Dual modes of death induced by etoposide in human epithelial tumor cells allow Bcl-2 to inhibit apoptosis without affecting clonogenic survival.

Apoptosis in the Pathogenesis and Treatment of Disease

1995 • 6,610 citations

Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

1990 • 3,817 citations

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

1993 • 2,969 citations

Apoptosis. Its significance in cancer and cancer Therapy

1994 • 2,148 citations

p53 Status and the Efficacy of Cancer Therapy in Vivo

1994 • 1,483 citations

Investigation of the subcellular distribution of the bcl-2 oncoprotein: residence in the nuclear envelope, endoplasmic reticulum, and outer mitochondrial membranes.

1993 • 1,044 citations

Induction of endonucleolytic DNA cleavage in human acute myelogenous leukemia cells by etoposide, camptothecin, and other cytotoxic anticancer drugs: a cautionary note.

1989 • 937 citations

Bcl-2 oncoprotein blocks chemotherapy-induced apoptosis in a human leukemia cell line

1993 • 898 citations

Pharmacological characterization of multidrug resistant MRP-transfected human tumor cells.

1994 • 777 citations

DNA Topoisomerases: Essential Enzymes and Lethal Targets

1994 • 722 citations

DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhibitable by Bcl-2

1994 • 671 citations

A rapid and simple method for the isolation of apoptotic DNA fragments

1994 • 660 citations

Estrogen promotes chemotherapeutic drug resistance by a mechanism involving Bcl-2 proto-oncogene expression in human breast cancer cells.

1995 • 422 citations

Mechanism by which caffeine potentiates lethality of nitrogen mustard.

1982 • 294 citations

Bleomycin, an apoptosis-mimetic drug that induces two types of cell death depending on the number of molecules internalized.

1993 • 277 citations

Inhibition of p34cdc2 kinase activity by etoposide or irradiation as a mechanism of G2 arrest in Chinese hamster ovary cells.

1990 • 222 citations

bcl-2 protein inhibits etoposide-induced apoptosis through its effects on events subsequent to topoisomerase II-induced DNA strand breaks and their repair.

1993 • 218 citations

Expression of bcl-2 protein predicts efficacy of adjuvant treatments in operable node-positive breast cancer.

1995 • 203 citations

Prognostic value of bcl-2 expression in invasive breast cancer

1995 • 192 citations

Mitoxantrone resistance in HL-60 leukemia cells: reduced nuclear topoisomerase II catalytic activity and drug-induced DNA cleavage in association with reduced expression of the topoisomerase II .beta. isoform

1991 • 153 citations

The role of cell cycle progression in cisplatin-induced apoptosis in Chinese hamster ovary cells.

1994 • 145 citations

Cytofluorometric studies on the action of podophyllotoxin and epipodophyllotoxins (VM-26, VP-16-213) on the cell cycle traverse of human lymphoblasts.

1975 • 133 citations

Differentiation of neuroblastoma enhances Bcl-2 expression and induces alterations of apoptosis and drug resistance.

1995 • 121 citations

Mutagenic responses of thirteen anticancer drugs on mutation induction at multiple genetic loci and on sister chromatid exchanges in Chinese hamster ovary cells.

1983 • 117 citations

Possible role for p34cdc2 kinase in etoposide-induced cell death of Chinese hamster ovary cells.

1990 • 91 citations

Attenuated topoisomerase II content directly correlates with a low level of drug resistance in a Chinese hamster ovary cell line.

1991 • 85 citations

Etoposide (VP-16-213)-induced gene alterations: potential contribution to cell death.

1991 • 85 citations

Etoposide: current status and future perspectives in the management of malignant neoplasms

1994 • 82 citations

Concentration-dependent differences in the mechanisms by which caffeine potentiates etoposide cytotoxicity in HeLa cells.

1994 • 73 citations

Molecular cloning and identification of a point mutation in the topoisomerase II cDNA from an etoposide-resistant Chinese hamster ovary cell line.

1993 • 68 citations

Cytoplasmic localization of a mutant M(r) 160,000 topoisomerase II alpha is associated with the loss of putative bipartite nuclear localization signals in a drug-resistant human lung cancer cell line.

1995 • 63 citations

Inhibition of etoposide (VP-16)-induced DNA recombination and mutant frequency by Bcl-2 protein overexpression.

1995 • 27 citations

Resistance to inhibitors of DNA topoisomerases

1991 • 21 citations