ATM Mediates Phosphorylation at Multiple p53 Sites, Including Ser46, in Response to Ionizing Radiation

Efficient selection for high-expression transfectants with a novel eukaryotic vector

1991 • 5,120 citations

Activation of the ATM Kinase by Ionizing Radiation and Phosphorylation of p53

1998 • 2,034 citations

Cell cycle checkpoint signaling through the ATM and ATR kinases

2001 • 1,962 citations

Suppression of Human Colorectal Carcinoma Cell Growth by Wild-Type p53

1990 • 1,796 citations

Enhanced Phosphorylation of p53 by ATM in Response to DNA Damage

1998 • 1,734 citations

DNA Damage-Induced Activation of p53 by the Checkpoint Kinase Chk2

2000 • 1,269 citations

DNA damage activates p53 through a phosphorylation–acetylation cascade

1998 • 1,194 citations

p53AIP1, a Potential Mediator of p53-Dependent Apoptosis, and Its Regulation by Ser-46-Phosphorylated p53

2000 • 1,155 citations

p53- and ATM-Dependent Apoptosis Induced by Telomeres Lacking TRF2

1999 • 1,076 citations

Post‐translational modifications and activation of p53 by genotoxic stresses

2001 • 1,076 citations

A role for ATR in the DNA damage-induced phosphorylation of p53

1999 • 1,043 citations

DNA damage induces phosphorylation of the amino terminus of p53

1997 • 829 citations

Chk2/hCds1 functions as a DNA damage checkpoint in G₁by stabilizing p53

2000 • 781 citations

Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation

1999 • 690 citations

Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis

2001 • 670 citations

Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2

2001 • 582 citations

Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage

1999 • 570 citations

Inhibition of phosphoinositide 3-kinase related kinases by the radiosensitizing agent wortmannin.

1998 • 526 citations

Serine15 phosphorylation stimulates p53 transactivation but does not directly influence interaction with HDM2

1999 • 446 citations

Regulation of p53 Function and Stability by Phosphorylation

1999 • 443 citations

Phosphorylation of p53 Serine 15 Increases Interaction with CBP

1998 • 427 citations

The evolution of diverse biological responses to DNA damage: insights from yeast and p53

2001 • 372 citations

p53DINP1, a p53-Inducible Gene, Regulates p53-Dependent Apoptosis

2001 • 339 citations

DNA damage-inducible phosphorylation of p53 at N-terminal sites including a novel site, Ser20, requires tetramerization

1999 • 296 citations

Jun NH₂-Terminal Kinase Phosphorylation of p53 on Thr-81 Is Important for p53 Stabilization and Transcriptional Activities in Response to Stress

2001 • 290 citations

Damage-mediated Phosphorylation of Human p53 Threonine 18 through a Cascade Mediated by a Casein 1-like Kinase

2000 • 285 citations

Differential Activation of Target Cellular Promoters by p53 Mutants with Impaired Apoptotic Function

1996 • 271 citations

p53 transcriptional activity is essential for p53-dependent apoptosis following DNA damage

2000 • 252 citations

p53 dysfunction in B-cell chronic lymphocytic leukemia: inactivation of ATM as an alternative toTP53 mutation

2001 • 247 citations

Regulation of stress-induced cytokine production by pyridinylimidazoles; inhibition of CSBP kinase

1997 • 220 citations

Phosphorylation of murine p53 at Ser-18 regulates the p53 responses to DNA damage

2000 • 164 citations

Human p53 Is Phosphorylated on Serines 6 and 9 in Response to DNA Damage-inducing Agents

2000 • 125 citations

DNA damage-induced phosphorylation of p53 at serine 20 correlates with p21 and Mdm-2 induction in vivo

2000 • 54 citations

Requirement for HDM2 Activity in the Rapid Degradation of p53 in Neuroblastoma

2001 • 24 citations