Phosphorylation of p53: a Novel Pathway for p53 Inactivation in Human T-Cell Lymphotropic Virus Type 1-Transformed Cells

p53, the Cellular Gatekeeper for Growth and Division

1997 • 7,621 citations

Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma

1980 • 5,022 citations

ANTIBODIES TO HUMAN T-LYMPHOTROPIC VIRUS TYPE-I IN PATIENTS WITH TROPICAL SPASTIC PARAPARESIS

1985 • 2,840 citations

p53: puzzle and paradigm.

1996 • 2,363 citations

DNA Damage-Induced Phosphorylation of p53 Alleviates Inhibition by MDM2

1997 • 2,089 citations

Definition of a consensus binding site for p53

1992 • 2,000 citations

Suppression of Human Colorectal Carcinoma Cell Growth by Wild-Type p53

1990 • 1,796 citations

Regulation of the specific DNA binding function of p53

1992 • 914 citations

Monoclonal integration of human T-cell leukemia provirus in all primary tumors of adult T-cell leukemia suggests causative role of human T-cell leukemia virus in the disease.

1984 • 886 citations

Database of p53 gene somatic mutations in human tumors and cell lines.

1994 • 866 citations

DNA damage induces phosphorylation of the amino terminus of p53

1997 • 829 citations

p53 functions as a cell cycle control protein in osteosarcomas.

1990 • 774 citations

A transcriptionally active DNA-binding site for human p53 protein complexes.

1992 • 729 citations

Binding and modulation of p53 by p300/CBP coactivators

1997 • 698 citations

Recruitment of p300/CBP in p53-Dependent Signal Pathways

1997 • 671 citations

Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein.

1994 • 644 citations

Synergistic activation of transcription by CBP and p53

1997 • 599 citations

p53 modulation of TFIIH–associated nucleotide excision repair activity

1995 • 555 citations

Genetic Mechanisms of Tumor Suppression by the Human p53 Gene

1990 • 540 citations

Negative growth regulation in a glioblastoma tumor cell line that conditionally expresses human wild-type p53.

1990 • 502 citations

p53 in growth control and neoplasia

1996 • 488 citations

Human DNA-Activated Protein Kinase Phosphorylates Serines 15 and 37 in the Amino-Terminal Transactivation Domain of Human p53

1992 • 473 citations

Infective dermatitis of Jamaican children: a marker for HTLV-I infection

1990 • 452 citations

p53 Transcriptional Activation Mediated by Coactivators TAF _II 40 and TAF _II 60

1995 • 438 citations

Sequence-specific transcriptional activation is essential for growth suppression by p53.

1994 • 412 citations

Inhibition of DNA replication factor RPA by p53

1993 • 380 citations

Holo-TFIID supports transcriptional stimulation by diverse activators and from a TATA-less promoter.

1992 • 372 citations

Binding of basal transcription factor TFIIH to the acidic activation domains of VP16 and p53.

1994 • 355 citations

The acidic transcriptional activation domains of VP16 and p53 bind the cellular replication protein A and stimulate in vitro BPV-1 DNA replication

1993 • 329 citations

Human TAFII31 protein is a transcriptional coactivator of the p53 protein.

1995 • 297 citations

p53 Is Phosphorylated in Vitro and in Vivo by an Ultraviolet Radiation-induced Protein Kinase Characteristic of the c-Jun Kinase, JNK1

1995 • 256 citations

Direct interaction of the hepatitis B virus HBx protein with p53 leads to inhibition by HBx of p53 response element-directed transactivation

1995 • 250 citations

Phosphorylation of Serine 392 Stabilizes the Tetramer Formation of Tumor Suppressor Protein p53

1997 • 249 citations

A Transcriptionally Active DNA-Binding Site for Human p53 Protein Complexes

1992 • 234 citations

p53 Functions as a Cell Cycle Control Protein in Osteosarcomas

1990 • 224 citations

Mutations of the p53 gene in adult T-cell leukemia

1992 • 223 citations

The transactivator proteins VP16 and GAL4 bind replication factor A

1993 • 216 citations

Inhibition of p53 Transactivation Function by the Human T-Cell Lymphotropic Virus Type 1 Tax Protein

1998 • 174 citations

Functional interactions between p53 and the TFIIH complex are affected by tumour-associated mutations.

1996 • 172 citations

The p53 tumor suppressor protein, a modulator of cell proliferation.

1992 • 171 citations

p53 functional impairment and high p21waf1/cip1 expression in human T- cell lymphotropic/leukemia virus type I-transformed T cells

1996 • 145 citations

Mutation of the serine 15 phosphorylation site of human p53 reduces the ability of p53 to inhibit cell cycle progression.

1993 • 140 citations

Phosphorylation of the p53 tumour-suppressor protein at three N-terminal sites by a novel casein kinase I-like enzyme.

1992 • 121 citations

Binding of Basal Transcription Factor TFIIH to the Acidic Activation Domains of VP16 and p53

1994 • 112 citations

Stabilization of wild-type p53 in human T-lymphocytes transformed by HTLV-I.

1993 • 107 citations

How Phosphorylation Regulates the Activity of p53

1996 • 97 citations

Physical and functional interactions between p53 and cell cycle co-operating transcription factors, E2F1 and DP1.

1995 • 96 citations

Phosphorylation at Ser-15 and Ser-392 in mutant p53 molecules from human tumors is altered compared to wild-type p53.

1993 • 91 citations

Genetic Alteration of p53 in Some Patients with Adult T‐Cell Leukemia

1991 • 66 citations

Arthritis in a human T lymphotropic virus type I (HTLV-I) carrier.

1990 • 64 citations

Serine phosphorylation in the NH2 terminus of p53 facilitates transactivation.

1995 • 55 citations

A conformation hypothesis for the suppressor and promoter functions ofp53in cell growth control and in cancer

1991 • 54 citations

Retinal vasculitis in human T-lymphotropic virus type I associated myelopathy.

1989 • 40 citations

Functional inactivation of wild-type p53 protein correlates with loss of IL-2 dependence in HTLV-I transformed human T lymphocytes.

1995 • 31 citations