Protection From Apoptosis by Steel Factor But Not Interleukin-3 Is Reversed Through Blockade of Calcium Influx

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

1972 • 15,349 citations

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

1995 • 4,003 citations

Yama/CPP32β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase

1995 • 2,402 citations

Bcl-2 and the regulation of programmed cell death

1994 • 2,346 citations

Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo.

1994 • 2,141 citations

Double identity for proteins of the Bcl-2 family

1997 • 1,511 citations

BCL2 protein is topographically restricted in tissues characterized by apoptotic cell death.

1991 • 1,301 citations

bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes

1991 • 1,223 citations

Antibodies to CD3/T-cell receptor complex induce death by apoptosis in immature T cells in thymic cultures

1989 • 1,159 citations

bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship

1991 • 1,090 citations

Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis

1996 • 980 citations

Deregulated Bcl-2 gene expression selectively prolongs survival of growth factor-deprived hemopoietic cell lines.

1990 • 926 citations

Characterization of ionomycin as a calcium ionophore.

1978 • 535 citations

Apoptosis induced by withdrawal of interleukin-3 (IL-3) from an IL-3-dependent hematopoietic cell line is associated with repartitioning of intracellular calcium and is blocked by enforced Bcl-2 oncoprotein production.

1993 • 488 citations

ICE Family Proteases: Mediators of All Apoptotic Cell Death?

1996 • 440 citations

A Transplantable Mast-Cell Neoplasm in the Mouse

1957 • 438 citations

The cell-death machine

1996 • 351 citations

Calcium-dependent killing of immature thymocytes by stimulation via the CD3/T cell receptor complex.

1989 • 315 citations

Expression of the Bcl-2 protein in murine and human thymocytes and in peripheral T lymphocytes.

1993 • 286 citations

The c-kit ligand, stem cell factor, promotes mast cell survival by suppressing apoptosis.

1994 • 279 citations

The Steel/W transduction pathway: kit autophosphorylation and its association with a unique subset of cytoplasmic signaling proteins is induced by the Steel factor.

1991 • 264 citations

Calcineurin functions in Ca(2+)-activated cell death in mammalian cells.

1995 • 260 citations

Activation of a suicide process of thymocytes through DNA fragmentation by calcium ionophores and phorbol esters.

1989 • 242 citations

Ketotifen

1990 • 228 citations

Tumor necrosis factor-induced apoptosis is mediated by a CrmA-sensitive cell death pathway.

1995 • 222 citations

Ligand-independent activation of c-kit receptor tyrosine kinase in a murine mastocytoma cell line P-815 generated by a point mutation

1994 • 217 citations

The pharmacological properties of a new, orally active antianaphylactic compound: ketotifen, a benzocycloheptathiophene.

1978 • 216 citations

Peripheral Clonal Elimination of Functional T Cells

1990 • 213 citations

Characterization of seven murine caspase family members

1997 • 207 citations

Prevention of myeloma cell apoptosis by ectopic bcl-2 expression or interleukin 6-mediated up-regulation of bcl-xL.

1995 • 200 citations

Nuclear calcium transport and the role of calcium in apoptosis

1994 • 178 citations

Bcl-2 blocks glucocorticoid- but not Fas- or activation-induced apoptosis in a T cell hybridoma.

1995 • 178 citations

Chronic depolarization prevents programmed death of sympathetic neurons in vitro but does not support growth: requirement for Ca2+ influx but not Trk activation

1995 • 171 citations

Role of kit-ligand in proliferation and suppression of apoptosis in mast cells: basis for radiosensitivity of white spotting and steel mutant mice.

1994 • 170 citations

Interleukin‐1βconverting enzyme: A novel cysteine protease required for IL‐1β production and implicated in programmed cell death

1995 • 170 citations

Calcium influx and its control by calcium release

1993 • 167 citations

Different Interleukin-1β Converting Enzyme (ICE) Family Protease Requirements for the Apoptotic Death of T Lymphocytes Triggered by Diverse Stimuli

1996 • 164 citations

Non-specific effects of calcium entry antagonists in mast cells

1994 • 164 citations

Poly(ADP-ribose) polymerase enhances activator-dependent transcription in vitro

1997 • 153 citations

The c-kit ligand suppresses apoptosis of human natural killer cells through the upregulation of bcl-2.

1994 • 151 citations

Calcium/magnesium-dependent endonuclease from human spleen: Purification, properties, and role in apoptosis

1993 • 123 citations

Stem Cell Factor as a Survival and Growth Factor in Human Normal and Malignant Hematopoiesis

1996 • 118 citations

In vivo efficacy of a novel inhibitor of selected signal transduction pathways including calcium, arachidonate, and inositol phosphates.

1992 • 116 citations

The cell cycle block and lysis of an activated T cell hybridoma are distinct processes with different Ca2+ requirements and sensitivity to cyclosporine A.

1989 • 110 citations

Mast-cell stabilization to decrease neurofibroma growth. Preliminary experience with ketotifen.

1987 • 105 citations

Effects of interleukin-3 and c-kit ligand on the survival of various classes of human hematopoietic progenitor cells

1994 • 99 citations

Effects of interleukin-3 and c-kit ligand on the survival of various classes of human hematopoietic progenitor cells

1994 • 94 citations

Product of the steel locus suppresses apoptosis in hemopoietic cells. Comparison with pathways activated by granulocyte macrophage colony-stimulating factor.

1994 • 90 citations

Leukocyte common antigen (CD45) is required for immunoglobulin E-mediated degranulation of mast cells.

1994 • 89 citations

CD4⁺CD8⁺ thymocytes are susceptible to DNA fragmentation induced by phorbol ester, calcium ionophore and anti‐CD3 antibody

1990 • 78 citations

Mast-Cell Stabilization to Decrease Neurofibroma Growth

1987 • 76 citations

8 Calcium Regulation of Apoptosis

1995 • 68 citations

Substrate phosphorylation specificity of the human c-kit receptor tyrosine kinase.

1991 • 64 citations

The phosphoprotein phosphatase calcineurin controls calcium‐dependent apoptosis in B cell lines

1994 • 58 citations

Suppression of programmed neuronal death by a thapsigargin‐induced Ca²⁺ influx

1995 • 58 citations

Inhibition of apoptosis by calcium ionophores in IL-3-dependent bone marrow cells is dependent upon production of IL-4+.

1992 • 52 citations

Granulocyte‐Macrophage colony‐stimulating factor and steel factor induce phosphorylation of both unique and overlapping signal transduction intermediates in a human factor‐dependent hematopoietic cell line

1992 • 49 citations

Competence induction by PDGF requires sustained calcium influx by a mechanism distinct from storage-dependent calcium influx

1993 • 47 citations

Elevated Intracellular Calcium Blocks Programmed Neuronal Death

1994 • 45 citations

Human interleukin-3 stimulates a phosphatidylcholine specific phospholipase C and protein kinase C translocation.

1994 • 36 citations

Cross-linking of the Fas/APO-1 antigen suppresses the CD3-mediated signal transduction events in human T lymphocytes.

1995 • 35 citations

The role of calcium influx in cellular proliferation induced by interaction of endogenous ganglioside GM1 with the B subunit of cholera toxin

1995 • 24 citations

Studies of the intracellular Ca2+ levels in human adult skin mast cells activated by the ligand for the human c-kit receptor and anti-IgE

1994 • 23 citations

c-KIT expression enhances the leukemogenic potential of 32D cells.

1995 • 21 citations

The antiinflammatory activity of topically applied novel calcium-channel antagonists

1995 • 13 citations

Effects of ketotifen on human lymphocytes in vitro and in vivo.

1993 • 6 citations