Development of a Binding Assay for p53/HDM2 by Using Homogeneous Time-Resolved Fluorescence

Zwischenmolekulare Energiewanderung und Fluoreszenz

1948 • 7,839 citations

Mdm2 promotes the rapid degradation of p53

1997 • 4,336 citations

Regulation of p53 stability by Mdm2

1997 • 3,238 citations

Activation of p53 Sequence-Specific DNA Binding by Acetylation of the p53 C-Terminal Domain

1997 • 2,510 citations

DNA Damage-Induced Phosphorylation of p53 Alleviates Inhibition by MDM2

1997 • 2,089 citations

Activation of the ATM Kinase by Ionizing Radiation and Phosphorylation of p53

1998 • 2,034 citations

Enhanced Phosphorylation of p53 by ATM in Response to DNA Damage

1998 • 1,734 citations

DNA damage activates p53 through a phosphorylation–acetylation cascade

1998 • 1,194 citations

A role for ATR in the DNA damage-induced phosphorylation of p53

1999 • 1,043 citations

p73 is a human p53-related protein that can induce apoptosis

1997 • 951 citations

p53 Sites Acetylated In Vitro by PCAF and p300 Are Acetylated In Vivo in Response to DNA Damage

1999 • 764 citations

Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein.

1994 • 644 citations

In vivo ubiquitination and proteasome-mediated degradation of p53(1).

1996 • 643 citations

Signaling to p53

1998 • 636 citations

Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein

1998 • 610 citations

Use of Peptide Libraries to Map the Substrate Specificity of a Peptide-Modifying Enzyme: A 13 Residue Consensus Peptide Specifies Biotinylation in Escherichia coli

1993 • 586 citations

Functions of the MDM2 oncoprotein

1999 • 556 citations

Regulation of p53 Function and Stability by Phosphorylation

1999 • 443 citations

Design of a synthetic Mdm2-binding mini protein that activates the p53 response in vivo

1997 • 370 citations

MDM2 Suppresses p73 Function without Promoting p73 Degradation

1999 • 329 citations

Probing molecular interactions with homogeneous techniques based on rare earth cryptates and fluorescence energy transfer

1995 • 325 citations

Repression of p53-mediated transcription by MDM2: a dual mechanism

1997 • 272 citations

Molecular characterization of the hdm2-p53 interaction 1 1Edited by J. Karn

1997 • 249 citations

Viral Oncoproteins Discriminate between p53 and the p53 Homolog p73

1998 • 194 citations

Identification of novel mdm2 binding peptides by phage display.

1996 • 181 citations

The Emerging p53 Gene Family

1999 • 142 citations

Covalent and noncovalent modifiers of the p53 protein

1999 • 133 citations

Homogeneous Proximity Tyrosine Kinase Assays: Scintillation Proximity Assay versus Homogeneous Time-Resolved Fluorescence

1999 • 125 citations

p53 mediated death of cells overexpressing MDM2 by an inhibitor of MDM2 interaction with p53

1999 • 115 citations

Tyrosine kinase assays adapted to homogeneous time-resolved fluorescence

1998 • 79 citations

Use of a Novel Homogeneous Fluorescent Technology in High Throughput Screening

1996 • 57 citations

Use of a Phosphotyrosine-Antibody Pair as a General Detection Method in Homogeneous Time-Resolved Fluorescence: Application to Human Immunodeficiency Viral Protease

1999 • 29 citations

Development of a CD28/CD86 (B7-2) Binding Assay for High Throughput Screening by Homogeneous Time-Resolved Fluorescence

1998 • 28 citations