The G Protein-Coupling Profile of Metabotropic Glutamate Receptors, as Determined with Exogenous G Proteins, Is Independent of Their Ligand Recognition Domain

PHARMACOLOGY AND FUNCTIONS OF METABOTROPIC GLUTAMATE RECEPTORS

1997 • 3,070 citations

Cloning and characterization of an extracellular Ca2+-sensing receptor from bovine parathyroid

1993 • 2,625 citations

Molecular Diversity of Glutamate Receptors and Implications for Brain Function

1992 • 2,535 citations

Differential signal transduction by five splice variants of the PACAP receptor

1993 • 1,185 citations

Expression cloning of GABAB receptors uncovers similarity to metabotropic glutamate receptors

1997 • 1,020 citations

A novel family of genes encoding putative pheromone receptors in mammals

1995 • 1,003 citations

Substitution of three amino acids switches receptor specificity of Gqα to that of Giα

1993 • 702 citations

A Multigene Family Encoding a Diverse Array of Putative Pheromone Receptors in Mammals

1997 • 700 citations

The ligand-binding domain in metabotropic glutamate receptors is related to bacterial periplasmic binding proteins

1993 • 695 citations

A Novel Family of Putative Pheromone Receptors in Mammals with a Topographically Organized and Sexually Dimorphic Distribution

1997 • 694 citations

Site of G Protein Binding to Rhodopsin Mapped with Synthetic Peptides from the α Subunit

1988 • 491 citations

Gα15 and Gα16 Couple a Wide Variety of Receptors to Phospholipase C

1995 • 488 citations

In vitro mutagenesis and the search for structure-function relationships among G protein-coupled receptors

1992 • 470 citations

Structural elements of Gα subunits that interact with Gβγ, receptors, and effectors

1993 • 417 citations

Characterization of G-protein alpha subunits in the Gq class: expression in murine tissues and in stromal and hematopoietic cell lines.

1991 • 278 citations

Molecular, functional, and pharmacological characterization of the metabotropic glutamate receptor type 5 splice variants: comparison with mGluR1

1995 • 275 citations

Fluorescent Labeling of Purified β2 Adrenergic Receptor

1995 • 271 citations

G alpha 16, a G protein alpha subunit specifically expressed in hematopoietic cells.

1991 • 263 citations

G _z -Mediated Hormonal Inhibition of Cyclic AMP accumulation

1992 • 258 citations

Agonist-specific coupling of a cloned Drosophila octopamine/tyramine receptor to multiple second messenger systems.

1994 • 243 citations

Identification of a receptor/G-protein contact site critical for signaling specificity and G-protein activation.

1995 • 204 citations

NMR structure of a receptor-bound G-protein peptide

1993 • 202 citations

Domains involved in the specificity of G protein activation in phospholipase C-coupled metabotropic glutamate receptors.

1994 • 197 citations

Constitutive activation of a single effector pathway: evidence for multiple activation states of a G protein-coupled receptor.

1996 • 188 citations

Evolutionarily conserved Galphabetagamma binding surfaces support a model of the G protein-receptor complex.

1996 • 181 citations

Carboxyl-terminal mutations of Gq alpha and Gs alpha that alter the fidelity of receptor activation.

1996 • 171 citations

The Second Intracellular Loop of Metabotropic Glutamate Receptor 1 Cooperates with the Other Intracellular Domains to Control Coupling to G-proteins

1996 • 155 citations

Synthesis and Pharmacological Characterization of Aminocyclopentanetricarboxylic Acids: New Tools to Discriminate between Metabotropic Glutamate Receptor Subtypes

1997 • 142 citations

Role of the large extracellular domain of metabotropic glutamate receptors in agonist selectivity determination.

1993 • 141 citations

Changes in the carboxyl-terminal domain of metabotropic glutamate receptor 1 by alternative splicing generate receptors with differing agonist-independent activity.

1996 • 139 citations

Contribution of ligand structure to activation of alpha 2-adrenergic receptor subtype coupling to Gs.

1994 • 133 citations

Cloning and functional expression of a Drosophila metabotropic glutamate receptor expressed in the embryonic CNS.

1996 • 116 citations

Pharmacology of Muscarinic Receptor Subtypes Constitutively Activated by G Proteins

1997 • 111 citations

Coupling of metabotropic glutamate receptors 2 and 4 to G alpha 15, G alpha 16, and chimeric G alpha q/i proteins: characterization of new antagonists.

1996 • 105 citations

Cloning and Functional Expression of aDrosophilaMetabotropic Glutamate Receptor Expressed in the Embryonic CNS

1996 • 97 citations

A Cluster of Basic Residues in the Carboxyl-terminal Tail of the Short Metabotropic Glutamate Receptor 1 Variants Impairs Their Coupling to Phospholipase C

1998 • 81 citations

Novel localization of a G protein, Gz-alpha, in neurons of brain and retina

1990 • 74 citations

Multiple regions of G alpha 16 contribute to the specificity of activation by the C5a receptor.

1995 • 63 citations

The agonist selectivity of a class III metabotropic glutamate receptor, human mGluR4a, is determined by the N-terminal extracellular domain.

1995 • 48 citations

The agonist selectivity of a class III metabotropic glutamate receptor, human mGluR4a, is determined by the N-terminal extracellular domain

1995 • 28 citations