The mdm-2 gene is induced in response to UV light in a p53-dependent manner.

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

1992 • 3,110 citations

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

1992 • 3,092 citations

Wild-type p53 is a cell cycle checkpoint determinant following irradiation.

1992 • 1,877 citations

The p53-mdm-2 autoregulatory feedback loop.

1993 • 1,795 citations

mdm2 expression is induced by wild type p53 activity.

1993 • 1,286 citations

Activating mutations in p53 produce a common conformational effect. A monoclonal antibody specific for the mutant form.

1990 • 978 citations

UV irradiation stimulates levels of p53 cellular tumor antigen in nontransformed mouse cells.

1984 • 874 citations

Presence of a Potent Transcription Activating Sequence in the p53 Protein

1990 • 811 citations

Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53

1990 • 801 citations

Induction of nuclear accumulation of the tumor-suppressor protein p53 by DNA-damaging agents.

1993 • 770 citations

High levels of p53 protein in UV-irradiated normal human skin.

1993 • 689 citations

Rapid and preferential activation of the c-jun gene during the mammalian UV response.

1991 • 685 citations

Transcriptional Activation by Wild-Type but Not Transforming Mutants of the p53 Anti-Oncogene

1990 • 644 citations

DNA damage-inducible transcripts in mammalian cells.

1988 • 613 citations

Cellular localization and cell cycle regulation by a temperature-sensitive p53 protein.

1991 • 544 citations

p53 alteration is a common event in the spontaneous immortalization of primary BALB/c murine embryo fibroblasts.

1991 • 455 citations

Induction of cellular p53 activity by DNA-damaging agents and growth arrest.

1993 • 440 citations

Wild-type p53 mediates positive regulation of gene expression through a specific DNA sequence element.

1992 • 328 citations

UV Irradiation Stimulates Levels of p53 Cellular Tumor Antigen in Nontransformed Mouse Cells

1984 • 225 citations

Identification and characterization of multiple mdm-2 proteins and mdm-2-p53 protein complexes.

1993 • 193 citations

Response to adversity: molecular control of gene activation following genotoxic stress.

1991 • 189 citations

Rapid and Preferential Activation of the c-jun Gene during the Mammalian UV Response

1991 • 120 citations

Guanine nucleotide biosynthesis is regulated by the cellular p53 concentration.

1991 • 99 citations