p16^INK4A Participates in a G₁ Arrest Checkpoint in Response to DNA Damage

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

1993 • 5,680 citations

Cancer Cell Cycles

1996 • 5,379 citations

High-efficiency transformation of mammalian cells by plasmid DNA.

1987 • 5,377 citations

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

1993 • 3,680 citations

p21 is a universal inhibitor of cyclin kinases

1993 • 3,408 citations

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

1993 • 2,969 citations

A Cell Cycle Regulator Potentially Involved in Genesis of Many Tumor Types

1994 • 2,821 citations

Thymocyte apoptosis induced by p53-dependent and independent pathways

1993 • 2,322 citations

p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest.

1994 • 1,970 citations

pl5INK4B is a potentia| effector of TGF-β-induced cell cycle arrest

1994 • 1,932 citations

Role of the INK4a Locus in Tumor Suppression and Cell Mortality

1996 • 1,580 citations

Germline p16 mutations in familial melanoma

1994 • 1,241 citations

Complex formation of human papillomavirus E7 proteins with the retinoblastoma tumor suppressor gene product.

1989 • 1,186 citations

A p16 ^INK4a -Insensitive CDK4 Mutant Targeted by Cytolytic T Lymphocytes in a Human Melanoma

1995 • 1,147 citations

Distinct Roles for Cyclin-Dependent Kinases in Cell Cycle Control

1993 • 1,096 citations

D-type cyclin-dependent kinase activity in mammalian cells.

1994 • 1,073 citations

Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts

1996 • 944 citations

Identification and properties of an atypical catalytic subunit (p34PSK-J3/cdk4) for mammalian D type G1 cyclins

1992 • 906 citations

Retinoblastoma-protein-dependent cell-cycle inhibition by the tumour suppressor p16

1995 • 894 citations

Analysis of the p16 gene (CDKN2) as a candidate for the chromosome 9p melanoma susceptibility locus

1994 • 860 citations

Regulation of p16^CDKN2 Expression and Its Implications for Cell Immortalization and Senescence

1996 • 713 citations

Novel INK4 Proteins, p19 and p18, Are Specific Inhibitors of the Cyclin D-Dependent Kinases CDK4 and CDK6

1995 • 657 citations

Increased Risk of Pancreatic Cancer in Melanoma-Prone Kindreds withp16^INK4Mutations

1995 • 620 citations

Hypermethylation-associated inactivation indicates a tumor suppressor role for p15INK4B.

1996 • 585 citations

Expression of the p16INK4a tumor suppressor versus other INK4 family members during mouse development and aging

1997 • 555 citations

Tumour-derived p16 alleles encoding proteins defective in cell-cycle inhibition

1995 • 515 citations

Growth suppression by p16ink4 requires functional retinoblastoma protein.

1995 • 441 citations

Inhibition of Ras-Induced Proliferation and Cellular Transformation by p16 ^INK4

1995 • 382 citations

D-Type Cyclin-Dependent Kinase Activity in Mammalian Cells

1994 • 322 citations

Functional interaction between E2F-4 and p130: evidence for distinct mechanisms underlying growth suppression by different retinoblastoma protein family members.

1995 • 299 citations

Cyclin D1-mediated inhibition of repair and replicative DNA synthesis in human fibroblasts.

1994 • 296 citations

A Familial Syndrome of Pancreatic Cancer and Melanoma with a Mutation in theCDKN2Tumor-Suppressor Gene

1995 • 283 citations

CDK6 (PLSTIRE) and CDK4 (PSK-J3) are a distinct subset of the cyclin-dependent kinases that associate with cyclin D1.

1994 • 260 citations

Redistribution of the CDK inhibitor p27 between different cyclin.CDK complexes in the mouse fibroblast cell cycle and in cells arrested with lovastatin or ultraviolet irradiation.

1995 • 237 citations

Differential expression and cell cycle regulation of the cyclin-dependent kinase 4 inhibitor p16Ink4.

1994 • 231 citations

Self-contained, tetracycline-regulated retroviral vector system for gene delivery to mammalian cells

1996 • 206 citations

Transforming Growth Factor β Stabilizes p15^INK4B Protein, Increases p15^INK4B-cdk4 Complexes, and Inhibits Cyclin D1-cdk4 Association in Human Mammary Epithelial Cells

1997 • 196 citations

Requirement for tyrosine phosphorylation of Cdk4 in Gl arrest induced by ultraviolet irradiation

1995 • 187 citations

Multiple mechanisms of p16INK4A inactivation in non-small cell lung cancer cell lines.

1995 • 184 citations

Elevated p16 at senescence and loss of p16 at immortalization in human papillomavirus 16 E6, but not E7, transformed human uroepithelial cells.

1996 • 176 citations

p53-dependent repression of CDK4 translation in TGF-beta-induced G1 cell-cycle arrest.

1995 • 162 citations

Detection of p53 in primary lung tumors and nonsmall cell lung carcinoma cell lines.

1991 • 78 citations

Reversible, p16-mediated cell cycle arrest as protection from chemotherapy.

1996 • 55 citations