Comparison of intracellular drug retention, DNA damage and cytotoxicity of derivatives of doxorubicin and daunorubicin in a human colon adenocarcinoma cell line (LoVo)

Adriamycin-Induced DNA Damage Mediated by Mammalian DNA Topoisomerase II

1984 • 1,477 citations

DNA Topoisomerases

1981 • 977 citations

Topoisomerase II is a structural component of mitotic chromosome scaffolds.

1985 • 751 citations

DNA topoisomerase II is required at the time of mitosis in yeast

1985 • 747 citations

DNA topoisomerase II mutant of Saccharomyces cerevisiae: topoisomerase II is required for segregation of daughter molecules at the termination of DNA replication.

1984 • 685 citations

The Anticancer Agent Adriamycin Can Be Actively Cytotoxic Without Entering Cells

1982 • 578 citations

Metaphase chromosome structure

1986 • 538 citations

Protein-associated deoxyribonucleic acid strand breaks in L1210 cells treated with the deoxyribonucleic acid intercalating agents 4'-(9-acridinylamino)methanesulfon-m-anisidide and adriamycin

1981 • 382 citations

A replication model for sister-chromatid exchange

1980 • 289 citations

Establishment of a human carcinoembryonic antigen-producing colon adenocarcinoma cell line.

1976 • 277 citations

Reduction of adriamycin to a semiquinone-free radical by NADPH cytochrome P-450 reductase produces DNA cleavage in a reaction mediated by molecular oxygen.

1981 • 275 citations

DNA topoisomerases as targets for cancer therapy

1985 • 197 citations

Catenation of DNA rings by topoisomerases. Mechanism of control by spermidine.

1982 • 190 citations

Isolation of intercalator-dependent protein-linked DNA strand cleavage activity from cell nuclei and identification as topoisomerase II

1986 • 145 citations

Effects of DNA intercalating agents on topoisomerase II induced DNA strand cleavage in isolated mammalian cell nuclei

1985 • 127 citations

Effects of the DNA intercalators 4'-(9-acridinylamino)methanesulfon-m-anisidide and 2-methyl-9-hydroxyellipticinium on topoisomerase II mediated DNA strand cleavage and strand passage

1985 • 127 citations

Cytotoxicity and DNA strand breaks by 5-iminodaunorubicin in mouse leukemia L1210 cells: comparison with adriamycin and 4'-(9-acridinylamino)methanesulfon-m-anisidide.

1982 • 97 citations

Protein-associated deoxyribonucleic acid strand breaks produced in mouse leukemia L1210 cells by ellipticine and 2-methyl-9-hydroxyellipticinium

1982 • 90 citations

Idarubicin (4-demethoxydaunorubicin)

1986 • 76 citations

New doxorubicin analogs active against doxorubicin-resistant colon tumor xenografts in the nude mouse.

1980 • 66 citations

A Chemical Perspective on the Anthracycline Antitumor Antibiotics

1985 • 59 citations

A chemical perspective on the anthracycline antitumor antibiotics.

1985 • 55 citations

Cellular discriminants for a biological classification of human colon carcinoma.

1984 • 53 citations

Adriamycin and daunomycin induce interstrand DNA crosslinks in HeLa S3 cells

1983 • 40 citations

Influence of DNA-binding drugs on chromatin condensation

1986 • 40 citations

Single-strand DNA breaks induced by chromophore-modified anthracyclines in P388 leukemia cells.

1986 • 34 citations

Molecular pharmacology of the anthracycline drug 9,10-anthracenedicarboxaldehyde bis[(4,5-dihydro-1 H-imidazol-2-yl)hydrazone] dihydrochloride (Cl 216,942).

1982 • 29 citations

Intracellular doxorubicin concentrations and drug-induced DNA damage in a human colon adenocarcinoma cell line and in a drug-resistant subline

1988 • 23 citations

Mutagenic and cytotoxic activity of doxorubicin and daunorubicin derivatives on prokaryotic and eukaryotic cells

1984 • 21 citations

Absence of generation of oxygen-containing free radicals with 4′-deoxydoxorubicin, a non-cardiotoxic anthracycline drug

1984 • 21 citations

Metabolic activation of N-acylanthracyclines precedes their interaction with DNA topoisomerase II.

1987 • 12 citations