Calcium signaling and cytotoxicity.

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

1972 • 15,349 citations

Calcium's Role in Mechanotransduction during Muscle Development

2014 • 14,293 citations

Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade

1997 • 7,177 citations

Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c

1996 • 5,133 citations

Apoptosis by Death Factor

1997 • 5,038 citations

Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked

1997 • 4,921 citations

The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis

1997 • 4,728 citations

Caspases: the executioners of apoptosis

1997 • 4,674 citations

Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation

1980 • 4,591 citations

Cleavage of BID by Caspase 8 Mediates the Mitochondrial Damage in the Fas Pathway of Apoptosis

1998 • 4,383 citations

Bid, a Bcl2 Interacting Protein, Mediates Cytochrome c Release from Mitochondria in Response to Activation of Cell Surface Death Receptors

1998 • 3,603 citations

Apoptosis, oncosis, and necrosis. An overview of cell death.

1995 • 3,325 citations

Programmed Cell Death in Animal Development

1997 • 2,690 citations

A model for receptor-regulated calcium entry

1986 • 2,535 citations

Caspases: killer proteases

1997 • 2,440 citations

The mitochondrial permeability transition

1995 • 2,412 citations

INTRACELLULAR CALCIUM HOMEOSTASIS

1987 • 2,183 citations

Close Contacts with the Endoplasmic Reticulum as Determinants of Mitochondrial Ca ²⁺ Responses

1998 • 2,130 citations

THE MITOCHONDRIAL DEATH/LIFE REGULATOR IN APOPTOSIS AND NECROSIS

1998 • 1,982 citations

Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures.

1995 • 1,968 citations

Lethal effect of the anti-Fas antibody in mice

1993 • 1,915 citations

Intracellular Adenosine Triphosphate (ATP) Concentration: A Switch in the Decision Between Apoptosis and Necrosis

1997 • 1,851 citations

Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species

1993 • 1,692 citations

Chromatin cleavage in apoptosis: Association with condensed chromatin morphology and dependence on macromolecular synthesis

1984 • 1,586 citations

Bax directly induces release of cytochrome c from isolated mitochondria

1998 • 1,514 citations

Glucocorticoid activation of a calcium-dependent endonuclease in thymocyte nuclei leads to cell death.

1984 • 1,441 citations

Store depletion and calcium influx

1997 • 1,422 citations

Apoptosis: Mechanisms and Roles in Pathology

1991 • 1,368 citations

Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization

1998 • 1,226 citations

Calcium Channels, Stores, and Oscillations

1990 • 1,208 citations

Apoptotic death in epithelial cells: cleavage of DNA to 300 and/or 50 kb fragments prior to or in the absence of internucleosomal fragmentation.

1993 • 1,144 citations

Molecular and cellular physiology of intracellular calcium stores

1994 • 1,132 citations

bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship

1991 • 1,090 citations

Elementary and global aspects of calcium signalling.

1997 • 1,031 citations

Superoxide in Apoptosis

1998 • 773 citations

The Permeability Transition Pore Complex: A Target for Apoptosis Regulation by Caspases and Bcl-2–related Proteins

1998 • 700 citations

Evidence that BCL-2 represses apoptosis by regulating endoplasmic reticulum-associated Ca2+ fluxes.

1994 • 605 citations

The Overexpression of Bax Produces Cell Death upon Induction of the Mitochondrial Permeability Transition

1998 • 588 citations

Nitric oxide synthase activity in mitochondria

1997 • 576 citations

Caspases and caspase inhibitors

1997 • 573 citations

How proteins enter the nucleus

1991 • 555 citations

Bleb Formation in Hepatocytes During Drug Metabolism Is Caused by Disturbances in Thiol and Calcium Ion Homeostasis

1982 • 553 citations

Glucocorticoids activate a suicide process in thymocytes through an elevation of cytosolic Ca2+ concentration

1989 • 549 citations

Calcium‐activated DNA fragmentation kills immature thymocytes

1989 • 533 citations

The Inositol Phosphate-Calcium Signaling System in Nonexcitable Cells

1993 • 505 citations

Intracellular calcium; its universal role as regulator

1984 • 500 citations

Apoptosis induced by withdrawal of interleukin-3 (IL-3) from an IL-3-dependent hematopoietic cell line is associated with repartitioning of intracellular calcium and is blocked by enforced Bcl-2 oncoprotein production.

1993 • 488 citations

The permeability transition pore as a mitochondrial calcium release channel: A critical appraisal

1996 • 466 citations

Picomolar concentrations of lead stimulate brain protein kinase C

1988 • 442 citations

ICE Family Proteases: Mediators of All Apoptotic Cell Death?

1996 • 440 citations

Non-erythroid α-spectrin breakdown by calpain and interleukin 1 β-converting-enzyme-like protease(s) in apoptotic cells: contributory roles of both protease families in neuronal apoptosis

1996 • 427 citations

Bcl-2 potentiates the maximal calcium uptake capacity of neural cell mitochondria.

1996 • 411 citations

Protease Involvement in Fodrin Cleavage and Phosphatidylserine Exposure in Apoptosis

1996 • 409 citations

The Pathways of Cell Death: Oncosis, Apoptosis, and Necrosis

1997 • 409 citations

DAP-kinase is a Ca2+/calmodulin-dependent, cytoskeletal-associated protein kinase, with cell death-inducing functions that depend on its catalytic activity

1997 • 408 citations

Role of Ca2+ channels in the ability of membrane depolarization to prevent neuronal death induced by trophic-factor deprivation: evidence that levels of internal Ca2+ determine nerve growth factor dependence of sympathetic ganglion cells.

1989 • 405 citations

Different prooxidant levels stimulate growth, trigger apoptosis, or produce necrosis of insulin-secreting RINm5F cells. The role of intracellular polyamines.

1994 • 372 citations

Endoplasmic Reticulum Chaperones GRP78 and Calreticulin Prevent Oxidative Stress, Ca2+ Disturbances, and Cell Death in Renal Epithelial Cells

1997 • 370 citations

Suppression of signalling through transcription factor NF-AT by interactions between calcineurin and Bcl-2

1997 • 368 citations

APOPTOSIS AND DISEASE: Regulation and Clinical Relevance of Programmed Cell Death

1997 • 361 citations

Calcium content of mitochondria and endoplasmic reticulum in liver frozen rapidly in vivo

1985 • 356 citations

Rapid and Specific Efflux of Reduced Glutathione during Apoptosis Induced by Anti-Fas/APO-1 Antibody

1996 • 354 citations

Mitochondrial Ca2+ homeostasis in intact cells.

1994 • 320 citations

Monitoring dynamic changes in free Ca2+ concentration in the endoplasmic reticulum of intact cells.

1995 • 308 citations

Oxidative stress in mitochondria: Its relationship to cellular Ca2+ homeostasis, cell death, proliferation, and differentiation

1991 • 307 citations

Apoptosis and necrosis: Intracellular ATP level as a determinant for cell death modes

1997 • 296 citations

Maintenance of Calcium Homeostasis in the Endoplasmic Reticulum by Bcl-2

1997 • 296 citations

Disruption of the outer mitochondrial membrane as a result of large amplitude swelling: the impact of irreversible permeability transition

1998 • 294 citations

ATP stimulates Ca2+ uptake and increases the free Ca2+ concentration in isolated rat liver nuclei.

1989 • 284 citations

PROTEOLYTIC ACTIVITIES THAT MEDIATE APOPTOSIS

1998 • 282 citations

Inhibition of tumor progression by suppression of stress protein GRP78/BiP induction in fibrosarcoma B/C10ME.

1996 • 280 citations

BiP, a Major Chaperone Protein of the Endoplasmic Reticulum Lumen, Plays a Direct and Important Role in the Storage of the Rapidly Exchanging Pool of Ca2+

1997 • 277 citations

Evidence for a graft-versus-tumor effect in a patient treated with marrow ablative chemotherapy and allogeneic bone marrow transplantation for breast cancer

1996 • 277 citations

Imaging the Permeability Pore Transition in Single Mitochondria

1998 • 269 citations

Lymphocyte Apoptosis: Mediation by Increased Type 3 Inositol 1,4,5-Trisphosphate Receptor

1996 • 268 citations

2,5-Di-(tert-butyl)-1,4-benzohydroquinone rapidly elevates cytosolic Ca2+ concentration by mobilizing the inositol 1,4,5-trisphosphate-sensitive Ca2+ pool

1989 • 261 citations

Calcineurin functions in Ca(2+)-activated cell death in mammalian cells.

1995 • 260 citations

Retardation of chemical hypoxia-induced necrotic cell death by Bcl-2 and ICE inhibitors: possible involvement of common mediators in apoptotic and necrotic signal transductions.

1996 • 260 citations

T Cells Deficient in Inositol 1,4,5-Trisphosphate Receptor Are Resistant to Apoptosis

1997 • 259 citations

Intracellular Ca2+ Signals Activate Apoptosis in Thymocytes: Studies Using the Ca2+-ATPase Inhibitor Thapsigargin

1994 • 253 citations

The calcium ion and cell death.

1994 • 248 citations

Subcellular imaging of intramitochondrial Ca2+ with recombinant targeted aequorin: significance for the regulation of pyruvate dehydrogenase activity.

1996 • 247 citations

Calcium ions and oxidative cell injury

1992 • 246 citations

Intracellular calcium-release channels: regulators of cell life and death

1997 • 236 citations

Regulation of apoptosis in interleukin-3-dependent hemopoietic cells by interleukin-3 and calcium ionophores.

1990 • 226 citations

Loss of Function of Cytochrome c in Jurkat Cells Undergoing Fas-mediated Apoptosis

1996 • 225 citations

Genetic and metabolic status of NGF-deprived sympathetic neurons saved by an inhibitor of ICE family proteases.

1996 • 223 citations

Expression of bcl‐2 inhibits necrotic neural cell death

1995 • 216 citations

Calbindin D28k blocks the proapoptotic actions of mutant presenilin 1: Reduced oxidative stress and preserved mitochondrial function

1998 • 216 citations

The mitochondrial permeability transition in toxic, hypoxic and reperfusion injury.

1997 • 214 citations

Apoptosis and necrosis in toxicology: A continuum or distinct modes of cell death?

1997 • 213 citations

Cadmium evokes inositol polyphosphate formation and calcium mobilization

1989 • 212 citations

Calcium signaling in the cell nucleus

1997 • 208 citations

Release of Cytochrome c from Liver Mitochondria during Permeability Transition

1997 • 197 citations

Endoplasmic Reticulum Stress Proteins Block Oxidant-induced Ca2+ Increases and Cell Death

1998 • 193 citations

Mitochondrial Modifications during Rat Thymocyte Apoptosis: A Study at the Single Cell Level

1994 • 192 citations

Calpain, an upstream regulator of thymocyte apoptosis.

1997 • 191 citations

Non-oxidative Loss of Glutathione in Apoptosis via GSH Extrusion

1995 • 190 citations

The formation of plasma membrane blebs in hepatocytes exposed to agents that increase cytosolic Ca²⁺ is mediated by the activation of a non‐lysosomal proteolytic system

1986 • 188 citations

Tributyltin stimulates apoptosis in rat thymocytes

1990 • 187 citations

Role of Calpain‐ and Interleukin‐1β Converting Enzyme‐Like Proteases in the β‐Amyloid‐Induced Death of Rat Hippocampal Neurons in Culture

1997 • 184 citations

Nuclear calcium transport and the role of calcium in apoptosis

1994 • 178 citations

Surface expression of TRAIL/Apo-2 ligand in activated mouse T and B cells

1998 • 167 citations

Roles of cytoplasmic Ca2+ and intracellular Ca2+ stores in induction and suppression of apoptosis in S49 cells

1997 • 167 citations

Apoptosis suppression by bcl-2 is correlated with the regulation of nuclear and cytosolic Ca2+.

1996 • 164 citations

An ICE‐like protease is a common mediator of apoptosis induced by diverse stimuli in human monocytic THP.1 cells

1995 • 158 citations

Inhibition of protein synthesis and early protein processing by thapsigargin in cultured cells

1993 • 157 citations

Chromatin condensation during apoptosis requires ATP

1996 • 157 citations

Receptor-operated calcium influx in rat hepatocytes. Identification and characterization using manganese.

1990 • 147 citations

Lymphocyte granule-mediated apoptosis: matters of viral mimicry and deadly proteases

1998 • 144 citations

Transient elevations of cytosolic free calcium retard subsequent apoptosis in neutrophils in vitro.

1993 • 141 citations

Decoding calcium signals by multifunctional CaM kinase

1992 • 131 citations

The role of altered [Ca2+]i regulation in apoptosis, oncosis, and necrosis

1996 • 126 citations

Stable expression of the calbindin-D28K complementary DNA interferes with the apoptotic pathway in lymphocytes.

1992 • 125 citations

Importance of the redox state of cytochrome c during caspase activation in cytosolic extracts

1998 • 120 citations

Induction of a Caspase-3-like Activity by Calcium in Normal Cytosolic Extracts Triggers Nuclear Apoptosis in a Cell-free System

1998 • 113 citations

Activation of caspases triggered by cytochrome c in vitro¹

1998 • 113 citations

Tributyltin increases cytosolic free Ca2+ concentration in thymocytes by mobilizing intracellular Ca2+, activating a Ca2+ entry pathway, and inhibiting Ca2+ efflux

1992 • 110 citations

Role of EGR-1 in Thapsigargin-Inducible Apoptosis in the Melanoma Cell Line A375-C6

1995 • 107 citations

Cellular Events in Fas/APO-1-Mediated Apoptosis in JURKAT T Lymphocytes

1995 • 105 citations

Mouse Lymphoma Cells Destined to Undergo Apoptosis in Response to Thapsigargin Treatment Fail to Generate a Calcium-mediated grp78/grp94 Stress Response

1997 • 103 citations

Effect of glucocorticosteroid treatment on intracellular calcium homeostasis in mouse lymphoma cells.

1993 • 103 citations

Intracellular Calcium Homeostasis

1987 • 100 citations

Transduction of Calcium Stress through Interaction of the Human Transcription Factor CBF with the Proximal CCAAT Regulatory Element of the grp78/BiP Promoter

1995 • 97 citations

A stress‐inducible rat liver endoplasmic reticulum protein, ERp29

1998 • 95 citations

Cyclosporin a protects hepatocytes against prooxidant-induced cell killing

1992 • 94 citations

Fas-mediated apoptosis in mouse hepatocytes involves the processing and activation of caspases

1998 • 93 citations

Evidence for two pathways of receptor-mediated Ca2+ entry in hepatocytes

1992 • 89 citations

Organotin compounds induce calcium overload and apoptosis in PC12 cells.

1995 • 89 citations

Comparison between the effects of the microsomal Ca2+-translocase inhibitors thapsigargin and 2,5-di-(t-butyl)-1,4-benzohydroquinone on cellular calcium fluxes

1991 • 89 citations

The mechanism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity: Role of intracellular calcium

1988 • 87 citations

The effect of β-alanine on motor behaviour, body temperature and cerebral monoamine metabolism in rat

1978 • 85 citations

Induction ofHSP70 gene expression by modulation of Ca+2 ion and cellular p53 protein by curcumin in colorectal carcinoma cells

1996 • 85 citations

Thapsigargin-induced persistent intracellular calcium pool depletion and apoptosis in human hepatoma cells

1994 • 85 citations

Calmodulin‐dependent protein kinase II mediates signal transduction in apoptosis

1997 • 84 citations

The plasma membrane calcium pump: Recent developments and future perspectives

1996 • 83 citations

Activation of CPP32-like Proteases Is Not Sufficient to Trigger Apoptosis: Inhibition of Apoptosis by Agents that Suppress Activation of AP24, but Not CPP32-like Activity

1997 • 82 citations

Fas (CD95/Apo-1)–Mediated Damage to Ventricular Myocytes Induced by Cytotoxic T Lymphocytes From Perforin-Deficient Mice

1998 • 79 citations

Nuclear targeting of aequorin

1994 • 79 citations

Temporal relationships between de novo protein synthesis, calpain and caspase 3-like protease activation, and DNA fragmentation during apoptosis in septo-hippocampal cultures

1998 • 78 citations

Induction of the Mammalian GRP78/BiP Gene by Ca²⁺ Depletion and Formation of Aberrant Proteins: Activation of the Conserved Stress-Inducible grp Core Promoter Element by the Human Nuclear Factor YY1

1997 • 78 citations

Decreasing calreticulin expression lowers the Ca2+ response to bradykinin and increases sensitivity to ionomycin in NG-108-15 cells.

1994 • 77 citations

Cyclosporin A Rescues Thymocytes from Apoptosis Induced by Very Low Concentrations of Thapsigargin: Effects on Mitochondrial Function

1996 • 72 citations

Chemical hypoxia triggers apoptosis of cultured neonatal rat cardiac myocytes: modulation by calcium-regulated proteases and protein kinases.

1998 • 72 citations

Calcium-sensitive Transcriptional Activation of the Proximal CCAAT Regulatory Element of the grp78/BiP Promoter by the Human Nuclear Factor CBF/NF-Y

1996 • 72 citations

Calmodulin Is Involved in Membrane Depolarization-Mediated Survival of Motoneurons by Phosphatidylinositol-3 Kinase- and MAPK-Independent Pathways

1998 • 67 citations

Calcium-dependent, Interleukin 1β-converting Enzyme Inhibitor-insensitive Degradation of Lamin B1 and DNA Fragmentation in Isolated Thymocyte Nuclei

1996 • 65 citations

Calcium Channels, Stores, And Oscillations

1990 • 65 citations

Identification of a common signal associated with cellular proliferation stimulated by four haemopoietic growth factors in a highly enriched population of granulocyte/macrophage colony-forming cells.

1989 • 64 citations

Ca2+-Mobilizing Hormones Stimulate Ca2+ Efflux from Hepatocytes

1989 • 63 citations

Modifications of Ca ²⁺ signaling by inorganic mercury in PC 12 cells

1993 • 62 citations

Protection From Apoptosis by Steel Factor But Not Interleukin-3 Is Reversed Through Blockade of Calcium Influx

1998 • 58 citations

Suppression of programmed neuronal death by a thapsigargin‐induced Ca²⁺ influx

1995 • 58 citations

Requirement of Tyrosine- and Serine/Threonine Kinases in the Transcriptional Activation of the Mammalian grp78/BiP Promoter by Thapsigargin

1995 • 57 citations

Stable expression of the calbindin-D28K complementary DNA interferes with the apoptotic pathway in lymphocytes

1992 • 54 citations

Different mechanisms for suppression of apoptosis by cytokines and calcium mobilizing compounds

1998 • 52 citations

Effects of alterations in calcium homeostasis on apoptosis during neoplastic progression.

1997 • 51 citations

Transmembrane signals and protooncogene induction evoked by carcinogenic metals and prevented by zinc.

1994 • 48 citations

Propagation of cytosolic calcium waves into the nuclei of hepatocytes

1994 • 46 citations

Complexes between hexokinase, mitochondrial porin and adenylate translocator in brain: regulation of hexokinase, oxidative phosphorylation and permeability transition pore

1997 • 46 citations

Elevated Intracellular Calcium Blocks Programmed Neuronal Death

1994 • 45 citations

Baculovirus p35 and Z-VAD-fmk inhibit thapsigargin-induced apoptosis of breast cancer cells

1997 • 43 citations

Inhibition of phosphatidylserine synthesis by glutamate, acetylcholine, thapsigargin and ionophore A23187 in glioma C6 cells

1992 • 40 citations

Further characterization of the events involved in mitochondrial Ca2+ release and pore formation by prooxidants

1994 • 39 citations

Novel Aspects of the Electrophysiology of Mitochondrial Porin

1998 • 39 citations

Effect of glucocorticosteroid treatment on intracellular calcium homeostasis in mouse lymphoma cells

1993 • 38 citations

Agonist-induced inhibition of phosphatidylserine synthesis is secondary to the emptying of intracellular Ca2+ stores in Jurkat T-cells

1992 • 36 citations

The inositol phosphate-calcium signaling system in nonexcitable cells

1993 • 35 citations

The mitochondrial permeability transition in toxic, hypoxic and reperfusion injury

1997 • 32 citations

Apoptotic cell death and CPP32-like activation induced by thapsigargin and their prevention by nerve growth factor in PC12 cells

1998 • 30 citations

Increased calreticulin stability in differentiated NG-108-15 cells correlates with resistance to apoptosis induced by antisense treatment

1998 • 26 citations

Two separate plasma membrane Ca2+ carriers participate in receptor-mediated Ca2+ influx in rat hepatocytes

1994 • 24 citations

Induction of Bip mRNA upon Programmed Cell Death of Differentiated PC12 Cells as Well as Rat Sympathetic Neurons

1997 • 23 citations

Lead intoxication alters basal and parathyroid hormone-regulated cellular calcium homeostasis in rat osteosarcoma (ROS 17/2.8) cells

1992 • 19 citations

Suppression of Apoptotic Cell Death of IL-3-Dependent Cell Lines by ER/SR Ca2+-ATPase Inhibitors upon IL-3 Deprivation

1996 • 17 citations

Adenosine Stimulates Calcium Influx in Isolated Rat Hepatocytes

1996 • 16 citations

Adenosine Inhibits Protein Synthesis in Isolated Rat Hepatocytes

1995 • 16 citations

m‐Iodobenzylguanidine increases the mitochondrial Ca²⁺ pool in isolated hepatocytes

1992 • 15 citations

Molecular Biological Studies of the Cardiac Sodium‐Calcium Exchanger^a

1996 • 15 citations

Temporal relationships between de novo protein synthesis, calpain and caspase 3‐like protease activation, and DNA fragmentation during apoptosis in septo‐hippocampal cultures

1998 • 8 citations

Extracellular calcium is not required for gliotoxin or dexamethasone-induced DNA fragmentation: A reappraisal of the use of EGTA

1995 • 8 citations

Eicosanoids released following inhibition of the endoplasmic reticulum Ca2+ pump stimulate Ca2+ efflux in the perfused rat liver

1993 • 7 citations

Transmembrane Signals and Protooncogene Induction Evoked by Carcinogenic Metals and Prevented by Zinc

1994 • 7 citations

Protection From Apoptosis by Steel Factor But Not Interleukin-3 Is Reversed Through Blockade of Calcium Influx

1998 • 5 citations

Calcium-Modulated Cellular Effects of Oxidants

1992 • 3 citations

Adenosine Inhibits Protein Synthesis in Isolated Rat Hepatocytes. Evidence for a Lack of Involvement of Intracellular Calcium in the Mechanism of Inhibition

1995 • 2 citations

Novel Aspects of the Electrophysiology of Mitochondrial Porin

1998 • 2 citations