclic AMP Accumulation

1992 • 74 citations

Multiple metabotropic glutamate receptors regulate hippocampal function

1992 • 57 citations

Pharmacological characterization of the quisqualate receptor coupled to phospholipase C (Qp) in striatal neurons

1991 • 57 citations

Developmental Changes in the Modulation of Cyclic AMP Formation by the Metabotropic Glutamate Receptor Agonist 1S,3R‐Aminocyclopentane‐1,3‐Dicarboxylic Acid in Brain Slices

1992 • 54 citations

Pharmacology and physiology of metabotropic glutamate receptors in mammalian central nervous system

1991 • 48 citations

L-2-amino-3-phosphonopropionate blocks late synaptic long-term potentiation

1991 • 44 citations

Inhibition of Forskolin‐Stimulated Cyclic AMP Formation by 1‐Aminocyclopentane‐trans‐1,3‐Dicarboxylate in Guinea‐Pig Cerebral Cortical Slices

1992 • 36 citations

Evidence for Metabotropic Excitatory Amino Acid Receptor Heterogeneity: Developmental and Brain Regional Studies

1992 • 35 citations

Trans-ACPD inhibits cAMP formation via a pertussis toxin-sensitive G-protein

1992 • 30 citations

Trans-ACPD-induced phosphoinositide hydrolysis and modulation of hippocampal pyramidal cell excitability do not undergo parallel developmental regulation

1992 • 24 citations

2‐Amino‐3‐phosphonopropionate fails to block postsynaptic effects of metabotropic glutamate receptors in rat hippocampal neurones

1992 • 15 citations

Effects of serotonin and carbachol on glial and neuronal rubidium uptake in leech CNS

1992 • 7 citations