Sequential deposition of latent TGF-β binding proteins (LTBPs) during formation of the extracellular matrix in human lung fibroblasts

Dysregulation of TGF-β activation contributes to pathogenesis in Marfan syndrome

2003 • 1,359 citations

An Assay for Transforming Growth Factor-β Using Cells Transfected with a Plasminogen Activator Inhibitor-1 Promoter-Luciferase Construct

1994 • 749 citations

Latent high molecular weight complex of transforming growth factor beta 1. Purification from human platelets and structural characterization.

1988 • 648 citations

Latent Transforming Growth Factor β-binding Protein 1 Interacts with Fibrillin and Is a Microfibril-associated Protein

2003 • 531 citations

The Marfan Syndrome

2000 • 507 citations

Integrin αVβ6-mediated activation of latent TGF-β requires the latent TGF-β binding protein-1

2004 • 459 citations

Latent transforming growth factor-beta 1 associates to fibroblast extracellular matrix via latent TGF-beta binding protein

1994 • 450 citations

TGF-β1 binding protein: A component of the large latent complex of TGF-β1 with multiple repeat sequences

1990 • 447 citations

Latent Transforming Growth Factor-β Binding Protein Domains Involved in Activation and Transglutaminase-dependent Cross-Linking of Latent Transforming Growth Factor-β

1997 • 397 citations

Latent TGF-β Binding Proteins: Extracellular Matrix Association and Roles in TGF-β Activation

2004 • 346 citations

Physicochemical Activation of Recombinant Latent Transforming Growth Factor-beta's 1, 2, and 3

1990 • 343 citations

Latent transforming growth factor-β binding proteins (LTBPs)—structural extracellular matrix proteins for targeting TGF-β action

1999 • 302 citations

Fibronectin Regulates Latent Transforming Growth Factor-β (TGFβ) by Controlling Matrix Assembly of Latent TGFβ-binding Protein-1

2005 • 293 citations

Specific Sequence Motif of 8-Cys Repeats of TGF-β Binding Proteins, LTBPs, Creates a Hydrophobic Interaction Surface for Binding of Small Latent TGF-β

2000 • 281 citations

Extracellular Matrix and Cytokines: A Functional Unit

2000 • 265 citations

Disruption of the gene encoding the latent transforming growth factor-β binding protein 4 (LTBP-4) causes abnormal lung development, cardiomyopathy, and colorectal cancer

2002 • 251 citations

Association of the small latent transforming growth factor-beta with an eight cysteine repeat of its binding protein LTBP-1.

1996 • 236 citations

Latent transforming growth factor-beta 1 and its binding protein are components of extracellular matrix microfibrils.

1996 • 222 citations

Release and activation of platelet latent TGF–β in blood clots during dissolution with plasmin

1995 • 216 citations

Extracellular Matrix-Associated Transforming Growth Factor-β: Role in Cancer Cell Growth and Invasion

1998 • 209 citations

Release of transforming growth factor-beta 1 from the pericellular matrix of cultured fibroblasts and fibrosarcoma cells by plasmin and thrombin.

1992 • 204 citations

Assembly of extracellular matrix

1992 • 159 citations

Bone abnormalities in latent TGF-β binding protein (Ltbp)-3–null mice indicate a role for Ltbp-3 in modulating TGF-β bioavailability

2002 • 158 citations

Role of the Latent Transforming Growth Factor β–Binding Protein 1 in Fibrillin-Containing Microfibrils in Bone Cells In Vitro and In Vivo

2000 • 156 citations

Fibrillin mutations in Marfan syndrome and related phenotypes

1996 • 135 citations

Identification and Characterization of a New Latent Transforming Growth Factor-β-binding Protein, LTBP-4

1998 • 128 citations

Fibrillins Can Co-assemble in Fibrils, but Fibrillin Fibril Composition Displays Cell-specific Differences

2003 • 127 citations

Fibrillin microfibrils: multipurpose extracellular networks in organismal physiology

2004 • 118 citations

Fibrillin: from domain structure to supramolecular assembly

2000 • 117 citations

Latent TGF-β binding protein LTBP-1 contains three potential extracellular matrix interacting domains

2001 • 106 citations

Efficient Association of an Amino-terminally Extended Form of Human Latent Transforming Growth Factor-β Binding Protein with the Extracellular Matrix

1995 • 89 citations

Disruption of LTBP-4 function reduces TGF-β activation and enhances BMP-4 signaling in the lung

2004 • 75 citations

Recombinant Latent Transforming Growth Factor β-binding Protein 2 Assembles to Fibroblast Extracellular Matrix and Is Susceptible to Proteolytic Processing and Release

1998 • 74 citations

Secretion of human latent TGF-β-binding protein-3 (LTBP-3) is dependent on co-expression of TGF-β

2002 • 65 citations

Amino Acid Requirements for Formation of the TGF-β-Latent TGF-β Binding Protein Complexes

2004 • 56 citations

Novel non-TGF-β-binding splice variant of LTBP-4 in human cells and tissues provides means to decrease TGF-β deposition

2001 • 34 citations