Nuclear calcium transport and the role of calcium in apoptosis

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

Thapsigargin, a tumor promoter, discharges intracellular Ca2+ stores by specific inhibition of the endoplasmic reticulum Ca2(+)-ATPase.

1990 • 3,250 citations

Apoptosis: Mechanisms and Roles in Pathology

1991 • 1,368 citations

Regulation of Gene Expression in Hippocampal Neurons by Distinct Calcium Signaling Pathways

1993 • 1,165 citations

Contingent Genetic Regulatory Events in T Lymphocyte Activation

1989 • 1,108 citations

Role of ion flux in the control of c-fos expression

1986 • 1,006 citations

Continuous c-fos expression precedes programmed cell death in vivo

1993 • 784 citations

Calcium‐activated DNA fragmentation kills immature thymocytes

1989 • 533 citations

Calcium-Mediated Mechanisms in Chemically Induced Cell Death

1992 • 518 citations

Architecture and design of the nuclear pore complex

1992 • 452 citations

Calpain activation in apoptosis

1994 • 445 citations

The Caenorhabditis elegans cell death gene ced-4 encodes a novel protein and is expressed during the period of extensive programmed cell death

1992 • 387 citations

Subcellular Calcium Transients Visualized by Confocal Microscopy in a Voltage-Clamped Vertebrate Neuron

1990 • 341 citations

ATP stimulates Ca2+ uptake and increases the free Ca2+ concentration in isolated rat liver nuclei.

1989 • 284 citations

Calcium-activated DNA Fragmentation in Rat Liver Nuclei

1989 • 281 citations

2,5-Di-(tert-butyl)-1,4-benzohydroquinone rapidly elevates cytosolic Ca2+ concentration by mobilizing the inositol 1,4,5-trisphosphate-sensitive Ca2+ pool

1989 • 261 citations

Characterization of SAF-A, a novel nuclear DNA binding protein from HeLa cells with high affinity for nuclear matrix/scaffold attachment DNA elements.

1992 • 255 citations

Intracellular Ca2+ Signals Activate Apoptosis in Thymocytes: Studies Using the Ca2+-ATPase Inhibitor Thapsigargin

1994 • 253 citations

Ratiometric confocal Ca2+-measurements with visible wavelength indicators in isolated cardiac myocytes

1993 • 244 citations

Changes in calmodulin and its mrna accompany reentry of quiescent (G0) cells into the cell cycle

1984 • 229 citations

Nuclear Ca2+ concentration measured with specifically targeted recombinant aequorin.

1993 • 200 citations

Tumor necrosis factor alpha induces apoptosis in mammary adenocarcinoma cells by an increase in intranuclear free Ca2+ concentration and DNA fragmentation.

1992 • 190 citations

Stereospecific inositol 1,4,5-[32P]trisphosphate binding to isolated rat liver nuclei: evidence for inositol trisphosphate receptor-mediated calcium release from the nucleus.

1990 • 188 citations

Increased Activity of L-Type Ca ²⁺ Channels Exposed to Serum from Patients with Type I Diabetes

1993 • 188 citations

Spermine prevents endonuclease activation and apoptosis in thymocytes*1

1991 • 181 citations

Regional Changes in Calcium Underlying Contraction of Single Smooth Muscle Cells

1987 • 179 citations

An inositol 1,4,5-trisphosphate-sensitive Ca2+ pool in liver nuclei.

1990 • 165 citations

Calcium and calmodulin function in the cell nucleus.

1992 • 164 citations

Evidence for early induction of calmodulin gene expression in lymphocytes undergoing glucocorticoid-mediated apoptosis.

1991 • 157 citations

The calcium pump of the liver nuclear membrane is identical to that of endoplasmic reticulum.

1992 • 143 citations

Calcium-promoted DNA cleavage by eukaryotic topoisomerase II: trapping the covalent enzyme-DNA complex in an active form

1987 • 134 citations

Stimulation of nuclear protein kinase C leads to phosphorylation of nuclear inositol 1,4,5-trisphosphate receptor and accelerated calcium release by inositol 1,4,5-trisphosphate from isolated rat liver nuclei.

1993 • 133 citations

Calcium ionophore A23187 induces expression of the growth arrest and DNA damage inducible CCAAT/enhancer-binding protein (C/EBP)-related gene, gadd153. Ca2+ increases transcriptional activity and mRNA stability.

1992 • 129 citations

Stable expression of the calbindin-D28K complementary DNA interferes with the apoptotic pathway in lymphocytes.

1992 • 125 citations

Some Electrical Properties of a Nuclear Membrane Examined with a Microelectrode

1963 • 122 citations

A model for chromatin opening: stimulation of topoisomerase II and restriction enzyme cleavage of chromatin by distamycin.

1993 • 120 citations

Role of calcium in the programmed death of rat prostatic glandular cells

1990 • 115 citations

Expression of a constitutive form of calcium/calmodulin dependent protein kinase II leads to arrest of the cell cycle in G2.

1992 • 108 citations

Differences in regulation between nuclear and cytoplasmic Ca2+ in cultured smooth muscle cells

1992 • 108 citations

Integrin receptor-mediated mobilisation of intranuclear calcium in rat osteoclasts

1993 • 98 citations

Stimulated rise in neuronal calcium is faster and greater in the nucleus than the cytosol

1991 • 97 citations

Estimation of intramitochondrial pCa and pH by fura-2 and 2,7 biscarboxyethyl-5(6)-carboxyfluorescein (BCECF) fluorescence

1987 • 96 citations

Intracellular calcium mobilization by inositol 1,4,5-trisphosphate: intracellular movements and compartmentalization

1993 • 95 citations

Measurement of matrix free Mg2+ concentration in rat heart mitochondria by using entrapped fluorescent probes

1990 • 74 citations

Involvement of Ca2+ in the Formation of High-Molecular-Weight DNA Fragments in Thymocyte Apoptosis

1994 • 74 citations

Intracellular Ca2+ and the regulation of early response gene expression in HL-60 myeloid leukemia cells

1993 • 73 citations

Nuclear Ca2+: physiological regulation and role in apoptosis

1994 • 65 citations

Nuclear calcium gradients in cultured rat hepatocytes

1991 • 56 citations

Evidence for stereospecific inositol 1,3,4,5-[3H]tetrakisphosphate binding sites on rat liver nuclei. Delineating inositol 1,3,4,5-tetrakisphosphate interaction in nuclear calcium signaling process.

1993 • 50 citations

Ca(2+)-regulated serine protease associated with the nuclear scaffold.

1992 • 45 citations

Kinetics of nucleocytoplasmic Ca2+ transients in DDT1 MF-2 smooth muscle cells

1992 • 35 citations

Chromatin aggregation changes substantially as pH varies within the physiological range

1989 • 33 citations

Differential control of free calcium and free zinc levels in isolated bovine liver nuclei

1993 • 31 citations

Ion Signalling in Apoptosis

1994 • 25 citations

Novobiocin induces the in vivo cleavage of active gene sequences in intact cells.

1986 • 24 citations

Calcium ionophore‐induced apoptosis of human B cells is preceded by the induced expression of early response genes

1993 • 23 citations

[49] Ca2+/Calmodulin regulation of prolactin gene expression

1987 • 20 citations

Patchy accumulation of apical Na+ transporters allows cross talk between extracellular space and cell nucleus.

1992 • 17 citations

Effect of nicotinamide-adenine dinucleotides on Ca2+ transport system in rat liver nuclei: stimulation of Ca2+ release by NAD+

1993 • 15 citations