Inactivation of cytochrome c oxidase activity in mitochondrial membranes during redox cycling of doxorubicin

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Phosphorus Assay in Column Chromatography

1959 • 12,895 citations

[30] Microsomal lipid peroxidation

1978 • 12,818 citations

Esters of Methanesulfonic Acid as Irreversible Inhibitors of Acetylcholinesterase

1962 • 1,510 citations

Quantitative Aspects of the Production of Superoxide Anion Radical by Milk Xanthine Oxidase

1970 • 1,037 citations

Redox cycling of anthracyclines by cardiac mitochondria. I. Anthracycline radical formation by NADH dehydrogenase.

1986 • 608 citations

Ferritin and superoxide-dependent lipid peroxidation.

1985 • 532 citations

Redox cycling of anthracyclines by cardiac mitochondria. II. Formation of superoxide anion, hydrogen peroxide, and hydroxyl radical.

1986 • 525 citations

N-hydroxysulfosuccinimide active esters: bis(N-hydroxysulfosuccinimide) esters of two dicarboxylic acids are hydrophilic, membrane-impermeant, protein cross-linkers

1982 • 481 citations

Transport of Oxygen in Muscle

1989 • 468 citations

Antioxidant effects of ubiquinones in microsomes and mitochondria are mediated by tocopherol recycling

1990 • 358 citations

Evidence of a specific complex between adriamycin and negatively-charged phospholipids

1980 • 307 citations

Anthracycline antibiotic-stimulated superoxide, hydrogen peroxide, and hydroxyl radical production by NADH dehydrogenase.

1983 • 282 citations

Adriamycin stimulated superoxide formation in submitochondrial particles

1977 • 256 citations

NADH- and NADPH-dependent lipid peroxidation in bovine heart submitochondrial particles. Dependence on the rate of electron flow in the respiratory chain and an antioxidant role of ubiquinol

1980 • 200 citations

Anthracycline glycoside-membrane interactions

1984 • 172 citations

Stimulation by adriamycin of rat heart and liver microsomal NADPH-dependent lipid peroxidation

1981 • 166 citations

Evidence of a complex between adriamycin derivatives and cardiolipin: Possible role in cardiotoxicity

1980 • 156 citations

Enhancement of reactive oxygen-dependent mitochondrial membrane lipid peroxidation by the anticancer drug adriamycin

1985 • 154 citations

[87] Energy-coupling in nonphosphorylating submitochondrial particles

1967 • 152 citations

[76] The quantitative determination of mitochondrial hemoproteins

1967 • 143 citations

Adriamycin inactivates cytochrome c oxidase by exclusion of the enzyme from its cardiolipin essential environment

1982 • 143 citations

[24] Micro methods for the quantitative determination of iron and copper in biological material

1978 • 141 citations

Oxidative and non-oxidative mechanisms in the inactivation of cardiac mitochondrial electron transport chain components by doxorubicin

1989 • 141 citations

Mitochondria contain a proteolytic system which can recognize and degrade oxidatively-denatured proteins

1988 • 122 citations

Release of iron from ferritin by cardiotoxic anthracycline antibiotics

1986 • 115 citations

Cytochrome c reduction by semiquinone radicals can be indirectly inhibited by superoxide dismutase

1981 • 108 citations

Mitochondrial iron not bound in heme and iron-sulfur centers. Estimation, compartmentation and redox state

1980 • 104 citations

Specificity and binding affinity of phospholipids to the high-affinity cardiolipin sites of beef heart cytochrome c oxidase

1982 • 103 citations

Effects of adriamycin on respiratory chain activities in mitochondria from rat liver, rat heart and bovine heart. Evidence for a preferential inhibition of complex III and IV

1987 • 101 citations

Reactions of the semiquinone free radicals of anti‐tumour agents with oxygen and iron complexes

1985 • 86 citations

The interaction of adriamycin with cardiolipin in model and rat liver mitochondrial membranes

1984 • 85 citations

Rat liver microsomal NADPH-dependent release of iron from ferritin and lipid peroxidation

1985 • 84 citations

Destruction of Phosphilipids and Respiratory‐Chain Activity in Pig=Heart Submitochondrial Particles Induced by an Adriamycin‐Iron Complex

1983 • 83 citations

Adriamycin as a probe for the transversal distribution of cardiolipin in the inner mitochondrial membrane.

1985 • 77 citations

Interaction of adriamycin with negatively charged model membranes: evidence of two types of binding sites

1985 • 76 citations

Mitochondrial membrane modifications induced by adriamycin-mediated electron transport

1983 • 72 citations

Dissociation of microsomal oxygen reduction and lipid peroxidation with the electron acceptors, paraquat and menadione

1979 • 64 citations

Differences in O2 reduction by the iron complexes of adriamycin and daunomycin: the importance of the sidechain hydroxyl group

1986 • 64 citations

Adriamycin inhibits the formation of non-bilayer lipid structures in cardiolipin-containing model membranes

1982 • 62 citations

Cytofluorescence detection of adriamycin-mitochondria interactions in isolated, perfused rat heart

1986 • 61 citations

Effects of adriamycin on lipid polymorphism in cardiolipin-containing model and mitochondrial membranes

1985 • 60 citations

A method for removal of trace iron contamination from biological buffers

1987 • 55 citations

Release of Iron from Ferritin and its Role in Oxygen Radical Toxicities

1988 • 51 citations

Adriamycin-dependent release of iron from microsomal membranes

1989 • 49 citations

NADH oxidation in submitochondrial particles protects respiratory chain activity against damage by adriamycin‐Fe³⁺

1983 • 47 citations

Transfer of ferritin‐bound iron to adriamycin

1984 • 46 citations

Identification of the site of adriamycin-activation in the heart cell

1988 • 43 citations

Anthracycline binding to synthetic and natural membranes. A study using resonance energy transfer

1986 • 37 citations

[21] Polylysine—drug conjugates

1985 • 35 citations

Adriamycin-dependent peroxidation of rat liver and heart microsomes catalysed by iron chelates and ferritin

1988 • 33 citations

The iron(III)-adriamycin complex inhibits cytochrome c oxidase before its inactivation

1988 • 32 citations

Relevance of ferritin-binding sites on isolated mitochondria to the mobilization of iron from ferritin

1982 • 30 citations

Inhibition and inactivation of NADH-cytochrome c reductase activity of bovine heart submitochondrial particles by the iron(III)-adriamycin complex

1990 • 28 citations

A new class of free radical scavengers reducing adriamycin mitochondrial toxicity

1988 • 26 citations

In vivo and in vitro modifications of the mitochondrial membrane induced by 4' Epi-adriamycin

1986 • 26 citations

Interaction of adriamycin with cardiolipin-containing vesicles. Evidence of an embedded site for the dihydroanthraquinone moiety

1986 • 23 citations

Binding of transferrin‐iron by adriamycin at acidic pH

1986 • 21 citations

Adriamycin and derivatives interaction with the mitochondrial membrane: O2 consumption and free radicals formation.

1984 • 17 citations

The Adriamycin (doxorubicin)-induced inactivation of cytochrome c oxidase depends on the presence of iron or copper

1989 • 16 citations

The structural basis for anthracycline antibiotic stimulation of oxygen consumption by HL-60 cells and mitochondria.

1987 • 13 citations

Lack of competition between cytochrome c and anthraquinone type drugs for the reductive sites of NADH dehydrogenase

1989 • 8 citations

Evidence of a covalent linkage in the adriamycin-cardiolipin complex induced by adriamycin-mediated electron transport.

1983 • 7 citations

Ubiquinone and cytochrome b in isolated rat heart

1977 • 6 citations