Transforming growth factor-beta 1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts

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Tumors: Wounds That Do Not Heal

1986 • 4,202 citations

Transforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro.

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Transforming growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix.

1986 • 2,499 citations

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A monoclonal antibody against alpha-smooth muscle actin: a new probe for smooth muscle differentiation.

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Presence of modified fibroblasts in granulation tissue and their possible role in wound contraction

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Some recent advances in the chemistry and biology of transforming growth factor-beta.

1987 • 1,308 citations

Alpha-smooth muscle actin is transiently expressed by myofibroblasts during experimental wound healing.

1990 • 1,176 citations

Transforming growth factor-beta in disease: the dark side of tissue repair.

1992 • 1,126 citations

Natural inhibitor of transforming growth factor-β protects against scarring in experimental kidney disease

1992 • 984 citations

Differentiation repertoire of fibroblastic cells: expression of cytoskeletal proteins as marker of phenotypic modulations.

1990 • 838 citations

Transforming growth factor-beta: recent progress and new challenges.

1992 • 781 citations

Tumor Necrosis Factor (Cachectin) as an Essential Mediator in Murine Cerebral Malaria

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Control of scarring in adult wounds by neutralising antibody to transforming growth factor β

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Myofibroblasts from diverse pathologic settings are heterogeneous in their content of actin isoforms and intermediate filament proteins.

1989 • 473 citations

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1981 • 465 citations

Expression of smooth muscle cell phenotype by rat mesangial cells in immune complex nephritis. Alpha-smooth muscle actin is a marker of mesangial cell proliferation.

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Enhanced production and extracellular deposition of the endothelial-type plasminogen activator inhibitor in cultured human lung fibroblasts by transforming growth factor-beta.

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Alpha-smooth muscle actin, a differentiation marker of smooth muscle cells, is present in microfilamentous bundles of pericytes.

1989 • 367 citations

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1986 • 339 citations

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The functional importance of multiple actin isoforms

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Transforming growth factor beta (TGF-β) induces fibrosis in a fetal wound model

1988 • 220 citations

The stellate cell (Ito-cell, fat-storing cell, lipocyte, perisinusoidal cell) of the liver

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α-Smooth muscle actin is expressed in a subpopulation of cultured and cloned fibroblasts and is modulated by γ-interferon

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1985 • 156 citations

Locally applied GM-CSF induces the accumulation of α-smooth muscle act in containing myofibroblasts

1991 • 154 citations

Desmin and actin in the identification of Ito cells and in monitoring their evolution to myofibroblasts in experimental liver fibrosis

1988 • 153 citations

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1990 • 147 citations

Heparin induces alpha-smooth muscle actin expression in cultured fibroblasts and in granulation tissue myofibroblasts.

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Evidence for the nonmuscle nature of the "myofibroblast" of granulation tissue and hypertropic scar. An immunofluorescence study.

1988 • 122 citations

MINIREVIEW: Interactions of Retinoids and Transforming Growth Factor-β in Regulation of Cell Differentiation and Proliferation

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Transforming growth factor type β regulation of actin mRNA

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1990 • 107 citations

Alpha-smooth muscle actin in parenchymal cells of bleomycin-injured rat lung.

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1987 • 103 citations

Antibodies to peptide determinants in transforming growth factor .beta. and their applications

1988 • 102 citations

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1990 • 101 citations

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1988 • 99 citations

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Fat storing cells (FSC) of rat liver synthesize and secrete fibronectin

1987 • 95 citations

Stromal myofibroblasts in primary invasive and metastatic carcinomas

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Isolation of the Oncogene and Epidermal Growth Factor-Induced Transin Gene: Complex Control in Rat Fibroblasts

1986 • 90 citations

Cultured aortic smooth muscle cells from newborn and adult rats show distinct cytoskeletal features

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1986 • 84 citations

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Organization of actin cytoskeleton during early endothelial regeneration in vitro

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Growth factors as wound healing agents

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Modulation of actin isoform expression in cultured arterial smooth muscle cells by heparin and culture conditions.

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The matrix of human breast tumor cells is mitogenic for fibroblasts.

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1988 • 33 citations

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Collagens in scar carcinoma of the lung

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1990 • 9 citations