A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin

Participation of p53 protein in the cellular response to DNA damage.

1991 • 3,818 citations

Adriamycin-Induced DNA Damage Mediated by Mammalian DNA Topoisomerase II

1984 • 1,477 citations

Apoptotic death in epithelial cells: cleavage of DNA to 300 and/or 50 kb fragments prior to or in the absence of internucleosomal fragmentation.

1993 • 1,144 citations

Adriamycin: The Role of Lipid Peroxidation in Cardiac Toxicity and Tumor Response

1977 • 1,116 citations

Intercalative antitumor drugs interfere with the breakage-reunion reaction of mammalian DNA topoisomerase II.

1984 • 896 citations

PCNA: structure, functions and interactions

1997 • 886 citations

Ceramide synthase mediates daunorubicin-induced apoptosis: An alternative mechanism for generating death signals

1995 • 835 citations

Doxorubicin cardiotoxicity: analysis of prevailing hypotheses

1990 • 688 citations

Increased accumulation of vincristine and adriamycin in drug-resistant P388 tumor cells following incubation with calcium antagonists and calmodulin inhibitors.

1982 • 667 citations

A general mechanism for microsomal activation of quinone anticancer agents to free radicals.

1978 • 645 citations

Effect of anthracycline antibiotics on oxygen radical formation in rat heart.

1983 • 634 citations

Redox cycling of anthracyclines by cardiac mitochondria. I. Anthracycline radical formation by NADH dehydrogenase.

1986 • 608 citations

The Anticancer Agent Adriamycin Can Be Actively Cytotoxic Without Entering Cells

1982 • 578 citations

Augmentation of adriamycin, melphalan, and cisplatin cytotoxicity in drug-resistant and -sensitive human ovarian carcinoma cell lines by buthionine sulfoximine mediated glutathione depletion

1985 • 545 citations

Generation of free radicals and lipid peroxidation by redox cycling of adriamycin and daunomycin

1977 • 545 citations

Redox cycling of anthracyclines by cardiac mitochondria. II. Formation of superoxide anion, hydrogen peroxide, and hydroxyl radical.

1986 • 525 citations

Doxorubicin (adriamycin): A critical review of free radical-dependent mechanisms of cytotoxicity

1990 • 512 citations

The protective role of manganese superoxide dismutase against adriamycin-induced acute cardiac toxicity in transgenic mice.

1996 • 454 citations

Interference by doxorubicin with DNA unwinding in MCF-7 breast tumor cells.

1994 • 424 citations

Effect of adriamycin on DNA, RNA, and protein synthesis in cell-free systems and intact cells.

1976 • 413 citations

Clinical Pharmacokinetics of Doxorubicin

1988 • 388 citations

On physico-chemical interactions between daunomycin and nucleic acids

1965 • 372 citations

Daunorubicin-induced apoptosis: triggering of ceramide generation through sphingomyelin hydrolysis.

1996 • 371 citations

Anthracycline antibiotic augmentation of microsomal electron transport and free radical formation.

1977 • 365 citations

Early and delayed clinical cardiotoxicity of doxorubicin

1985 • 300 citations

Plasma pharmacokinetics of adriamycin and adriamycinol: implications for the design of in vitro experiments and treatment protocols.

1983 • 288 citations

Anthracycline antibiotic-stimulated superoxide, hydrogen peroxide, and hydroxyl radical production by NADH dehydrogenase.

1983 • 282 citations

Reduction of adriamycin to a semiquinone-free radical by NADPH cytochrome P-450 reductase produces DNA cleavage in a reaction mediated by molecular oxygen.

1981 • 275 citations

Interaction of daunomycin and its derivatives with DNA

1972 • 265 citations

Role of hydrogen peroxide and hydroxyl radical formation in the killing of Ehrlich tumor cells by anticancer quinones.

1986 • 263 citations

Direct correlation between DNA topoisomerase II activity and cytotoxicity in adriamycin-sensitive and -resistant P388 leukemia cell lines.

1989 • 263 citations

Strand scission of DNA by bound adriamycin and daunorubicin in the presence of reducing agents

1977 • 258 citations

Adriamycin-induced free radical formation in the perfused rat heart: implications for cardiotoxicity.

1988 • 251 citations

Doxorubicin selectively inhibits muscle gene expression in cardiac muscle cells in vivo and in vitro.

1990 • 247 citations

Prevention of doxorubicin cardiac toxicity in the mouse by N-acetylcysteine.

1981 • 247 citations

Qualitative and quantitative aspects of intercalator-induced DNA strand breaks

1979 • 244 citations

Protein-associated DNA breaks in cells treated with adriamycin or ellipticine

1978 • 234 citations

Randomized trial of the cardioprotective agent ICRF-187 in pediatric sarcoma patients treated with doxorubicin.

1996 • 228 citations

Protective role of the glutathione redox cycle against adriamycin-mediated toxicity in isolated hepatocytes

1981 • 221 citations

Overview of cardiac pathology in relation to anthracycline cardiotoxicity.

1978 • 220 citations

Differential formation of hydroxyl radicals by adriamycin in sensitive and resistant MCF-7 human breast tumor cells: implications for the mechanism of action

1987 • 214 citations

Pharmacokinetics and metabolism of adriamycin in man

1973 • 213 citations

Dual modes of death induced by etoposide in human epithelial tumor cells allow Bcl-2 to inhibit apoptosis without affecting clonogenic survival.

1996 • 206 citations

Cell cycle-dependent cytotoxicity, G2/M phase arrest, and disruption of p34cdc2/cyclin B1 activity induced by doxorubicin in synchronized P388 cells.

1996 • 206 citations

Mechanisms of regulation of WAF1/Cip1 gene expression in human breast carcinoma: role of p53-dependent and independent signal transduction pathways.

1994 • 196 citations

Adriamycin metabolism in man. Evidence from urinary metabolites.

1976 • 194 citations

Adriamycin and daunomycin induce programmed cell death (apoptosis) in tumour cells

1993 • 194 citations

Local sequence requirements for DNA cleavage by mammalian topoisomerase II in the presence of doxorubicin

1990 • 181 citations

Apoptosis induced by anthracycline antibiotics in P388 parent and multidrug-resistant cells.

1993 • 177 citations

Oxidative destruction of DNA by the adriamycin-iron complex

1984 • 173 citations

Anthracycline glycoside-membrane interactions

1984 • 172 citations

Nuclear topoisomerase II levels correlate with the sensitivity of mammalian cells to intercalating agents and epipodophyllotoxins.

1988 • 166 citations

Inhibition of DNA and RNA metabolism by daunorubicin and adriamycin in L1210 mouse leukemia.

1972 • 166 citations

Stimulation by adriamycin of rat heart and liver microsomal NADPH-dependent lipid peroxidation

1981 • 166 citations

p16^INK4A Participates in a G₁ Arrest Checkpoint in Response to DNA Damage

1998 • 163 citations

DNA double-strand breaks in mammalian cells after exposure to intercalating agents

1981 • 160 citations

Adriamycin activation and oxygen free radical formation in human breast tumor cells: protective role of glutathione peroxidase in adriamycin resistance.

1989 • 159 citations

Flow cytometric detection of hydrogen peroxide production induced by doxorubicin in cancer cells

1994 • 151 citations

The molecular pharmacology of doxorubicin in vivo

1991 • 151 citations

Hydroxyl radical production and DNA damage induced by anthracycline‐iron complex

1984 • 149 citations

Prevention of doxorubicin-induced killing of MCF-7 human breast cancer cells by oxygen radical scavengers and iron chelating agents

1986 • 143 citations

Characterization of the cycle of iron-mediated electron transfer from Adriamycin to molecular oxygen.

1985 • 140 citations

Stimulation of mouse heart and liver microsomal lipid peroxidation by anthracycline anticancer drugs: characterization and effects of reactive oxygen scavengers.

1983 • 138 citations

Inhibition of E2F Activity by the Cyclin-Dependent Protein Kinase Inhibitor p21 in Cells Expressing or Lacking a Functional Retinoblastoma Protein

1996 • 136 citations

The role of E2F in the mammalian cell cycle

1993 • 136 citations

Potentiation of doxorubicin cytotoxicity by buthionine sulfoximine in multidrug-resistant human breast tumor cells.

1989 • 128 citations

Comparison of the effectiveness of (+/-)-1,2-bis(3,5-dioxopiperazinyl-1-yl)propane (ICRF-187) and N-acetylcysteine in preventing chronic doxorubicin cardiotoxicity in beagles.

1985 • 119 citations

Lethal effect of adriamycin on the division cycle of HeLa cells.

1972 • 115 citations

Adriamycin-induced myocardial dysfunction in vitro is mediated by free radicals

1991 • 114 citations

Epirubicin and doxorubicin comparative metabolism and pharmacokinetics

1988 • 108 citations

Synthesis of adriamycin-coupled polyglutaraldehyde microspheres and evaluation of their cytostatic activity.

1982 • 106 citations

Free radicals in anticancer drug pharmacology

1989 • 106 citations

Verapamil reversal of doxorubicin resistance in multidrug-resistant human myeloma cells and association with drug accumulation and DNA damage.

1988 • 105 citations

The Cause of G2-Arrest in Chinese Hamster Ovary Cells Treated With Anticancer Drugs2

1976 • 104 citations

Binding mode of chemically activated semiquinone free radicals from quinone anticancer agents to DNA

1979 • 104 citations

Adriamycin-induced changes in the surface membrane of sarcoma 180 ascites cells

1981 • 102 citations

Helicase inhibition by anthracycline anticancer agents.

1992 • 99 citations

Adriamycin-enhanced membrane lipid peroxidation in isolated rat nuclei.

1985 • 98 citations

Cytotoxicity and DNA strand breaks by 5-iminodaunorubicin in mouse leukemia L1210 cells: comparison with adriamycin and 4'-(9-acridinylamino)methanesulfon-m-anisidide.

1982 • 97 citations

G2 block induced by DNA crosslinking agents and its possible consequences

1988 • 96 citations

Enzymatic activation and binding of adriamycin to nuclear DNA.

1984 • 94 citations

Deoxyribose breakdown by the adriamycin semiquinone and H₂O₂: evidence for hydroxyl radical participation

1982 • 91 citations

Relationship between Lethal Effects and Topoisomerase II-Mediated Double-Stranded DNA Breaks Produced by Anthracyclines with Different Sequence Specificity

1997 • 91 citations

INHIBITING EFFECT OF THE NEW CYTOTOXIC ANTIBIOTIC DAUNOMYCIN ON NUCLEIC ACIDS AND MITOTIC ACTIVITY OF HELA CELLS

1965 • 87 citations

The inhibition in vitro of DNA polymerase and RNA polymerases by daunomycin and adriamycin

1975 • 87 citations

Serum lipid peroxides in rats treated chronically with adriamycin

1984 • 86 citations

Attenuated topoisomerase II content directly correlates with a low level of drug resistance in a Chinese hamster ovary cell line.

1991 • 85 citations

Induction of stable transcriptional blockage sites by Adriamycin: GpC specificity of apparent Adriamycin-DNA adducts and dependence on iron(III) ions

1990 • 84 citations

Evidence for the production of hydroxyl radicals from the adriamycin semiquinone and H₂O₂

1981 • 83 citations

Cellular and plasma adriamycin concentrations in long-term infusion therapy of leukemia patients

1987 • 82 citations

Induction of differentiation and growth arrest associated with nascent (nonoligosomal) DNA fragmentation and reduced c-myc expression in MCF-7 human breast tumor cells after continuous exposure to a sublethal concentration of doxorubicin.

1994 • 82 citations

Decreased DNA topoisomerase II in daunorubicin-resistant Ehrlich ascites tumor cells.

1991 • 78 citations

Dependence of nucleic acid degradation on in situ free-radical production by Adriamycin

1993 • 78 citations

Resistance to adriamycin: relationship of cytotoxicity to drug uptake and DNA single- and double-strand breakage in cloned cell lines of adriamycin-sensitive and -resistant P388 leukemia.

1986 • 77 citations

Reduction of O2 by iron-adriamycin.

1984 • 77 citations

Topoisomerase II-mediated DNA damage produced by 4'-(9-acridinylamino)methanesulfon-m-anisidide and related acridines in L1210 cells and isolated nuclei: relation to cytotoxicity.

1988 • 77 citations

Evaluation of free radical effects and catecholamine alterations in adriamycin cardiotoxicity.

1984 • 76 citations

Relationship between effects on nucleic acid synthesis in cell cultures and cytotoxicity of 4-demethoxy derivatives of daunorubicin and adriamycin.

1977 • 76 citations

Cell surface-mediated cytotoxicity of polymer-bound Adriamycin against drug-resistant hepatocytes.

1983 • 75 citations

Inhibition of DNA and RNA synthesis by daunorubicin in sensitive and resistant Ehrlich ascites tumor cells in vitro.

1972 • 74 citations

Growth arrest and non-apoptotic cell death associated with the suppression of c-myc Expression in MCF-7 breast tumor cells following acute exposure to doxorubicin

1996 • 74 citations

Interstrand DNA crosslinking induced by anthracyclines in tumour cells

1994 • 73 citations

Clinical effects and pharmacokinetics of different dosage schedules of adriamycin.

1976 • 73 citations

Antineoplastic drug sensitivity of human MCF-7 breast cancer cells stably transfected with a human alpha class glutathione S-transferase gene.

1991 • 69 citations

Comparative biochemical studies of adriamycin and daunomycin in leukemic cells.

1972 • 67 citations

Contribution of glutathione and glutathione‐dependent enzymes in the reversal of adriamycin resistance in colon carcinoma cell lines

1991 • 66 citations

Improved cellular accumulation is characteristic of anthracyclines which retain high activity in multidrug resistant cell lines, alone or in combination with verapamil or cyclosporin A

1989 • 62 citations

Cellular pharmacokinetics of doxorubicin in patients with chronic lymphocytic leukemia: comparison of bolus administration and continuous infusion

1993 • 61 citations

Relevance of interstrand DNA crosslinking induced by anthracyclines for their biological activity

1994 • 61 citations

Interactions of Adriamycin aglycones with mitochondria may mediate Adriamycin cardiotoxicity

1994 • 61 citations

Inhibition of DNA Unwinding and ATPase Activities of Human DNA Helicase II by Chemotherapeutic Agents

1997 • 60 citations

Temperature dependence studies of adriamycin uptake and cytotoxicity.

1987 • 60 citations

Markedly reduced levels of anthracycline-induced DNA strand breaks in resistant P388 leukemia cells and isolated nuclei.

1987 • 59 citations

A Chemical Perspective on the Anthracycline Antitumor Antibiotics

1985 • 59 citations

Adriamycin-induced lipid peroxidation in mitochondria and microsomes

1988 • 59 citations

Comparative flavoprotein catalysis of anthracycline antibiotic. Reductive cleavage and oxygen consumption.

1981 • 58 citations

Comparative cytotoxicity, DNA synthesis inhibition and drug incorporation of eight anthracyclines in a model of doxorubicin-sensitive and -resistant rat glioblastoma cells

1989 • 57 citations

Does bulk damage to DNA explain the cytostatic and cytotoxic effects of topoisomerase II inhibitors?

1991 • 56 citations

A chemical perspective on the anthracycline antitumor antibiotics.

1985 • 55 citations

Formation of adriamycin-DNA adductsin vitro

1994 • 55 citations

p53 status affects the rate of the onset but not the overall extent of doxorubicin-induced cell death in rat-1 fibroblasts constitutively expressing c-Myc.

1997 • 54 citations

Improved high-performance liquid chromatography assay of doxorubicin: Detection of circulating aglycones in human plasma and comparison with thin-layer chromatography

1985 • 54 citations

Enhanced cytotoxicity against colon carcinoma by combinations of noncompeting monoclonal antibodies to the 17-1A antigen.

1988 • 53 citations

The role of lipid peroxidation in acute doxorubicin-induced cardiotoxicity as studied in rat isolated heart

1986 • 52 citations

Adriamycin and Daunorubicin Inhibition of Mutant T4 DNA Polymerases

1974 • 51 citations

DNA Topoisomerase II Inhibitors

1997 • 50 citations

Comparison of dna cleavage induced by etoposide and doxorubicin in two human small‐cell lung cancer lines with different sensitivities to topoisomerase ii inhibitors

1990 • 49 citations

Doxorubicin Resistance Conferred by Selective Enhancement of Intracellular Glutathione Peroxidase or Superoxide Dismutase Content in Human MCF-7 Breast Cancer Cells

1991 • 49 citations

Adriamycin interactions with T4 DNA polymerase. Two modes of template-mediated inhibition.

1977 • 49 citations

Cellular pharmacokinetics of daunorubicin: relationships with the response to treatment in patients with acute myeloid leukemia.

1988 • 48 citations

Doxorubicin-induced DNA degradation in murine thymocytes.

1994 • 48 citations

Two mechanisms of adriamycin-DNA interaction in L1210 cells

1984 • 47 citations

DNA unwinding and inhibition of T4 DNA ligase by anthracyclines

1988 • 47 citations

Estrogen-induced potentiation of DNA damage and cytotoxicity in human breast cancer cells treated with topoisomerase II-interactive antitumor drugs.

1988 • 47 citations

Role of DNA breakage in cytotoxicity of doxorubicin, 9-deoxydoxorubicin, and 4-demethyl-6-deoxydoxorubicin in murine leukemia P388 cells.

1989 • 47 citations

DNA sequence‐specific adducts of adriamycin and mitomycin C

1989 • 47 citations

Mechanism of the Inhibition of Calf Thymus DNA Polymerases α and β by Daunomycin and Adriamycin1

1980 • 47 citations

Factors affecting topotecan-induced programmed cell death: adhesion protects cells from apoptosis and impairs cleavage of poly(ADP-ribose)polymerase.

1997 • 45 citations

The consequences of doxorubicin quinone reduction in vivo in tumour tissue

1992 • 45 citations

Free radical damage to deoxyribose by anthracycline, aureolic acid and aminoquinone antitumour antibiotics

1985 • 44 citations

Comparison of doxorubicin‐induced DNA damage in doxorubicin‐sensitive and ‐resistant P388 murine leukemia cells

1986 • 44 citations

Adriamycin: protection from cell death by removal of extracellular drug.

1992 • 43 citations

Repair of deoxyribonucleic acid lesions caused by adriamycin and ellipticine

1982 • 43 citations

Evaluation of adriamycin-induced lipid peroxidation

1992 • 43 citations

The effect of the anthrapyrazole antitumour agent CI941 on rat liver microsome and cytochrome P-450 reductase mediated free radical processes

1987 • 43 citations

The Interaction of Daunomycin with Polydeoxynucleotides

1978 • 43 citations

Role of glutathione and its associated enzymes in multidrug-resistant human myeloma cells

1989 • 41 citations

Reduction of doxorubicin cytotoxicity by ouabain: correlation with topoisomerase-induced DNA strand breakage in human and hamster cells.

1988 • 40 citations

Use of ICRF-187 for Prevention of Anthracycline Cardiotoxicity in Children: Preliminary Results

1997 • 39 citations

Free radical modes of cytotoxicity of adriamycin® and streptonigrin

1994 • 39 citations

Influence of ionizing radiation on proliferation, c-myc expression and the induction of apoptotic cell death in two breast tumour cell lines differing in p53 status

1997 • 39 citations

Usefulness of a free radical scavenger in preventing doxorubicin-induced heart failure in dogs

1985 • 39 citations

Leukemic cell and plasma daunomycin concentrations after bolus injection and 72 h infusion

1987 • 38 citations

Evidence for the lack of relationship between inhibition of nucleic acid synthesis and cytotoxicity of adriamycin.

1983 • 37 citations

Anthracycline antibiotics. Interaction with DNA and nucleosomes and inhibition of DNA synthesis

1987 • 37 citations

Doxorubicin-induced DNA breaks, topoisomerase II activity and gene expression in human melanoma cells

1993 • 36 citations

Anthracycline resistance in murine leukemic P388 CELLS

1990 • 35 citations

The role of oxygen-derived free radicals in the cytotoxicity of doxorubicin in multidrug resistant and sensitive human ovarian cancer cells

1988 • 35 citations

Resistance to oxidants associated with elevated catalase activity in HL-60 leukemia cells that overexpress multidrug-resistance protein does not contribute to the resistance to daunorubicin manifested by these cells

1995 • 35 citations

Interaction of anthracyclinic antibiotics with cytoskeletal components of cultured carcinoma cells (CG5)

1990 • 34 citations

Inactivation of cytochrome c oxidase activity in mitochondrial membranes during redox cycling of doxorubicin

1991 • 34 citations

Determination of covalent binding to intact DNA, RNA, and oligonucleotides by intercalating anticancer drugs using high-performance liquid chromatography. Studies with doxorubicin and NADPH cytochrome P-450 reductase

1991 • 33 citations

DNA polymerases and DNA topoisomerases as targets for the development of anticancer drugs.

1986 • 33 citations

Direct relation of DNA lesions in multidrug-resistant human myeloma cells to intracellular doxorubicin concentration.

1988 • 32 citations

Inhibitory effects of anthracenedione antineoplastic agents on hepatic and cardiac lipid peroxidation.

1983 • 31 citations

Antihelicase action of DNA-binding anticancer agents: relationship to guanosine-cytidine intercalator binding.

1993 • 30 citations

Anthracycline-induced DNA breaks and resealing in doxorubicin-resistant murine leukemic P388 cells

1988 • 30 citations

Effect of buthionine sulfoximine on toxicity of verapamil and doxorubicin to multidrug resistant cells and to mice.

1991 • 30 citations

Cytokinetic and biochemical effects of 5-iminodaunorubicin in human colon carcinoma in culture.

1982 • 28 citations

Effect of endogenous glutathione, superoxide dismutases, catalase, and glutathione peroxidase on adriamycin tolerance of Chinese hamster ovary cells.

1988 • 28 citations

Enhanced glutathione peroxidase expression protects cells from hydroperoxides but not from radiation or doxorubicin.

1995 • 28 citations

Correlation between anthracycline structure and human DNA ligase inhibition

1991 • 27 citations

Metabolism of adriamycin in hepatocytes isolated from the rat and the rabbit

1987 • 27 citations

Doxorubicin‐induced oxygen free radical formation in sensitive and doxorubicin‐resistant variants of rat glioblastoma cell lines

1993 • 26 citations

Effects of 3'-deamino-3'-(3-cyano-4-morpholinyl)doxorubicin and doxorubicin on the survival, DNA integrity, and nucleolar morphology of human leukemia cells in vitro.

1986 • 25 citations

Measurement of doxorubicin-induced lipid peroxidation under the conditions that determine cytotoxicity in cultured tumor cells

1992 • 25 citations

Evidence for inhibition of growth related to compromised DNA synthesis in the interaction of daunorubicin with H-35 rat hepatoma.

1988 • 25 citations

Temperature dependence of adriamycin-induced DNA damage in L1210 cells.

1989 • 24 citations

Dose-dependence of doxorubicin effect on actin assembly in vitro

1988 • 24 citations

Clinical importance of anthracyclines in the treatment of acute myeloid leukemia.

1992 • 22 citations

Some effects of daunomycin on the nucleic acid synthesis in synchronized L-cells

1969 • 21 citations

Adriamycin effects on hydroperoxide metabolism and growth of human breast tumor cells

1990 • 21 citations

Comparison of intracellular drug retention, DNA damage and cytotoxicity of derivatives of doxorubicin and daunorubicin in a human colon adenocarcinoma cell line (LoVo)

1989 • 21 citations

Dissociation between bulk damage to DNA and the antiproliferative activity of teniposide (VM-26) in the MCF-7 breast tumor cell line: evidence for induction of gene-specific damage and alterations in gene expression.

1993 • 21 citations

Circumvention of resistance by doxorubicin, but not by idarubicin, in a human leukemia cell line containing an intercalator-resistant form of topoisomerase II: evidence for a non-topoisomerase II-mediated mechanism of doxorubicin cytotoxicity

1993 • 21 citations

P‐glycoprotein and alterations in the glutathione/glutathione‐peroxidase cycle underlie doxorubicin resistance in HL‐60‐R, a subclone of the HL‐60 human leukemia cell line

1993 • 18 citations

Anthracycline Antibiotic Blockade of SV40 T Antigen Helicase Action

1998 • 16 citations

Cytotoxicity and differentiating actions of adriamycin in WEHI-3B D+ leukemia cells.

1987 • 16 citations

Lethal and sublethal effects of the combination of doxorubicin and the bisdioxopiperazine, (+)-1,2,-bis (3-5-dioxopiperazinyl-1-yl) propane (ICRF 187), on murine sarcoma S180 in vitro

1987 • 16 citations

The spin trap alpha-phenyl-tert-butyl nitrone protects against myelotoxicity and cardiotoxicity of adriamycin while preserving the cytotoxic activity.

1993 • 15 citations

Metabolic disposition of 5-iminodaunorubicin in the rat.

1984 • 15 citations

Doxorubicin induced alterations in lipid metabolism of cultured myocardial cells

1985 • 14 citations

Oxygen-dependent effect of microsomes on the binding of doxorubicin to rat hepatic nuclear DNA.

1987 • 14 citations

Development of Mechanisms of Protection Against Oxidative Stress in Doxorubicin-Resistant Rat Tumoral Cells in Culture

1990 • 14 citations

DNA Topoisomerases and Their Inhibition by Anthracyclines

1994 • 14 citations

Lipid peroxidation, phosphoinositide turnover and protein kinase C activation in human platelets treated with anthracyclines and their complexes with Fe(III)

1992 • 8 citations

An anticancer drug-sensitive murine erythroleukemia clone: implications for the mechanism of action of antineoplastic drugs.

1993 • 5 citations

Dissociation of cytotoxicity and DNA cleavage activity induced by topoisomerase II-reactive intercalating agents in hamster-human somatic cell hybrids

1992 • 5 citations