A general mechanism for microsomal activation of quinone anticancer agents to free radicals.

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Mitomycins and Porfiromycin: Chemical Mechanism of Activation and Cross-linking of DNA

1964 • 565 citations

PHENOBARBITAL-INDUCED SYNTHESIS OF THE MICROSOMAL DRUG-METABOLIZING ENZYME SYSTEM AND ITS RELATIONSHIP TO THE PROLIFERATION OF ENDOPLASMIC MEMBRANES

1965 • 531 citations

Anthracycline antibiotic augmentation of microsomal electron transport and free radical formation.

1977 • 365 citations

Toxicity of Antineoplastic Agents in Man: Chromosomal Aberrations, Antifertility Effects, Congenital Malformations, and Carcinogenic Potential

1976 • 276 citations

Sarcoplasmic Reticulum

1968 • 226 citations

The mechanism of the degradation of DNA by streptonigrin

1976 • 187 citations

Generation of free radicals of quinone group-containing anti-cancer chemicals in NADPH-microsome system as evidenced by initiation of sulfite oxidation.

1975 • 154 citations

Mitomycin C: Chemical and Biological Studies on Alkylation

1963 • 132 citations

Adriamycin: amelioration of toxicity by alpha-tocopherol.

1976 • 105 citations

Structure-antitumor activity relationships among quinone derivatives.

1974 • 85 citations

H2O2 generation during the redox cycle of mitomycin C and DNA-bound mitomycin C

1976 • 78 citations

Daunomycin (Daunorubicin) and Adriamycin and Structural Analogues: Biological Activity and Mechanism of Action

1975 • 76 citations

Lethal action and metabolic effects of streptonigrin on Escherichia coli.

1968 • 62 citations

Circular dichroism of mitomycin-DNA complexes. Evidence for a conformational change in DNA

1977 • 51 citations

Adriamycin interactions with T4 DNA polymerase. Two modes of template-mediated inhibition.

1977 • 49 citations

A unique, dicoumarol-sensitive, non-phosphorylating oxidation of DPNH and TPNH catalyzed by streptonigrin

1965 • 33 citations

Effects of streptonigrin on nucleic acid metabolism of tissue culture cells

1965 • 27 citations

The coenzyme Q10 and vitamin K1 semiquinone free radicals

1960 • 27 citations

The effect of lysogenic induction with mitomycin C on the DNA and DNA polymerase of Escherichiacoli K12λ

1963 • 15 citations