Contribution of glutathione and glutathione‐dependent enzymes in the reversal of adriamycin resistance in colon carcinoma cell lines

Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: Applications to mammalian blood and other tissues

1969 • 6,007 citations

[51] Assays for differentiation of glutathione S-Transferases

1981 • 2,259 citations

Glutathione metabolism and its selective modification.

1988 • 1,975 citations

Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (S-n-butyl homocysteine sulfoximine).

1979 • 1,680 citations

Expression of a multidrug-resistance gene in human tumors and tissues.

1987 • 1,547 citations

The Role of Glutathione and Glutathione S-Transferases in the Metabolism of Chemical Carcinogens and Other Electrophilic Agents

1979 • 1,179 citations

Overexpression of a novel anionic glutathione transferase in multidrug-resistant human breast cancer cells.

1986 • 791 citations

Glutathione : chemical, biochemical, and medical aspects

1989 • 746 citations

Augmentation of adriamycin, melphalan, and cisplatin cytotoxicity in drug-resistant and -sensitive human ovarian carcinoma cell lines by buthionine sulfoximine mediated glutathione depletion

1985 • 545 citations

Glutathione metabolism as a determinant of therapeutic efficacy: a review.

1984 • 505 citations

Role of the Glutathione Redox Cycle in Acquired and de Novo Multidrug Resistance

1988 • 301 citations

Glutathione S-transferases and drug resistance

1991 • 299 citations

Glutathione export by human lymphoid cells: depletion of glutathione by inhibition of its synthesis decreases export and increases sensitivity to irradiation.

1981 • 230 citations

Protective role of the glutathione redox cycle against adriamycin-mediated toxicity in isolated hepatocytes

1981 • 221 citations

Clinical management of advanced gastrointestinal cancer

1975 • 212 citations

Glutathione-S-transferase pi as a determinant of drug resistance in transfectant cell lines.

1990 • 199 citations

P‐glycoprotein expression and schedule dependence of adriamycin cytotoxicity in human colon carcinoma cell lines

1991 • 177 citations

Elevation of pi class glutathione S-transferase activity in human breast cancer cells by transfection of the GST pi gene and its effect on sensitivity to toxins.

1989 • 164 citations

Adriamycin activation and oxygen free radical formation in human breast tumor cells: protective role of glutathione peroxidase in adriamycin resistance.

1989 • 159 citations

Expression of recombinant glutathione S-transferase pi, Ya, or Yb1 confers resistance to alkylating agents.

1990 • 148 citations

Regulatory role of glutathione and soluble sulfhydryl groups in the toxicity of adriamycin.

1980 • 145 citations

Potentiation of doxorubicin cytotoxicity by buthionine sulfoximine in multidrug-resistant human breast tumor cells.

1989 • 128 citations

Multidrug resistance in cells transfected with human genes encoding a variant P-glycoprotein and glutathione S-transferase-pi.

1990 • 104 citations

Differential oxygen radical susceptibility of adriamycin-sensitive and -resistant MCF-7 human breast tumor cells.

1989 • 99 citations

An evaluation of the role of glutathione and its associated enzymes in the expression of differential sensitivities to antitumour agents shown by a range of human tumour cell lines

1990 • 97 citations

Role of glutathione and dependent enzymes in anthracycline-resistant HL60/AR cells.

1989 • 94 citations

Selenocysteine's mechanism of incorporation and evolution revealed in cDNAs of three glutathione peroxidases

1988 • 90 citations

Glutathione S—transferase and drug resistance

1989 • 90 citations

Potentiation and protection of doxorubicin cytotoxicity by cellular glutathione modulation.

1985 • 76 citations

Resistance mechanisms in three human small cell lung cancer cell lines established from one patient during clinical follow-up

1990 • 71 citations

Antioxidant and xenobiotic-metabolizing enzyme gene expression in doxorubicin-resistant MCF-7 breast cancer cells.

1990 • 67 citations

Role of glutathione and its associated enzymes in multidrug-resistant human myeloma cells

1989 • 41 citations

DNA topoisomerase II as a potential factor in drug resistance of human malignancies.

1987 • 17 citations