Fas-mediated apoptosis in mouse hepatocytes involves the processing and activation of caspases

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

1972 • 15,349 citations

Apoptosis by Death Factor

1997 • 5,038 citations

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

1995 • 4,003 citations

FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex

1996 • 3,065 citations

Programmed Cell Death in Animal Development

1997 • 2,690 citations

Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE

1994 • 2,575 citations

The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme

1993 • 2,484 citations

Caspases: killer proteases

1997 • 2,440 citations

FADD, a novel death domain-containing protein, interacts with the death domain of fas and initiates apoptosis

1995 • 2,436 citations

Yama/CPP32β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase

1995 • 2,402 citations

Involvement of MACH, a Novel MORT1/FADD-Interacting Protease, in Fas/APO-1- and TNF Receptor–Induced Cell Death

1996 • 2,306 citations

Lethal effect of the anti-Fas antibody in mice

1993 • 1,915 citations

Specific proteolytic cleavage of poly(ADP-ribose) polymerase: an early marker of chemotherapy-induced apoptosis.

1993 • 1,888 citations

Monoclonal Antibody-Mediated Tumor Regression by Induction of Apoptosis

1989 • 1,739 citations

A cell-killing monoclonal antibody (anti-Fas) to a cell surface antigen co-downregulated with the receptor of tumor necrosis factor.

1989 • 1,436 citations

Mice deficient in IL-1β-converting enzyme are defective in production of mature IL-1β and resistant to endotoxic shock

1995 • 1,413 citations

[4] Isolation and use of liver cells

1978 • 1,230 citations

FLICE is activated by association with the CD95 death-inducing signaling complex (DISC)

1997 • 1,207 citations

A Novel Protein That Interacts with the Death Domain of Fas/APO1 Contains a Sequence Motif Related to the Death Domain

1995 • 1,007 citations

Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis

1996 • 980 citations

Daxx, a Novel Fas-Binding Protein That Activates JNK and Apoptosis

1997 • 797 citations

Mice lacking ADPRT and poly(ADP-ribosyl)ation develop normally but are susceptible to skin disease.

1995 • 767 citations

Involvement of an ICE-like protease in Fas-mediated apoptosis

1995 • 757 citations

Involvement of the CD95 (APO-1/Fas) receptor and ligand in liver damage.

1995 • 706 citations

A Selective Procedure for DNA Extraction from Apoptotic Cells Applicable for Gel Electrophoresis and Flow Cytometry

1994 • 670 citations

Requirement of an ICE/CED-3 protease for Fas/APO-1-mediated apoptosis

1995 • 616 citations

Potential Involvement of Fas and Its Ligand in the Pathogenesis of Hashimoto's Thyroiditis

1997 • 584 citations

The Role of Fas in Autoimmune Diabetes

1997 • 503 citations

Essential roles of the Fas ligand in the development of hepatitis

1997 • 483 citations

Benzyloxycarbonyl-Val-Ala-Asp (OMe) fluoromethylketone (Z-VAD.FMK) inhibits apoptosis by blocking the processing of CPP32

1996 • 481 citations

Protease Involvement in Fodrin Cleavage and Phosphatidylserine Exposure in Apoptosis

1996 • 409 citations

Bcl–2 protects from lethal hepatic apoptosis induced by an ant–Fas antibody in mice

1996 • 370 citations

APOPTOSIS AND DISEASE: Regulation and Clinical Relevance of Programmed Cell Death

1997 • 361 citations

The Caenorhabditis elegans cell-death protein CED-3 is a cysteine protease with substrate specificities similar to those of the human CPP32 protease.

1996 • 331 citations

Fas-induced Activation of the Cell Death-related Protease CPP32 Is Inhibited by Bcl-2 and by ICE Family Protease Inhibitors

1996 • 321 citations

Mammalian cell death proteases: A family of highly conserved aspartate specific cysteine proteases

1997 • 316 citations

Systemic injection of a tripeptide inhibits the intracellular activation of CPP32-like proteases in vivo and fully protects mice against Fas-mediated fulminant liver destruction and death.

1996 • 281 citations

Substrate and Inhibitor Specificity of Interleukin-1β-converting Enzyme and Related Caspases

1997 • 243 citations

The Role of APO‐1‐Mediated Apoptosis in the Immune System

1994 • 242 citations

Activation of Multiple Interleukin-1β Converting Enzyme Homologues in Cytosol and Nuclei of HL-60 Cells during Etoposide-induced Apoptosis

1997 • 211 citations

Characterization of seven murine caspase family members

1997 • 207 citations

Fas-Mediated Apoptosis in Primary Cultured Mouse Hepatocytes

1994 • 202 citations

Calpain, an upstream regulator of thymocyte apoptosis.

1997 • 191 citations

Cathepsin B contributes to bile salt-induced apoptosis of rat hepatocytes

1997 • 185 citations

Pivotal role of a DEVD-sensitive step in etoposide-induced and Fas-mediated apoptotic pathways.

1996 • 167 citations

Different Interleukin-1β Converting Enzyme (ICE) Family Protease Requirements for the Apoptotic Death of T Lymphocytes Triggered by Diverse Stimuli

1996 • 164 citations

Apoptosis in the Absence of Poly- (ADP-ribose) Polymerase

1997 • 141 citations

Involvement of multiple proteases during Fas‐mediated apoptosis in T lymphocytes

1995 • 136 citations

ICE-protease inhibitors block murine liver injury and apoptosis caused by CD95 or by TNF-α

1997 • 136 citations

Processing/Activation of At Least Four Interleukin-1β Converting Enzyme–like Proteases Occurs during the Execution Phase of Apoptosis in Human Monocytic Tumor Cells

1997 • 135 citations

Activation of intracellular proteases is an early event in TNF-induced apoptosis.

1995 • 129 citations

Role of proteolysis in apoptosis: involvement of serine proteases in internucleosomal DNA fragmentation in immature thymocytes

1993 • 109 citations

Cellular Events in Fas/APO-1-Mediated Apoptosis in JURKAT T Lymphocytes

1995 • 105 citations

ICE inhibitor YVADcmk is a potent therapeutic agent against in vivo liver apoptosis

1996 • 97 citations

Formation of 50 kbp chromatin fragments in isolated liver nuclei is mediated by protease and endonuclease activation

1994 • 96 citations

Nuclear serine protease activity contributes to bile acid-induced apoptosis in hepatocytes

1995 • 90 citations

Processing/activation of CPP32-like proteases is involved in transforming growth factor ?1-induced apoptosis in rat hepatocytes

1997 • 88 citations

Apoptosis in cultured rat hepatocytes: The effects of tumour necrosis factor α and interferon γ

1991 • 88 citations

The mechanism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity: Role of intracellular calcium

1988 • 87 citations

A cleavage-site-directed inhibitor of interleukin-1β-converting enzyme-like proteases inhibits apoptosis in primary cultures of rat hepatocytes

1996 • 76 citations

Apoptosis of rat thymocytes triggered by prednisolone, camptothecin, or teniposide is selective to G0 cells and is prevented by inhibitors of proteases.

1992 • 75 citations

Selective induction of apoptosis in Hep 3B cells by topoisomerase I inhibitors: evidence for a protease-dependent pathway that does not activate cysteine protease P32.

1996 • 73 citations

In vivo analysis of Fas antigen-mediated apoptosis: effects of agonistic anti-mouse Fas mAb on thymus, spleen and liver

1997 • 69 citations

Induction of apoptosis in cultured hepatocytes and in the regressing liver by transforming growth factor-β1 occurs without activation of an endonuclease

1992 • 64 citations

Interleukin-1 beta-converting enzyme-like protease cleaves DNA-dependent protein kinase in cytotoxic T cell killing.

1996 • 54 citations

A pre‐existing protease is a common effector of thymocyte apoptosis mediated by diverse stimuli

1995 • 53 citations

Multiple Pathways of Fas-Induced Apoptosis in Primary Culture of Hepatocytes

1996 • 45 citations

Attenuation of TGF-β-Induced Apoptosis in Primary Cultures of Hepatocytes by Calpain Inhibitors

1997 • 44 citations

IL-1 beta convertase (ICE) does not play a requisite role in apoptosis induced in T lymphoblasts by Fas-dependent or Fas-independent CTL effector mechanisms.

1997 • 42 citations

A protease-dependent TCR-induced death pathway in mature lymphocytes.

1995 • 41 citations

Multi‐step DNA cleavage in rat liver nuclei is inhibited by thiol reactive agents

1995 • 18 citations