A Transforming Growth Factor β (TGFβ) Control Element Drives TGFβ-induced Stimulation of Smooth Muscle α-Actin Gene Expression in Concert with Two CArG Elements

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

A rapid alkaline extraction procedure for screening recombinant plasmid DNA

1979 • 15,511 citations

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

Genomic sequencing.

1984 • 8,343 citations

The Pathogenesis of Atherosclerosis — An Update

1986 • 4,951 citations

Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor

1987 • 3,057 citations

Transforming growth factor-beta 1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts

1993 • 2,169 citations

Regulation of differentiation of vascular smooth muscle cells

1995 • 1,681 citations

Alpha-smooth muscle actin is transiently expressed by myofibroblasts during experimental wound healing.

1990 • 1,176 citations

Angiotensin II induces hypertrophy, not hyperplasia, of cultured rat aortic smooth muscle cells.

1988 • 1,077 citations

A simple phase-extraction assay for chloramphenicol acyltransferase activity

1988 • 1,006 citations

Isolation and properties of cDNA clones encoding SRF, a transcription factor that binds to the c-fos serum response element

1988 • 983 citations

Alternative Neural Crest Cell Fates Are Instructively Promoted by TGFβ Superfamily Members

1996 • 785 citations

Vascular smooth muscle cell hypertrophy vs. hyperplasia. Autocrine transforming growth factor-beta 1 expression determines growth response to angiotensin II.

1992 • 648 citations

Production of transforming growth factor beta 1 during repair of arterial injury.

1991 • 539 citations

Cloning of GT box-binding proteins: a novel Sp1 multigene family regulating T-cell receptor gene expression.

1992 • 533 citations

TGF-β1 inhibition of transin/stromelysin gene expression is mediated through a fos binding sequence

1990 • 444 citations

Functional Analysis of the Transforming Growth Factor βResponsive Elements in the WAF1/Cip1/p21 Promoter

1995 • 440 citations

SM22α, a Marker of Adult Smooth Muscle, Is Expressed in Multiple Myogenic Lineages During Embryogenesis

1996 • 397 citations

Direct transfer of transforming growth factor beta 1 gene into arteries stimulates fibrocellular hyperplasia.

1993 • 387 citations

Expression of transforming growth factor-beta 1 is increased in human vascular restenosis lesions.

1992 • 383 citations

Expression of the SM22alpha promoter in transgenic mice provides evidence for distinct transcriptional regulatory programs in vascular and visceral smooth muscle cells.

1996 • 321 citations

Human and Drosophila Homeodomain Proteins That Enhance the DNA-Binding Activity of Serum Response Factor

1992 • 314 citations

Transforming growth factor-beta stimulates alpha 2(I) collagen gene expression through a cis-acting element that contains an Sp1-binding site.

1994 • 311 citations

Transforming growth factor-beta-induced growth inhibition and cellular hypertrophy in cultured vascular smooth muscle cells.

1988 • 305 citations

Antibodies against transforming growth factor-beta 1 suppress intimal hyperplasia in a rat model.

1994 • 303 citations

A growth factor-induced kinase phosphorylates the serum response factor at a site that regulates its DNA-binding activity.

1993 • 253 citations

Displacement of BrdUrd-induced YY1 by serum response factor activates skeletal alpha-actin transcription in embryonic myoblasts.

1992 • 221 citations

M-CAT Binding Factor, a Novel trans-Acting Factor Governing Muscle-Specific Transcription

1990 • 193 citations

Angiotensin II-induced mitogenesis of spontaneously hypertensive rat-derived cultured smooth muscle cells is dependent on autocrine production of transforming growth factor-beta.

1992 • 188 citations

Myosin heavy chain isoform diversity in smooth muscle is produced by differential RNA processing

1989 • 187 citations

Avian Serum Response Factor Expression Restricted Primarily to Muscle Cell Lineages Is Required for α-Actin Gene Transcription

1996 • 186 citations

Activation of the second promoter of the transforming growth factor-β1 gene by transforming growth factor-β1 and phorbol ester occurs through the same target sequences

1989 • 185 citations

Induction of alpha-smooth muscle actin expression in cultured human brain pericytes by transforming growth factor-beta 1.

1994 • 184 citations

α-Smooth muscle actin is transiently expressed in embryonic rat cardiac and skeletal muscles

1988 • 183 citations

Effects of transforming growth factor-beta 1 on human arterial smooth muscle cells in vitro.

1991 • 171 citations

Transforming growth factor-beta response elements of the skeletal alpha-actin gene. Combinatorial action of serum response factor, YY1, and the SV40 enhancer-binding protein, TEF-1

1994 • 167 citations

The Smooth Muscle α-Actin Gene Promoter Is Differentially Regulated in Smooth Muscle versus Non-smooth Muscle Cells

1995 • 167 citations

Serum-regulated transcription by serum response factor (SRF): a novel role for the DNA binding domain.

1994 • 162 citations

An Improved CAT Assay for Promoter Analysis in Either Transgenic Mice or Tissue Culture Cells

1992 • 162 citations

Multiple 5'-flanking regions of the human alpha-skeletal actin gene synergistically modulate muscle-specific expression.

1987 • 150 citations

The CArG promoter sequence is necessary for muscle-specific transcription of the cardiac actin gene in Xenopus embryos.

1989 • 140 citations

Expression of the Smooth Muscle Cell Calponin Gene Marks the Early Cardiac and Smooth Muscle Cell Lineages during Mouse Embryogenesis

1996 • 131 citations

A combination of closely associated positive and negative cis-acting promoter elements regulates transcription of the skeletal alpha-actin gene.

1990 • 124 citations

Molecular analysis of cloned human 18S ribosomal DNA segments.

1978 • 124 citations

Elements of the smooth muscle alpha-actin promoter required in cis for transcriptional activation in smooth muscle. Evidence for cell type-specific regulation.

1992 • 123 citations

A ubiquitous factor (HF-1a) and a distinct muscle factor (HF-1b/MEF-2) form an E-box-independent pathway for cardiac muscle gene expression.

1992 • 123 citations

Factor-binding element in the human c-myc promoter involved in transcriptional regulation by transforming growth factor beta 1 and by the retinoblastoma gene product.

1991 • 120 citations

Differential Effect of Platelet-derived Growth Factor- Versus Serum-induced Growth on Smooth Muscle α-Actin and Nonmuscle β-Actin mRNA Expression in Cultured Rat Aortic Smooth Muscle Cells

1989 • 118 citations

Platelet-derived growth factor regulates actin isoform expression and growth factor regulates actin isoform expression and growth state in cultured rat aortic smooth muscle cells

1990 • 114 citations

Developmental Pattern of Expression and Genomic Organization of the Calponin-h1 Gene

1996 • 111 citations

Expression of the Smooth Muscle Myosin Heavy Chain Gene Is Regulated by a Negative-acting GC-rich Element Located between Two Positive-acting Serum Response Factor-binding Elements

1997 • 105 citations

Transforming growth factor beta induces myoblast differentiation in the presence of mitogens.

1992 • 99 citations

Interaction of Nuclear Proteins with Muscle-Specific Regulatory Sequences of the Human Cardiac α-Actin Promoter

1988 • 93 citations

The 5'-flanking region of the mouse vascular smooth muscle alpha-actin gene contains evolutionarily conserved sequence motifs within a functional promoter.

1990 • 92 citations

Mechanisms of angiotensin II- and arginine vasopressin-induced increases in protein synthesis and content in cultured rat aortic smooth muscle cells. Evidence for selective increases in smooth muscle isoactin expression.

1991 • 79 citations

A 29-Nucleotide DNA Segment Containing an Evolutionarily Conserved Motif is Required in cis for Cell-Type-Restricted Repression of the Chicken α-Smooth Muscle Actin Gene Core Promoter

1988 • 76 citations

Negative regulation of gene expression by TGF‐β

1992 • 71 citations

Identification of functional promoter elements in the rabbit smooth muscle myosin heavy chain gene.

1994 • 67 citations

Effects of transforming growth factor-β1 on growth of aortic smooth muscle cells Influences of interaction with growth factors, cell state, cell phenotype, and cell cycle

1991 • 64 citations

Transcriptional regulatory elements in the 5′ upstream and first intron regions of the human smooth muscle (aortic type) α-actin-encoding gene

1991 • 54 citations

Transcriptional Regulation of the Chicken Caldesmon Gene

1995 • 53 citations

Transforming growth factor-beta 1 gene activation and growth of smooth muscle from hypertensive rats.

1994 • 53 citations

Differential expression of SM1 and SM2 myosin isoforms in cultured vascular smooth muscle

1992 • 52 citations

Identification of Promoter Elements Involved in Cell-specific Regulation of Rat Smooth Muscle Myosin Heavy Chain Gene Transcription

1996 • 48 citations

Suppression of Ras transformation by serum response factor.

1994 • 44 citations

Identification of a TGF-β Responsive Element in the Human Elastin Promoter

1994 • 44 citations

TGF-beta 1 potentiates growth factor-stimulated proliferation of vascular smooth muscle cells in genetic hypertension

1992 • 39 citations

A novel protein interacts with the major transforming growth factor-beta responsive element in the plasminogen activator inhibitor type-1 gene.

1994 • 31 citations

Transcriptional regulation of the early growth response 1 gene in human myeloid leukemia cells by okadaic acid.

1993 • 31 citations

Transcriptional control of the chicken cardiac myosin light-chain gene is mediated by two AT-rich cis-acting DNA elements and binding of serum response factor.

1993 • 31 citations

Expression of myosin regulatory light-chain isoforms and regulation of phosphorylation in smooth muscle

1993 • 26 citations