Thy-1 Expression Regulates the Ability of Rat Lung Fibroblasts to Activate Transforming Growth Factor-β in Response to Fibrogenic Stimuli

Transforming growth factor-beta 1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts

1993 • 2,169 citations

A Mechanism for Regulating Pulmonary Inflammation and Fibrosis: The Integrin αvβ6 Binds and Activates Latent TGF β1

1999 • 1,965 citations

The myofibroblast in wound healing and fibrocontractive diseases

2003 • 1,548 citations

Transforming growth factor beta modulates the expression of collagenase and metalloproteinase inhibitor.

1987 • 1,243 citations

Thrombospondin-1 Is a Major Activator of TGF-β1 In Vivo

1998 • 1,151 citations

Diversity, topographic differentiation, and positional memory in human fibroblasts

2002 • 1,082 citations

Adenovector-mediated gene transfer of active transforming growth factor-beta1 induces prolonged severe fibrosis in rat lung.

1997 • 1,010 citations

Growth factors in the extracellular matrix

1997 • 879 citations

An Assay for Transforming Growth Factor-β Using Cells Transfected with a Plasminogen Activator Inhibitor-1 Promoter-Luciferase Construct

1994 • 749 citations

The integrin αvβ8 mediates epithelial homeostasis through MT1-MMP–dependent activation of TGF-β1

2002 • 701 citations

Cooperation of Liver Cells in Health and Disease

2001 • 565 citations

The Myofibroblast in Pulmonary Fibrosis*

2002 • 498 citations

Thrombospondin causes activation of latent transforming growth factor- beta secreted by endothelial cells by a novel mechanism [published erratum appears in J Cell Biol 1993 Sep;122(5):following 1143]

1993 • 467 citations

Transforming growth factor-beta increases steady state levels of type I procollagen and fibronectin messenger RNAs posttranscriptionally in cultured human dermal fibroblasts.

1987 • 467 citations

Transforming growth factor beta increases mRNA for matrix proteins both in the presence and in the absence of changes in mRNA stability.

1988 • 420 citations

Regulation of Transforming Growth Factor-β Activation by Discrete Sequences of Thrombospondin 1

1995 • 413 citations

Effect of antibody to transforming growth factor beta on bleomycin induced accumulation of lung collagen in mice.

1993 • 402 citations

Cultured lung fibroblasts isolated from patients with idiopathic pulmonary fibrosis have a diminished capacity to synthesize prostaglandin E2 and to express cyclooxygenase-2.

1995 • 385 citations

Fibroblasts from Idiopathic Pulmonary Fibrosis and Normal Lungs Differ in Growth Rate, Apoptosis, and Tissue Inhibitor of Metalloproteinases Expression

2001 • 348 citations

Inhibition of Myofibroblast Apoptosis by Transforming Growth Factor β₁

1999 • 343 citations

The Activation Sequence of Thrombospondin-1 Interacts with the Latency-associated Peptide to Regulate Activation of Latent Transforming Growth Factor-β

1999 • 336 citations

Thrombospondin binds and activates the small and large forms of latent transforming growth factor-beta in a chemically defined system.

1994 • 274 citations

Thy-1 Expression in Human Fibroblast Subsets Defines Myofibroblastic or Lipofibroblastic Phenotypes

2003 • 265 citations

Cooperation of Liver Cells in Health and Disease

2001 • 258 citations

Transdifferentiation of hepatic stellate cells (Ito cells) to myofibroblasts: a key event in hepatic fibrogenesis.

1996 • 237 citations

Lung fibroblast alpha-smooth muscle actin expression and contractile phenotype in bleomycin-induced pulmonary fibrosis.

1996 • 230 citations

Dual Roles of IL-4 in Lung Injury and Fibrosis

2003 • 222 citations

Reduction of bleomycin induced lung fibrosis by transforming growth factor beta soluble receptor in hamsters

1999 • 188 citations

Subsets of murine lung fibroblasts express membrane-bound and soluble IL-4 receptors. Role of IL-4 in enhancing fibroblast proliferation and collagen synthesis.

1994 • 188 citations

Future Research Directions in Idiopathic Pulmonary Fibrosis

2002 • 183 citations

Activation of Rat Alveolar Macrophage-Derived Latent Transforming Growth Factor β-1 by Plasmin Requires Interaction with Thrombospondin-1 and its Cell Surface Receptor, CD36

1999 • 173 citations

Release of biologically active TGF-β1 by alveolar epithelial cells results in pulmonary fibrosis

2003 • 167 citations

Triggering the Induction of Myofibroblast and Fibrogenesis by Airway Epithelial Shedding

2001 • 159 citations

Regulation of the effects of TGF-beta 1 by activation of latent TGF-beta 1 and differential expression of TGF-beta receptors (Tbeta R-I and Tbeta R-II) in idiopathic pulmonary fibrosis

2001 • 158 citations

Characterization of Two Major Populations of Lung Fibroblasts: Distinguishing Morphology and Discordant Display of Thy 1 and Class II MHC

1989 • 144 citations

Idiopathic pulmonary fibrosis: new insights in its pathogenesis

2002 • 133 citations

Interstitial fibrosis and growth factors.

2000 • 129 citations

Fibroblast migration and proliferation during in vitro wound healing

1993 • 120 citations

Urokinase Receptor Deficiency Accelerates Renal Fibrosis in Obstructive Nephropathy

2003 • 107 citations

Thy-1 regulates fibroblast focal adhesions, cytoskeletal organization and migration through modulation of p190 RhoGAP and Rho GTPase activity

2004 • 103 citations

Regulation of lung fibroblast alpha-smooth muscle actin expression, contractile phenotype, and apoptosis by IL-1beta.

1997 • 102 citations

Fibroblast phenotypes in pulmonary fibrosis.

2003 • 88 citations

A CD36 Synthetic Peptide Inhibits Bleomycin-Induced Pulmonary Inflammation and Connective Tissue Synthesis in the Rat

2000 • 76 citations

Induction of Telomerase Activity in Fibroblasts from Bleomycin-Injured Lungs

2000 • 73 citations

Integrin αvβ8-Mediated Activation of Transforming Growth Factor-β Inhibits Human Airway Epithelial Proliferation in Intact Bronchial Tissue

2003 • 61 citations

Differential collagen and fibronectin production by Thy 1+ and Thy 1- lung fibroblast subpopulations

1992 • 58 citations

Thy1 (+) and (-) lung fibrosis subpopulations in LEW and F344 rats

1994 • 50 citations

Morphologic and functional characteristics of subpopulations of murine lung fibroblasts grown in vitro

1992 • 49 citations

Differential expression of platelet-derived growth factor-α receptor by Thy-1⁻and Thy-1⁺lung fibroblasts

1999 • 45 citations

Idiopathic pulmonary fibrosis. New insights into classification and pathogenesis usher in a new era therapeutic approaches.

2003 • 42 citations

Cell surface Thy-1-cross-reactive glycoprotein in cultured PC12 cells: modulation by nerve growth factor and association with the cytoskeleton

1985 • 39 citations

The interaction of lymphocyte membrane proteins with the lymphocyte cytoskeletal matrix.

1984 • 39 citations

Differential Expression, Surface Binding, and Response to Connective Tissue Growth Factor in Lung Fibroblast Subpopulations

2001 • 39 citations

Concordant and Discordant Interleukin-1–Mediated Signaling in Lung Fibroblast Thy-1 Subpopulations

2002 • 32 citations

Induction of urokinase-type plasminogen activator receptor by IL-1 beta.

1997 • 32 citations

Tamoxifen and Estrogen Effects on TGF-β Formation: Role of Thrombospondin-1, αvβ3, and Integrin-Associated Protein

2001 • 28 citations

Cytoskeletal involvement in the sequential capping of rat thymocyte surface glycoproteins

1988 • 16 citations

Lung fibrosis

1999 • 12 citations

Lung fibrosis

2000 • 7 citations