The Acetylase Activity of p300 Is Dispensable for MDM2 Stabilization

Mdm2 promotes the rapid degradation of p53

1997 • 4,336 citations

Regulation of p53 stability by Mdm2

1997 • 3,238 citations

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

1992 • 3,110 citations

hSIR2SIRT1 Functions as an NAD-Dependent p53 Deacetylase

2001 • 2,550 citations

Activation of p53 Sequence-Specific DNA Binding by Acetylation of the p53 C-Terminal Domain

1997 • 2,510 citations

Negative Control of p53 by Sir2α Promotes Cell Survival under Stress

2001 • 2,042 citations

Phosphorylated CREB binds specifically to the nuclear protein CBP

1993 • 2,039 citations

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

1997 • 1,906 citations

The p53-mdm-2 autoregulatory feedback loop.

1993 • 1,795 citations

CBP/p300 in cell growth, transformation, and development

2000 • 1,712 citations

ARF Promotes MDM2 Degradation and Stabilizes p53: ARF-INK4a Locus Deletion Impairs Both the Rb and p53 Tumor Suppression Pathways

1998 • 1,584 citations

DNA damage activates p53 through a phosphorylation–acetylation cascade

1998 • 1,194 citations

Duration of Nuclear NF-κB Action Regulated by Reversible Acetylation

2001 • 1,193 citations

Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptor.

1994 • 1,046 citations

Gene Dosage–Dependent Embryonic Development and Proliferation Defects in Mice Lacking the Transcriptional Integrator p300

1998 • 984 citations

Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2

1998 • 906 citations

Deacetylation of p53 modulates its effect on cell growth and apoptosis

2000 • 794 citations

p53 Sites Acetylated In Vitro by PCAF and p300 Are Acetylated In Vivo in Response to DNA Damage

1999 • 764 citations

Tumor surveillance via the ARF–p53 pathway

1998 • 735 citations

Association of p19ARF with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53

1999 • 731 citations

Acetylation of p53 Activates Transcription through Recruitment of Coactivators/Histone Acetyltransferases

2001 • 704 citations

Binding and modulation of p53 by p300/CBP coactivators

1997 • 698 citations

Recruitment of p300/CBP in p53-Dependent Signal Pathways

1997 • 671 citations

Mapping of the p53 and mdm-2 interaction domains.

1993 • 658 citations

Synergistic activation of transcription by CBP and p53

1997 • 599 citations

p300/CBP-mediated p53 acetylation is commonly induced by p53-activating agents and inhibited by MDM2

2001 • 554 citations

Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53

2001 • 505 citations

The p300/CBP family: integrating signals with transcription factors and chromatin

1997 • 482 citations

Transcriptional Regulation by p53 through Intrinsic DNA/Chromatin Binding and Site-Directed Cofactor Recruitment

2001 • 437 citations

Histone Deacetylases Specifically Down-regulate p53-dependent Gene Activation

2000 • 415 citations

p300/MDM2 Complexes Participate in MDM2-Mediated p53 Degradation

1998 • 415 citations

p300 and estrogen receptor cooperatively activate transcription via differential enhancement of initiation and reinitiation

1998 • 337 citations

Wild type p53 can mediate sequence-specific transactivation of an internal promoter within the mdm2 gene.

1993 • 332 citations

MDM2 Suppresses p73 Function without Promoting p73 Degradation

1999 • 329 citations

MDM2 interacts with MDMX through their RING finger domains

1999 • 319 citations

DNA Damage-Dependent Acetylation of p73 Dictates the Selective Activation of Apoptotic Target Genes

2002 • 319 citations

Mdm4 (Mdmx) Regulates p53-Induced Growth Arrest and Neuronal Cell Death during Early Embryonic Mouse Development

2002 • 305 citations

Human TAFII31 protein is a transcriptional coactivator of the p53 protein.

1995 • 297 citations

Stabilization of the MDM2 Oncoprotein by Interaction with the Structurally Related MDMX Protein

1999 • 282 citations

Mutual Dependence of MDM2 and MDMX in Their Functional Inactivation of p53

2002 • 260 citations

Analysis of E1A-mediated growth regulation functions: binding of the 300-kilodalton cellular product correlates with E1A enhancer repression function and DNA synthesis-inducing activity

1990 • 251 citations

Mdmx stabilizes p53 and Mdm2 via two distinct mechanisms

2001 • 230 citations

Multiple Lysine Mutations in the C-Terminal Domain of p53 Interfere with MDM2-Dependent Protein Degradation and Ubiquitination

2000 • 194 citations

MDM2 inhibits p300-mediated p53 acetylation and activation by forming a ternary complex with the two proteins

2000 • 188 citations

mdmx is a negative regulator of p53 activity in vivo.

2002 • 188 citations

Activation of p53 by oncogenes.

1999 • 106 citations

The N-Terminal Domain of p73 Interacts with the CH1 Domain of p300/CREB Binding Protein and Mediates Transcriptional Activation and Apoptosis

2000 • 98 citations

MDM2 Inhibits PCAF (p300/CREB-binding Protein-associated Factor)-mediated p53 Acetylation

2002 • 85 citations

Hdmx Recruitment into the Nucleus by Hdm2 Is Essential for Its Ability to Regulate p53 Stability and Transactivation

2002 • 81 citations

Regulation of p63 Function by Mdm2 and MdmX

2001 • 75 citations

p300 Does Not Require Its Acetylase Activity to Stimulate p73 Function

2001 • 42 citations

Dual Role of p300 in the Regulation of p53 Stability

2001 • 35 citations

Functional quantification of DNA-binding proteins p53 and estrogen receptor in cells and tumor tissues by DNA affinity immunoblotting.

2001 • 34 citations

UV but not gamma irradiation accelerates p53-induced apoptosis of teratocarcinoma cells by repressing MDM2 transcription.

2000 • 27 citations