The microenvironment of the tumour–host interface
Data up to Jan 2025
Total Citations Per Year
Abstract
References (66)
The Hallmarks of Cancer
2000 • 27,569 citations
Angiogenesis in cancer and other diseases
2000 • 8,734 citations
Involvement of chemokine receptors in breast cancer metastasis
2001 • 5,203 citations
Chemokines
2000 • 3,773 citations
Cancer metastasis and angiogenesis: An imbalance of positive and negative regulation
1991 • 2,774 citations
Genes Expressed in Human Tumor Endothelium
2000 • 1,838 citations
Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice
1995 • 1,810 citations
The urokinase-type plasminogen activator system in cancer metastasis: A review
1997 • 1,561 citations
Carcinoma-associated fibroblasts stimulate tumor progression of initiated human epithelium
2000 • 1,445 citations
ECM and Cell Surface Proteolysis: Regulating Cellular Ecology
1997 • 1,311 citations
MMP-9 Supplied by Bone Marrow–Derived Cells Contributes to Skin Carcinogenesis
2000 • 1,306 citations
PIK3CA is implicated as an oncogene in ovarian cancer
1999 • 1,170 citations
Integrins and anoikis
1997 • 1,145 citations
Control of adhesion-dependent cell survival by focal adhesion kinase.
1996 • 1,113 citations
Reverse phase protein microarrays which capture disease progression show activation of pro-survival pathways at the cancer invasion front
2001 • 954 citations
The Stromal Proteinase MMP3/Stromelysin-1 Promotes Mammary Carcinogenesis
1999 • 916 citations
Antiintegrin alpha v beta 3 blocks human breast cancer growth and angiogenesis in human skin.
1995 • 840 citations
Intravascular origin of metastasis from the proliferation of endothelium-attached tumor cells: a new model for metastasis
2000 • 695 citations
Distinct Roles of Rock (Rho-Kinase) and Mlck in Spatial Regulation of Mlc Phosphorylation for Assembly of Stress Fibers and Focal Adhesions in 3t3 Fibroblasts
2000 • 664 citations
Anti-epidermal growth factor receptor antibody C225 inhibits angiogenesis in human transitional cell carcinoma growing orthotopically in nude mice.
1999 • 599 citations
Integrins and cancer
1996 • 520 citations
Molecular insights into cancer invasion: strategies for prevention and intervention.
1995 • 500 citations
TGF-β: Regulation of extracellular matrix
1992 • 485 citations
Molecular profiling of human cancer
2000 • 451 citations
Transmembrane/cytoplasmic domain-mediated membrane type 1-matrix metalloprotease docking to invadopodia is required for cell invasion
1997 • 419 citations
The influence of the microenvironment on the malignant phenotype
2000 • 398 citations
Frequent activation of AKT2 and induction of apoptosis by inhibition of phosphoinositide-3-OH kinase/Akt pathway in human ovarian cancer
2000 • 385 citations
Targeted antiangiogenic therapy for cancer using Vitaxin: a humanized monoclonal antibody to the integrin alphavbeta3.
2000 • 372 citations
Vascular stroma formation in carcinoma in situ, invasive carcinoma, and metastatic carcinoma of the breast.
1999 • 361 citations
An invasion-related complex of cortactin, paxillin and PKCμ associates with invadopodia at sites of extracellular matrix degradation
1999 • 355 citations
Effects of pirfenidone on transforming growth factor-beta gene expression at the transcriptional level in bleomycin hamster model of lung fibrosis.
1999 • 354 citations
Cross-talk between Epidermal Growth Factor Receptor and c-Met Signal Pathways in Transformed Cells
2000 • 335 citations
Affinity of integrins for damaged extracellular matrix: αvβ3 binds to denatured collagen type I through RGD sites
1992 • 326 citations
Angiogenesis: role of calcium-mediated signal transduction.
1995 • 283 citations
Lysophospholipid Growth Factors in the Initiation, Progression, Metastases, and Management of Ovarian Cancer
2000 • 243 citations
Matrix metalloproteinase inhibition: A review of anti-tumour activity
1995 • 226 citations
Vascular permeability factor (Vascular endothelial growth factor) expression and angiogenesis in patients with ductal carcinoma in situ of the breast
1997 • 216 citations
Integrins, angiogenesis and vascular cell survival
1996 • 190 citations
The multiple roles of tumour stroma
1997 • 174 citations
Critical determinants of cancer metastasis: rationale for therapy
1999 • 169 citations
Squalamine inhibits angiogenesis and solid tumor growth in vivo and perturbs embryonic vasculature.
1998 • 165 citations
The Ras/Phosphatidylinositol 3-Kinase and Ras/ERK Pathways Function as Independent Survival Modules Each of Which Inhibits a Distinct Apoptotic Signaling Pathway in Sympathetic Neurons
2000 • 149 citations
Review: The Integrin αvβ3: Angiogenesis and Apoptosis
1995 • 134 citations
Synergy between an antiangiogenic integrin αvantagonist and an antibody–cytokine fusion protein eradicates spontaneous tumor metastases
1999 • 128 citations
Tissue Inhibitor of Metalloproteinases-2 (TIMP-2) Suppresses TKR-Growth Factor Signaling Independent of Metalloproteinase Inhibition
2001 • 123 citations
Cellular interactions that control primordial follicle development and folliculogenesis
2001 • 110 citations
Overexpression of edg-2/vzg-1 induces apoptosis and anoikis in ovarian cancer cells in a lysophosphatidic acid-independent manner.
1999 • 110 citations
Mesenchymal reprogramming of adult human epithelial differentiation
1999 • 100 citations
Phase I and Pharmacologic Study of the Specific Matrix Metalloproteinase Inhibitor BAY 12-9566 on a Protracted Oral Daily Dosing Schedule in Patients With Solid Malignancies
2000 • 85 citations
Tyrosine Phosphorylation of Focal Adhesion Kinase Stimulated by Hepatocyte Growth Factor Leads to Mitogen-activated Protein Kinase Activation
1998 • 85 citations
Release of Biological Activities from Quiescent Fibronectin by a Conformational Change and Limited Proteolysis by Matrix Metalloproteinases
1995 • 76 citations
Colon cancer chemopreventive drugs modulate integrin-mediated signaling pathways.
2000 • 75 citations
Regulation of the RhoA pathway in human endothelial cell spreading on type IV collagen: role of calcium influx
1999 • 73 citations
Cellular Interactions That Control Primordial Follicle Development and Folliculogenesis
2001 • 62 citations
Dynamic Remodeling of the Vascular Bed Precedes Tumor Growth: MLS Ovarian Carcinoma Spheroids Implanted in Nude Mice
1999 • 60 citations
A phase I trial of carboxyamido-triazole and paclitaxel for relapsed solid tumors: potential efficacy of the combination and demonstration of pharmacokinetic interaction.
2001 • 55 citations
Cell Interactions Control the Fate of Malignant Keratinocytes in an Organotypic Model of Early Neoplasia
1999 • 53 citations
Plasticity of the urothelial phenotype: Effects of gastro-intestinal mesenchyme/stroma and implications for urinary tract reconstruction
2000 • 46 citations
Defects of basement membrane and hemidesmosome structure correlate with malignant phenotype and stromal interactions in HaCaT-Ras xenografts
1999 • 42 citations
β1 integrin antagonism on adherent, differentiated human neuroblastoma cells triggers an apoptotic signaling pathway
2000 • 37 citations
Signalling by adhesion receptors
2000 • 37 citations
Differential Stromal Regulation of MMP-1 Expression in Benign and Malignant Keratinocytes
2001 • 35 citations
Angiogenesis and expression of thymidine phosphorylase by inflammatory and carcinoma cells in ductal carcinomain situ of the breast
1999 • 34 citations
The crossroads between cell–cell adhesion and motility
2000 • 24 citations
Farnesyltransferase Inhibitors: Preclinical Development
1999 • 17 citations
Cell regulation
2001 • 2 citations
Cited By (0)
No citing papers found in database