PROTEOLYTIC ACTIVITIES THAT MEDIATE APOPTOSIS

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

1972 • 15,349 citations

Cell Death: The Significance of Apoptosis

1980 • 7,281 citations

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death

1993 • 6,009 citations

Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c

1996 • 5,133 citations

Apoptosis by Death Factor

1997 • 5,038 citations

Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked

1997 • 4,921 citations

The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis

1997 • 4,728 citations

Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation

1980 • 4,591 citations

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

1995 • 4,003 citations

Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

1990 • 3,817 citations

Bcl-2 functions in an antioxidant pathway to prevent apoptosis

1993 • 3,465 citations

Post-embryonic cell lineages of the nematode, Caenorhabditis elegans

1977 • 3,432 citations

Principles of CDK regulation

1995 • 3,267 citations

Inhibitors of mammalian G1 cyclin-dependent kinases.

1995 • 3,258 citations

Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells

1988 • 3,194 citations

Apaf-1, a Human Protein Homologous to C. elegans CED-4, Participates in Cytochrome c–Dependent Activation of Caspase-3

1997 • 3,130 citations

bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death

1993 • 3,111 citations

FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex

1996 • 3,065 citations

Cell Death During Development of the Nervous System

1991 • 3,033 citations

Induction of apoptosis in fibroblasts by c-myc protein

1992 • 2,977 citations

p53 is required for radiation-induced apoptosis in mouse thymocytes

1993 • 2,911 citations

Identification and characterization of a new member of the TNF family that induces apoptosis

1995 • 2,890 citations

G1 phase progression: Cycling on cue

1994 • 2,706 citations

Serine Phosphorylation of Death Agonist BAD in Response to Survival Factor Results in Binding to 14-3-3 Not BCL-XL

1996 • 2,627 citations

Inhibition of death receptor signals by cellular FLIP

1997 • 2,577 citations

Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE

1994 • 2,575 citations

The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme

1993 • 2,484 citations

FADD, a novel death domain-containing protein, interacts with the death domain of fas and initiates apoptosis

1995 • 2,436 citations

Bcl-2 and the regulation of programmed cell death

1994 • 2,346 citations

Involvement of MACH, a Novel MORT1/FADD-Interacting Protease, in Fas/APO-1- and TNF Receptor–Induced Cell Death

1996 • 2,306 citations

Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor.

1995 • 2,142 citations

Mechanisms and Functions of Cell Death

1991 • 2,061 citations

Fas Ligand-Induced Apoptosis as a Mechanism of Immune Privilege

1995 • 2,028 citations

The TNF receptor 1-associated protein TRADD signals cell death and NF-κB activation

1995 • 1,979 citations

TRADD–TRAF2 and TRADD–FADD Interactions Define Two Distinct TNF Receptor 1 Signal Transduction Pathways

1996 • 1,976 citations

Dissection of TNF Receptor 1 Effector Functions: JNK Activation Is Not Linked to Apoptosis While NF-κB Activation Prevents Cell Death

1996 • 1,962 citations

X-linked IAP is a direct inhibitor of cell-death proteases

1997 • 1,961 citations

Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice

1996 • 1,902 citations

DFF, a Heterodimeric Protein That Functions Downstream of Caspase-3 to Trigger DNA Fragmentation during Apoptosis

1997 • 1,848 citations

Induction of Apoptosis by Apo-2 Ligand, a New Member of the Tumor Necrosis Factor Cytokine Family

1996 • 1,793 citations

Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis

1996 • 1,784 citations

The Receptor for the Cytotoxic Ligand TRAIL

1997 • 1,755 citations

Monoclonal Antibody-Mediated Tumor Regression by Induction of Apoptosis

1989 • 1,739 citations

Altered Cytokine Export and Apoptosis in Mice Deficient in Interleukin-1β Converting Enzyme

1995 • 1,625 citations

Fas(CD95)/FasL interactions required for programmed cell death after T-cell activation

1995 • 1,549 citations

Double identity for proteins of the Bcl-2 family

1997 • 1,511 citations

Dominant interfering fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome

1995 • 1,477 citations

X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death

1996 • 1,456 citations

Mice deficient in IL-1β-converting enzyme are defective in production of mature IL-1β and resistant to endotoxic shock

1995 • 1,413 citations

Induction of apoptosis in fibroblasts by IL-1β-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3

1993 • 1,387 citations

Apoptosis in cancer therapy: Crossing the threshold

1994 • 1,351 citations

Somatic Frameshift Mutations in the BAX Gene in Colon Cancers of the Microsatellite Mutator Phenotype

1997 • 1,329 citations

Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors

1997 • 1,305 citations

BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax

1994 • 1,303 citations

CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme.

1994 • 1,239 citations

FLICE is activated by association with the CD95 death-inducing signaling complex (DISC)

1997 • 1,207 citations

CELL DEATHS IN NORMAL VERTEBRATE ONTOGENY

1951 • 1,194 citations

Cloning the chromosomal breakpoint of t(14;18) human lymphomas: clustering around Jh on chromosome 14 and near a transcriptional unit on 18

1985 • 1,188 citations

Lpr and gld: Single Gene Models of Systemic Autoimmunity and Lymphoproliferative Disease

1991 • 1,185 citations

A role for CD95 ligand in preventing graft rejection

1995 • 1,184 citations

Suppression of ICE and Apoptosis in Mammary Epithelial Cells by Extracellular Matrix

1995 • 1,184 citations

TNF-Dependent Recruitment of the Protein Kinase RIP to the TNF Receptor-1 Signaling Complex

1996 • 1,154 citations

Complementation used to clone a human homologue of the fission yeast cell cycle control gene cdc2

1987 • 1,153 citations

C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2

1994 • 1,145 citations

Bcl-2 inhibits the mitochondrial release of an apoptogenic protease.

1996 • 1,143 citations

Induction of apoptosis in mature T cells by tumour necrosis factor

1995 • 1,139 citations

bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship

1991 • 1,090 citations

Bcl-2 initiates a new category of oncogenes: regulators of cell death

1992 • 1,078 citations

Genetic Control of Programmed Cell Death in Drosophila

1994 • 1,028 citations

Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes

1996 • 1,027 citations

The t(14;18) Chromosome Translocations Involved in B-Cell Neoplasms Result from Mistakes in VDJ Joining

1985 • 1,021 citations

Viral inhibition of inflammation: Cowpox virus encodes an inhibitor of the interleukin-1β converting enzyme

1992 • 981 citations

Apoptotic cell death induced by c-myc is inhibited by bcl-2

1992 • 981 citations

Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis

1996 • 980 citations

Molecular cloning and expression of a receptor for human tumor necrosis factor

1990 • 973 citations

Nucleotide sequence of a t(14;18) chromosomal breakpoint in follicular lymphoma and demonstration of a breakpoint-cluster region near a transcriptionally active locus on chromosome 18.

1985 • 972 citations

RIP: A novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death

1995 • 964 citations

Haemopoietic colony stimulating factors promote cell survival by suppressing apoptosis

1990 • 945 citations

Death in Embryonic Systems

1966 • 943 citations

Molecular cloning and expression of the human 55 kd tumor necrosis factor receptor

1990 • 918 citations

BAX-induced cell death may not require interleukin 1β-converting enzyme-like proteases

1996 • 911 citations

Caenorhabditis elegans gene ced-9 protects cells from programmed cell death

1992 • 889 citations

Apoptosis induced by anticancer drugs

1992 • 861 citations

Constitutive c-myc expression in an IL-3-dependent myeloid cell line suppresses cell cycle arrest and accelerates apoptosis.

1991 • 861 citations

Bcl-2 initiates a new category of oncogenes: regulators of cell death

1992 • 860 citations

Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells

1994 • 844 citations

Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death

1994 • 843 citations

Structure and mechanism of interleukin-lβ converting enzyme

1994 • 842 citations

Multiple Bcl-2 family members demonstrate selective dimerizations with Bax.

1995 • 832 citations

Prevention of Apoptosis by a Baculovirus Gene During Infection of Insect Cells

1991 • 810 citations

Checkpoints of dueling dimers foil death wishes

1994 • 806 citations

Two tumour necrosis factor receptors: structure and function

1995 • 800 citations

Daxx, a Novel Fas-Binding Protein That Activates JNK and Apoptosis

1997 • 797 citations

Bcl-2 Targets the Protein Kinase Raf-1 to Mitochondria

1996 • 785 citations

FADD/MORT1 Is a Common Mediator of CD95 (Fas/APO-1) and Tumor Necrosis Factor Receptor-induced Apoptosis

1996 • 780 citations

Induction of Apoptosis by the Low-Affinity NGF Receptor

1993 • 774 citations

Cooperative interaction between c-myc and bcl-2 proto-oncogenes

1992 • 766 citations

Induction of cell death by endogenous nerve growth factor through its p75 receptor

1996 • 750 citations

c-Myc-induced apoptosis in fibroblasts is inhibited by specific cytokines.

1994 • 747 citations

Membrane and Morphological Changes in Apoptotic Cells Regulated by Caspase-Mediated Activation of PAK2

1997 • 742 citations

Induction of apoptosis by the Bcl-2 homologue Bak

1995 • 738 citations

Drosophila homologs of baculovirus inhibitor of apoptosis proteins function to block cell death

1995 • 728 citations

Prevention of Programmed Cell Death of Sympathetic Neurons by the bcl-2 Proto-Oncogene

1992 • 724 citations

Activation of the apoptotic protease CPP32 by cytotoxic T-cell-derived granzyme B

1995 • 720 citations

The head involution defective gene of Drosophila melanogaster functions in programmed cell death.

1995 • 685 citations

Proteolytic activation of protein kinase C delta by an ICE-like protease in apoptotic cells.

1995 • 684 citations

Signal Transduction by DR3, a Death Domain-Containing Receptor Related to TNFR-1 and CD95

1996 • 653 citations

A License to Kill

1996 • 649 citations

Inhibition of ICE Family Proteases by Baculovirus Antiapoptotic Protein p35

1995 • 645 citations

A conserved family of cellular genes related to the baculovirus iap gene and encoding apoptosis inhibitors.

1996 • 637 citations

Interaction of CED-4 with CED-3 and CED-9: A Molecular Framework for Cell Death

1997 • 635 citations

Prevention of Vertebrate Neuronal Death by the crmA Gene

1994 • 618 citations

Requirement of an ICE/CED-3 protease for Fas/APO-1-mediated apoptosis

1995 • 616 citations

Prevention of Programmed Cell Death in Caenorhabditis elegans by Human bcl-2

1992 • 608 citations

Post-translational modification of poly(ADP-ribose) polymerase induced by DNA strand breaks

1995 • 600 citations

Lamin proteolysis facilitates nuclear events during apoptosis.

1996 • 587 citations

Cell-free apoptosis in Xenopus egg extracts: Inhibition by Bcl-2 and requirement for an organelle fraction enriched in mitochondria

1994 • 577 citations

Requirement for the orphan steroid receptor Nur77 in apoptosis of T-cell hybridomas

1994 • 571 citations

Programmed cell death and Bcl-2 protection in the absence of a nucleus.

1994 • 560 citations

Inhibition of Ced-3/ICE-related Proteases Does Not Prevent Cell Death Induced by Oncogenes, DNA Damage, or the Bcl-2 Homologue Bak

1997 • 555 citations

Apoptotic signals delivered through the T-cell receptor of a T-cell hybrid require the immediate–early gene nur77

1994 • 551 citations

RAIDD is a new 'death' adaptor molecule

1997 • 547 citations

RIP mediates tumor necrosis factor receptor 1 activation of NF-kappaB but not Fas/APO-1-initiated apoptosis.

1996 • 540 citations

Proteolysis of Fodrin (Non-erythroid Spectrin) during Apoptosis

1995 • 539 citations

Cleavage of lamin A by Mch2 alpha but not CPP32: multiple interleukin 1 beta-converting enzyme-related proteases with distinct substrate recognition properties are active in apoptosis.

1996 • 529 citations

Apoptosis: a different type of cell death

1992 • 523 citations

Evidence for an Active-Center Histidine in Trypsin through Use of a Specific Reagent, 1-Chloro-3-tosylamido-7-amino-2-heptanone, the Chloromethyl Ketone Derived from N^α-Tosyl-L-lysine^*

1965 • 521 citations

Molecular ordering of the Fas-apoptotic pathway: The Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteine proteases

1996 • 519 citations

Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors.

1996 • 515 citations

Modulation of apoptosis by the widely distributed Bcl-2 homologue Bak

1995 • 514 citations

The Regulation of Anoikis: MEKK-1 Activation Requires Cleavage by Caspases

1997 • 507 citations

Cloning of a bcl-2 homologue by interaction with adenovirus E1B 19K

1995 • 501 citations

Induction of apoptosis (programmed cell death) in human leukemic HL-60 cells by inhibition of RNA or protein synthesis.

1990 • 489 citations

Proteolytic Activation of Protein Kinase C δ by an ICE/CED 3-like Protease Induces Characteristics of Apoptosis

1996 • 484 citations

Substrates for p34cdc2: In vivo veritas?

1990 • 472 citations

Cathepsin D protease mediates programmed cell death induced by interferon-gamma, Fas/APO-1 and TNF-alpha.

1996 • 467 citations

Inhibition of the Caenorhabditis elegans cell-death protease CED-3 by a CED-3 cleavage site in baculovirus p35 protein

1995 • 467 citations

The CED-3/ICE-like Protease Mch2 Is Activated during Apoptosis and Cleaves the Death Substrate Lamin A

1996 • 466 citations

Proapoptotic Protein Bax Heterodimerizes with Bcl-2 and Homodimerizes with Bax via a Novel Domain (BH3) Distinct from BH1 and BH2

1996 • 462 citations

Nuclear events of apoptosis in vitro in cell-free mitotic extracts: a model system for analysis of the active phase of apoptosis.

1993 • 452 citations

ICE Family Proteases: Mediators of All Apoptotic Cell Death?

1996 • 440 citations

Cell nucleus and DNA fragmentation are not required for apoptosis.

1994 • 436 citations

Death effector domain-containing herpesvirus and poxvirus proteins inhibit both Fas- and TNFR1-induced apoptosis

1997 • 433 citations

The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 signaling complex

1996 • 415 citations

grim, a novel cell death gene in Drosophila.

1996 • 414 citations

Mch2, a new member of the apoptotic Ced-3/Ice cysteine protease gene family.

1995 • 407 citations

The cell cycle related differences in susceptibility of HL-60 cells to apoptosis induced by various antitumor agents.

1993 • 403 citations

Casper Is a FADD- and Caspase-Related Inducer of Apoptosis

1997 • 398 citations

Naturally Occurring Neuronal Death in Vertebrates

1990 • 389 citations

Constitutive expression of the machinery for programmed cell death.

1996 • 386 citations

Phosphatidylserine Externalization during CD95-induced Apoptosis of Cells and Cytoplasts Requires ICE/CED-3 Protease Activity

1996 • 386 citations

NMR structure and mutagenesis of the Fas (APO-1/CD95) death domain

1996 • 379 citations

Braking the cycle

1993 • 378 citations

Targeted mutation in the Fas gene causes hyperplasia in peripheral lymphoid organs and liver

1995 • 377 citations

Cell Killing by the Drosophila Gene reaper

1996 • 375 citations

I-FLICE, a Novel Inhibitor of Tumor Necrosis Factor Receptor-1- and CD-95-induced Apoptosis

1997 • 372 citations

Role of Ced-3/ICE-family proteases in staurosporine-induced programmed cell death.

1996 • 371 citations

Bcl-2 blocks p53-dependent apoptosis.

1994 • 371 citations

Suppression of signalling through transcription factor NF-AT by interactions between calcineurin and Bcl-2

1997 • 368 citations

The Baculovirus p35 Protein Inhibits Fas- and Tumor Necrosis Factor-induced Apoptosis

1995 • 366 citations

Bcl-2 interacting protein, BAG-1, binds to and activates the kinase Raf-1.

1996 • 364 citations

The 19-Kilodalton Adenovirus E1B Transforming Protein Inhibits Programmed Cell Death and Prevents Cytolysis by Tumor Necrosis Factor α

1992 • 354 citations

Inhibition of interleukin-1 beta converting enzyme by the cowpox virus serpin CrmA. An example of cross-class inhibition.

1994 • 352 citations

The cell-death machine

1996 • 351 citations

Signal Transduction Pathways Regulated by Mitogen-activated/Extracellular Response Kinase Kinase Kinase Induce Cell Death

1996 • 346 citations

Chromatin condensation during apoptosis is accompanied by degradation of lamin A+B, without enhanced activation of cdc2 kinase.

1994 • 345 citations

Interaction and Regulation of Subcellular Localization of CED-4 by CED-9

1997 • 345 citations

Cross talk between cell death and cell cycle progression: BCL-2 regulates NFAT-mediated activation.

1996 • 344 citations

A Novel Family of Viral Death Effector Domain-containing Molecules That Inhibit Both CD-95- and Tumor Necrosis Factor Receptor-1-induced Apoptosis

1997 • 343 citations

Multiple agents rescue PC12 cells from serum-free cell death by translation- and transcription-independent mechanisms

1991 • 337 citations

A death-domain-containing receptor that mediates apoptosis

1996 • 333 citations

Peptide inhibitors of the ice protease family arrest programmed cell death of motoneurons in vivo and in vitro

1995 • 324 citations

CASH, a Novel Caspase Homologue with Death Effector Domains

1997 • 323 citations

Fas-induced Activation of the Cell Death-related Protease CPP32 Is Inhibited by Bcl-2 and by ICE Family Protease Inhibitors

1996 • 321 citations

Regulation of apoptosis in the immune system

1994 • 321 citations

Contenders in FasL/TNF death signaling

1995 • 319 citations

Caspase-3-mediated Cleavage of Protein Kinase C θ in Induction of Apoptosis

1997 • 308 citations

Divergent signalling via APO-1/Fas and the TNF receptor, two homologous molecules involved in physiological cell death.

1994 • 304 citations

ICE-LAP6, a Novel Member of the ICE/Ced-3 Gene Family, Is Activated by the Cytotoxic T Cell Protease Granzyme B

1996 • 304 citations

Bcl-2 interrupts the ceramide-mediated pathway of cell death.

1996 • 302 citations

The Ced-3/Interleukin 1β Converting Enzyme-like Homolog Mch6 and the Lamin-cleaving Enzyme Mch2α Are Substrates for the Apoptotic Mediator CPP32

1996 • 295 citations

Metabolism and evolution of Haemophilus influenzae deduced from a whole-genome comparison with Escherichia coli

1996 • 295 citations

Identification of mRNAs Associated with Programmed Cell Death in Immature Thymocytes

1991 • 286 citations

Molecular Cloning and Pro-apoptotic Activity of ICErelII and ICErelIII, Members of the ICE/CED-3 Family of Cysteine Proteases

1995 • 281 citations

The cytotoxic cell protease granzyme B initiates apoptosis in a cell-free system by proteolytic processing and activation of the ICE/CED-3 family protease, CPP32, via a novel two-step mechanism.

1996 • 279 citations

TRAMP, a Novel Apoptosis-Mediating Receptor with Sequence Homology to Tumor Necrosis Factor Receptor 1 and Fas(Apo-1/CD95)

1997 • 268 citations

Identification and Characterization of ICH-2, a Novel Member of the Interleukin-1β-converting Enzyme Family of Cysteine Proteases

1995 • 262 citations

Requirement of an ICE-Like Protease for Induction of Apoptosis and Ceramide Generation by REAPER

1996 • 262 citations

Calcineurin functions in Ca(2+)-activated cell death in mammalian cells.

1995 • 260 citations

Fas-associated Death Domain Protein Interleukin-1β-converting Enzyme 2 (FLICE2), an ICE/Ced-3 Homologue, Is Proximally Involved in CD95- and p55-mediated Death Signaling

1997 • 256 citations

Apo-3, a new member of the tumor necrosis factor receptor family, contains a death domain and activates apoptosis and NF-κB

1996 • 251 citations

Actin cleavage by CPP-32/apopain during the development of apoptosis

1997 • 251 citations

Specific cleavage of the retinoblastoma protein by an ICE-like protease in apoptosis.

1996 • 247 citations

Substrate and Inhibitor Specificity of Interleukin-1β-converting Enzyme and Related Caspases

1997 • 243 citations

Cytotoxicity with target DNA breakdown by rat basophilic leukemia cells expressing both cytolysin and granzyme A

1992 • 243 citations

Identification of mRNAs associated with programmed cell death in immature thymocytes.

1991 • 242 citations

CAR1, a TNFR–Related Protein, Is a Cellular Receptor for Cytopathic Avian Leukosis–Sarcoma Viruses and Mediates Apoptosis

1996 • 236 citations

Cellular substrates of p34cdc2 and its companion cyclin-dependent kinases

1993 • 235 citations

Identification and Characterization of Ich-3, a Member of the Interleukin-1β Converting Enzyme (ICE)/Ced-3 Family and an Upstream Regulator of ICE

1996 • 231 citations

Bcl-x_Lcan inhibit apoptosis in cells that have undergone Fas-induced protease activation

1997 • 222 citations

D4-GDI, a Substrate of CPP32, Is Proteolyzed during Fas-induced Apoptosis

1996 • 216 citations

Myc-mediated apoptosis is blocked by ectopic expression of Bcl-2.

1993 • 214 citations

PITSLRE protein kinase activity is associated with apoptosis

1995 • 212 citations

Activation of Multiple Interleukin-1β Converting Enzyme Homologues in Cytosol and Nuclei of HL-60 Cells during Etoposide-induced Apoptosis

1997 • 211 citations

Specific Cleavage of α-Fodrin during Fas- and Tumor Necrosis Factor-induced Apoptosis Is Mediated by an Interleukin-1β-converting Enzyme/Ced-3 Protease Distinct from the Poly(ADP-ribose) Polymerase Protease

1996 • 211 citations

CrmA, a Poxvirus-encoded Serpin, Inhibits Cytotoxic T-lymphocyte-mediated Apoptosis

1995 • 207 citations

The 19-kilodalton adenovirus E1B transforming protein inhibits programmed cell death and prevents cytolysis by tumor necrosis factor alpha.

1992 • 199 citations

TRAF-interacting Protein (TRIP): A Novel Component of the Tumor Necrosis Factor Receptor (TNFR)- and CD30-TRAF Signaling Complexes That Inhibits TRAF2-mediated NF-κB Activation

1997 • 196 citations

A Fas-associated protein factor, FAF1, potentiates Fas-mediated apoptosis.

1995 • 194 citations

Internucleosomal DNA cleavage and neuronal cell survival/death

1993 • 194 citations

Activation of the Native 45-kDa Precursor Form of Interleukin-1-converting Enzyme

1996 • 193 citations

The contrasting roles of ICE family proteases and interleukin-1beta in apoptosis induced by trophic factor withdrawal and by copper/zinc superoxide dismutase down-regulation.

1996 • 190 citations

Proteolytic activation of the cell death protease Yama/CPP32 by granzyme B.

1996 • 175 citations

Degradation of Retinoblastoma Protein in Tumor Necrosis Factor- and CD95-induced Cell Death

1997 • 170 citations

Pivotal role of a DEVD-sensitive step in etoposide-induced and Fas-mediated apoptotic pathways.

1996 • 167 citations

Apoptosis by a cytosolic extract from Fas-activated cells.

1995 • 167 citations

Glucocorticoid-induced apoptosis in the thymus.

1992 • 167 citations

Bcl-2 prevents death of factor-deprived cells but fails to prevent apoptosis in targets of cell mediated killing

1992 • 165 citations

Different Interleukin-1β Converting Enzyme (ICE) Family Protease Requirements for the Apoptotic Death of T Lymphocytes Triggered by Diverse Stimuli

1996 • 164 citations

Bax- and Bak-induced cell death in the fission yeast Schizosaccharomyces pombe.

1997 • 160 citations

The ICE family of cysteine proteases as effectors of cell death.

1996 • 158 citations

Cleavage of Poly(ADP-ribose) Polymerase by Interleukin-1β Converting Enzyme and Its Homologs TX and Nedd-2

1995 • 155 citations

Drawings of British Plants, Being Illustrations of the Species of Flowering Plants Growing Naturally in the British Isles. Parts I-III: Ranunculaceae to Cruciferae.Stella Ross-Craig

1951 • 154 citations

Cloning and Expression of Four Novel Isoforms of Human Interleukin-1β Converting Enzyme with Different Apoptotic Activities

1995 • 149 citations

An Alternatively Spliced C. elegans ced-4 RNA Encodes a Novel Cell Death Inhibitor

1996 • 146 citations

The CD95 (APO-1/Fas) Receptor Activates NF- B Independently of Its Cytotoxic Function

1996 • 146 citations

Increased Expression of the Insulin-like Growth Factor-II Gene in Wilms' Tumor Is Not Dependent on Loss of Genomic Imprinting or Loss of Heterozygosity

1996 • 140 citations

The control of apoptosis in mammalian cells

1993 • 139 citations

Cleavage of PITSLRE Kinases by ICE/CASP-1 and CPP32/CASP-3 during Apoptosis Induced by Tumor Necrosis Factor

1997 • 138 citations

The Distal Pathway of Lipoprotein-induced Cholesterol Esterification, but Not Sphingomyelinase-induced Cholesterol Esterification, Is Energy-dependent

1996 • 137 citations

Purification of an Interleukin-1β Converting Enzyme-related Cysteine Protease That Cleaves Sterol Regulatory Element-binding Proteins between the Leucine Zipper and Transmembrane Domains

1995 • 135 citations

Processing/Activation of At Least Four Interleukin-1β Converting Enzyme–like Proteases Occurs during the Execution Phase of Apoptosis in Human Monocytic Tumor Cells

1997 • 135 citations

Phosphorylation of Bcl-2 Protein and Association with p21Ras in Ras-induced Apoptosis

1996 • 132 citations

Cloning of a novel tumor necrosis factor-alpha-inducible primary response gene that is differentially expressed in development and capillary tube-like formation in vitro.

1992 • 129 citations

ICE/CED-3 proteasesin apoptosis

1996 • 128 citations

Human Bak Induces Cell Death in Schizosaccharomyces pombe with Morphological Changes Similar to Those with Apoptosis in Mammalian Cells

1997 • 125 citations

CED-4 induces chromatin condensation in Schizosaccharomyces pombe and is inhibited by direct physical association with CED-9

1997 • 120 citations

A Mouse Fas-Associated Protein with Homology to the Human Mort1/FADD Protein Is Essential for Fas-Induced Apoptosis

1996 • 117 citations

The substrates of the cdc2 kinase.

1991 • 115 citations

Involvement of extracellular calcium in phosphatidylserine exposure during apoptosis

1996 • 114 citations

RIP and FADD: two "death domain"-containing proteins can induce apoptosis by convergent, but dissociable, pathways.

1996 • 114 citations

Active Site Amino Acids That Participate in the Catalytic Mechanism of Nucleoside 2′-Deoxyribosyltransferase

1996 • 113 citations

A Peptide Sequence from Bax That Converts Bcl-2 into an Activator of Apoptosis

1996 • 111 citations

The death domain motif found in Fas (Apo‐1) and TNF receptor is present in proteins involved in apoptosis and axonal guidance

1995 • 109 citations

Activation of thereaperGene during Ectopic Cell Killing inDrosophila

1996 • 109 citations

Cell-mediated cytotoxicity

1993 • 108 citations

Identification of a Decay in Transcription Potential That Results in Elongation Factor Dependence of RNA Polymerase II

1995 • 108 citations

Bcl-2 Prevents CD95 (Fas/APO-1)-induced Degradation of Lamin B and Poly(ADP-ribose) Polymerase and Restores the NF-κB Signaling Pathway

1996 • 107 citations

The killer and the executioner: how apoptosis controls malignancy

1995 • 104 citations

Nuclear Transport of Granzyme B (Fragmentin-2)

1996 • 104 citations

Identification of the MDM2 Oncoprotein as a Substrate for CPP32-like Apoptotic Proteases

1997 • 103 citations

TNF-induced intracellular signaling leading to gene induction or to cytotoxicity by necrosis or by apoptosis.

1995 • 102 citations

Molecular control of life and death

1995 • 95 citations

The target cell nucleus is not required for cell-mediated granzyme- or Fas-based cytotoxicity.

1995 • 92 citations

Anti-apoptotic genes of baculoviruses.

1996 • 88 citations

Doom, a Product of the Drosophila mod(mdg4) Gene, Induces Apoptosis and Binds to Baculovirus Inhibitor-of-Apoptosis Proteins

1997 • 86 citations

Inhibitors of proteases prevent endonucleolysis accompanying apoptotic death of HL-60 leukemic cells and normal thymocytes.

1992 • 86 citations

Activation of an interleukin 1 converting enzyme-dependent apoptosis pathway by granzyme B.

1996 • 83 citations

Mechanisms And Functions Of Cell Death

1991 • 77 citations

CD95 (APO-1/Fas)-associating signalling proteins.

1996 • 76 citations

Cellular signaling in thymocyte apoptosis.

1992 • 75 citations

Apoptosis in erythroid progenitors deprived of erythropoietin occurs during the G1 and S phases of the cell cycle without growth arrest or stabilization of wild-type p53.

1994 • 73 citations

CrmA/SPI-2 Inhibition of an Endogenous ICE-related Protease Responsible for Lamin A Cleavage and Apoptotic Nuclear Fragmentation

1996 • 72 citations

Bik and Bak Induce Apoptosis Downstream of CrmA but Upstream of Inhibitor of Apoptosis

1997 • 72 citations

Baculovirus P35 inhibits the glucocorticoid-mediated pathway of cell death.

1997 • 64 citations

Rapid turnover of endogenous endonuclease activity in thymocytes: Effects of inhibitors of macromolecular synthesis

1990 • 60 citations

TRAF protiens and meprins share a conserved domain

1996 • 59 citations

Coming to terms with death: apoptosis in cancer and immune development

1994 • 56 citations

The cytotoxic T cell proteinase granzyme B does not activate interleukin-1 beta-converting enzyme.

1994 • 55 citations

Interleukin-1 beta-converting enzyme-like protease cleaves DNA-dependent protein kinase in cytotoxic T cell killing.

1996 • 54 citations

Inhibition of ceramide-induced apoptosis by Bcl-2.

1995 • 54 citations

Neither Macromolecular Synthesis nor Myc Is Required for Cell Death via the Mechanism That Can Be Controlled by Bcl-2

1993 • 53 citations

DNA Fragmentation Induced by Protease Activation in p53-Null Human Leukemia HL60 Cells Undergoing Apoptosis Following Treatment with the Topoisomerase I Inhibitor Camptothecin: Cell-Free System Studies

1996 • 50 citations

Apoptotic Activity of REAPER Is Distinct from Signaling by the Tumor Necrosis Factor Receptor 1 Death Domain

1996 • 48 citations

Viral inhibition of apoptosis

1996 • 44 citations

Inhibition of CPP32-like proteases prevents granzyme B- and Fas-, but not granzyme A-based cytotoxicity exerted by CTL clones.

1997 • 39 citations

Neither macromolecular synthesis nor myc is required for cell death via the mechanism that can be controlled by Bcl-2.

1993 • 34 citations

TRAF proteins and meprins share a conserved domain

1996 • 33 citations

Mechanisms of cytotoxicity caused by antitumour drugs

1992 • 27 citations

Dissecting processing and apoptotic activity of a cysteine protease by mutant analysis.

1996 • 26 citations

TCR cross-linking induces CTL death via internal action of TNF.

1994 • 25 citations

The ability of Bcl-x(L) and Bcl-2 to prevent apoptosis can be differentially regulated.

1996 • 24 citations

Fas activates NF-κB and induces apoptosis in T-cell lines by signaling pathways distinct from those induced by TNF-α

1997 • 23 citations

Activation of apoptosis pathways by granzyme B.

1996 • 22 citations

The involvement of RNA and protein synthesis in programmed cell death (apoptosis) in human leukaemia HL-60 cells

1990 • 17 citations

Target cell death triggered by cytotoxic T lymphocytes: a target cell mutant distinguishes passive pore formation and active cell suicide mechanisms

1994 • 13 citations

A link between cell-surface receptors and ICE proteases

1996 • 12 citations

Target cell death triggered by cytotoxic T lymphocytes: a target cell mutant distinguishes passive pore formation and active cell suicide mechanisms.

1994 • 9 citations