In Vitro and In Vivo Pharmacology of trans‐ and cis‐(±)‐1‐Amino‐1,3‐Cyclopentanedicarboxylic Acid: Dissociation of Metabotropic and Ionotropic Excitatory Amino Acid Receptor Effects

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1957 • 3,309 citations

The Excitatory Amino Acid Receptors: Their Classes, Pharmacology, and Distinct Properties in the Function of the Central Nervous System

1989 • 2,203 citations

Calcium-mediated neurotoxicity: relationship to specific channel types and role in ischemic damage

1988 • 1,745 citations

Excitatory amino acid receptors in the vertebrate central nervous system.

1989 • 1,316 citations

Lesion of striatal neurons with kainic acid provides a model for Huntington's chorea

1976 • 1,247 citations

Remington's pharmaceutical sciences

1976 • 1,125 citations

Cytotoxic effects of acidic and sulphur containing amino acids on the infant mouse central nervous system

1971 • 808 citations

A new type of glutamate receptor linked to inositol phospholipid metabolism

1987 • 743 citations

Glutamate stimulates inositol phosphate formation in striatal neurones

1985 • 734 citations

Analysis of combined drug effects: a new look at a very old problem

1983 • 593 citations

Two classes of N-methyl-D-aspartate recognition sites: differential distribution and differential regulation by glycine.

1988 • 495 citations

Neurotoxicity ofN-methyl-d-aspartate is markedly enhanced in developing rat central nervous system

1988 • 465 citations

Coupling of Inositol Phospholipid Metabolism with Excitatory Amino Acid Recognition Sites in Rat Hippocampus

1986 • 444 citations

Excitatory amino acid recognition sites coupled with inositol phospholipid metabolism: developmental changes and interaction with alpha 1-adrenoceptors.

1986 • 399 citations

Trans-ACPD, a selective agonist of the phosphoinositide-coupled excitatory amino acid receptor

1989 • 318 citations

BINDING OF [³H]KAINIC ACID, AN ANALOGUE OF <scp>l</scp>‐GLUTAMATE, TO BRAIN MEMBRANES

1976 • 308 citations

Astrocyte glutamate receptor activation promotes inositol phospholipid turnover and calcium flux

1986 • 187 citations

Excitatory Amino Acid Agonist‐Antagonist Interactions at 2‐Amino‐4‐Phosphonobutyric Acid‐Sensitive Quisqualate Receptors Coupled to Phosphoinositide Hydrolysis in Slices of Rat Hippocampus

1988 • 181 citations

Characterization of the binding of [³H]‐CGS 19755: a novel N‐methyl‐<scp>d</scp>‐aspartate antagonist with nanomolar affinity in rat brain

1988 • 164 citations

Inhibition of Excitatory Amino Acid‐Stimulated Phosphoinositide Hydrolysis in the Neonatal Rat Hippocampus by 2‐Amino‐3‐Phosphonopropionate

1989 • 114 citations

Glutamate receptors and phosphoinositide metabolism: stimulation via quisqualate receptors is inhibited by receptor activation

1988 • 104 citations

Quantitative assessment of neuroprotection against NMDA-induced brain injury

1989 • 102 citations

Convulsions induced in 10-day-old rats by intraperitional injection of monosodium glutamate and related excitant amino acids

1973 • 98 citations

N-Methyl-d-aspartic acid-induced lethality in mice: selective antagonism by phencylidine-like drugs

1988 • 97 citations

Selective activation of phosphoinositide hydrolysis by a rigid analogue of glutamate

1990 • 92 citations

A new quisqualate receptor subtype (sAA2) responsible for the glutamate-induced inositol phosphate formation in rat brain synaptoneurosomes

1988 • 90 citations

4-(Tetrazolylalkyl)piperidine-2-carboxylic acids. Potent and selective N-methyl-D-aspartic acid receptor antagonists with a short duration of action

1991 • 84 citations

Kindling enhances the stimulation of inositol phospholipid hydrolysis elicited by ibotenic acid in rat hippocampal slices

1986 • 70 citations

Excitatory amino acid-induced convulsions in neonatal rats mediated by distinct receptor subtypes

1990 • 69 citations

Excitotoxicity and N‐methyl‐D‐Aspartate receptors

1989 • 57 citations

α-Amino-ω-phosphono carboxylates block ibotenate but not kainate neurotoxicity in rat hippocampus

1982 • 45 citations

CGS-19755 and MK-801 selectively prevent rat striatal cholinergic and gabaergic neuronal degeneration induced by N-methyl-D-aspartate and ibotenate in vivo

1989 • 21 citations

Selective activation of oscillatory currents by trans-ACPD in rat brain mRNA-injected Xenopus oocytes and their blockade by NMDA

1990 • 20 citations

Current Aspects of the Neurosciences

1990 • 17 citations

Structural requirements for activation of excitatory amino acid receptors in the rat spinal cord in vitro

1988 • 16 citations