Formation and Function of the Myofibroblast during Tissue Repair

Biomechanics. Mechanical Properties of Living Tissues

1982 • 6,144 citations

Tissue Cells Feel and Respond to the Stiffness of Their Substrate

2005 • 5,909 citations

Smad-dependent and Smad-independent pathways in TGF-β family signalling

2003 • 5,052 citations

Myofibroblasts and mechano-regulation of connective tissue remodelling

2002 • 3,938 citations

Tensional homeostasis and the malignant phenotype

2005 • 3,655 citations

Regulation of Wound Healing by Growth Factors and Cytokines

2003 • 3,383 citations

Smad transcription factors

2005 • 2,366 citations

The microenvironment of the tumour–host interface

2001 • 2,307 citations

Effects of substrate stiffness on cell morphology, cytoskeletal structure, and adhesion

2004 • 2,220 citations

Local force and geometry sensing regulate cell functions

2006 • 2,178 citations

Transforming growth factor-beta 1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts

1993 • 2,169 citations

Putting tumours in context

2001 • 2,145 citations

Transmembrane crosstalk between the extracellular matrix and the cytoskeleton

2001 • 2,141 citations

A Mechanism for Regulating Pulmonary Inflammation and Fibrosis: The Integrin αvβ6 Binds and Activates Latent TGF β1

1999 • 1,965 citations

SPECIFICITY AND VERSATILITY IN TGF-β SIGNALING THROUGH SMADS

2005 • 1,804 citations

Friends or foes — bipolar effects of the tumour stroma in cancer

2004 • 1,742 citations

Making sense of latent TGFβ activation

2002 • 1,579 citations

The myofibroblast in wound healing and fibrocontractive diseases

2003 • 1,548 citations

Regulation of cadherin-mediated adhesion in morphogenesis

2005 • 1,475 citations

Alpha-Smooth Muscle Actin Expression Upregulates Fibroblast Contractile Activity

2001 • 1,207 citations

Apoptosis mediates the decrease in cellularity during the transition between granulation tissue and scar.

1995 • 1,167 citations

Non-Smad TGF-β signals

2005 • 1,030 citations

Role of tissue stroma in cancer cell invasion

2003 • 1,021 citations

Peripheral Blood Fibrocytes: Differentiation Pathway and Migration to Wound Sites

2001 • 921 citations

Perspective Article: Tissue repair, contraction, and the myofibroblast

2005 • 849 citations

Fibroblast biology in three-dimensional collagen matrices

2003 • 809 citations

The Fibronectin Domain ED-A Is Crucial for Myofibroblastic Phenotype Induction by Transforming Growth Factor-β1

1998 • 801 citations

Mechanisms of Pulmonary Fibrosis

2004 • 714 citations

Integrins in Mechanotransduction

2004 • 690 citations

Focal adhesion size controls tension-dependent recruitment of α-smooth muscle actin to stress fibers

2006 • 673 citations

Selected Methods for Imaging Elastic Properties of Biological Tissues

2003 • 659 citations

Bone marrow–derived progenitor cells in pulmonary fibrosis

2004 • 649 citations

THE CARDIAC FIBROBLAST: Therapeutic Target in Myocardial Remodeling and Failure

2005 • 628 citations

Mechanical Tension Controls Granulation Tissue Contractile Activity and Myofibroblast Differentiation

2001 • 605 citations

Bone marrow–derived progenitor cells in pulmonary fibrosis

2004 • 598 citations

Get a ligand, get a life: integrins, signaling and cell survival

2002 • 591 citations

Intercellular adhesion, signalling and the cytoskeleton

2002 • 578 citations

Myofibroblast Differentiation by Transforming Growth Factor-ॆ1 Is Dependent on Cell Adhesion and Integrin Signaling via Focal Adhesion Kinase

2003 • 574 citations

Galectin-3 regulates myofibroblast activation and hepatic fibrosis

2006 • 568 citations

The stroma reaction myofibroblast: a key player in the control of tumor cell behavior

2004 • 543 citations

Mechanosensitive ion channels: molecules of mechanotransduction

2004 • 526 citations

Tenascins: regulation and putative functions during pathological stress

2003 • 524 citations

Mechanotransduction at Cell-Matrix and Cell-Cell Contacts

2004 • 520 citations

[Mechanical properties of living tissues].

1986 • 513 citations

Induction of alpha-smooth muscle actin by transforming growth factor-beta 1 in quiescent human breast gland fibroblasts. Implications for myofibroblast generation in breast neoplasia.

1993 • 511 citations

The Myofibroblast in Pulmonary Fibrosis*

2002 • 498 citations

Contribution of Adventitial Fibroblasts to Neointima Formation and Vascular Remodeling

2001 • 488 citations

The Compliance of Collagen Gels Regulates Transforming Growth Factor-β Induction of α-Smooth Muscle Actin in Fibroblasts

1999 • 462 citations

Integrin αVβ6-mediated activation of latent TGF-β requires the latent TGF-β binding protein-1

2004 • 459 citations

A significant proportion of myofibroblasts are of bone marrow origin in human liver fibrosis☆

2004 • 439 citations

Clinging to life: cell to matrix adhesion and cell survival

2005 • 435 citations

Cadherin switching in human prostate cancer progression.

2000 • 403 citations

Mechanisms of force generation and transmission by myofibroblasts

2003 • 399 citations

Tenascin‐C and SF/HGF produced by myofibroblasts in vitro provide convergent proinvasive signals to human colon cancer cells through RhoA and Rac

2004 • 389 citations

Fibrocytes contribute to the myofibroblast population in wounded skin and originate from the bone marrow

2004 • 376 citations

TGF-β1-mediated fibroblast–myofibroblast terminal differentiation—the role of smad proteins

2003 • 360 citations

Endothelin-1 Promotes Myofibroblast Induction through the ETA Receptor via a rac/Phosphoinositide 3-Kinase/Akt-dependent Pathway and Is Essential for the Enhanced Contractile Phenotype of Fibrotic Fibroblasts

2004 • 351 citations

Interstitial fluid flow induces myofibroblast differentiation and collagen alignment in vitro

2005 • 349 citations

Normal and Pathologic Soft Tissue Remodeling: Role of the Myofibroblast, with Special Emphasis on Liver and Kidney Fibrosis

2003 • 349 citations

Smad3 Mediates Transforming Growth Factor-β–Induced α-Smooth Muscle Actin Expression

2003 • 304 citations

α-Smooth Muscle Actin Is Crucial for Focal Adhesion Maturation in Myofibroblasts

2003 • 297 citations

A Transforming Growth Factor β (TGFβ) Control Element Drives TGFβ-induced Stimulation of Smooth Muscle α-Actin Gene Expression in Concert with Two CArG Elements

1997 • 297 citations

Focal adhesion features during myofibroblastic differentiation are controlled by intracellular and extracellular factors

2001 • 296 citations

Direct cadherin-activated cell signaling

2002 • 285 citations

Myofibroblast and Endothelial Cell Proliferation during Murine Myocardial Infarct Repair

2003 • 284 citations

Release of Mechanical Tension Triggers Apoptosis of Human Fibroblasts in a Model of Regressing Granulation Tissue

1999 • 282 citations

Bone-marrow-derived myofibroblasts contribute to the cancer-induced stromal reaction

2003 • 276 citations

Masters and servants of the force: The role of matrix adhesions in myofibroblast force perception and transmission

2005 • 271 citations

Thy-1 Expression in Human Fibroblast Subsets Defines Myofibroblastic or Lipofibroblastic Phenotypes

2003 • 265 citations

The role of Smad3 in mediating mouse hepatic stellate cell activation

2001 • 253 citations

Tubular epithelial-myofibroblast transdifferentiation mechanisms in proximal tubule cells

2003 • 252 citations

Cell-matrix and cell-cell contacts of myofibroblasts: role in connective tissue remodeling

2003 • 252 citations

Global Expression Profiling of Fibroblast Responses to Transforming Growth Factor-β1 Reveals the Induction of Inhibitor of Differentiation-1 and Provides Evidence of Smooth Muscle Cell Phenotypic Switching

2003 • 252 citations

Glioma Expansion in Collagen I Matrices: Analyzing Collagen Concentration-Dependent Growth and Motility Patterns

2005 • 251 citations

Modulation of Fibroblast Morphology and Adhesion during Collagen Matrix Remodeling

2002 • 247 citations

Smoothelin, a novel cytoskeletal protein specific for smooth muscle cells.

1996 • 245 citations

Hepatic fibrosis and cirrhosis: The (myo)fibroblastic cell subpopulations involved

2005 • 244 citations

Multiple Organ Engraftment by Bone‐Marrow‐Derived Myofibroblasts and Fibroblasts in Bone‐Marrow‐Transplanted Mice

2003 • 243 citations

Nerve growth factor displays stimulatory effects on human skin and lung fibroblasts, demonstrating a direct role for this factor in tissue repair

2001 • 236 citations

The NH2-terminal peptide of α–smooth muscle actin inhibits force generation by the myofibroblast in vitro and in vivo

2002 • 226 citations

Assembly and mechanosensory function of focal adhesions: experiments and models

2005 • 225 citations

Shared expression of phenotypic markers in systemic sclerosis indicates a convergence of pericytes and fibroblasts to a myofibroblast lineage in fibrosis

2005 • 222 citations

Myofibroblast Development Is Characterized by Specific Cell-Cell Adherens Junctions

2004 • 222 citations

The Role of Matrix Stiffness in Hepatic Stellate Cell Activation and Liver Fibrosis

2005 • 221 citations

Inhibition of cardiac myofibroblast formation and collagen synthesis by activation and overexpression of adenylyl cyclase

2004 • 219 citations

Loss of Fibroblast Thy-1 Expression Correlates with Lung Fibrogenesis

2005 • 217 citations

Increased Expression of Integrin αvβ3 Contributes to the Establishment of Autocrine TGF-β Signaling in Scleroderma Fibroblasts

2005 • 217 citations

Connective tissue growth factor: A new and important player in the pathogenesis of fibrosis

2002 • 212 citations

Individual domains of connective tissue growth factor regulate fibroblast proliferation and myofibroblast differentiation

2005 • 199 citations

Transforming Growth Factor-β Activation of Phosphatidylinositol 3-Kinase Is Independent of Smad2 and Smad3 and Regulates Fibroblast Responses via p21-Activated Kinase-2

2005 • 198 citations

Impaired vascular contractility and blood pressure homeostasis in the smooth muscle α‐actin null mouse

2000 • 195 citations

Tenascin-C Regulates Recruitment of Myofibroblasts during Tissue Repair after Myocardial Injury

2005 • 190 citations

Smads 2 and 3 Are Differentially Activated by Transforming Growth Factor-β (TGF-β) in Quiescent and Activated Hepatic Stellate Cells

2003 • 185 citations

Cadherin Switching in Human Prostate Cancer Progression

2000 • 179 citations

FIZZ1 Stimulation of Myofibroblast Differentiation

2004 • 177 citations

Myofibroblast Differentiation Is Induced in Keratinocyte-Fibroblast Co-Cultures and Is Antagonistically Regulated by Endogenous Transforming Growth Factor-β and Interleukin-1

2004 • 172 citations

Multiple roles of α-smooth muscle actin in mechanotransduction

2005 • 169 citations

Expression of extra domain A fibronectin sequence in vascular smooth muscle cells is phenotype dependent.

1989 • 165 citations

The fibroblast‐populated collagen matrix as a model of wound healing: a review of the evidence

2004 • 163 citations

Mechanisms of Neointima Formation and Remodeling in the Porcine Coronary Artery

2001 • 158 citations

Interferon-γ Interferes with Transforming Growth Factor-β Signaling through Direct Interaction of YB-1 with Smad3

2003 • 157 citations

In Vivo Characterization of Bone Marrow–Derived Fibroblasts Recruited into Fibrotic Lesions

2005 • 156 citations

Cadherins Mediate Intercellular Mechanical Signaling in Fibroblasts by Activation of Stretch-sensitive Calcium-permeable Channels

2001 • 155 citations

Type VI collagen induces cardiac myofibroblast differentiation: implications for postinfarction remodeling

2005 • 151 citations

Smad2 and Smad3 Play Different Roles in Rat Hepatic Stellate Cell Function and α-Smooth Muscle Actin Organization

2005 • 148 citations

Characterization of Human Palladin, a Microfilament-associated Protein

2001 • 144 citations

Involvement of αvβ5 integrin–mediated activation of latent transforming growth factor β1 in autocrine transforming growth factor β signaling in systemic sclerosis fibroblasts

2005 • 129 citations

IL-6 Modulates Alpha-Smooth Muscle Actin Expression in Dermal Fibroblasts from IL-6-Deficient Mice

2006 • 125 citations

Regulation of α-smooth muscle actin gene expression in myofibroblast differentiation from rat lung fibroblasts

2001 • 124 citations

The integrin alphavbeta3 is a receptor for the latency-associated peptides of transforming growth factors beta1 and beta3

2003 • 119 citations

Thy-1 Expression Regulates the Ability of Rat Lung Fibroblasts to Activate Transforming Growth Factor-β in Response to Fibrogenic Stimuli

2004 • 119 citations

Histology for Pathologists

2007 • 116 citations

Transforming Growth Factor-β1 Specifically Induce Proteins Involved in the Myofibroblast Contractile Apparatus

2004 • 114 citations

Myofibroblasts are responsible for collagen synthesis in the stroma of human hepatocellular carcinoma: an in vivo and in vitro study

1999 • 113 citations

Transforming Growth Factor β Stimulates Fibroblast–Collagen Matrix Contraction by Different Mechanisms in Mechanically Loaded and Unloaded Matrices

2002 • 112 citations

Latent TGF-β binding protein LTBP-1 contains three potential extracellular matrix interacting domains

2001 • 106 citations

Expression of the Integrin α8β1 during Pulmonary and Hepatic Fibrosis

2000 • 104 citations

Regulation of α-Smooth Muscle Actin Expression in Granulation Tissue Myofibroblasts Is Dependent on the Intronic CArG Element and the Transforming Growth Factor-β1 Control Element

2005 • 97 citations

Active Transforming Growth Factor-β in Wound Repair

1999 • 96 citations

FAK‐dependent regulation of myofibroblast differentiation

2006 • 95 citations

Y-box Protein-1 Is the Crucial Mediator of Antifibrotic Interferon-γ Effects

2005 • 93 citations

Isoform-Specific Regulation of the Actin-Organizing Protein Palladin during TGF-β1-Induced Myofibroblast Differentiation

2006 • 85 citations

Upregulation of TGF-β1 Expression May Be Necessary but Is Not Sufficient for Excessive Scarring

2006 • 84 citations

TGF-beta receptor expression and smad2 localization are cell density dependent in fibroblasts.

2000 • 82 citations

The specific NH2-terminal sequence Ac-EEED of alpha-smooth muscle actin plays a role in polymerization in vitro and in vivo.

1995 • 82 citations

TGF-β activation by traction?

2004 • 82 citations

Dissecting the roles of endothelin,TGF-β and GM-CSF on myofibroblast differentiation by keratinocytes

2004 • 81 citations

On the mechanism of skin wound "contraction": a granulation tissue "knockout" with a normal phenotype.

1995 • 80 citations

Integrin α8β1 mediates adhesion to LAP-TGFβ1

2002 • 78 citations

The myofibroblast: a study of normal, reactive and neoplastic tissues, with an emphasis on ultrastructure.

2007 • 76 citations

Collagen remodeling and cardiac dysfunction in patients with hypertrophic cardiomyopathy: The significance of type III and VI collagens

2001 • 75 citations

Transforming growth factor-beta-stimulated connective tissue growth factor expression during corneal myofibroblast differentiation.

2001 • 72 citations

Contractile activity and smooth muscle α-actin organization in thrombin-induced human lung myofibroblasts

2003 • 69 citations

Constitutive Phosphorylation of Focal Adhesion Kinase Is Involved in the Myofibroblast Differentiation of Scleroderma Fibroblasts

2005 • 68 citations

Vascular Smooth Muscle α-Actin Gene Transcription during Myofibroblast Differentiation Requires Sp1/3 Protein Binding Proximal to the MCAT Enhancer

2002 • 67 citations

Contraction-Dependent Apoptosis of Normal Dermal Fibroblasts

2001 • 67 citations

Wound splinting regulates granulation tissue survival

2003 • 65 citations

The origins and regulation of tissue tension: Identification of collagen tension-fixation process in vitro

2005 • 61 citations

The myofibroblast: a study of normal, reactive and neoplastic tissues, with an emphasis on ultrastructure. Part 1--normal and reactive cells.

2005 • 61 citations

α8β1 integrin is upregulated in myofibroblasts of fibrotic and scarring myocardium

2003 • 60 citations

Regulation of connective tissue homeostasis in the skin by mechanical forces.

2004 • 58 citations

Induction of Vascular Smooth Muscle α-Actin Gene Transcription in Transforming Growth Factor β1-Activated Myofibroblasts Mediated by Dynamic Interplay between the Pur Repressor Proteins and Sp1/Smad Coactivators

2004 • 57 citations

Sequential deposition of latent TGF-β binding proteins (LTBPs) during formation of the extracellular matrix in human lung fibroblasts

2005 • 54 citations

Cryptic MCAT Enhancer Regulation in Fibroblasts and Smooth Muscle Cells

2002 • 50 citations

The N-terminal Ac-EEED sequence plays a role in α-smooth-muscle actin incorporation into stress fibers

2005 • 46 citations

Novel Functions of Intracellular IL-1ra in Human Dermal Fibroblasts: Implications in the Pathogenesis of Fibrosis

2006 • 36 citations

Demonstration of collagen type VI and alpha-smooth muscle actin in renal fibrotic injury in man.

1998 • 35 citations

Two MCAT elements of the SM α-actin promoter function differentially in SM vs. non-SM cells

1998 • 33 citations

Expression of isoforms and splice variants of the latent transforming growth factor β binding protein (LTBP) in cultured human liver myofibroblasts

2001 • 33 citations