Tyrosine phosphorylation of Mdm2 by c-Abl: implications for p53 regulation

Mdm2 promotes the rapid degradation of p53

1997 • 4,336 citations

Regulation of p53 stability by Mdm2

1997 • 3,238 citations

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

1992 • 3,092 citations

DNA Damage-Induced Phosphorylation of p53 Alleviates Inhibition by MDM2

1997 • 2,089 citations

The complexity of p53 modulation: emerging patterns from divergent signals

1998 • 1,319 citations

A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus

2001 • 1,180 citations

Mdm2 Is a RING Finger-dependent Ubiquitin Protein Ligase for Itself and p53

2000 • 1,026 citations

HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation

2001 • 931 citations

The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage

1999 • 914 citations

The many substrates and functions of ATM

2000 • 777 citations

Association of p19ARF with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53

1999 • 731 citations

A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking

1999 • 727 citations

Tumorigenic potential associated with enhanced expression of a gene that is amplified in a mouse tumor cell line.

1991 • 712 citations

ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage

2001 • 681 citations

The ARF/p53 pathway

2000 • 647 citations

MDM2 — master regulator of the p53 tumor suppressor protein

2000 • 637 citations

Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein

1998 • 610 citations

ATM and ATR: networking cellular responses to DNA damage

2001 • 595 citations

The cellular response to p53: the decision between life and death

1999 • 594 citations

p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage

1999 • 584 citations

Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage

1999 • 570 citations

Regulation of the p53 Tumor Suppressor Protein

1999 • 566 citations

Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation

1997 • 542 citations

Interaction of c-Abl and p73α and their collaboration to induce apoptosis

1999 • 542 citations

Activation of the c-Abl tyrosine kinase in the stress response to DMA-damaging agents

1995 • 486 citations

Interaction between ATM protein and c-Abl in response to DNA damage

1997 • 481 citations

Cross-talk between Akt, p53 and Mdm2: possible implications for the regulation of apoptosis

2002 • 449 citations

Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage

1999 • 449 citations

Serine15 phosphorylation stimulates p53 transactivation but does not directly influence interaction with HDM2

1999 • 446 citations

Regulation of p53 Function and Stability by Phosphorylation

1999 • 443 citations

Multiple C-Terminal Lysine Residues Target p53 for Ubiquitin-Proteasome-Mediated Degradation

2000 • 383 citations

A p53 Amino-Terminal Nuclear Export Signal Inhibited by DNA Damage-Induced Phosphorylation

2001 • 375 citations

Nucleocytoplasmic shuttling of oncoprotein Hdm2 is required for Hdm2-mediated degradation of p53

1999 • 366 citations

Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2

1999 • 362 citations

mdm-2 Inhibits the G₁ Arrest and Apoptosis Functions of the p53 Tumor Suppressor Protein

1996 • 354 citations

The MDM2 RING-finger domain is required to promote p53 nuclear export

2000 • 352 citations

An intact HDM2 RING-finger domain is required for nuclear exclusion of p53

2000 • 330 citations

Cycling, stressed-out and nervous: cellular functions of c-Abl

1999 • 324 citations

DNA damage-inducible phosphorylation of p53 at N-terminal sites including a novel site, Ser20, requires tetramerization

1999 • 296 citations

The p53 and Mdm2 families in cancer

2002 • 281 citations

The nuclear tyrosine kinase c-abl negatively regulates cell growth

1994 • 277 citations

Mdm-2 phosphorylation by DNA-dependent protein kinase prevents interaction with p53.

1997 • 243 citations

Mechanisms of switching on p53: a role for covalent modification?

1999 • 236 citations

Cell type-specific inhibition of p53-mediated apoptosis by mdm2.

1996 • 234 citations

Role for c-Abl tyrosine kinase in growth arrest response to DNA damage

1996 • 220 citations

The cytostatic function of c-Abl is controlled by multiple nuclear localization signals and requires the p53 and Rb tumor suppressor gene products.

1996 • 196 citations

Multiple Lysine Mutations in the C-Terminal Domain of p53 Interfere with MDM2-Dependent Protein Degradation and Ubiquitination

2000 • 194 citations

Regulation of DNA damage-induced apoptosis by the c-Abl tyrosine kinase

1997 • 191 citations

p53 regulation by post-translational modification and nuclear retention in response to diverse stresses

1999 • 178 citations

Determination of cell fate by c-Abl activation in the response to DNA damage

1998 • 170 citations

Activation of the Cytoplasmic c-Abl Tyrosine Kinase by Reactive Oxygen Species

2000 • 158 citations

DNA damage induced p53 stabilization: no indication for an involvement of p53 phosphorylation

1999 • 152 citations

c-Abl: activation and nuclear targets

2000 • 137 citations

p53 dependent growth suppression by the c-Abl nuclear tyrosine kinase.

1995 • 133 citations

An Inhibitor of Nuclear Export Activates the p53 Response and Induces the Localization of HDM2 and p53 to U1A-Positive Nuclear Bodies Associated with the PODs

1999 • 133 citations

Cocompartmentalization of p53 and Mdm2 Is a Major Determinant for Mdm2-Mediated Degradation of p53

2001 • 125 citations

MDM2-dependent ubiquitination of nuclear and cytoplasmic P53

2000 • 119 citations

c-Abl Neutralizes the Inhibitory Effect of Mdm2 on p53

1999 • 104 citations

c-Abl Regulates p53 Levels under Normal and Stress Conditions by Preventing Its Nuclear Export and Ubiquitination

2001 • 95 citations

The contribution of the acidic domain of MDM2 to p53 and MDM2 stability

2001 • 88 citations

A Genetic Approach to Mapping the p53 Binding Site in the MDM2 Protein

1997 • 87 citations

Stimulation of p53 DNA Binding by c-Abl Requires the p53 C Terminus and Tetramerization

2000 • 75 citations

Genotoxic Drugs Induce Interaction of the c-Abl Tyrosine Kinase and the Tumor Suppressor Protein p53

1996 • 69 citations

Nuclear c-Abl is a COOH-terminal repeated domain (CTD)-tyrosine (CTD)-tyrosine kinase-specific for the mammalian RNA polymerase II: possible role in transcription elongation.

1999 • 69 citations

The carboxy terminus of p53 mimics the polylysine effect of protein kinase CK2-catalyzed MDM2 phosphorylation

1997 • 62 citations

Multiple sites of in vivo phosphorylation in the MDM2 oncoprotein cluster within two important functional domains

2000 • 61 citations

mdm2 deletion does not alter growth characteristics of p53-deficient embryo fibroblasts.

1996 • 47 citations

Phosphorylation of murine double minute clone 2 (MDM2) protein at serine-267 by protein kinase CK2 in vitro and in cultured cells

2001 • 43 citations

Pro-apoptotic effect of the c-Abl tyrosine kinase in the cellular response to 1-β-D-arabinofuranosylcytosine

1997 • 42 citations

Protein kinase CK2 interacts with a multi-protein binding domain of p53

1999 • 33 citations

Engineering the Substrate Specificity of the Abl Tyrosine Kinase

1999 • 31 citations

Cross-talk between Akt, p53 and Mdm2: possible implications for the regulation of apoptosis

2002 • 25 citations

The Regulation of p53 Growth Suppression

2013 • 12 citations