Cyclobutane Quisqualic Acid Analogues as Selective mGluR5a Metabotropic Glutamic Acid Receptor Ligands

Molecular Diversity of Glutamate Receptors and Implications for Brain Function

1992 • 2,535 citations

The Excitatory Amino Acid Receptors: Their Classes, Pharmacology, and Distinct Properties in the Function of the Central Nervous System

1989 • 2,203 citations

Physiological and pathophysiological roles of excitatory amino acids during central nervous system development

1990 • 1,427 citations

Pharmacological and functional characteristics of metabotropic excitatory amino acid receptors

1990 • 464 citations

Excitatory amino acid recognition sites coupled with inositol phospholipid metabolism: developmental changes and interaction with alpha 1-adrenoceptors.

1986 • 399 citations

Positive feedback of glutamate exocytosis by metabotropic presynaptic receptor stimulation

1992 • 354 citations

(RS)-2-Chloro-5-Hydroxyphenylglycine (CHPG) Activates mGlu5, but not mGlu1, Receptors Expressed in CHO Cells and Potentiates NMDA Responses in the Hippocampus

1997 • 306 citations

Multistep Carcinogenesis: a 1992 Perspective

1992 • 279 citations

The Binding of [³H]AMPA, a Structural Analogue of Glutamic Acid, to Rat Brain Membranes

1982 • 223 citations

A novel metabotropic glutamate receptor agonist: marked depression of monosynaptic excitation in the newborn rat isolated spinal cord

1993 • 197 citations

Excitatory Amino Acid Agonist‐Antagonist Interactions at 2‐Amino‐4‐Phosphonobutyric Acid‐Sensitive Quisqualate Receptors Coupled to Phosphoinositide Hydrolysis in Slices of Rat Hippocampus

1988 • 181 citations

Structural requirements for the inhibition for L-glutamate uptake by glia and nerve endings

1975 • 157 citations

Expression and Coupling to Polyphosphoinositide Hydrolysis of Group I Metabotropic Glutamate Receptors in Early Postnatal and Adult Rat Brain

1997 • 149 citations

Metabotropic glutamate receptors are required for the induction of long-term potentiation

1992 • 147 citations

Actions of phenylglycine analogs at subtypes of the metabotropic glutamate receptor family

1994 • 139 citations

Subtypes of Sodium-Dependent High-Affinity L-[³H]Glutamate Transport Activity: Pharmacologic Specificity and Regulation by Sodium and Potassium

1993 • 136 citations

L-2-amino-4-phosphonobutyrate (L-AP4) is an agonist at the type iv metabotropic glutamate receptor which is negatively coupled to adenylate cyclase

1992 • 135 citations

Attenuation of Excitatory Amino Acid Toxicity by Metabotropic Glutamate Receptor Agonists and Aniracetam in Primary Cultures of Cerebellar Granule Cells

1993 • 109 citations

A pharmacological characterization of the mGluR1α subtype of the metabotropic glutamate receptor expressed in a cloned baby hamster kidney cell line

1993 • 96 citations

Synthesis and activity of a potent N-methyl-D-aspartic acid agonist, trans-1-aminocyclobutane-1,3-dicarboxylic acid, and related phosphonic and carboxylic acids

1990 • 94 citations

A new quisqualate receptor subtype (sAA2) responsible for the glutamate-induced inositol phosphate formation in rat brain synaptoneurosomes

1988 • 90 citations

2-Amino-3-phosphonopropionate blocks the induction and maintenance of long-term potentiation in rat hippocampal slices

1991 • 89 citations

Changes in excitatory amino acid modulation of phosphoinositide metabolism during development

1990 • 81 citations

Cell-free expression of functional Shaker potassium channels

1992 • 65 citations

Characteristics of chloride-dependent incorporation of glutamate into brain membranes argue against a receptor binding site

1987 • 60 citations

Exposure of hippocampal slices to quisqualate sensitizes synaptic responses to phosphonate-containing analogues of glutamate

1986 • 46 citations

Neurobiology of Stereotyped Behaviour

1990 • 35 citations

Multiple Mechanisms for Inhibition of Excitatory Amino Acid Receptors Coupled to Phosphoinositide Hydrolysis

1992 • 32 citations

Novel recognition site forl-quisqualate sensitizes neurons to depolarization byl-2-amino-4-phosphonobutanoate (l-AP4)

1989 • 30 citations

Effects of quisqualic acid analogs on metabotropic glutamate receptors coupled to phosphoinositide hydrolysis in rat hippocampus

1995 • 24 citations

The Effects of <scp>l</scp>‐Glutamate and trans‐(±)‐1‐Amino‐1,3‐Cyclopentanedicarboxylate on Phosphoinositide Hydrolysis Can Be Pharmacologically Differentiated

1994 • 18 citations

Quisqualic acid induced sensitization and the active uptake ofl-quisqualic acid by hippocampal slices

1993 • 15 citations

Synthesis of Oxadiazolidinedione Derivatives as Quisqualic Acid Analogs and Their Evaluation at a Quisqualate-Sensitized Site in the Rat Hippocampus

1994 • 13 citations