Involvement of αvβ5 integrin–mediated activation of latent transforming growth factor β1 in autocrine transforming growth factor β signaling in systemic sclerosis fibroblasts

Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease

1992 • 2,969 citations

A Mechanism for Regulating Pulmonary Inflammation and Fibrosis: The Integrin αvβ6 Binds and Activates Latent TGF β1

1999 • 1,965 citations

Making sense of latent TGFβ activation

2002 • 1,579 citations

Thrombospondin-1 Is a Major Activator of TGF-β1 In Vivo

1998 • 1,151 citations

Mechanism of activation of latent recombinant transforming growth factor beta 1 by plasmin.

1990 • 740 citations

The integrin αvβ8 mediates epithelial homeostasis through MT1-MMP–dependent activation of TGF-β1

2002 • 701 citations

Increased Collagen Synthesis by Scleroderma Skin Fibroblasts In Vitro A POSSIBLE DEFECT IN THE REGULATION OR ACTIVATION OF THE SCLERODERMA FIBROBLAST

1974 • 545 citations

Cecil Textbook of Medicine.

1991 • 503 citations

Increased Expression of TGF-β Receptors by Scleroderma Fibroblasts: Evidence for Contribution of Autocrine TGF-β Signaling to Scleroderma Phenotype

1998 • 257 citations

The type 1 repeats of thrombospondin 1 activate latent transforming growth factor-beta.

1994 • 250 citations

c-myc Is a Downstream Target of the Smad Pathway

2002 • 238 citations

Interactions between Growth Factors and Integrins: Latent Forms of Transforming Growth Factor-β Are Ligands for the Integrin αvβ1

1998 • 229 citations

Normal Development, Wound Healing, and Adenovirus Susceptibility in β5-Deficient Mice

2000 • 214 citations

Impaired Smad7-Smurf–mediated negative regulation of TGF-β signaling in scleroderma fibroblasts

2004 • 211 citations

A strategy for determining the pathogenesis of systemic sclerosis. Is transforming growth factor beta the answer?

1989 • 181 citations

Blockade of endogenous transforming growth factor β signaling prevents up‐regulated collagen synthesis in scleroderma fibroblasts: Association with increased expression of transforming growth factor β receptors

2001 • 169 citations

Blockade of endogenous transforming growth factor ? signaling prevents up-regulated collagen synthesis in scleroderma fibroblasts: Association with increased expression of transforming growth factor ? receptors

2001 • 159 citations

Systemic sclerosis: scleroderma

2003 • 153 citations

Transcriptional Regulation of the Human α2(I) Collagen Gene

1996 • 148 citations

Fibroblast-specific Expression of a Kinase-deficient Type II Transforming Growth Factor β (TGFβ) Receptor Leads to Paradoxical Activation of TGFβ Signaling Pathways with Fibrosis in Transgenic Mice

2003 • 135 citations

A STRATEGY FOR DETERMINING THE PATHOGENESIS OF SYSTEMIC SCLEROSIS: Is Transforming Growth Factor β the Answer?

1989 • 134 citations

Cecil Textbook of Medicine : 19th edition

1992 • 127 citations

The integrin alphavbeta3 is a receptor for the latency-associated peptides of transforming growth factors beta1 and beta3

2003 • 119 citations

Heterogeneity of collagen synthesis in normal and systemic sclerosis skin fibroblasts. Increased proportion of high collagen‐producing cells in systemic sclerosis fibroblasts

1996 • 116 citations

Improved sandwich enzyme-linked immunosorbent assays for transforming growth factor β1

1993 • 112 citations

Tetranucleotide GGGA Motif in Primary RNA Transcripts

1998 • 95 citations

Structural characterization of the latent complex between transforming growth factor β1 and β1-latency-associated peptide

1996 • 76 citations

Increased Expression Levels of Integrin αvβ5 on Scleroderma Fibroblasts

2004 • 76 citations

Immunologic aspects of scleroderma

1989 • 65 citations

Increased transcriptional activities of transforming growth factor β receptors in scleroderma fibroblasts

2002 • 52 citations

Conserved functions of the cytoplasmic domains of integrin beta subunits

1998 • 14 citations