Release of Mechanical Tension Triggers Apoptosis of Human Fibroblasts in a Model of Regressing Granulation Tissue

Wound Healing--Aiming for Perfect Skin Regeneration

1997 • 4,630 citations

Geometric Control of Cell Life and Death

1997 • 4,614 citations

Disruption of epithelial cell-matrix interactions induces apoptosis

1994 • 3,167 citations

Induction of apoptosis in fibroblasts by c-myc protein

1992 • 2,977 citations

Transforming growth factor-beta 1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts

1993 • 2,169 citations

Production of a tissue-like structure by contraction of collagen lattices by human fibroblasts of different proliferative potential in vitro.

1979 • 2,025 citations

The extracellular matrix as a cell survival factor.

1993 • 1,541 citations

Apoptosis mediates the decrease in cellularity during the transition between granulation tissue and scar.

1995 • 1,167 citations

Fibroblasts, myofibroblasts, and wound contraction

1994 • 1,150 citations

The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal.

1997 • 1,075 citations

Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway

1997 • 1,050 citations

Anchorage dependence, integrins, and apoptosis

1994 • 1,016 citations

c-Myc-induced apoptosis in fibroblasts is inhibited by specific cytokines.

1994 • 747 citations

Wound Healing: Biochemical and Clinical Aspects

1993 • 535 citations

Induction of alpha-smooth muscle actin by transforming growth factor-beta 1 in quiescent human breast gland fibroblasts. Implications for myofibroblast generation in breast neoplasia.

1993 • 511 citations

The Reconstitution of Living Skin

1983 • 499 citations

Isometric contraction by fibroblasts and endothelial cells in tissue culture: a quantitative study

1992 • 456 citations

Wound Healing: Biochemical & Clinical Aspects

1992 • 447 citations

Fluid Shear Stress Stimulates Phosphorylation of Akt in Human Endothelial Cells

1998 • 420 citations

Shear stress inhibits apoptosis of human endothelial cells

1996 • 329 citations

Fibroblast contraction occurs on release of tension in attached collagen lattices: Dependency on an organized actin cytoskeleton and serum

1992 • 249 citations

Stress relaxation of contracted collagen gels: Disruption of actin filament bundles, release of cell surface fibronectin, and down-regulation of DNA and protein synthesis

1991 • 217 citations

Extracellular matrix organization modulates fibroblast growth and growth factor responsiveness

1989 • 216 citations

Apoptosis is increased in a model of diabetes-impaired wound healing in genetically diabetic mice

1997 • 198 citations

A culture force monitor for measurement of contraction forces generated in human dermal fibroblast cultures: evidence for cell-matrix mechanical signalling

1994 • 197 citations

Lack of Hemodynamic Forces Triggers Apoptosis in Vascular Endothelial Cells

1997 • 163 citations

The Biology of the Myofibroblast Relationship to Wound Contraction and Fibrocontractive Diseases

1988 • 156 citations

Programmed cell death by default in embryonic cells, fibroblasts, and cancer cells.

1995 • 145 citations

Apoptosis down-regulates inflammation under the advancing epithelial wound edge: Delayed patterns in diabetes and improvement with topical growth factors

1997 • 137 citations

Long-Term Culture of Fibroblasts in Contracted Collagen Gels: Effects on Cell Growth and Biosynthetic Activity

1989 • 135 citations

Normal Human Primary Fibroblasts Undergo Apoptosis in Three-Dimensional Contractile Collagen Gels

1998 • 130 citations

Decreased level of PDGF-stimulated receptor autophosphorylation by fibroblasts in mechanically relaxed collagen matrices

1993 • 105 citations

Inhibition of Myofibroblasts by Skin Grafts

1979 • 102 citations

Cyclosporine A delays wound healing and apoptosis and suppresses activin beta-A expression in rats.

1998 • 58 citations

Covering by a flap induces apoptosis of granulation tissue myofibroblasts and vascular cells

1996 • 42 citations

Fibroblasts contracting collagen matrices form transient plasma membrane passages through which the cells take up fluorescein isothiocyanate-dextran and Ca2+.

1997 • 39 citations

Decreased PDGF Receptor Kinase Activity in Fibroblasts Contracting Stressed Collagen Matrices

1998 • 16 citations