Prevention of doxorubicin cardiac toxicity in the mouse by N-acetylcysteine.

Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent

1968 • 7,671 citations

Evaluation of survival data and two new rank order statistics arising in its consideration.

1966 • 7,595 citations

Statistical Methods in Medical Research.

1972 • 4,731 citations

The Importance of Beta, the Type II Error and Sample Size in the Design and Interpretation of the Randomized Control Trial

1978 • 1,634 citations

Adriamycin: The Role of Lipid Peroxidation in Cardiac Toxicity and Tumor Response

1977 • 1,116 citations

Enzymatic Defenses of the Mouse Heart Against Reactive Oxygen Metabolites

1980 • 711 citations

A general mechanism for microsomal activation of quinone anticancer agents to free radicals.

1978 • 645 citations

Glutathione: interorgan translocation, turnover, and metabolism.

1979 • 601 citations

Adriamycin—A Review

1975 • 458 citations

An Improved Approximate Formula for Calculating Sample Sizes for Comparing Two Binomial Distributions

1978 • 423 citations

Doxorubicin Cardiomyopathy: Evaluation by Phonocardiography, Endomyocardial Biopsy, and Cardiac Catheterization

1978 • 412 citations

Early anthracycline cardiotoxicity

1978 • 333 citations

Adriamycin stimulated superoxide formation in submitochondrial particles

1977 • 256 citations

Overview of cardiac pathology in relation to anthracycline cardiotoxicity.

1978 • 220 citations

Plasma pharmacokinetics of adriamycin and its metabolites in humans with normal hepatic and renal function.

1977 • 211 citations

REACTIONS OF O^‐₂, H₂O₂ AND OTHER OXIDANTS WITH SULFHYDRYL ENZYMES‡

1978 • 118 citations

Estimation and identification of thiols in rat spleen after cysteine or glutathione treatment: Relevance to protection against nitrogen mustards

1966 • 114 citations

Heart weight as a function of body weight in mammals.

1979 • 111 citations

Effect of vitamin E against adriamycin-induced toxicity in rabbits.

1980 • 111 citations

A fluorometric assay for daunomycin and adriamycin in animal tissues

1973 • 108 citations

The Power Function of the "Exact" Test for Comparing Two Binomial Distributions

1978 • 92 citations

Metabolic studies with acetylcysteine

1966 • 87 citations

The effect of doxorubicin on hepatic and cardiac glutathione.

1979 • 79 citations

Quantitative experimental evaluation of adriamycin cardiotoxicity in the mouse.

1979 • 74 citations

The effects of α-tocopherol on the toxicity, disposition, and metabolism of adriamycin in mice

1979 • 66 citations

Effect of alpha-tocopherol on the cardiotoxicity of adriamycin in the rat.

1978 • 62 citations

Beneficial effects of penicillamine treatment on hereditary avian muscular dystrophy.

1975 • 51 citations

Cysteine adds to lipid hydroperoxide

1977 • 44 citations

A proposed reaction mechanism for the enzymatic reductive cleavage of glycosidic bond in anthracycline antibiotics.

1979 • 43 citations

Alterations in DNA synthesis in cardiac tissue induced by adriamycin in vivo—Relationship to fatal toxicity

1975 • 43 citations

Pathologic features of adriamycin toxicosis in young pigs: nonskeletal lesions.

1979 • 40 citations

Effect of sulfhydryl-containing compounds on the antitumor effects of adriamycin

1980 • 36 citations

Enzymological studies on hereditary avian muscular dystrophy.

1976 • 33 citations

Effect of thiols in biological systems on protein sulfhydryl content

1970 • 32 citations

Addition ofN-acetylcysteine to linoleic acid hydroperoxide

1976 • 25 citations

A role for glutathione in muscle contraction

1970 • 23 citations

Quantitative thin-layer chromatography: thin-film fluorescence scanning analysis of adriamycin and metabolites in tissue

1979 • 19 citations

Effect of adriamycin on the metabolism of heart slices

1979 • 17 citations

Salutary effects of cysteine on cardiogenic shock in cats

1978 • 16 citations

Evaluation of antitumor drug side effects in small animals

1980 • 7 citations