A New Twist in the Feedback Loop: Stress-Activated MDM2 Destabilization is Required for p53 Activation

In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2

2004 • 4,416 citations

Mdm2 promotes the rapid degradation of p53

1997 • 4,336 citations

Regulation of p53 stability by Mdm2

1997 • 3,238 citations

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

1992 • 3,110 citations

Activation of p53 Sequence-Specific DNA Binding by Acetylation of the p53 C-Terminal Domain

1997 • 2,510 citations

DNA Damage-Induced Phosphorylation of p53 Alleviates Inhibition by MDM2

1997 • 2,089 citations

Amplification of a gene encoding a p53-associated protein in human sarcomas

1992 • 1,959 citations

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

1997 • 1,906 citations

The p53-mdm-2 autoregulatory feedback loop.

1993 • 1,795 citations

Recognition of the polyubiquitin proteolytic signal

2000 • 1,651 citations

The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus

1999 • 1,549 citations

The Ink4a Tumor Suppressor Gene Product, p19Arf, Interacts with MDM2 and Neutralizes MDM2's Inhibition of p53

1998 • 1,538 citations

Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest

1995 • 1,500 citations

Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

1993 • 1,445 citations

Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

1995 • 1,401 citations

Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

1995 • 1,263 citations

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

1998 • 1,248 citations

A Single Nucleotide Polymorphism in the MDM2 Promoter Attenuates the p53 Tumor Suppressor Pathway and Accelerates Tumor Formation in Humans

2004 • 1,241 citations

DNA damage activates p53 through a phosphorylation–acetylation cascade

1998 • 1,194 citations

The proteasome: a suitable antineoplastic target

2004 • 1,189 citations

The alternative product from the human CDKN2A locus, p14ARF, participates in a regulatory feedback loop with p53 and MDM2

1998 • 1,152 citations

Post‐translational modifications and activation of p53 by genotoxic stresses

2001 • 1,076 citations

Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization

2002 • 982 citations

The MDM2 gene amplification database

1998 • 958 citations

Nucleolar Arf sequesters Mdm2 and activates p53

1999 • 937 citations

Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis

1999 • 828 citations

Mono- Versus Polyubiquitination: Differential Control of p53 Fate by Mdm2

2003 • 783 citations

The p53–Mdm2 module and the ubiquitin system

2002 • 759 citations

Small molecule RITA binds to p53, blocks p53–HDM-2 interaction and activates p53 function in tumors

2004 • 732 citations

A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking

1999 • 727 citations

Tumorigenic potential associated with enhanced expression of a gene that is amplified in a mouse tumor cell line.

1991 • 712 citations

ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage

2001 • 681 citations

Mapping of the p53 and mdm-2 interaction domains.

1993 • 658 citations

A Dynamic Role of HAUSP in the p53-Mdm2 Pathway

2004 • 644 citations

In vivo ubiquitination and proteasome-mediated degradation of p53(1).

1996 • 643 citations

MDMX: a novel p53-binding protein with some functional properties of MDM2.

1996 • 624 citations

The RING Heterodimer BRCA1-BARD1 Is a Ubiquitin Ligase Inactivated by a Breast Cancer-derived Mutation

2001 • 623 citations

E1A signaling to p53 involves the p19^ARFtumor suppressor

1998 • 614 citations

Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein

1998 • 610 citations

Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage

1999 • 570 citations

p300/CBP-mediated p53 acetylation is commonly induced by p53-activating agents and inhibited by MDM2

2001 • 554 citations

Inhibition of phosphoinositide 3-kinase related kinases by the radiosensitizing agent wortmannin.

1998 • 526 citations

Nuclear Export Is Required for Degradation of Endogenous p53 by MDM2 and Human Papillomavirus E6

1998 • 513 citations

Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53

2001 • 505 citations

Stimulation of E2F1/DP1 transcriptional activity by MDM2 oncoprotein

1995 • 459 citations

Polyubiquitination of p53 by a Ubiquitin Ligase Activity of p300

2003 • 458 citations

Serine15 phosphorylation stimulates p53 transactivation but does not directly influence interaction with HDM2

1999 • 446 citations

Regulation of p53 Function and Stability by Phosphorylation

1999 • 443 citations

Phosphorylation of p53 Serine 15 Increases Interaction with CBP

1998 • 427 citations

Wild-type p53 protein undergoes cytoplasmic sequestration in undifferentiated neuroblastomas but not in differentiated tumors.

1995 • 421 citations

p300/MDM2 Complexes Participate in MDM2-Mediated p53 Degradation

1998 • 415 citations

A Comparison of the Activity, Sequence Specificity, and CRM1-Dependence of Different Nuclear Export Signals

2000 • 392 citations

Accelerated MDM2 auto-degradation induced by DNA-damage kinases is required for p53 activation

2004 • 385 citations

Activity of MDM2, a ubiquitin ligase, toward p53 or itself is dependent on the RING finger domain of the ligase

2000 • 378 citations

The evolution of diverse biological responses to DNA damage: insights from yeast and p53

2001 • 372 citations

Design of a synthetic Mdm2-binding mini protein that activates the p53 response in vivo

1997 • 370 citations

HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53

2003 • 355 citations

Stress Signals Utilize Multiple Pathways To Stabilize p53

2000 • 355 citations

The MDM2 RING-finger domain is required to promote p53 nuclear export

2000 • 352 citations

Molecular Mechanism of the Interaction between MDM2 and p53

2002 • 343 citations

Tumor spectrum in ARF-deficient mice.

1999 • 339 citations

Wild type p53 can mediate sequence-specific transactivation of an internal promoter within the mdm2 gene.

1993 • 332 citations

An intact HDM2 RING-finger domain is required for nuclear exclusion of p53

2000 • 330 citations

MDM2 Suppresses p73 Function without Promoting p73 Degradation

1999 • 329 citations

MDM2 interacts with MDMX through their RING finger domains

1999 • 319 citations

Mdm4 (Mdmx) Regulates p53-Induced Growth Arrest and Neuronal Cell Death during Early Embryonic Mouse Development

2002 • 305 citations

ATM Mediates Phosphorylation at Multiple p53 Sites, Including Ser46, in Response to Ionizing Radiation

2002 • 292 citations

Posttranslational modification of MDM2.

2003 • 285 citations

Damage-mediated Phosphorylation of Human p53 Threonine 18 through a Cascade Mediated by a Casein 1-like Kinase

2000 • 285 citations

Stabilization of the MDM2 Oncoprotein by Interaction with the Structurally Related MDMX Protein

1999 • 282 citations

p16INK4A and p19ARF act in overlapping pathways in cellular immortalization

2000 • 281 citations

Mutual Dependence of MDM2 and MDMX in Their Functional Inactivation of p53

2002 • 260 citations

Phosphorylation Site Interdependence of Human p53 Post-translational Modifications in Response to Stress

2003 • 250 citations

The mdm-2 gene is induced in response to UV light in a p53-dependent manner.

1993 • 250 citations

Mdm-2 phosphorylation by DNA-dependent protein kinase prevents interaction with p53.

1997 • 243 citations

MDM2 Promotes Ubiquitination and Degradation of MDMX

2003 • 242 citations

C-Terminal Ubiquitination of p53 Contributes to Nuclear Export

2001 • 241 citations

Phosphorylation of p53 on Key Serines Is Dispensable for Transcriptional Activation and Apoptosis

2004 • 235 citations

mdm2 Is Critical for Inhibition of p53 during Lymphopoiesis and the Response to Ionizing Irradiation

2003 • 234 citations

Prognostic significance of cytoplasmic p53 oncoprotein in colorectal adenocarcinoma

1992 • 233 citations

Mdmx stabilizes p53 and Mdm2 via two distinct mechanisms

2001 • 230 citations

Autoubiquitination of the BRCA1·BARD1 RING Ubiquitin Ligase

2002 • 218 citations

Role of p14^ARF in Replicative and Induced Senescence of Human Fibroblasts

2001 • 217 citations

MdmX Protects p53 from Mdm2-Mediated Degradation

2000 • 212 citations

N-terminal polyubiquitination and degradation of the Arf tumor suppressor

2004 • 207 citations

Mdm2 binds p73α without targeting degradation

1999 • 206 citations

The RING Domain of Mdm2 Mediates Histone Ubiquitylation and Transcriptional Repression

2004 • 199 citations

MDM2 and prognosis.

2004 • 196 citations

Tyrosine phosphorylation of Mdm2 by c-Abl: implications for p53 regulation

2002 • 195 citations

Nuclear localization is essential for the activity of p53 protein.

1991 • 190 citations

mdmx is a negative regulator of p53 activity in vivo.

2002 • 188 citations

MDM2 inhibits p300-mediated p53 acetylation and activation by forming a ternary complex with the two proteins

2000 • 188 citations

Comparative study of the p53-mdm2 and p53-MDMX interfaces

1999 • 182 citations

Human mdm2 Mediates Multiple Mono-ubiquitination of p53 by a Mechanism Requiring Enzyme Isomerization

2001 • 166 citations

DNA Damage-induced MDMX Degradation Is Mediated by MDM2

2003 • 163 citations

Transformation of normal human cells in the absence of telomerase activation

2002 • 154 citations

mdm2 and bax, downstream mediators of the p53 response, are degraded by the ubiquitin-proteasome pathway.

1998 • 153 citations

DNA damage induced p53 stabilization: no indication for an involvement of p53 phosphorylation

1999 • 152 citations

Phosphorylation of Serine 18 Regulates Distinct p53 Functions in Mice

2004 • 151 citations

Hdmx Protein Stability Is Regulated by the Ubiquitin Ligase Activity of Mdm2

2003 • 146 citations

Hdmx Stabilizes Mdm2 and p53

2000 • 145 citations

Hypophosphorylation of Mdm2 Augments p53 Stability

2002 • 142 citations

Cell Type- and Promoter-specific Roles of Ser18 Phosphorylation in Regulating p53 Responses

2003 • 138 citations

Novel phosphorylation sites of human tumour suppressor protein p53 at Ser20 and Thr18 that disrupt the binding of mdm2 (mouse double minute 2) protein are modified in human cancers

1999 • 138 citations

Phosphorylation of p53: a Novel Pathway for p53 Inactivation in Human T-Cell Lymphotropic Virus Type 1-Transformed Cells

1998 • 134 citations

Mdm2 haplo-insufficiency profoundly inhibits Myc-induced lymphomagenesis

2003 • 129 citations

The Promyelocytic Leukemia Protein Protects p53 from Mdm2-mediated Inhibition and Degradation

2003 • 129 citations

Cocompartmentalization of p53 and Mdm2 Is a Major Determinant for Mdm2-Mediated Degradation of p53

2001 • 125 citations

Defective apoptosis and B-cell lymphomas in mice with p53 point mutation at Ser 23

2004 • 123 citations

Flavopiridol Induces p53 via Initial Inhibition of Mdm2 and p21 and, Independently of p53, Sensitizes Apoptosis-Reluctant Cells to Tumor Necrosis Factor

2004 • 121 citations

Critical Contribution of the MDM2 Acidic Domain to p53 Ubiquitination

2003 • 116 citations

p53 mediated death of cells overexpressing MDM2 by an inhibitor of MDM2 interaction with p53

1999 • 115 citations

Inhibition of p53 degradation by Mdm2 acetylation

2004 • 106 citations

The Ubiquitin-Associated (UBA) Domain: On the Path from Prudence to Prurience

2002 • 106 citations

Analysis of the degradation function of Mdm2.

1999 • 104 citations

Differential requirement for p19ARF in the p53-dependent arrest induced by DNA damage, microtubule disruption, and ribonucleotide depletion

2000 • 103 citations

MDM2 and MDMX can interact differently with ARF and members of the p53 family

2001 • 97 citations

Involvement of the DNA Repair Protein hHR23 in p53 Degradation

2003 • 93 citations

Nuclear degradation of p53 occurs during down‐regulation of the p53 response after DNA damage

2002 • 92 citations

The contribution of the acidic domain of MDM2 to p53 and MDM2 stability

2001 • 88 citations

p19^ARF Is Dispensable for Oncogenic Stress-Induced p53-Mediated Apoptosis and Tumor Suppression In Vivo

2002 • 86 citations

The p53 Tumor Suppressor Protein Does Not Regulate Expression of Its Own Inhibitor, MDM2, Except under Conditions of Stress

2000 • 86 citations

Functional role of Mdm2 phosphorylation by ATR in attenuation of p53 nuclear export

2003 • 86 citations

MDM2 Inhibits PCAF (p300/CREB-binding Protein-associated Factor)-mediated p53 Acetylation

2002 • 85 citations

Oncogenic Ras induces p19ARF and growth arrest in mouse embryo fibroblasts lacking p21Cip1 and p27Kip1 without activating cyclin D-dependent kinases

2000 • 81 citations

Nuclear Exclusion of Wild-Type p53 in Immortalized Human Retinoblastoma Cells

1997 • 75 citations

A post-ubiquitination role for MDM2 and hHR23A in the p53 degradation pathway

2004 • 70 citations

Physical and Functional Interactions between PML and MDM2

2003 • 68 citations

Increased p53 phosphorylation after microtubule disruption is mediated in a microtubule inhibitor- and cell-specific manner

2001 • 67 citations

The proliferation of normal human fibroblasts is dependent upon negative regulation of p53 function by mdm2

1998 • 66 citations

ATM complexes with HDM2 and promotes its rapid phosphorylation in a p53-independent manner in normal and tumor human cells exposed to ionizing radiation

2000 • 65 citations

Cellular accumulation of p53 protein: an independent prognostic factor in stage II breast cancer

1994 • 65 citations

Nucleotide Binding by the MDM2 RING Domain Facilitates Arf-Independent MDM2 Nucleolar Localization

2003 • 62 citations

A potential proteasome-interacting motif within the ubiquitin-like domain of parkin and other proteins

2003 • 60 citations

Mdm2 Mutant Defective in Binding p300 Promotes Ubiquitination but Not Degradation of p53

2001 • 56 citations

Radiation-induced apoptosis in developing mouse retina exhibits dose-dependent requirement for ATM phosphorylation of p53

2004 • 54 citations

Involvement of wild-type p53 protein in the cell cycle requires nuclear localization.

1991 • 53 citations

Development of a Binding Assay for p53/HDM2 by Using Homogeneous Time-Resolved Fluorescence

2000 • 45 citations

Inhibition of Transcription Results in Accumulation of Wt p53 Followed by Delayed Outburst of p53-Inducible Proteins: p53 as a Sensor of Transcriptional Integrity

2002 • 39 citations

Loss of one allele of ARF rescues Mdm2 haploinsufficiency effects on apoptosis and lymphoma development

2004 • 34 citations

MDM2 and Promyelocytic Leukemia Antagonize Each Other through Their Direct Interaction with p53

2003 • 30 citations

The Acetylase Activity of p300 Is Dispensable for MDM2 Stabilization

2003 • 17 citations