Defective apoptosis and B-cell lymphomas in mice with p53 point mutation at Ser 23

p53, the Cellular Gatekeeper for Growth and Division

1997 • 7,621 citations

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

1992 • 4,648 citations

Mdm2 promotes the rapid degradation of p53

1997 • 4,336 citations

Regulation of p53 stability by Mdm2

1997 • 3,238 citations

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

1992 • 3,092 citations

p53 is required for radiation-induced apoptosis in mouse thymocytes

1993 • 2,911 citations

Thymocyte apoptosis induced by p53-dependent and independent pathways

1993 • 2,322 citations

Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

1995 • 2,115 citations

DNA Damage-Induced Phosphorylation of p53 Alleviates Inhibition by MDM2

1997 • 2,089 citations

Tumor spectrum analysis in p53-mutant mice

1994 • 2,034 citations

Activation of the ATM Kinase by Ionizing Radiation and Phosphorylation of p53

1998 • 2,034 citations

Enhanced Phosphorylation of p53 by ATM in Response to DNA Damage

1998 • 1,734 citations

Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

1993 • 1,445 citations

The complexity of p53 modulation: emerging patterns from divergent signals

1998 • 1,319 citations

Linkage of ATM to Cell Cycle Regulation by the Chk2 Protein Kinase

1998 • 1,314 citations

DNA Damage-Induced Activation of p53 by the Checkpoint Kinase Chk2

2000 • 1,269 citations

Radiation-induced cell cycle arrest compromised by p21 deficiency

1995 • 1,249 citations

Post‐translational modifications and activation of p53 by genotoxic stresses

2001 • 1,076 citations

The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites

2000 • 956 citations

Heterozygous Germ Line hCHK2 Mutations in Li-Fraumeni Syndrome

1999 • 908 citations

DNA damage induces phosphorylation of the amino terminus of p53

1997 • 829 citations

Chk2/hCds1 functions as a DNA damage checkpoint in G₁by stabilizing p53

2000 • 781 citations

Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage

1999 • 570 citations

Serine15 phosphorylation stimulates p53 transactivation but does not directly influence interaction with HDM2

1999 • 446 citations

Regulation of p53 Function and Stability by Phosphorylation

1999 • 443 citations

Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription

2002 • 430 citations

Requirement for Atm in Ionizing Radiation-Induced Cell Death in the Developing Central Nervous System

1998 • 425 citations

Chk2 Is a Tumor Suppressor That Regulates Apoptosis in both an Ataxia Telangiectasia Mutated (ATM)-Dependent and an ATM-Independent Manner

2002 • 393 citations

Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2

1999 • 362 citations

Threonine 68 is required for radiation-induced phosphorylation and activation of Cds1

2000 • 310 citations

DNA damage-inducible phosphorylation of p53 at N-terminal sites including a novel site, Ser20, requires tetramerization

1999 • 296 citations

Effects of genetic background on tumorigenesis in p53‐deficient mice

1995 • 252 citations

Mutations in serines 15 and 20 of human p53 impair its apoptotic activity

1999 • 193 citations

Production and analysis of chimeric mice

1987 • 175 citations

Involvement of wild-type p53 in pre-B-cell differentiation in vitro.

1991 • 168 citations

The Chk2 Tumor Suppressor Is Not Required for p53 Responses in Human Cancer Cells

2003 • 152 citations

DNA damage induced p53 stabilization: no indication for an involvement of p53 phosphorylation

1999 • 152 citations

Phosphorylation of Serine 18 Regulates Distinct p53 Functions in Mice

2004 • 151 citations

Cell Type- and Promoter-specific Roles of Ser18 Phosphorylation in Regulating p53 Responses

2003 • 138 citations

Reactive Oxygen Species-induced Phosphorylation of p53 on Serine 20 Is Mediated in Part by Polo-like Kinase-3

2001 • 138 citations

Different impact of p53 and p21 on the radiation response of mouse tissues

2000 • 123 citations

Increased Sensitivity to UV Radiation in Mice with a p53 Point Mutation at Ser389

2004 • 120 citations

Accumulation of wild-type p53 protein upon gamma-irradiation induces a G2 arrest-dependent immunoglobulin kappa light chain gene expression.

1995 • 105 citations

Mutation of Mouse p53 Ser23 and the Response to DNA Damage

2002 • 103 citations

Critical roles for the serine 20, but not the serine 15, phosphorylation site and for the polyproline domain in regulating p53 turnover

2001 • 70 citations

Splenic marginal zone B-cell and thymic T-cell lymphomas in p53-deficient mice.

1999 • 48 citations

Decreased immunoglobulin deposition in tumors and increased immature B cells in p53-null mice.

1997 • 16 citations