Dependence of nucleic acid degradation on in situ free-radical production by Adriamycin

DNA Damage and Oxygen Radical Toxicity

1988 • 1,964 citations

Fused transcript of abl and bcr genes in chronic myelogenous leukaemia

1985 • 1,650 citations

Hepatic Triphosphopyridine Nucleotide-Cytochrome c Reductase: Isolation, Characterization, and Kinetic Studies

1962 • 1,431 citations

Oxidants and human disease: some new concepts ¹

1987 • 1,171 citations

Quantitative Aspects of the Production of Superoxide Anion Radical by Milk Xanthine Oxidase

1970 • 1,037 citations

Studies on interaction of anthracycline antibiotics and deoxyribonucleic acid: equilibrium binding studies on the interaction of daunomycin with deoxyribonucleic acid

1982 • 923 citations

Considerations in the spin trapping of superoxide and hydroxyl radical in aqueous systems using 5,5-dimethyl-1-pyrroline-1-oxide

1978 • 569 citations

Structural comparison of anticancer drug-DNA complexes: adriamycin and daunomycin

1990 • 568 citations

Hydroxyl radical "footprinting": high-resolution information about DNA-protein contacts and application to lambda repressor and Cro protein.

1986 • 518 citations

DNA strand scission by enzymically generated oxygen radicals

1981 • 428 citations

Free radical formation by antitumor quinones

1989 • 419 citations

Stereochemistry of Intercalation: Interaction of Daunomycin with DNA

1972 • 360 citations

On the cytotoxicity of vitamin C and metal ions

1983 • 328 citations

Effects of Superoxide on the Erythrocyte Membrane

1978 • 267 citations

Bleomycin-DNA interactions: fluorescence and proton magnetic resonance studies

1977 • 238 citations

Differential formation of hydroxyl radicals by adriamycin in sensitive and resistant MCF-7 human breast tumor cells: implications for the mechanism of action

1987 • 214 citations

Iron(II)-ethylenediaminetetraacetic acid catalyzed cleavage of RNA and DNA oligonucleotides: similar reactivity toward single- and double-stranded forms

1990 • 192 citations

Research into Fish Diseases

1972 • 158 citations

Site-specific cleavage of RNA by Fe(II).bleomycin.

1990 • 130 citations

Binding mode of chemically activated semiquinone free radicals from quinone anticancer agents to DNA

1979 • 104 citations

Reactions of the semiquinone free radicals of anti‐tumour agents with oxygen and iron complexes

1985 • 86 citations

Biophysical chemistry of the daunomycin-DNA interaction

1990 • 85 citations

Induction of stable transcriptional blockage sites by Adriamycin: GpC specificity of apparent Adriamycin-DNA adducts and dependence on iron(III) ions

1990 • 84 citations

Inhibition of DNA replicon initiation by 4-nitroquinoline 1-oxide, adriamycin, and ethyleneimine.

1978 • 77 citations

Spectrophotometric and fluorescence polarization studies of the binding of ethidium, daunomycin and mepacrine to DNA and to poly(I · C)

1977 • 61 citations

The interaction of adriamycin and adriamycin analogues with nucleic acids in the B and A conformations

1979 • 47 citations

Role of quinone-iron(III) interaction in NADPH-dependent enzymic generation of hydroxyl radicals

1992 • 46 citations

Relationship of adriamycin concentrations to the DNA lesions induced in hypoxic and euoxic L1210 cells.

1983 • 45 citations

Anthracycline-DNA interactions studied with linear dichroism and fluorescence spectroscopy

1988 • 38 citations

Complex formation of daunomycin with double‐stranded RNA

1973 • 36 citations

Permeation of liposome membrane by superoxide radical

1979 • 33 citations

Reaction of single-stranded DNA with hydroxyl radical generated by iron(II)-ethylenediaminetetraacetic acid

1990 • 28 citations

Multiple mechanisms of adriamycin resistance in the human leukemia cell line CCRF-CEM

1989 • 25 citations

Effect of the methylation of aglycone hydroxyl groups on the biological and biochemical properties of daunorubicin

1981 • 24 citations

Phorbol esters and thyroliberin have distinct actions regarding stimulation of prolactin secretion and activation of adenylate cyclase in rat pituitary tumour cells (GH4C1 cells)

1988 • 23 citations

Mechanisms of the in vivo resistance to adriamycin and modulation by calcium channel blockers in mice.

1989 • 20 citations

Hydroxyl radical generation and DNA strand scission mediated by natural anticancer and synthetic quinones

1989 • 18 citations

Influence of some chromophore substituents on the intercalation of anthracycline antibiotics into DNA

1982 • 9 citations

[65] Oxygen radicals and drugs: In vitro measurements

1990 • 9 citations

¹H-NMR study of the interaction of daunomycin with B-DNA helices of methylated oligodeoxynucleotides

1984 • 6 citations