Alpha-Smooth Muscle Actin Expression Upregulates Fibroblast Contractile Activity

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

1979 • 54,907 citations

Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues

2013 • 47,043 citations

Cell locomotion and focal adhesions are regulated by substrate flexibility

1997 • 2,930 citations

Transforming growth factor-beta 1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts

1993 • 2,169 citations

A monoclonal antibody against alpha-smooth muscle actin: a new probe for smooth muscle differentiation.

1986 • 1,644 citations

The Molecular and Cellular Biology of Wound Repair

1988 • 1,508 citations

Presence of modified fibroblasts in granulation tissue and their possible role in wound contraction

1971 • 1,458 citations

Silicone Rubber Substrata: A New Wrinkle in the Study of Cell Locomotion

1980 • 1,333 citations

Stresses at the Cell-to-Substrate Interface during Locomotion of Fibroblasts

1999 • 1,253 citations

Alpha-smooth muscle actin is transiently expressed by myofibroblasts during experimental wound healing.

1990 • 1,176 citations

Fibroblasts, myofibroblasts, and wound contraction

1994 • 1,150 citations

Myofibroblasts. I. Paracrine cells important in health and disease

1999 • 908 citations

Fibroblast traction as a mechanism for collagen morphogenesis

1981 • 862 citations

Differentiation repertoire of fibroblastic cells: expression of cytoskeletal proteins as marker of phenotypic modulations.

1990 • 838 citations

The Fibronectin Domain ED-A Is Crucial for Myofibroblastic Phenotype Induction by Transforming Growth Factor-β1

1998 • 801 citations

Cellular changes involved in conversion of normal to malignant breast: importance of the stromal reaction

1996 • 772 citations

Mechanisms of Myofibroblast Activity and Phenotypic Modulation

1999 • 580 citations

Transforming growth factor beta stimulates collagen-matrix contraction by fibroblasts: implications for wound healing.

1988 • 559 citations

Induction of alpha-smooth muscle actin by transforming growth factor-beta 1 in quiescent human breast gland fibroblasts. Implications for myofibroblast generation in breast neoplasia.

1993 • 511 citations

Reappearance of an embryonic pattern of fibronectin splicing during wound healing in the adult rat.

1989 • 489 citations

Transforming Growth Factor-β1 Promotes the Morphological and Functional Differentiation of the Myofibroblast

2000 • 466 citations

The Compliance of Collagen Gels Regulates Transforming Growth Factor-β Induction of α-Smooth Muscle Actin in Fibroblasts

1999 • 462 citations

Fibroblast–collagen-matrix contraction: growth-factor signalling and mechanical loading

2000 • 405 citations

Traction forces generated by locomoting keratocytes.

1994 • 376 citations

Isoform-specific 3'-untranslated sequences sort alpha-cardiac and beta- cytoplasmic actin messenger RNAs to different cytoplasmic compartments [published erratum appears in J Cell Biol 1993 Dec;123(6 Pt 2):following 1907]

1993 • 332 citations

Release of Mechanical Tension Triggers Apoptosis of Human Fibroblasts in a Model of Regressing Granulation Tissue

1999 • 282 citations

Dependence of collagen remodelling on α‐smooth muscle actin expression by fibroblasts

1994 • 275 citations

High Resolution Detection of Mechanical Forces Exerted by Locomoting Fibroblasts on the Substrate

1999 • 254 citations

Fibroblast contraction occurs on release of tension in attached collagen lattices: Dependency on an organized actin cytoskeleton and serum

1992 • 249 citations

Are stress fibres contractile?

1981 • 224 citations

Stress relaxation of contracted collagen gels: Disruption of actin filament bundles, release of cell surface fibronectin, and down-regulation of DNA and protein synthesis

1991 • 217 citations

α-Smooth muscle actin is expressed in a subpopulation of cultured and cloned fibroblasts and is modulated by γ-interferon

1992 • 209 citations

Monoclonal antibodies in the analysis of fibronectin isoforms generated by alternative splicing of mRNA precursors in normal and transformed human cells.

1987 • 204 citations

Traction forces in locomoting cells

1995 • 204 citations

Isolation and Contraction of the Stress Fiber

1998 • 203 citations

Human eosinophils regulate human lung- and skin-derived fibroblast propertiesin vitro: A role for transforming growth factor β (TGF-β)

1999 • 202 citations

Tumor suppression by RNA from the 3′ untranslated region of α-tropomyosin

1993 • 201 citations

Macrophages and fibroblasts express embryonic fibronectins during cutaneous wound healing.

1993 • 191 citations

Regulation of LPA-Promoted Myofibroblast Contraction: Role of Rho, Myosin Light Chain Kinase, and Myosin Light Chain Phosphatase

2000 • 183 citations

The Role of α1β1 Integrin in Wound Contraction

1997 • 177 citations

Differences in the Regulation of Fibroblast Contraction of Floating Versus Stressed Collagen Matrices

1999 • 177 citations

Identification and localization of immunoreactive forms of caldesmon in smooth and nonmuscle cells: a comparison with the distributions of tropomyosin and alpha-actinin.

1985 • 170 citations

Smooth-muscle contraction without smooth-muscle myosin

2000 • 158 citations

Enhanced expression of transforming growth factor-beta type I and type II receptors in wound granulation tissue and hypertrophic scar.

1998 • 152 citations

Regulation of fibroblast-mediated collagen gel contraction by platelet-derived growth factor, interleukin-1 α and transforming growth factor-β1

1992 • 142 citations

Re-evaluation of fibroblasts and fibroblast-like cells

1990 • 138 citations

Transforming Growth Factor-β1 Expression and Myofibroblast Formation During Arterial Repair

1996 • 136 citations

The Soluble Exoplasmic Domain of the Type II Transforming Growth Factor (TGF)-β Receptor

1995 • 116 citations

Transforming Growth Factor-β Regulates Collagen Gel Contraction by Increasing α2β1 Integrin Expression in Osteogenic Cells

1995 • 115 citations

Fibroblasts from wounds of different stages of repair vary in their ability to contract a collagen gel in response to growth factors

1990 • 114 citations

Calponin and SM 22 isoforms in avian and mammalian smooth muscle

1992 • 112 citations

Polarized distribution of actin isoforms in gastric parietal cells.

1995 • 111 citations

Correlation between the distribution of smooth muscle or non muscle myosins and ?-smooth muscle actin in normal and pathological soft tissues

1988 • 99 citations

Dominant negative effect of cytoplasmic actin isoproteins on cardiomyocyte cytoarchitecture and function.

1995 • 92 citations

Localization of the cellular‐fibronectin‐specific epitope recognized by the monoclonal antibody IST‐9 using fusion proteins expressed in E. coli

1987 • 92 citations

Transforming growth factor-beta 1 promotes contraction of collagen gel by bovine corneal fibroblasts through differentiation of myofibroblasts.

1998 • 83 citations

The specific NH2-terminal sequence Ac-EEED of alpha-smooth muscle actin plays a role in polymerization in vitro and in vivo.

1995 • 82 citations

Rat Fibroblasts Cultured from Various Organs Exhibit Differences in α-Smooth Muscle Actin Expression, Cytoskeletal Pattern, and Adhesive Structure Organization

1998 • 75 citations

Intracompartmental sorting of essential myosin light chains: Molecular dissection and in vivo monitoring by epitope tagging

1991 • 71 citations

Pharmacologic regulation of Dupuytren's fibroblast contraction in vitro

1996 • 69 citations

Chimeric extracellular domain of type II transforming growth factor (TGF)‐β receptor fused to the Fc region of human immunoglobulin as a TGF‐β antagonist

1998 • 66 citations

Exertion of tractional force requires the coordinated up-regulation of cell contractility and adhesion

1999 • 64 citations

Effects of TGF-beta and TGF-beta neutralizing antibodies on fibroblast-induced collagen gel contraction: implications for proliferative vitreoretinopathy.

1994 • 54 citations

Transfected muscle and non-muscle actins are differentially sorted by cultured smooth muscle and non-muscle cells

1997 • 54 citations

Vinculin, talin, integrin ?6?1 and laminin can serve as components of attachment complex mediating contraction force transmission from cardiomyocytes to extracellular matrix

1999 • 51 citations

Differential regulation of tropomyosin isoform organization and gene expression in response to altered actin gene expression.

1993 • 46 citations

Cellular retinol-binding protein-1 is transiently expressed in granulation tissue fibroblasts and differentially expressed in fibroblasts cultured from different organs.

1997 • 44 citations

Thrombin Stimulates Fibroblast-Mediated Collagen Lattice Contraction by Its Proteolytically Activated Receptor

1994 • 39 citations

Quantification of Single Human Dermal Fibroblast Contraction

1998 • 31 citations

A Role for Gelsolin in Stress Fiber-Dependent Cell Contraction

1999 • 28 citations

Subcutaneous tissue fibroblasts transfected with muscle and nonmuscle actins: A good in vitro model to study fibroblastic cell plasticity

1999 • 9 citations