Constitutive Phosphorylation of Focal Adhesion Kinase Is Involved in the Myofibroblast Differentiation of Scleroderma Fibroblasts

Integrins: Versatility, modulation, and signaling in cell adhesion

1992 • 9,986 citations

Transforming Growth Factor β in Tissue Fibrosis

1994 • 3,055 citations

The Transforming Growth Factor-beta Family

1990 • 3,028 citations

Transforming growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix.

1986 • 2,499 citations

Integrins: Emerging Paradigms of Signal Transduction

1995 • 1,591 citations

Tyrosine phosphorylation of paxillin and pp125FAK accompanies cell adhesion to extracellular matrix: a role in cytoskeletal assembly.

1992 • 1,330 citations

Alpha-smooth muscle actin is transiently expressed by myofibroblasts during experimental wound healing.

1990 • 1,176 citations

Autophosphorylation of the Focal Adhesion Kinase, ppl25^FAK, Directs SH2-Dependent Binding of pp60^src

1994 • 1,168 citations

Tyrosine Phosphorylation of Focal Adhesion Kinase at Sites in the Catalytic Domain Regulates Kinase Activity: a Role for Src Family Kinases

1995 • 989 citations

Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src.

1994 • 844 citations

Differentiation repertoire of fibroblastic cells: expression of cytoskeletal proteins as marker of phenotypic modulations.

1990 • 838 citations

Regulation of focal adhesion-associated protein tyrosine kinase by both cellular adhesion and oncogenic transformation

1992 • 831 citations

Focal adhesion protein-tyrosine kinase phosphorylated in response to cell attachment to fibronectin.

1992 • 811 citations

Cell adhesion or integrin clustering increases phosphorylation of a focal adhesion-associated tyrosine kinase.

1992 • 743 citations

Regulation of Cell Adhesion Receptors by Transforming Growth Factor-β

1989 • 672 citations

Integrin-dependent phosphorylation and activation of the protein tyrosine kinase pp125FAK in platelets.

1992 • 669 citations

Myofibroblast Differentiation by Transforming Growth Factor-ॆ1 Is Dependent on Cell Adhesion and Integrin Signaling via Focal Adhesion Kinase

2003 • 574 citations

Increased Collagen Synthesis by Scleroderma Skin Fibroblasts In Vitro A POSSIBLE DEFECT IN THE REGULATION OR ACTIVATION OF THE SCLERODERMA FIBROBLAST

1974 • 545 citations

Phosphorylation of Tyrosine 397 in Focal Adhesion Kinase Is Required for Binding Phosphatidylinositol 3-Kinase

1996 • 540 citations

Myofibroblasts and their role in lung collagen gene expression during pulmonary fibrosis. A combined immunohistochemical and in situ hybridization study.

1994 • 470 citations

Signal transduction pathways regulating Rho-mediated stress fibre formation: requirement for a tyrosine kinase.

1994 • 469 citations

Activation of an H2O2-generating NADH Oxidase in Human Lung Fibroblasts by Transforming Growth Factor β1

1995 • 426 citations

Hepatocyte growth factor/scatter factor induces tyrosine phosphorylation of focal adhesion kinase (p125FAK) and promotes migration and invasion by oral squamous cell carcinoma cells.

1994 • 320 citations

Platelet-derived growth factor modulation of focal adhesion kinase (p125FAK) and paxillin tyrosine phosphorylation in Swiss 3T3 cells. Bell-shaped dose response and cross-talk with bombesin.

1994 • 305 citations

Bombesin, vasopressin, and endothelin stimulation of tyrosine phosphorylation in Swiss 3T3 cells. Identification of a novel tyrosine kinase as a major substrate.

1992 • 296 citations

Bombesin stimulation of p125 focal adhesion kinase tyrosine phosphorylation. Role of protein kinase C, Ca2+ mobilization, and the actin cytoskeleton

1993 • 277 citations

Lysophosphatidic acid stimulates tyrosine phosphorylation of focal adhesion kinase, paxillin, and p130. Signaling pathways and cross-talk with platelet-derived growth factor.

1994 • 264 citations

Activation of Collagen Gene Expression in Keloids: Co-Localization of Type I and VI Collagen and Transforming Growth Factor-β1 mRNA

1991 • 250 citations

Scleroderma

1979 • 241 citations

Diphenylhydantoin (dilantin) gingival hyperplasia: drug-induced abnormality of connective tissue.

1976 • 221 citations

ADP-ribosylation of rho p21 inhibits lysophosphatidic acid-induced protein tyrosine phosphorylation and phosphatidylinositol 3-kinase activation in cultured Swiss 3T3 cells.

1993 • 212 citations

Altered steady-state ratio of type I/III procollagen mRNAs correlates with selectively increased type I procollagen biosynthesis in cultured keloid fibroblasts.

1985 • 208 citations

Variability in Collagen and Fibronectin Synthesis by Scleroderma Fibroblasts in Primary Culture

1981 • 201 citations

Identification of Tyr-397 as the Primary Site of Tyrosine Phosphorylation and pp60^src Association in the Focal Adhesion Kinase, pp125^FAK

1995 • 185 citations

Identification of Fibroblasts Responsible for Increased Collagen Production in Localized Scleroderma by In Situ Hybridization

1988 • 176 citations

Co-ordinate increase in the expression of type I and type III collagen genes in progressive systemic sclerosis fibroblasts

1986 • 173 citations

Blockade of endogenous transforming growth factor β signaling prevents up‐regulated collagen synthesis in scleroderma fibroblasts: Association with increased expression of transforming growth factor β receptors

2001 • 169 citations

The RhoA-dependent assembly of focal adhesions in Swiss 3T3 cells is associated with increased tyrosine phosphorylation and the recruitment of both pp125FAK and protein kinase C-δ to focal adhesions

1994 • 168 citations

Blockade of endogenous transforming growth factor ? signaling prevents up-regulated collagen synthesis in scleroderma fibroblasts: Association with increased expression of transforming growth factor ? receptors

2001 • 159 citations

Myofibroblasts from Scleroderma Skin Synthesize Elevated Levels of Collagen and Tissue Inhibitor of Metalloproteinase (TIMP-1) with Two Forms of TIMP-1

1995 • 153 citations

Tyrosine phosphorylation is involved in reorganization of the actin cytoskeleton in response to serum or LPA stimulation

1994 • 147 citations

Inhibition of TGF-beta 3 (but not TGF-beta 1 or TGF-beta 2) activity prevents normal mouse embryonic palate fusion.

1995 • 140 citations

A transmembrane-anchored chimeric focal adhesion kinase is constitutively activated and phosphorylated at tyrosine residues identical to pp125FAK.

1994 • 134 citations

Focal adhesion kinase is abundant in developing blood vessels and elevation of its phosphotyrosine content in vascular smooth muscle cells is a rapid response to angiotensin II

1994 • 122 citations

Transforming Growth Factor-β1-induced Activation of the ERK Pathway/Activator Protein-1 in Human Lung Fibroblasts Requires the Autocrine Induction of Basic Fibroblast Growth Factor

2000 • 101 citations

Increased expression of type VI collagen genes in systemic sclerosis

1990 • 97 citations

IL-4 Up-Regulates the Expression of Tissue Inhibitor of Metalloproteinase-2 in Dermal Fibroblasts Via the p38 Mitogen-Activated Protein Kinase-Dependent Pathway

2002 • 84 citations

Increased Expression Levels of Integrin αvβ5 on Scleroderma Fibroblasts

2004 • 76 citations

Progressive systemic sclerosis (PSS, scleroderma) dermal fibroblasts synthesize increased amounts of glycosaminoglycan.

1983 • 71 citations

Stimulation of Collagen Synthesis by the Anabolic Steroid Stanozolol

1998 • 64 citations

Growth and characterization of fibroblasts obtained from bronchoalveolar lavage of patients with scleroderma.

1992 • 61 citations

Upregulated Expression of Fibroblast Growth Factor (FGF) Receptors by Transforming Growth Factor-β1 (TGF-β1) Mediates Enhanced Mitogenic Responses to FGFs in Cultured Human Lung Fibroblasts

1998 • 60 citations

SPONTANEOUS PRODUCTION OF FIBRONECTIN BY ALVEOLAR MACROPHAGES IN PATIENTS WITH SCLERODERMA

1989 • 50 citations

Mitogenic Activity of Dermatofibrosarcoma Protuberans is Mediated via an Extracellular Signal Related Kinase Dependent Pathway

2002 • 13 citations