Human mdm2 Mediates Multiple Mono-ubiquitination of p53 by a Mechanism Requiring Enzyme Isomerization

THE UBIQUITIN SYSTEM

1998 • 8,360 citations

Mdm2 promotes the rapid degradation of p53

1997 • 4,336 citations

Regulation of p53 stability by Mdm2

1997 • 3,238 citations

Requirement for p53 and p21 to Sustain G ₂ Arrest After DNA Damage

1998 • 2,784 citations

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

1997 • 1,906 citations

Recognition of the polyubiquitin proteolytic signal

2000 • 1,651 citations

RING Finger Proteins

2000 • 1,216 citations

Protein regulation by monoubiquitin

2001 • 1,195 citations

RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination

1999 • 1,134 citations

The Tyrosine Kinase Negative Regulator c-Cbl as a RING-Type, E2-Dependent Ubiquitin-Protein Ligase

1999 • 1,045 citations

A Novel Ubiquitination Factor, E4, Is Involved in Multiubiquitin Chain Assembly

1999 • 1,031 citations

Mdm2 Is a RING Finger-dependent Ubiquitin Protein Ligase for Itself and p53

2000 • 1,026 citations

Regulation of p53 in response to DNA damage

1999 • 960 citations

Structure of a c-Cbl–UbcH7 Complex

2000 • 824 citations

A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking

1999 • 727 citations

Rad6-Dependent Ubiquitination of Histone H2B in Yeast

2000 • 662 citations

Signaling to p53

1998 • 636 citations

Does this have a familiar RING?

1996 • 632 citations

Regulation of the p53 Tumor Suppressor Protein

1999 • 566 citations

Signal-induced degradation of I kappa B alpha requires site-specific ubiquitination.

1995 • 558 citations

Functions of the MDM2 oncoprotein

1999 • 556 citations

Nuclear Export Is Required for Degradation of Endogenous p53 by MDM2 and Human Papillomavirus E6

1998 • 513 citations

Ubiquitin in chains

2000 • 445 citations

Ubiquitin-activating enzyme. Mechanism and role in protein-ubiquitin conjugation.

1982 • 413 citations

Regulation of p53 stability

1999 • 413 citations

Cdc53/cullin and the essential Hrt1 RING-H2 subunit of SCF define a ubiquitin ligase module that activates the E2 enzyme Cdc34

1999 • 406 citations

Multiple C-Terminal Lysine Residues Target p53 for Ubiquitin-Proteasome-Mediated Degradation

2000 • 383 citations

Activity of MDM2, a ubiquitin ligase, toward p53 or itself is dependent on the RING finger domain of the ligase

2000 • 378 citations

The MDM2 RING-finger domain is required to promote p53 nuclear export

2000 • 352 citations

An intact HDM2 RING-finger domain is required for nuclear exclusion of p53

2000 • 330 citations

Regulation of Transcription by Ubiquitination without Proteolysis

2000 • 292 citations

SUMO-1 Modification of Mdm2 Prevents Its Self-Ubiquitination and Increases Mdm2 Ability to Ubiquitinate p53

2000 • 271 citations

Occurrence of a polyubiquitin structure in ubiquitin-protein conjugates

1985 • 263 citations

Ubiquitin-Activating/Conjugating Activity of TAF _II 250, a Mediator of Activation of Gene Expression in Drosophila

2000 • 238 citations

Inhibition of the 26 S Proteasome by Polyubiquitin Chains Synthesized to Have Defined Lengths

1997 • 229 citations

Multiple Lysine Mutations in the C-Terminal Domain of p53 Interfere with MDM2-Dependent Protein Degradation and Ubiquitination

2000 • 194 citations

Regulation of Mdm2-Directed Degradation by the C Terminus of p53

1998 • 194 citations

Physical Interaction between Specific E2 and Hect E3 Enzymes Determines Functional Cooperativity

1997 • 150 citations

Human Papillomavirus Type 16 E6 Induces Self-Ubiquitination of the E6AP Ubiquitin-Protein Ligase

2000 • 124 citations

Reconstitution of p53-ubiquitinylation reactions from purified components: the role of human ubiquitin-conjugating enzyme UBC4 and E6-associated protein (E6AP).

1995 • 117 citations

The SCF^HOS/β-TRCP-ROC1 E3 Ubiquitin Ligase Utilizes Two Distinct Domains within CUL1 for Substrate Targeting and Ubiquitin Ligation

2000 • 108 citations

Functional receptors for vasoactive intestinal peptide in cultured vascular smooth muscle cells from rat aorta

1985 • 61 citations

SCFβ-TRCP and phosphorylation dependent ubiquitination of IκBα catalyzed by Ubc3 and Ubc4

2000 • 40 citations

Ubiquitin pathway: Another link in the polyubiquitin chain?

1999 • 34 citations

Steady-State Kinetic Analysis of Human Ubiquitin-Activating Enzyme (E1) Using a Fluorescently Labeled Ubiquitin Substrate

2000 • 23 citations