Serine15 phosphorylation stimulates p53 transactivation but does not directly influence interaction with HDM2

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

p53, the Cellular Gatekeeper for Growth and Division

1997 • 7,621 citations

Mdm2 promotes the rapid degradation of p53

1997 • 4,336 citations

Regulation of p53 stability by Mdm2

1997 • 3,238 citations

Activation of p53 Sequence-Specific DNA Binding by Acetylation of the p53 C-Terminal Domain

1997 • 2,510 citations

DNA Damage-Induced Phosphorylation of p53 Alleviates Inhibition by MDM2

1997 • 2,089 citations

Activation of the ATM Kinase by Ionizing Radiation and Phosphorylation of p53

1998 • 2,034 citations

Definition of a consensus binding site for p53

1992 • 2,000 citations

Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

1993 • 1,445 citations

The p53 pathway

1999 • 1,322 citations

The complexity of p53 modulation: emerging patterns from divergent signals

1998 • 1,319 citations

DNA damage activates p53 through a phosphorylation–acetylation cascade

1998 • 1,194 citations

Site-directed mutagenesis of virtually any plasmid by eliminating a unique site

1992 • 1,089 citations

A role for ATR in the DNA damage-induced phosphorylation of p53

1999 • 1,043 citations

Regulation of the specific DNA binding function of p53

1992 • 914 citations

DNA damage induces phosphorylation of the amino terminus of p53

1997 • 829 citations

p53 Sites Acetylated In Vitro by PCAF and p300 Are Acetylated In Vivo in Response to DNA Damage

1999 • 764 citations

Binding and modulation of p53 by p300/CBP coactivators

1997 • 698 citations

Recruitment of p300/CBP in p53-Dependent Signal Pathways

1997 • 671 citations

Synergistic activation of transcription by CBP and p53

1997 • 599 citations

Wild-type p53 binds to the TATA-binding protein and represses transcription.

1992 • 527 citations

Human DNA-Activated Protein Kinase Phosphorylates Serines 15 and 37 in the Amino-Terminal Transactivation Domain of Human p53

1992 • 473 citations

ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins

1998 • 471 citations

Regulation of p53 Function and Stability by Phosphorylation

1999 • 443 citations

p53 Transcriptional Activation Mediated by Coactivators TAF _II 40 and TAF _II 60

1995 • 438 citations

Phosphorylation of p53 Serine 15 Increases Interaction with CBP

1998 • 427 citations

Sensitivity and selectivity of the DNA damage sensor responsible for activating p53-dependent G1 arrest.

1996 • 385 citations

Design of a synthetic Mdm2-binding mini protein that activates the p53 response in vivo

1997 • 370 citations

Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2

1999 • 362 citations

Increased and altered DNA binding of human p53 by S and G2/M but not Gl cyclin-dependent kinases

1995 • 334 citations

Specific repression of TATA-mediated but not initiator-mediated transcription by wild-type p53

1993 • 329 citations

Human TAFII31 protein is a transcriptional coactivator of the p53 protein.

1995 • 297 citations

DNA damage-inducible phosphorylation of p53 at N-terminal sites including a novel site, Ser20, requires tetramerization

1999 • 296 citations

p53: a transdominant regulator of transcription whose function is ablated by mutations occurring in human cancer.

1992 • 278 citations

p53 Is Phosphorylated in Vitro and in Vivo by an Ultraviolet Radiation-induced Protein Kinase Characteristic of the c-Jun Kinase, JNK1

1995 • 256 citations

The p53 Activation Domain Binds the TATA Box-Binding Polypeptide in Holo-TFIID, and a Neighboring p53 Domain Inhibits Transcription

1993 • 246 citations

Mechanisms of switching on p53: a role for covalent modification?

1999 • 236 citations

Direct interaction between the transcriptional activation domain of human p53 and the TATA box-binding protein.

1993 • 209 citations

Regulation of the Sequence-specific DNA Binding Function of p53 by Protein Kinase C and Protein Phosphatases

1995 • 199 citations

Mutations in serines 15 and 20 of human p53 impair its apoptotic activity

1999 • 193 citations

CREB-binding protein and p300/CBP-associated factor are transcriptional coactivators of the p53 tumor suppressor protein.

1997 • 183 citations

p53 Is Phosphorylated by CDK7-Cyclin H in a p36^MAT1-Dependent Manner

1997 • 173 citations

The CDK₇-cycH-p36 Complex of Transcription Factor IIH Phosphorylates p53, Enhancing Its Sequence-Specific DNA Binding Activity In Vitro

1997 • 152 citations

DNA damage induced p53 stabilization: no indication for an involvement of p53 phosphorylation

1999 • 152 citations

Mutation of the serine 15 phosphorylation site of human p53 reduces the ability of p53 to inhibit cell cycle progression.

1993 • 140 citations

Phosphorylation of p53: a Novel Pathway for p53 Inactivation in Human T-Cell Lymphotropic Virus Type 1-Transformed Cells

1998 • 134 citations

Cooperative DNA binding of p53 with TFIID (TBP): a possible mechanism for transcriptional activation.

1993 • 124 citations

Phosphorylation of the p53 tumour-suppressor protein at three N-terminal sites by a novel casein kinase I-like enzyme.

1992 • 121 citations

p53 binds to the TATA-binding protein-TATA complex

1993 • 113 citations

Functional Interaction between p53, the TATA-Binding Protein (TBP), and TBP-Associated Factors In Vivo

1996 • 112 citations

Role for p300 in Stabilization of p53 in the Response to DNA Damage

1999 • 98 citations

Phosphorylation of p53 at the casein kinase II site selectively regulates p53-dependent transcriptional repression but not transactivation

1996 • 73 citations

p53-dependent growth arrest following calcium phosphate-mediated transfection of murine fibroblasts.

1995 • 69 citations

Serine phosphorylation in the NH2 terminus of p53 facilitates transactivation.

1995 • 55 citations