Synthesis and biological evaluation of two analogues of (S)-α-methyl-3-carboxyphenylalanine

Self‐Regeneration of Stereocenters (SRS)—Applications, Limitations, and Abandonment of a Synthetic Principle

1996 • 473 citations

Design, Synthesis, and Pharmacological Characterization of (+)-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY354740): A Potent, Selective, and Orally Active Group 2 Metabotropic Glutamate Receptor Agonist Possessing Anticonvulsant and Anxiolytic Properties

1997 • 389 citations

Phenylglycine derivatives as antagonists of metabotropic glutamate receptors

1994 • 303 citations

N‐Acetylaspartylglutamate Selectively Activates mGluR3 Receptors in Transfected Cells

1997 • 295 citations

A novel class of antagonists for metabotropic glutamate receptors, 7-(Hydroxyimino)cyclopropa[b]chromen-1a-carboxylates

1996 • 178 citations

1-Aminoindan-1,5-dicarboxylic Acid: A Novel Antagonist at Phospholipase C-Linked Metabotropic Glutamate Receptors

1995 • 173 citations

N‐Acetylaspartylglutamate Inhibits Forskolin‐Stimulated Cyclic AMP Levels via a Metabotropic Glutamate Receptor in Cultured Cerebellar Granule Cells

1993 • 109 citations

Structure‐activity relationships of new agonists and antagonists of different metabotropic glutamate receptor subtypes

1996 • 97 citations

Synthesis and Pharmacological Characterization of All Sixteen Stereoisomers of 2-(2‘-Carboxy-3‘-phenylcyclopropyl)glycine. Focus on (2S,1‘S,2‘S,3‘R)-2-(2‘-Carboxy-3‘-phenylcyclopropyl)glycine, a Novel and Selective Group II Metabotropic Glutamate Receptors Antagonist

1996 • 86 citations

α-Alkylation of acyclic amino acids with self-reproduction of the Center of Chirality. A new route to (S)-(+)-α-alkylated aspartic acids.

1987 • 67 citations

Asymmetric dipolar cycloaddition reactions: a practical, convergent synthesis of chiral pyrrolidines

1997 • 60 citations

Synthesis and Biology of the Conformationally Restricted ACPD Analogue, 2-Aminobicyclo[2.1.1]hexane-2,5-dicarboxylic Acid-I, a Potent mGluR Agonist

1998 • 58 citations

(2S,4S)-2-Amino-4-(4,4-diphenylbut-1-yl)- pentane-1,5-dioic Acid: A Potent and Selective Antagonist for Metabotropic Glutamate Receptors Negatively Linked to Adenylate Cyclase

1996 • 58 citations

Syntheses of 6-oxodecahydroisoquinoline-3-carboxylates. Useful intermediates for the preparation of conformationally defined excitatory amino acid antagonists

1991 • 42 citations

Synthesis, molecular modeling, and biology of the 1-benzyl derivative of APDC-an apparent mGluR6 selective ligand

1997 • 37 citations

Palladium-Catalyzed Reaction of Aryl Polyfluoroalkanesulfonates withO,O-Dialkyl Phosphonates

1987 • 36 citations

Synthesis and biological activity of cyclic analogues of MPPG and MCPG as metabotropic glutamate receptor antagonists

1997 • 32 citations

Pharmacological characterization of metabotropic glutamate receptors linked to the inhibition of adenylate cyclase activity in rat striatal slices

1997 • 30 citations

Stereoselective synthesis of (S )-MPPG, (S)-MTPG and (S )-(+)-αM4CPG from (R)-4-hydroxyphenylglycine

1997 • 26 citations

Metabotropic glutamate receptors: potential drug targets

1996 • 26 citations

Synthesis of (2S,1′ S,2′ S)-2-methyl-2-(carboxycyclopropyl)glycine and (S)-2-amino-2-methyl-4-phosphonobutyric acid from l-alanine

1997 • 15 citations

Agonists and Antagonists for Metabotropic Glutamate Receptors

1995 • 12 citations

Studies on 1-Azabicyclo Compounds. XX. Synthesis of Hexahydroisoquino[3, 2-c][1, 4]benzodiazepine and Related Compounds and Formation of 6-Methyl-hexahydro-5H-dibenzo [b, g][1, 5] diazacycloundecine from Hexahydroisoquino [3, 2-c][1, 4]benzodiazepin-13-one

1974 • 8 citations